GREMLIN Database
CLSB - Cardiolipin synthase B
UniProt: P0AA84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13671
Length: 413 (355)
Sequences: 7138 (5227)
Seq/√Len: 277.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_A61_R5.4161.00
29_G57_A4.9921.00
27_A125_F4.3711.00
280_Q346_Q4.0901.00
124_A159_I3.6811.00
28_I54_A3.6211.00
24_V117_V3.5051.00
249_R280_Q3.4051.00
29_G54_A3.3251.00
298_D333_R2.9721.00
10_K152_E2.9331.00
27_A150_R2.7611.00
25_F54_A2.7531.00
302_T320_N2.6581.00
251_K280_Q2.5121.00
12_Q23_A2.5061.00
301_A332_L2.4241.00
26_K30_E2.4171.00
35_I119_I2.3661.00
36_I66_E2.3551.00
224_I251_K2.3271.00
57_A61_R2.3051.00
301_A329_N2.2501.00
23_A150_R2.2351.00
42_W67_V2.2331.00
25_F51_L2.2011.00
20_Y24_V2.1931.00
222_E298_D2.1651.00
121_A160_L2.0801.00
323_I328_F2.0711.00
124_A156_V2.0641.00
253_I344_C2.0631.00
23_A27_A2.0241.00
8_G154_P2.0231.00
44_E49_K2.0171.00
56_L88_A2.0041.00
333_R337_N1.9981.00
28_I35_I1.9791.00
222_E333_R1.9651.00
14_L23_A1.8891.00
151_L321_V1.8831.00
244_A279_V1.8711.00
223_V296_M1.8441.00
27_A123_I1.8331.00
338_G341_A1.8321.00
56_L60_Q1.8191.00
64_K91_V1.8101.00
52_H84_E1.7861.00
23_A26_K1.7821.00
345_Q351_M1.7591.00
216_L223_V1.7581.00
27_A30_E1.7501.00
45_D48_G1.7451.00
34_R121_A1.7391.00
123_I150_R1.7331.00
295_L329_N1.7231.00
151_L155_I1.7181.00
52_H56_L1.6911.00
20_Y39_T1.6861.00
215_M296_M1.6831.00
224_I249_R1.6821.00
286_R343_D1.6821.00
37_L117_V1.6751.00
12_Q150_R1.6631.00
145_Q339_I1.6601.00
69_L94_Y1.6581.00
282_F346_Q1.6531.00
222_E249_R1.6241.00
54_A57_A1.6231.00
196_L321_V1.6151.00
285_R345_Q1.5871.00
54_A58_A1.5741.00
355_R363_S1.5701.00
256_G285_R1.5641.00
27_A119_I1.5641.00
251_K340_I1.5531.00
224_I337_N1.5331.00
85_L90_V1.5211.00
32_Q122_R1.5061.00
83_N87_A1.4991.00
34_R160_L1.4991.00
349_E353_P1.4971.00
122_R152_E1.4781.00
23_A125_F1.4781.00
29_G50_Q1.4711.00
271_Y281_V1.4711.00
253_I340_I1.4581.00
25_F50_Q1.4381.00
221_R298_D1.4161.00
226_A253_I1.4111.00
125_F150_R1.3921.00
46_D133_A1.3841.00
16_N19_Q1.3761.00
116_I159_I1.3711.00
18_E22_P1.3661.00
258_P264_R1.3601.00
147_Y293_V1.3531.00
52_H81_F1.3521.00
226_A289_L1.3351.00
36_I160_L1.3311.00
208_I306_S1.3141.00
243_A246_R1.3091.00
241_R273_Y1.3021.00
66_E91_V1.3001.00
56_L84_E1.3001.00
46_D138_S1.2961.00
155_I194_V1.2941.00
309_D316_N1.2881.00
219_A296_M1.2831.00
215_M300_W1.2781.00
224_I333_R1.2611.00
53_A56_L1.2511.00
126_I159_I1.2501.00
25_F29_G1.2441.00
217_T239_A1.2361.00
272_N276_K1.2351.00
306_S320_N1.2201.00
43_F134_E1.2191.00
118_V124_A1.2171.00
276_K349_E1.2161.00
49_K53_A1.2111.00
254_I271_Y1.2011.00
19_Q22_P1.1991.00
47_V133_A1.1971.00
85_L88_A1.1841.00
241_R245_R1.1781.00
251_K337_N1.1711.00
14_L125_F1.1661.00
358_W362_K1.1631.00
22_P50_Q1.1591.00
68_L170_Q1.1561.00
155_I196_L1.1551.00
