GREMLIN Database
CODB - Cytosine permease
UniProt: P0AA82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11327
Length: 419 (396)
Sequences: 4809 (3073)
Seq/√Len: 154.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
352_H355_T6.9941.00
341_A392_A6.8371.00
341_A396_L5.6821.00
74_G212_A4.1881.00
371_L394_S4.0181.00
53_F241_I4.0041.00
14_Q220_N3.8801.00
368_A394_S3.2951.00
368_A372_G3.2671.00
345_M392_A3.1301.00
372_G391_G3.0751.00
368_A398_L3.0541.00
337_G341_A2.8731.00
43_L196_A2.8221.00
58_I197_L2.7901.00
375_A390_G2.7481.00
193_F197_L2.7451.00
372_G394_S2.7371.00
55_A193_F2.5631.00
345_M396_L2.5571.00
13_P16_A2.5361.00
170_W174_N2.5041.00
342_D347_R2.4921.00
254_D257_D2.4671.00
48_S51_D2.4601.00
363_W367_L2.3481.00
338_V369_V2.3281.00
30_L282_N2.2831.00
109_F310_G2.2821.00
169_V238_L2.2801.00
17_R78_G2.2391.00
298_S301_T2.2341.00
280_N283_A2.2241.00
62_L201_V2.1451.00
366_I370_A2.1371.00
7_F16_A2.0641.00
52_F244_A2.0531.00
166_G170_W1.9681.00
385_V389_L1.9541.00
130_L134_V1.9471.00
219_R223_L1.9321.00
140_T307_G1.9211.00
71_G215_V1.9191.00
337_G388_V1.9111.00
113_V139_M1.9061.00
390_G394_S1.8961.00
96_L366_I1.8951.00
222_K226_L1.8891.00
372_G390_G1.8841.00
92_K95_W1.8681.00
304_V308_I1.8561.00
108_W111_V1.8391.00
7_F10_G1.8361.00
376_G387_A1.8331.00
88_S342_D1.8291.00
137_L141_V1.8201.00
109_F280_N1.7451.00
338_V368_A1.7401.00
353_F357_R1.7381.00
116_F135_S1.7281.00
73_I84_L1.6921.00
297_M301_T1.6691.00
54_L193_F1.6591.00
351_E357_R1.6521.00
394_S398_L1.6491.00
337_G391_G1.6441.00
110_G310_G1.6391.00
367_L398_L1.6391.00
107_G324_W1.6101.00
87_F351_E1.6101.00
145_F149_A1.6041.00
389_L392_A1.5951.00
94_S293_N1.5911.00
139_M280_N1.5901.00
68_S229_M1.5891.00
125_G128_I1.5801.00
393_L397_I1.5701.00
152_V155_V1.5701.00
371_L390_G1.5641.00
297_M302_L1.5551.00
396_L400_P1.5491.00
49_Y53_F1.5481.00
226_L230_V1.5191.00
297_M305_I1.5151.00
397_I400_P1.5031.00
392_A396_L1.4951.00
43_L52_F1.4821.00
50_H54_L1.4811.00
96_L361_V1.4791.00
55_A196_A1.4651.00
387_A391_G1.4531.00
20_V223_L1.4441.00
56_V240_F1.4431.00
374_A378_W1.4371.00
84_L212_A1.4361.00
338_V365_A1.4191.00
136_G311_T1.4081.00
365_A395_Y1.3991.00
353_F356_T1.3991.00
361_V366_I1.3861.00
370_A374_A1.3831.00
22_A155_V1.3791.00
121_G131_L1.3711.00
74_G215_V1.3471.00
142_T153_L1.3461.00
133_A137_L1.3331.00
163_C167_Y1.3291.00
365_A368_A1.3271.00
89_F365_A1.3131.00
233_F237_S1.3071.00
223_L227_V1.3001.00
87_F356_T1.2721.00
382_I386_N1.2701.00
389_L393_L1.2641.00
342_D346_N1.2571.00
