CLSB - ECOLI - GREMLIN Contacts

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CLSB - Cardiolipin synthase B

UniProt:	P0AA84	Sequences: MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHALRKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRVETENTGVKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13671
Length:	413 (355)
Sequences:	7138 (5227)
Seq/√Len:	277.4

ECOLI - CLSB CLSA CLSC
BACSU - CLSA CLS1 CLSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_A	61_R	5.416	1.00
29_G	57_A	4.992	1.00
27_A	125_F	4.371	1.00
280_Q	346_Q	4.090	1.00
124_A	159_I	3.681	1.00
28_I	54_A	3.621	1.00
24_V	117_V	3.505	1.00
249_R	280_Q	3.405	1.00
29_G	54_A	3.325	1.00
298_D	333_R	2.972	1.00
10_K	152_E	2.933	1.00
27_A	150_R	2.761	1.00
25_F	54_A	2.753	1.00
302_T	320_N	2.658	1.00
251_K	280_Q	2.512	1.00
12_Q	23_A	2.506	1.00
301_A	332_L	2.424	1.00
26_K	30_E	2.417	1.00
35_I	119_I	2.366	1.00
36_I	66_E	2.355	1.00
224_I	251_K	2.327	1.00
57_A	61_R	2.305	1.00
301_A	329_N	2.250	1.00
23_A	150_R	2.235	1.00
42_W	67_V	2.233	1.00
25_F	51_L	2.201	1.00
20_Y	24_V	2.193	1.00
222_E	298_D	2.165	1.00
121_A	160_L	2.080	1.00
323_I	328_F	2.071	1.00
124_A	156_V	2.064	1.00
253_I	344_C	2.063	1.00
23_A	27_A	2.024	1.00
8_G	154_P	2.023	1.00
44_E	49_K	2.017	1.00
56_L	88_A	2.004	1.00
333_R	337_N	1.998	1.00
28_I	35_I	1.979	1.00
222_E	333_R	1.965	1.00
14_L	23_A	1.889	1.00
151_L	321_V	1.883	1.00
244_A	279_V	1.871	1.00
223_V	296_M	1.844	1.00
27_A	123_I	1.833	1.00
338_G	341_A	1.832	1.00
56_L	60_Q	1.819	1.00
64_K	91_V	1.810	1.00
52_H	84_E	1.786	1.00
23_A	26_K	1.782	1.00
345_Q	351_M	1.759	1.00
216_L	223_V	1.758	1.00
27_A	30_E	1.750	1.00
45_D	48_G	1.745	1.00
34_R	121_A	1.739	1.00
123_I	150_R	1.733	1.00
295_L	329_N	1.723	1.00
151_L	155_I	1.718	1.00
52_H	56_L	1.691	1.00
20_Y	39_T	1.686	1.00
215_M	296_M	1.683	1.00
224_I	249_R	1.682	1.00
286_R	343_D	1.682	1.00
37_L	117_V	1.675	1.00
12_Q	150_R	1.663	1.00
145_Q	339_I	1.660	1.00
69_L	94_Y	1.658	1.00
282_F	346_Q	1.653	1.00
222_E	249_R	1.624	1.00
54_A	57_A	1.623	1.00
196_L	321_V	1.615	1.00
285_R	345_Q	1.587	1.00
54_A	58_A	1.574	1.00
355_R	363_S	1.570	1.00
256_G	285_R	1.564	1.00
27_A	119_I	1.564	1.00
251_K	340_I	1.553	1.00
224_I	337_N	1.533	1.00
85_L	90_V	1.521	1.00
32_Q	122_R	1.506	1.00
83_N	87_A	1.499	1.00
34_R	160_L	1.499	1.00
349_E	353_P	1.497	1.00
122_R	152_E	1.478	1.00
23_A	125_F	1.478	1.00
29_G	50_Q	1.471	1.00
271_Y	281_V	1.471	1.00
253_I	340_I	1.458	1.00
25_F	50_Q	1.438	1.00
221_R	298_D	1.416	1.00
226_A	253_I	1.411	1.00
125_F	150_R	1.392	1.00
46_D	133_A	1.384	1.00
16_N	19_Q	1.376	1.00
116_I	159_I	1.371	1.00
18_E	22_P	1.366	1.00