195_L199_R1.1551.00
116_I319_A1.1461.00
299_H324_H1.1371.00
53_A57_A1.1351.00
213_L239_A1.1351.00
352_L355_R1.1211.00
9_N151_L1.1191.00
234_Y238_H1.1181.00
84_E88_A1.1071.00
330_Q334_D1.0981.00
198_W201_N1.0961.00
12_Q331_T1.0961.00
84_E87_A1.0901.00
209_E233_G1.0871.00
348_D351_M1.0831.00
32_Q61_R1.0691.00
20_Y129_L1.0681.00
130_N135_H1.0671.00
268_R283_E1.0611.00
163_E167_L1.0591.00
15_E335_N1.0581.00
302_T322_I1.0571.00
298_D330_Q1.0561.00
336_L340_I1.0551.00
24_V51_L1.0521.00
226_A293_V1.0481.00
301_A328_F1.0451.00
11_I323_I1.0441.00
271_Y283_E1.0431.00
118_V159_I1.0341.00
331_T334_D1.0311.00
37_L51_L1.0301.00
59_A90_V1.0251.00
71_G94_Y1.0201.00
237_L241_R1.0191.00
264_R267_A1.0121.00
295_L333_R1.0111.00
45_D49_K1.0111.00
22_P26_K1.0091.00
239_A243_A1.0081.00
93_R171_S1.0061.00
211_H322_I0.9971.00
256_G345_Q0.9961.00
123_I152_E0.9951.00
225_I294_A0.9891.00
162_F198_W0.9851.00
20_Y148_A0.9831.00
43_F132_S0.9751.00
35_I55_L0.9681.00
40_F316_N0.9651.00
263_V267_A0.9651.00
42_W131_Y0.9641.00
219_A223_V0.9621.00
251_K282_F0.9591.00
267_A271_Y0.9591.00
159_I319_A0.9581.00
222_E295_L0.9501.00
119_I125_F0.9501.00
357_W360_L0.9441.00
241_R277_G0.9361.00
39_T117_V0.9351.00
337_N340_I0.9331.00
359_N362_K0.9311.00
253_I336_L0.9241.00
196_L199_R0.9231.00
192_A325_D0.9221.00
56_L90_V0.9171.00
264_R268_R0.9131.00
36_I64_K0.9101.00
126_I319_A0.9101.00
129_L148_A0.9081.00
220_R299_H0.9071.00
12_Q152_E0.9051.00
294_A302_T0.9031.00
304_G320_N0.9021.00
81_F84_E0.8971.00
279_V282_F0.8961.00
48_G131_Y0.8951.00
334_D338_G0.8931.00
16_N143_A0.8881.00
279_V283_E0.8881.00
275_V349_E0.8851.00
356_T360_L0.8831.00
66_E167_L0.8791.00
38_E112_M0.8731.00
340_I344_C0.8701.00
14_L150_R0.8701.00
236_F313_L0.8681.00
17_G21_Y0.8621.00
78_S82_V0.8611.00
217_T242_K0.8611.00
174_R177_W0.8601.00
206_D209_E0.8571.00
109_F311_L0.8541.00
221_R299_H0.8531.00
283_E347_V0.8471.00
275_V352_L0.8471.00
242_K246_R0.8411.00
149_V323_I0.8411.00
216_L243_A0.8401.00
77_L82_V0.8381.00
226_A336_L0.8371.00
149_V303_V0.8351.00
346_Q349_E0.8351.00
338_G343_D0.8351.00
57_A60_Q0.8351.00
45_D133_A0.8331.00
194_V201_N0.8321.00
299_H326_R0.8271.00
82_V86_T0.8240.99
28_I58_A0.8220.99
50_Q53_A0.8210.99
9_N154_P0.8180.99
91_V173_A0.8160.99
26_K29_G0.8160.99
199_R202_E0.8150.99
126_I321_V0.8150.99
213_L217_T0.8140.99
337_N341_A0.8130.99
194_V321_V0.8130.99
11_I194_V0.8110.99
13_L335_N0.8110.99
222_E251_K0.8080.99
79_D83_N0.8070.99
223_V240_L0.8060.99
261_P264_R0.8050.99
196_L201_N0.8010.99
60_Q88_A0.7990.99
177_W180_H0.7950.99
212_Y302_T0.7930.99
78_S81_F0.7920.99
194_V199_R0.7900.99
311_L316_N0.7820.99
13_L328_F0.7810.99
42_W69_L0.7810.99
128_G135_H0.7770.99
256_G283_E0.7760.99
206_D314_S0.7740.99
51_L131_Y0.7740.99
214_K218_Q0.7730.99
160_L164_L0.7700.99
37_L67_V0.7700.99