76_K221_A1.2551.00
65_I69_F1.2431.00
72_Y76_K1.2331.00
334_P387_A1.2311.00
340_I344_L1.2221.00
19_G22_A1.2221.00
92_K360_S1.2161.00
118_I254_D1.2151.00
287_S306_N1.2141.00
129_N133_A1.2111.00
214_F286_A1.2091.00
107_G325_L1.1891.00
112_G283_A1.1871.00
89_F93_G1.1861.00
7_F12_V1.1811.00
182_L185_V1.1801.00
117_A131_L1.1781.00
66_Y208_G1.1771.00
169_V242_F1.1731.00
336_G340_I1.1721.00
185_V248_A1.1661.00
86_R94_S1.1661.00
397_I401_I1.1551.00
62_L197_L1.1461.00
105_Q210_L1.1391.00
364_V399_N1.1381.00
352_H356_T1.1381.00
358_M363_W1.1371.00
88_S339_I1.1371.00
56_V244_A1.1361.00
113_V136_G1.1301.00
55_A197_L1.1301.00
70_L339_I1.1291.00
54_L58_I1.1201.00
58_I193_F1.1191.00
205_I333_P1.1171.00
364_V398_L1.1090.99
47_L55_A1.0910.99
28_L235_G1.0890.99
375_A378_W1.0880.99
57_L237_S1.0850.99
346_N396_L1.0840.99
395_Y399_N1.0820.99
252_M257_D1.0740.99
173_V177_G1.0690.99
193_F196_A1.0680.99
338_V372_G1.0610.99
167_Y170_W1.0520.99
379_L386_N1.0510.99
7_F13_P1.0500.99
126_L131_L1.0420.99
64_G68_S1.0410.99
132_I315_L1.0410.99
351_E356_T1.0360.99
253_A256_S1.0330.99
242_F246_G1.0330.99
368_A391_G1.0310.99
148_S152_V1.0240.99
69_F344_L1.0230.99
368_A395_Y1.0220.99
109_F307_G1.0200.99
193_F200_V1.0190.99
185_V188_A1.0190.99
172_A246_G1.0160.99
257_D261_A1.0160.99
359_M363_W1.0130.99
341_A345_M1.0130.99
56_V60_N1.0070.99
40_G243_G1.0030.99
152_V156_I1.0030.99
238_L242_F0.9900.99
60_N240_F0.9890.99
112_G280_N0.9840.99
390_G393_L0.9790.99
217_F289_L0.9770.99
59_G197_L0.9760.99
123_A266_L0.9740.99
100_L332_I0.9720.99
301_T304_V0.9710.99
83_L86_R0.9700.99
123_A269_I0.9690.99
55_A59_G0.9680.99
34_S276_I0.9680.99
13_P17_R0.9650.99
394_S397_I0.9650.99
53_F57_L0.9640.99
337_G392_A0.9630.99
56_V237_S0.9620.99
208_G336_G0.9590.99
367_L371_L0.9580.98
364_V368_A0.9560.98
73_I77_T0.9560.98
292_A302_L0.9540.98
126_L130_L0.9450.98
59_G200_V0.9320.98
89_F97_P0.9310.98
179_L182_L0.9300.98
110_G313_C0.9270.98
99_L294_I0.9270.98
167_Y171_L0.9260.98
71_G224_A0.9260.98
386_N389_L0.9230.98
194_N198_A0.9220.98
368_A392_A0.9170.98
159_P162_A0.9170.98
286_A290_G0.9040.98
212_A215_V0.9010.98
275_N279_T0.9000.98
108_W325_L0.9000.98
392_A395_Y0.8990.98
349_R353_F0.8970.98
23_L215_V0.8960.98
126_L129_N0.8950.98
226_L229_M0.8940.98
159_P163_C0.8900.98
197_L201_V0.8880.98
288_G302_L0.8850.97
393_L396_L0.8850.97
32_F161_I0.8850.97
109_F112_G0.8820.97
375_A386_N0.8810.97
371_L378_W0.8810.97
93_G366_I0.8800.97
196_A200_V0.8780.97
125_G129_N0.8770.97
60_N203_S0.8760.97