258_P	264_R	1.360	1.00
147_Y	293_V	1.353	1.00
52_H	81_F	1.352	1.00
226_A	289_L	1.335	1.00
36_I	160_L	1.331	1.00
208_I	306_S	1.314	1.00
243_A	246_R	1.309	1.00
241_R	273_Y	1.302	1.00
66_E	91_V	1.300	1.00
56_L	84_E	1.300	1.00
46_D	138_S	1.296	1.00
155_I	194_V	1.294	1.00
309_D	316_N	1.288	1.00
219_A	296_M	1.283	1.00
215_M	300_W	1.278	1.00
224_I	333_R	1.261	1.00
53_A	56_L	1.251	1.00
126_I	159_I	1.250	1.00
25_F	29_G	1.244	1.00
217_T	239_A	1.236	1.00
272_N	276_K	1.235	1.00
306_S	320_N	1.220	1.00
43_F	134_E	1.219	1.00
118_V	124_A	1.217	1.00
276_K	349_E	1.216	1.00
49_K	53_A	1.211	1.00
254_I	271_Y	1.201	1.00
19_Q	22_P	1.199	1.00
47_V	133_A	1.197	1.00
85_L	88_A	1.184	1.00
241_R	245_R	1.178	1.00
251_K	337_N	1.171	1.00
14_L	125_F	1.166	1.00
358_W	362_K	1.163	1.00
22_P	50_Q	1.159	1.00
68_L	170_Q	1.156	1.00
155_I	196_L	1.155	1.00
195_L	199_R	1.155	1.00
116_I	319_A	1.146	1.00
299_H	324_H	1.137	1.00
53_A	57_A	1.135	1.00
213_L	239_A	1.135	1.00
352_L	355_R	1.121	1.00
9_N	151_L	1.119	1.00
234_Y	238_H	1.118	1.00
84_E	88_A	1.107	1.00
330_Q	334_D	1.098	1.00
198_W	201_N	1.096	1.00
12_Q	331_T	1.096	1.00
84_E	87_A	1.090	1.00
209_E	233_G	1.087	1.00
348_D	351_M	1.083	1.00
32_Q	61_R	1.069	1.00
20_Y	129_L	1.068	1.00
130_N	135_H	1.067	1.00
268_R	283_E	1.061	1.00
163_E	167_L	1.059	1.00
15_E	335_N	1.058	1.00
302_T	322_I	1.057	1.00
298_D	330_Q	1.056	1.00
336_L	340_I	1.055	1.00
24_V	51_L	1.052	1.00
226_A	293_V	1.048	1.00
301_A	328_F	1.045	1.00
11_I	323_I	1.044	1.00
271_Y	283_E	1.043	1.00
118_V	159_I	1.034	1.00
331_T	334_D	1.031	1.00
37_L	51_L	1.030	1.00
59_A	90_V	1.025	1.00
71_G	94_Y	1.020	1.00
237_L	241_R	1.019	1.00
264_R	267_A	1.012	1.00
295_L	333_R	1.011	1.00
45_D	49_K	1.011	1.00
22_P	26_K	1.009	1.00
239_A	243_A	1.008	1.00
93_R	171_S	1.006	1.00
211_H	322_I	0.997	1.00
256_G	345_Q	0.996	1.00
123_I	152_E	0.995	1.00
225_I	294_A	0.989	1.00
162_F	198_W	0.985	1.00
20_Y	148_A	0.983	1.00
43_F	132_S	0.975	1.00
35_I	55_L	0.968	1.00
40_F	316_N	0.965	1.00
263_V	267_A	0.965	1.00
42_W	131_Y	0.964	1.00
219_A	223_V	0.962	1.00
251_K	282_F	0.959	1.00
267_A	271_Y	0.959	1.00
159_I	319_A	0.958	1.00
222_E	295_L	0.950	1.00
119_I	125_F	0.950	1.00
357_W	360_L	0.944	1.00
241_R	277_G	0.936	1.00
39_T	117_V	0.935	1.00
337_N	340_I	0.933	1.00
359_N	362_K	0.931	1.00
253_I	336_L	0.924	1.00
196_L	199_R	0.923	1.00
192_A	325_D	0.922	1.00
56_L	90_V	0.917	1.00
264_R	268_R	0.913	1.00
36_I	64_K	0.910	1.00
126_I	319_A	0.910	1.00
129_L	148_A	0.908	1.00
220_R	299_H	0.907	1.00
12_Q	152_E	0.905	1.00
294_A	302_T	0.903	1.00
304_G	320_N	0.902	1.00
81_F	84_E	0.897	1.00
279_V	282_F	0.896	1.00
48_G	131_Y	0.895	1.00
