GREMLIN Database
DSBE - Thiol:disulfide interchange protein DsbE
UniProt: P0AA86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12053
Length: 185 (159)
Sequences: 8576 (7237)
Seq/√Len: 574.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_P151_G3.3981.00
52_S56_P2.9321.00
96_Q169_E2.7731.00
109_R113_I2.7681.00
91_N122_P2.6991.00
69_K99_R2.6511.00
150_D154_I2.6021.00
91_N95_A2.5171.00
150_D156_R2.4821.00
61_Q64_V2.4111.00
21_L24_L2.1021.00
169_E173_K2.0331.00
84_R119_L2.0321.00
71_V99_R2.0281.00
102_G123_Y1.9881.00
74_N86_E1.9581.00
149_I155_I1.9571.00
51_E57_G1.9471.00
60_Y65_L1.9451.00
72_L148_L1.9371.00
49_R61_Q1.8741.00
45_V138_L1.8091.00
44_P154_I1.7751.00
108_D111_K1.7601.00
92_Q165_P1.6981.00
47_K63_D1.6771.00
52_S60_Y1.6571.00
74_N146_T1.6541.00
104_N112_A1.5731.00
49_R57_G1.5511.00
84_R118_E1.5351.00
85_A162_D1.5251.00
109_R128_F1.5171.00
70_P148_L1.5091.00
78_T112_A1.5081.00
171_E174_P1.4351.00
114_S118_E1.4311.00
47_K61_Q1.4231.00
72_L98_I1.4191.00
157_Y171_E1.4161.00
80_C83_C1.3911.00
89_Y92_Q1.3851.00
87_H121_N1.3601.00
19_A22_W1.3421.00
75_V138_L1.3381.00
72_L90_L1.3251.00
50_L127_L1.3241.00
90_L100_V1.3031.00
48_F134_L1.2921.00
77_A143_A1.2871.00
110_Q114_S1.2811.00
86_E146_T1.2481.00
71_V149_I1.2401.00
72_L146_T1.2381.00
167_V170_E1.2301.00
92_Q95_A1.2061.00
165_P169_E1.2061.00
115_W119_L1.1971.00
92_Q96_Q1.1861.00
89_Y165_P1.1821.00
22_W25_A1.1801.00
84_R115_W1.1731.00
113_I117_K1.1641.00
65_L101_V1.1631.00
17_A21_L1.1601.00
73_L149_I1.1551.00
75_V103_M1.1531.00
39_A42_G1.1371.00
116_L126_S1.1301.00
171_E175_L1.1201.00
114_S117_K1.0861.00
145_E158_R1.0851.00
47_K62_A1.0801.00
65_L71_V1.0771.00
166_R170_E1.0671.00
42_G154_I1.0581.00
112_A128_F1.0541.00
21_L25_A1.0511.00
105_Y143_A1.0501.00
164_N167_V1.0481.00
18_A21_L1.0431.00
18_A22_W1.0421.00
60_Y64_V1.0391.00
48_F62_A1.0391.00
129_D132_G1.0201.00
167_V171_E1.0201.00
156_R175_L1.0111.00
74_N82_T0.9981.00
133_M137_D0.9931.00
40_L43_K0.9781.00
71_V101_V0.9771.00
99_R124_A0.9741.00
147_F155_I0.9651.00
170_E173_K0.9521.00
94_S99_R0.9461.00
52_S127_L0.9421.00
72_L100_V0.9161.00
87_H123_Y0.9131.00
87_H115_W0.8961.00
91_N120_G0.8871.00
82_T143_A0.8821.00
116_L121_N0.8801.00
15_A19_A0.8781.00
170_E174_P0.8751.00
20_L24_L0.8711.00
67_Q71_V0.8701.00
51_E109_R0.8641.00
78_T115_W0.8621.00
63_D67_Q0.8541.00
70_P156_R0.8511.00
19_A24_L0.8411.00
155_I158_R0.8341.00
135_G140_V0.8311.00
53_L116_L0.8251.00
148_L157_Y0.8251.00
79_W143_A0.8231.00
95_A122_P0.8231.00
93_L169_E0.8221.00
62_A65_L0.8211.00
50_L134_L0.8211.00
105_Y135_G0.8211.00
159_H163_L0.8191.00
68_G151_G0.8061.00
102_G126_S0.8041.00