373_I376_G0.8760.97
19_G219_R0.8720.97
143_V303_S0.8690.97
71_G74_G0.8670.97
114_A117_A0.8670.97
364_V367_L0.8650.97
168_S171_L0.8650.97
72_Y344_L0.8640.97
367_L370_A0.8460.97
399_N402_L0.8450.97
181_A189_Q0.8450.97
352_H357_R0.8440.97
96_L370_A0.8430.97
68_S225_V0.8420.97
63_L204_F0.8400.97
100_L328_L0.8380.97
346_N399_N0.8360.96
231_A235_G0.8350.96
51_D54_L0.8330.96
183_K186_V0.8300.96
27_M82_H0.8290.96
64_G233_F0.8230.96
161_I279_T0.8220.96
220_N223_L0.8220.96
284_L307_G0.8210.96
61_L233_F0.8210.96
82_H290_G0.8160.96
109_F284_L0.8160.96
162_A166_G0.8120.96
89_F369_V0.8120.96
341_A346_N0.8110.96
287_S290_G0.8100.96
31_T235_G0.8090.96
154_S278_T0.8090.96
112_G276_I0.8070.96
123_A270_V0.8060.96
206_S332_I0.8040.96
102_G291_F0.8040.96
171_L175_G0.8030.96
24_T230_V0.8000.95
198_A385_V0.7970.95
386_N390_G0.7960.95
32_F279_T0.7950.95
180_D186_V0.7920.95
77_T351_E0.7920.95
373_I378_W0.7910.95
258_V261_A0.7900.95
167_Y264_L0.7890.95
303_S307_G0.7880.95
166_G371_L0.7870.95
113_V280_N0.7860.95
371_L374_A0.7830.95
142_T277_W0.7800.95
285_Y289_L0.7780.95
38_W41_G0.7760.95
92_K359_M0.7750.95
237_S241_I0.7750.95
257_D260_I0.7720.94
119_P256_S0.7710.94
81_T212_A0.7710.94
67_T70_L0.7700.94
86_R91_V0.7690.94
258_V262_Q0.7690.94
181_A186_V0.7690.94
122_K257_D0.7680.94
41_G247_A0.7670.94
37_M246_G0.7660.94
72_Y349_R0.7590.94
116_F276_I0.7560.94
134_V141_V0.7540.94
347_R351_E0.7530.94
320_N324_W0.7490.94
57_L134_V0.7470.93
92_K361_V0.7470.93
351_E354_A0.7470.93
173_V245_A0.7460.93
117_A121_G0.7460.93
60_N236_N0.7390.93
381_G386_N0.7380.93
127_D130_L0.7380.93
345_M348_R0.7370.93
136_G307_G0.7340.93
21_L25_F0.7340.93
363_W402_L0.7330.93
75_A218_G0.7320.93
110_G114_A0.7320.93
140_T304_V0.7290.93
124_T131_L0.7280.93
312_V315_L0.7250.92
182_L187_P0.7250.92
35_A276_I0.7190.92
171_L174_N0.7190.92
36_S243_G0.7170.92
147_I217_F0.7160.92
370_A373_I0.7160.92
73_I339_I0.7160.92
172_A176_M0.7150.92
363_W366_I0.7150.92
373_I377_H0.7150.92
201_V388_V0.7140.92
223_L226_L0.7120.92
194_N197_L0.7120.92
130_L133_A0.7090.92
210_L214_F0.7080.92
47_L51_D0.7060.91
144_F300_K0.7050.91
372_G375_A0.7050.91
64_G276_I0.7040.91
120_V131_L0.7020.91
298_S302_L0.7000.91
36_S203_S0.7000.91
86_R342_D0.6980.91
81_T286_A0.6940.91
107_G328_L0.6920.91
218_G221_A0.6920.91
200_V203_S0.6920.91
143_V307_G0.6880.90
9_Q83_L0.6880.90
86_R293_N0.6870.90
70_L211_T0.6860.90
362_N365_A0.6850.90
364_V402_L0.6850.90
269_I278_T0.6850.90
232_F236_N0.6840.90
24_T28_L0.6830.90
330_A377_H0.6790.90