334_D	338_G	0.893	1.00
16_N	143_A	0.888	1.00
279_V	283_E	0.888	1.00
275_V	349_E	0.885	1.00
356_T	360_L	0.883	1.00
66_E	167_L	0.879	1.00
38_E	112_M	0.873	1.00
340_I	344_C	0.870	1.00
14_L	150_R	0.870	1.00
236_F	313_L	0.868	1.00
17_G	21_Y	0.862	1.00
78_S	82_V	0.861	1.00
217_T	242_K	0.861	1.00
174_R	177_W	0.860	1.00
206_D	209_E	0.857	1.00
109_F	311_L	0.854	1.00
221_R	299_H	0.853	1.00
283_E	347_V	0.847	1.00
275_V	352_L	0.847	1.00
242_K	246_R	0.841	1.00
149_V	323_I	0.841	1.00
216_L	243_A	0.840	1.00
77_L	82_V	0.838	1.00
226_A	336_L	0.837	1.00
149_V	303_V	0.835	1.00
346_Q	349_E	0.835	1.00
338_G	343_D	0.835	1.00
57_A	60_Q	0.835	1.00
45_D	133_A	0.833	1.00
194_V	201_N	0.832	1.00
299_H	326_R	0.827	1.00
82_V	86_T	0.824	0.99
28_I	58_A	0.822	0.99
50_Q	53_A	0.821	0.99
9_N	154_P	0.818	0.99
91_V	173_A	0.816	0.99
26_K	29_G	0.816	0.99
199_R	202_E	0.815	0.99
126_I	321_V	0.815	0.99
213_L	217_T	0.814	0.99
337_N	341_A	0.813	0.99
194_V	321_V	0.813	0.99
11_I	194_V	0.811	0.99
13_L	335_N	0.811	0.99
222_E	251_K	0.808	0.99
79_D	83_N	0.807	0.99
223_V	240_L	0.806	0.99
261_P	264_R	0.805	0.99
196_L	201_N	0.801	0.99
60_Q	88_A	0.799	0.99
177_W	180_H	0.795	0.99
212_Y	302_T	0.793	0.99
78_S	81_F	0.792	0.99
194_V	199_R	0.790	0.99
311_L	316_N	0.782	0.99
13_L	328_F	0.781	0.99
42_W	69_L	0.781	0.99
128_G	135_H	0.777	0.99
256_G	283_E	0.776	0.99
206_D	314_S	0.774	0.99
51_L	131_Y	0.774	0.99
214_K	218_Q	0.773	0.99
160_L	164_L	0.770	0.99
37_L	67_V	0.770	0.99
186_N	189_P	0.766	0.99
29_G	61_R	0.765	0.99
42_W	52_H	0.765	0.99
282_F	340_I	0.763	0.99
195_L	198_W	0.762	0.99
270_L	273_Y	0.761	0.99
162_F	319_A	0.756	0.99
262_I	266_G	0.756	0.99
230_F	252_L	0.756	0.99
196_L	319_A	0.755	0.99
33_E	122_R	0.754	0.99
52_H	90_V	0.751	0.99
293_V	336_L	0.751	0.99
74_S	77_L	0.749	0.99
300_W	322_I	0.749	0.99
65_A	90_V	0.747	0.99
268_R	271_Y	0.744	0.99
94_Y	97_P	0.744	0.99
263_V	266_G	0.744	0.99
262_I	265_V	0.743	0.99
28_I	51_L	0.742	0.99
267_A	270_L	0.741	0.99
305_S	319_A	0.741	0.99
29_G	32_Q	0.741	0.99
44_E	81_F	0.736	0.99
326_R	330_Q	0.730	0.99
235_R	239_A	0.729	0.99
36_I	164_L	0.726	0.99
334_D	337_N	0.726	0.99
50_Q	54_A	0.726	0.99
30_E	122_R	0.725	0.99
54_A	61_R	0.723	0.99
325_D	328_F	0.723	0.99
112_M	166_N	0.722	0.99
100_R	103_G	0.721	0.99
21_Y	51_L	0.720	0.99
272_N	353_P	0.719	0.99
275_V	278_G	0.718	0.99
81_F	88_A	0.716	0.99
28_I	55_L	0.716	0.99
38_E	114_R	0.716	0.99
223_V	243_A	0.715	0.99
37_L	131_Y	0.712	0.99
191_E	327_H	0.708	0.98
250_I	279_V	0.708	0.98
330_Q	333_R	0.707	0.98
275_V	281_V	0.705	0.98
263_V	270_L	0.701	0.98
335_N	339_I	0.700	0.98
274_L	279_V	0.699	0.98
271_Y	275_V	0.695	0.98