186_N189_P0.7660.99
29_G61_R0.7650.99
42_W52_H0.7650.99
282_F340_I0.7630.99
195_L198_W0.7620.99
270_L273_Y0.7610.99
162_F319_A0.7560.99
262_I266_G0.7560.99
230_F252_L0.7560.99
196_L319_A0.7550.99
33_E122_R0.7540.99
52_H90_V0.7510.99
293_V336_L0.7510.99
74_S77_L0.7490.99
300_W322_I0.7490.99
65_A90_V0.7470.99
268_R271_Y0.7440.99
94_Y97_P0.7440.99
263_V266_G0.7440.99
262_I265_V0.7430.99
28_I51_L0.7420.99
267_A270_L0.7410.99
305_S319_A0.7410.99
29_G32_Q0.7410.99
44_E81_F0.7360.99
326_R330_Q0.7300.99
235_R239_A0.7290.99
36_I164_L0.7260.99
334_D337_N0.7260.99
50_Q54_A0.7260.99
30_E122_R0.7250.99
54_A61_R0.7230.99
325_D328_F0.7230.99
112_M166_N0.7220.99
100_R103_G0.7210.99
21_Y51_L0.7200.99
272_N353_P0.7190.99
275_V278_G0.7180.99
81_F88_A0.7160.99
28_I55_L0.7160.99
38_E114_R0.7160.99
223_V243_A0.7150.99
37_L131_Y0.7120.99
191_E327_H0.7080.98
250_I279_V0.7080.98
330_Q333_R0.7070.98
275_V281_V0.7050.98
263_V270_L0.7010.98
335_N339_I0.7000.98
274_L279_V0.6990.98
271_Y275_V0.6950.98
336_L339_I0.6940.98
345_Q349_E0.6920.98
132_S135_H0.6910.98
34_R64_K0.6910.98
193_Q196_L0.6900.98
356_T361_T0.6900.98
255_Q288_P0.6860.98
82_V92_F0.6860.98
30_E33_E0.6850.98
81_F85_L0.6830.98
172_A175_R0.6810.98
21_Y47_V0.6800.98
197_V202_E0.6790.98
228_A309_D0.6790.98
295_L298_D0.6780.98
197_V211_H0.6750.98
33_E64_K0.6730.98
268_R359_N0.6720.98
266_G270_L0.6680.98
305_S316_N0.6680.98
209_E235_R0.6670.98
71_G96_D0.6670.98
244_A277_G0.6670.98
175_R178_R0.6630.98
267_A274_L0.6630.98
59_A65_A0.6610.98
15_E19_Q0.6610.98
39_T148_A0.6570.98
192_A328_F0.6560.97
357_W361_T0.6560.97
236_F308_L0.6550.97
15_E338_G0.6530.97
359_N363_S0.6500.97
56_L59_A0.6490.97
157_E161_Q0.6480.97
151_L159_I0.6480.97
261_P265_V0.6470.97
59_A88_A0.6470.97
253_I289_L0.6450.97
327_H330_Q0.6440.97
343_D346_Q0.6430.97
22_P25_F0.6390.97
29_G58_A0.6390.97
39_T130_N0.6390.97
36_I118_V0.6380.97
243_A248_V0.6380.97
272_N352_L0.6380.97
41_I134_E0.6370.97
353_P356_T0.6360.97
285_R343_D0.6360.97
42_W51_L0.6360.97
36_I121_A0.6350.97
174_R178_R0.6340.97
224_I295_L0.6320.97
295_L301_A0.6300.97
310_P314_S0.6300.97
300_W324_H0.6290.97
197_V200_D0.6280.97
293_V332_L0.6240.97
332_L336_L0.6230.97
253_I339_I0.6230.97
241_R244_A0.6210.97
355_R359_N0.6210.97
194_V323_I0.6170.96
11_I328_F0.6170.96
192_A323_I0.6150.96
156_V160_L0.6140.96
90_V96_D0.6140.96
168_P174_R0.6110.96
219_A248_V0.6100.96
28_I117_V0.6090.96
204_H207_D0.6090.96
249_R337_N0.6070.96
279_V284_Y0.6060.96
331_T335_N0.6060.96
155_I158_D0.6050.96
229_Y259_D0.6040.96
7_E193_Q0.6020.96
191_E199_R0.6020.96
191_E201_N0.6010.96
93_R96_D0.6010.96
126_I149_V0.6010.96
239_A242_K0.5990.96
264_R283_E0.5990.96
47_V136_M0.5980.96
208_I212_Y0.5980.96
221_R249_R0.5950.96
224_I336_L0.5950.96
27_A152_E0.5940.96
197_V201_N0.5930.95
118_V156_V0.5920.95