221_A270_V0.6780.90
320_N323_G0.6760.90
166_G238_L0.6760.90
45_T192_D0.6750.90
201_V205_I0.6740.89
33_F36_S0.6740.89
275_N278_T0.6730.89
246_G259_M0.6720.89
67_T206_S0.6710.89
199_L322_V0.6670.89
72_Y221_A0.6660.89
191_L194_N0.6650.89
114_A118_I0.6650.89
95_W294_I0.6650.89
350_Y353_F0.6640.89
52_F56_V0.6640.89
100_L335_V0.6630.89
22_A151_T0.6630.89
153_L278_T0.6620.89
41_G115_M0.6590.88
34_S37_M0.6580.88
30_L207_A0.6580.88
204_F208_G0.6580.88
39_T322_V0.6570.88
135_S277_W0.6570.88
276_I279_T0.6550.88
75_A221_A0.6540.88
229_M233_F0.6520.88
216_R285_Y0.6510.88
133_A311_T0.6510.88
10_G16_A0.6500.88
172_A242_F0.6490.88
349_R357_R0.6460.87
362_N399_N0.6450.87
154_S281_D0.6440.87
116_F142_T0.6430.87
75_A224_A0.6420.87
35_A117_A0.6410.87
390_G399_N0.6400.87
70_L340_I0.6360.87
274_L278_T0.6360.87
101_L210_L0.6350.86
36_S39_T0.6330.86
38_W115_M0.6330.86
224_A228_A0.6320.86
291_F302_L0.6310.86
285_Y299_S0.6300.86
123_A273_G0.6300.86
105_Q287_S0.6300.86
272_L276_I0.6290.86
362_N402_L0.6280.86
368_A371_L0.6270.86
247_A250_L0.6270.86
59_G63_L0.6260.86
184_A187_P0.6250.86
230_V234_L0.6240.86
225_V229_M0.6240.86
288_G293_N0.6220.85
10_G13_P0.6200.85
61_L400_P0.6180.85
30_L236_N0.6170.85
139_M142_T0.6170.85
161_I275_N0.6150.85
308_I312_V0.6150.85
180_D393_L0.6140.85
259_M264_L0.6140.85
383_V387_A0.6140.85
20_V227_V0.6110.84
338_V391_G0.6100.84
98_S290_G0.6080.84
67_T211_T0.6080.84
85_A335_V0.6070.84
338_V346_N0.6070.84
42_T322_V0.6070.84
106_V292_A0.6070.84
342_D399_N0.6050.84
30_L204_F0.6050.84
109_F140_T0.6040.84
170_W363_W0.6030.84
60_N104_T0.6020.83
121_G129_N0.5990.83
259_M262_Q0.5980.83
105_Q283_A0.5960.83
117_A239_M0.5960.83
61_L237_S0.5960.83
12_V78_G0.5950.83
334_P372_G0.5940.83
30_L276_I0.5940.83
49_Y245_A0.5930.83
104_T325_L0.5920.82
79_L84_L0.5920.82
170_W380_P0.5900.82
192_D195_V0.5850.82
37_M239_M0.5840.82
372_G376_G0.5820.81
246_G250_L0.5810.81
85_A94_S0.5810.81
207_A282_N0.5810.81
139_M277_W0.5800.81
257_D263_G0.5800.81
226_L308_I0.5790.81
96_L130_L0.5770.81
143_V284_L0.5760.81
85_A88_S0.5750.81
204_F207_A0.5750.81
307_G310_G0.5750.81
98_S294_I0.5740.80
57_L222_K0.5740.80
168_S262_Q0.5730.80
36_S112_G0.5720.80
109_F139_M0.5720.80
182_L189_Q0.5710.80
207_A321_F0.5710.80
161_I278_T0.5710.80
187_P190_P0.5710.80
34_S258_V0.5700.80
381_G384_P0.5690.80
68_S71_G0.5680.80
9_Q86_R0.5670.80
141_V375_A0.5640.79
202_G329_S0.5620.79
185_V189_Q0.5610.79
156_I163_C0.5600.79
31_T236_N0.5600.79
375_A394_S0.5590.79
303_S306_N0.5580.79