336_L	339_I	0.694	0.98
345_Q	349_E	0.692	0.98
132_S	135_H	0.691	0.98
34_R	64_K	0.691	0.98
193_Q	196_L	0.690	0.98
356_T	361_T	0.690	0.98
255_Q	288_P	0.686	0.98
82_V	92_F	0.686	0.98
30_E	33_E	0.685	0.98
81_F	85_L	0.683	0.98
172_A	175_R	0.681	0.98
21_Y	47_V	0.680	0.98
197_V	202_E	0.679	0.98
228_A	309_D	0.679	0.98
295_L	298_D	0.678	0.98
197_V	211_H	0.675	0.98
33_E	64_K	0.673	0.98
268_R	359_N	0.672	0.98
266_G	270_L	0.668	0.98
305_S	316_N	0.668	0.98
209_E	235_R	0.667	0.98
71_G	96_D	0.667	0.98
244_A	277_G	0.667	0.98
175_R	178_R	0.663	0.98
267_A	274_L	0.663	0.98
59_A	65_A	0.661	0.98
15_E	19_Q	0.661	0.98
39_T	148_A	0.657	0.98
192_A	328_F	0.656	0.97
357_W	361_T	0.656	0.97
236_F	308_L	0.655	0.97
15_E	338_G	0.653	0.97
359_N	363_S	0.650	0.97
56_L	59_A	0.649	0.97
157_E	161_Q	0.648	0.97
151_L	159_I	0.648	0.97
261_P	265_V	0.647	0.97
59_A	88_A	0.647	0.97
253_I	289_L	0.645	0.97
327_H	330_Q	0.644	0.97
343_D	346_Q	0.643	0.97
22_P	25_F	0.639	0.97
29_G	58_A	0.639	0.97
39_T	130_N	0.639	0.97
36_I	118_V	0.638	0.97
243_A	248_V	0.638	0.97
272_N	352_L	0.638	0.97
41_I	134_E	0.637	0.97
353_P	356_T	0.636	0.97
285_R	343_D	0.636	0.97
42_W	51_L	0.636	0.97
36_I	121_A	0.635	0.97
174_R	178_R	0.634	0.97
224_I	295_L	0.632	0.97
295_L	301_A	0.630	0.97
310_P	314_S	0.630	0.97
300_W	324_H	0.629	0.97
197_V	200_D	0.628	0.97
293_V	332_L	0.624	0.97
332_L	336_L	0.623	0.97
253_I	339_I	0.623	0.97
241_R	244_A	0.621	0.97
355_R	359_N	0.621	0.97
194_V	323_I	0.617	0.96
11_I	328_F	0.617	0.96
192_A	323_I	0.615	0.96
156_V	160_L	0.614	0.96
90_V	96_D	0.614	0.96
168_P	174_R	0.611	0.96
219_A	248_V	0.610	0.96
28_I	117_V	0.609	0.96
204_H	207_D	0.609	0.96
249_R	337_N	0.607	0.96
279_V	284_Y	0.606	0.96
331_T	335_N	0.606	0.96
155_I	158_D	0.605	0.96
229_Y	259_D	0.604	0.96
7_E	193_Q	0.602	0.96
191_E	199_R	0.602	0.96
191_E	201_N	0.601	0.96
93_R	96_D	0.601	0.96
126_I	149_V	0.601	0.96
239_A	242_K	0.599	0.96
264_R	283_E	0.599	0.96
47_V	136_M	0.598	0.96
208_I	212_Y	0.598	0.96
221_R	249_R	0.595	0.96
224_I	336_L	0.595	0.96
27_A	152_E	0.594	0.96
197_V	201_N	0.593	0.95
118_V	156_V	0.592	0.95
257_E	260_M	0.591	0.95
137_S	143_A	0.590	0.95
47_V	50_Q	0.590	0.95
302_T	306_S	0.589	0.95
265_V	271_Y	0.588	0.95
80_E	87_A	0.588	0.95
82_V	88_A	0.586	0.95
24_V	131_Y	0.585	0.95
209_E	213_L	0.584	0.95
152_E	156_V	0.583	0.95
356_T	359_N	0.582	0.95
171_S	175_R	0.581	0.95
256_G	264_R	0.581	0.95
349_E	352_L	0.578	0.95
135_H	144_K	0.576	0.95
194_V	198_W	0.575	0.95
20_Y	117_V	0.574	0.95
27_A	122_R	0.573	0.95
173_A	177_W	0.573	0.95
238_H	242_K	0.573	0.95
230_F	308_L	0.572	0.95
125_F	148_A	0.571	0.94
205_R	245_R	0.571	0.94
48_G	52_H	0.571	0.94