257_E260_M0.5910.95
137_S143_A0.5900.95
47_V50_Q0.5900.95
302_T306_S0.5890.95
265_V271_Y0.5880.95
80_E87_A0.5880.95
82_V88_A0.5860.95
24_V131_Y0.5850.95
209_E213_L0.5840.95
152_E156_V0.5830.95
356_T359_N0.5820.95
171_S175_R0.5810.95
256_G264_R0.5810.95
349_E352_L0.5780.95
135_H144_K0.5760.95
194_V198_W0.5750.95
20_Y117_V0.5740.95
27_A122_R0.5730.95
173_A177_W0.5730.95
238_H242_K0.5730.95
230_F308_L0.5720.95
125_F148_A0.5710.94
205_R245_R0.5710.94
48_G52_H0.5710.94
328_F331_T0.5700.94
273_Y276_K0.5700.94
35_I63_V0.5680.94
77_L81_F0.5660.94
195_L201_N0.5650.94
34_R66_E0.5620.94
353_P358_W0.5620.94
24_V28_I0.5620.94
254_I283_E0.5620.94
245_R277_G0.5600.94
306_S313_L0.5570.94
328_F332_L0.5570.94
351_M354_K0.5560.94
251_K346_Q0.5550.94
188_Q191_E0.5540.94
209_E313_L0.5540.94
201_N317_L0.5540.94
70_D111_R0.5530.94
180_H183_A0.5520.93
67_V92_F0.5520.93
11_I192_A0.5510.93
332_L335_N0.5510.93
196_L200_D0.5500.93
168_P172_A0.5470.93
14_L20_Y0.5450.93
272_N349_E0.5440.93
298_D329_N0.5430.93
147_Y291_G0.5430.93
192_A327_H0.5430.93
197_V322_I0.5420.93
102_F105_R0.5420.93
208_I320_N0.5420.93
110_R315_L0.5400.93
213_L236_F0.5390.93
257_E261_P0.5370.93
16_N339_I0.5360.92
89_G92_F0.5360.92
68_L93_R0.5360.92
293_V303_V0.5330.92
264_R274_L0.5330.92
9_N155_I0.5320.92
69_L92_F0.5310.92
60_Q89_G0.5300.92
192_A196_L0.5300.92
128_G146_D0.5300.92
219_A243_A0.5260.92
11_I149_V0.5250.92
53_A84_E0.5240.92
177_W181_H0.5240.92
215_M322_I0.5230.92
354_K358_W0.5230.92
225_I240_L0.5230.92
184_E187_R0.5220.91
230_F240_L0.5200.91
44_E78_S0.5200.91
333_R336_L0.5190.91
216_L236_F0.5180.91
196_L202_E0.5180.91
72_Y75_P0.5180.91
10_K191_E0.5180.91
224_I340_I0.5170.91
176_W180_H0.5170.91
216_L294_A0.5160.91
219_A297_D0.5160.91
164_L168_P0.5160.91
35_I58_A0.5150.91
12_Q19_Q0.5140.91
47_V131_Y0.5130.91
80_E83_N0.5130.91
215_M302_T0.5110.91
243_A247_G0.5110.91
303_V332_L0.5110.91
115_K292_K0.5100.90
78_S88_A0.5100.90
274_L281_V0.5090.90
344_C347_V0.5080.90
44_E52_H0.5070.90
254_I267_A0.5060.90
293_V335_N0.5050.90
361_T364_V0.5050.90
149_V321_V0.5050.90
162_F165_E0.5040.90
236_F239_A0.5030.90
46_D49_K0.5030.90
271_Y347_V0.5020.90
80_E84_E0.5020.90
69_L74_S0.5020.90
34_R164_L0.5020.90
193_Q198_W0.5010.90
230_F237_L0.5000.90
117_V148_A0.5000.90
24_V148_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.8281 100 0.405 Contact Map
3hsiA 2 0.8935 100 0.428 Contact Map
1xdpA 4 0.7918 100 0.558 Contact Map
2o8rA 2 0.7869 100 0.558 Contact Map
4urjA 1 0.3971 99.9 0.757 Contact Map
1byrA 2 0.3632 99.9 0.765 Contact Map
4gelA 2 0.4407 99.9 0.772 Contact Map
4ggjA 2 0.3971 99.9 0.781 Contact Map
2c1lA 2 0.4915 99.8 0.804 Contact Map
4rctA 2 0.5085 99.4 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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