181_A184_A0.5580.79
31_T82_H0.5570.78
168_S204_F0.5550.78
184_A397_I0.5550.78
311_T315_L0.5540.78
98_S293_N0.5540.78
57_L241_I0.5540.78
177_G181_A0.5540.78
305_I309_I0.5510.78
223_L391_G0.5510.78
69_F345_M0.5510.78
87_F347_R0.5510.78
281_D284_L0.5510.78
101_L286_A0.5510.78
106_V328_L0.5510.78
164_L271_V0.5500.78
71_G228_A0.5490.77
164_L268_A0.5480.77
79_L86_R0.5480.77
137_L338_V0.5470.77
163_C170_W0.5460.77
96_L369_V0.5460.77
179_L189_Q0.5460.77
183_K189_Q0.5450.77
111_V318_Y0.5430.77
210_L213_D0.5430.77
23_L218_G0.5420.77
81_T101_L0.5420.77
79_L83_L0.5420.77
134_V170_W0.5410.76
333_P337_G0.5410.76
68_S235_G0.5400.76
14_Q166_G0.5390.76
134_V370_A0.5390.76
78_G146_G0.5380.76
57_L200_V0.5370.76
88_S338_V0.5360.76
351_E355_T0.5360.76
204_F232_F0.5360.76
101_L105_Q0.5350.76
49_Y183_K0.5340.76
64_G229_M0.5330.75
156_I159_P0.5330.75
134_V308_I0.5320.75
146_G285_Y0.5320.75
31_T40_G0.5310.75
152_V157_A0.5310.75
97_P108_W0.5310.75
358_M367_L0.5290.75
109_F283_A0.5280.75
282_N286_A0.5280.75
134_V137_L0.5280.75
137_L371_L0.5280.75
108_W112_G0.5280.75
234_L238_L0.5270.75
180_D189_Q0.5250.74
160_A271_V0.5250.74
141_V145_F0.5240.74
300_K303_S0.5240.74
372_G392_A0.5240.74
113_V116_F0.5230.74
51_D193_F0.5210.74
82_H293_N0.5200.74
60_N237_S0.5180.73
177_G182_L0.5180.73
170_W397_I0.5160.73
119_P123_A0.5160.73
264_L268_A0.5150.73
372_G387_A0.5150.73
172_A269_I0.5140.73
49_Y244_A0.5140.73
112_G278_T0.5140.73
343_Y346_N0.5140.73
63_L67_T0.5120.72
44_G244_A0.5110.72
96_L378_W0.5110.72
126_L134_V0.5110.72
26_V46_G0.5110.72
125_G190_P0.5110.72
13_P217_F0.5100.72
108_W207_A0.5090.72
222_K230_V0.5090.72
137_L319_N0.5090.72
264_L267_P0.5070.72
29_G279_T0.5040.71
30_L212_A0.5040.71
140_T144_F0.5030.71
183_K188_A0.5030.71
32_F162_A0.5020.71
144_F273_G0.5020.71
115_M276_I0.5020.71
33_F203_S0.5020.71
27_M33_F0.5020.71
199_L204_F0.5010.71
291_F308_I0.5010.71
54_L57_L0.5010.71
63_L209_T0.5010.71
304_V307_G0.5010.71
348_R359_M0.5000.71
198_A384_P0.5000.71
105_Q240_F0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.9952 100 0.172 Contact Map
3dh4A 3 0.9165 99.4 0.844 Contact Map
2xq2A 2 0.9141 99.4 0.847 Contact Map
3giaA 1 0.9356 99.3 0.85 Contact Map
3l1lA 2 0.9069 99.3 0.852 Contact Map
4djkA 2 0.8878 99.3 0.852 Contact Map
4wgvA 2 0.8162 98.4 0.893 Contact Map
4us3A 1 0.8687 97.5 0.915 Contact Map
2a65A 2 0.9403 96.2 0.928 Contact Map
3qe7A 2 0.852 89.3 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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