328_F	331_T	0.570	0.94
273_Y	276_K	0.570	0.94
35_I	63_V	0.568	0.94
77_L	81_F	0.566	0.94
195_L	201_N	0.565	0.94
34_R	66_E	0.562	0.94
353_P	358_W	0.562	0.94
24_V	28_I	0.562	0.94
254_I	283_E	0.562	0.94
245_R	277_G	0.560	0.94
306_S	313_L	0.557	0.94
328_F	332_L	0.557	0.94
351_M	354_K	0.556	0.94
251_K	346_Q	0.555	0.94
188_Q	191_E	0.554	0.94
209_E	313_L	0.554	0.94
201_N	317_L	0.554	0.94
70_D	111_R	0.553	0.94
180_H	183_A	0.552	0.93
67_V	92_F	0.552	0.93
11_I	192_A	0.551	0.93
332_L	335_N	0.551	0.93
196_L	200_D	0.550	0.93
168_P	172_A	0.547	0.93
14_L	20_Y	0.545	0.93
272_N	349_E	0.544	0.93
298_D	329_N	0.543	0.93
147_Y	291_G	0.543	0.93
192_A	327_H	0.543	0.93
197_V	322_I	0.542	0.93
102_F	105_R	0.542	0.93
208_I	320_N	0.542	0.93
110_R	315_L	0.540	0.93
213_L	236_F	0.539	0.93
257_E	261_P	0.537	0.93
16_N	339_I	0.536	0.92
89_G	92_F	0.536	0.92
68_L	93_R	0.536	0.92
293_V	303_V	0.533	0.92
264_R	274_L	0.533	0.92
9_N	155_I	0.532	0.92
69_L	92_F	0.531	0.92
60_Q	89_G	0.530	0.92
192_A	196_L	0.530	0.92
128_G	146_D	0.530	0.92
219_A	243_A	0.526	0.92
11_I	149_V	0.525	0.92
53_A	84_E	0.524	0.92
177_W	181_H	0.524	0.92
215_M	322_I	0.523	0.92
354_K	358_W	0.523	0.92
225_I	240_L	0.523	0.92
184_E	187_R	0.522	0.91
230_F	240_L	0.520	0.91
44_E	78_S	0.520	0.91
333_R	336_L	0.519	0.91
216_L	236_F	0.518	0.91
196_L	202_E	0.518	0.91
72_Y	75_P	0.518	0.91
10_K	191_E	0.518	0.91
224_I	340_I	0.517	0.91
176_W	180_H	0.517	0.91
216_L	294_A	0.516	0.91
219_A	297_D	0.516	0.91
164_L	168_P	0.516	0.91
35_I	58_A	0.515	0.91
12_Q	19_Q	0.514	0.91
47_V	131_Y	0.513	0.91
80_E	83_N	0.513	0.91
215_M	302_T	0.511	0.91
243_A	247_G	0.511	0.91
303_V	332_L	0.511	0.91
115_K	292_K	0.510	0.90
78_S	88_A	0.510	0.90
274_L	281_V	0.509	0.90
344_C	347_V	0.508	0.90
44_E	52_H	0.507	0.90
254_I	267_A	0.506	0.90
293_V	335_N	0.505	0.90
361_T	364_V	0.505	0.90
149_V	321_V	0.505	0.90
162_F	165_E	0.504	0.90
236_F	239_A	0.503	0.90
46_D	49_K	0.503	0.90
271_Y	347_V	0.502	0.90
80_E	84_E	0.502	0.90
69_L	74_S	0.502	0.90
34_R	164_L	0.502	0.90
193_Q	198_W	0.501	0.90
230_F	237_L	0.500	0.90
117_V	148_A	0.500	0.90
24_V	148_A	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v0wA	1	0.8281	100	0.405	Contact Map
3hsiA	2	0.8935	100	0.428	Contact Map
1xdpA	4	0.7918	100	0.558	Contact Map
2o8rA	2	0.7869	100	0.558	Contact Map
4urjA	1	0.3971	99.9	0.757	Contact Map
1byrA	2	0.3632	99.9	0.765	Contact Map
4gelA	2	0.4407	99.9	0.772	Contact Map
4ggjA	2	0.3971	99.9	0.781	Contact Map
2c1lA	2	0.4915	99.8	0.804	Contact Map
4rctA	2	0.5085	99.4	0.857	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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