17_A22_W0.7991.00
62_A71_V0.7971.00
97_G151_G0.7951.00
32_D35_N0.7911.00
163_L168_W0.7861.00
75_V134_L0.7861.00
39_A43_K0.7831.00
81_P85_A0.7811.00
111_K114_S0.7801.00
60_Y127_L0.7771.00
133_M136_L0.7761.00
87_H119_L0.7641.00
93_L172_I0.7641.00
93_L168_W0.7631.00
75_V140_V0.7611.00
87_H91_N0.7581.00
106_K132_G0.7551.00
91_N94_S0.7481.00
148_L171_E0.7481.00
102_G121_N0.7451.00
20_L23_Q0.7381.00
17_A20_L0.7371.00
110_Q113_I0.7361.00
104_N107_D0.7301.00
134_L138_L0.7281.00
56_P60_Y0.7271.00
70_P175_L0.7241.00
23_Q26_R0.7241.00
166_R169_E0.7171.00
112_A126_S0.7131.00
76_W102_G0.7121.00
148_L175_L0.7121.00
53_L113_I0.7081.00
91_N123_Y0.7071.00
159_H171_E0.7031.00
62_A67_Q0.6971.00
82_T88_Q0.6961.00
140_V145_E0.6891.00
134_L137_D0.6851.00
19_A23_Q0.6821.00
82_T162_D0.6791.00
149_I153_G0.6781.00
71_V153_G0.6721.00
16_I20_L0.6501.00
74_N90_L0.6471.00
76_W126_S0.6441.00
168_W171_E0.6231.00
89_Y93_L0.6201.00
33_P37_E0.6171.00
78_T104_N0.6171.00
90_L146_T0.6171.00
31_D35_N0.6161.00
89_Y164_N0.6161.00
83_C86_E0.6131.00
31_D34_T0.6131.00
165_P168_W0.6091.00
88_Q92_Q0.6091.00
94_S122_P0.6091.00
94_S97_G0.6061.00
16_I19_A0.6001.00
10_L17_A0.5981.00
14_L18_A0.5941.00
41_I157_Y0.5901.00
76_W104_N0.5881.00
142_G145_E0.5871.00
96_Q165_P0.5851.00
10_L13_F0.5831.00
82_T142_G0.5821.00
78_T111_K0.5811.00
85_A88_Q0.5771.00
45_V149_I0.5761.00
94_S124_A0.5761.00
81_P84_R0.5761.00
82_T115_W0.5731.00
51_E130_G0.5680.99
52_S55_N0.5650.99
57_G61_Q0.5600.99
147_F158_R0.5590.99
15_A18_A0.5570.99
13_F17_A0.5540.99
78_T82_T0.5510.99
62_A138_L0.5490.99
68_G153_G0.5490.99
74_N87_H0.5490.99
93_L100_V0.5490.99
13_F16_I0.5430.99
82_T86_E0.5390.99
22_W26_R0.5380.99
70_P97_G0.5380.99
100_V172_I0.5360.99
14_L17_A0.5340.99
54_D113_I0.5340.99
68_G71_V0.5300.99
112_A115_W0.5290.99
90_L102_G0.5220.99
80_C88_Q0.5210.99
16_I21_L0.5210.99
145_E160_A0.5170.99
141_Y160_A0.5160.99
109_R130_G0.5160.99
96_Q173_K0.5140.99
70_P98_I0.5140.99
76_W112_A0.5120.99
41_I158_R0.5110.99
78_T87_H0.5110.99
129_D133_M0.5100.99
32_D37_E0.5100.99
129_D135_G0.5060.99
148_L159_H0.5040.99
30_G34_T0.5040.99
132_G135_G0.5020.99
68_G99_R0.5010.99
70_P172_I0.5000.99
44_P67_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b1kA 1 0.7946 100 0.326 Contact Map
2hyxA 2 0.9189 100 0.335 Contact Map
3eytA 4 0.7514 100 0.345 Contact Map
3lorA 3 0.7351 100 0.35 Contact Map
1kngA 1 0.7297 100 0.352 Contact Map
2p5qA 3 0.7189 100 0.361 Contact Map
3fw2A 2 0.7351 100 0.368 Contact Map
3eurA 1 0.7081 100 0.371 Contact Map
4k9zA 3 0.7405 100 0.376 Contact Map
2f9sA 1 0.7297 100 0.377 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.