GREMLIN Database
YHBE - Uncharacterized inner membrane transporter YhbE
UniProt: P0AA73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11499
Length: 321 (275)
Sequences: 38194 (28006)
Seq/√Len: 1688.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_S164_G3.3031.00
11_L238_E2.8961.00
100_A161_V2.8661.00
238_E242_R2.7121.00
263_S277_P2.5641.00
91_S163_F2.4991.00
25_A224_F2.4021.00
40_F203_F2.3921.00
47_S196_T2.3891.00
88_L166_G2.3291.00
238_E241_A2.3071.00
131_G293_G2.3001.00
111_G168_A2.2191.00
122_E179_K2.1621.00
102_Q259_T2.1431.00
88_L163_F2.0931.00
115_A176_V2.0691.00
27_K277_P2.0611.00
67_R70_R2.0351.00
216_H220_A2.0151.00
12_A239_A1.9961.00
26_M90_S1.9921.00
45_M226_G1.9751.00
20_G258_F1.9741.00
117_V124_M1.9151.00
113_M132_A1.8321.00
44_L199_T1.8121.00
96_L161_V1.7921.00
84_G170_V1.7901.00
51_G192_F1.7831.00
200_I204_P1.7581.00
112_M249_S1.7551.00
107_L111_G1.7541.00
125_R128_Q1.7531.00
116_S122_E1.7391.00
95_Y159_W1.7181.00
96_L160_G1.7171.00
52_A55_A1.7121.00
20_G262_F1.7061.00
162_I166_G1.6891.00
186_A189_Q1.6861.00
295_M299_I1.6781.00
204_P207_K1.6761.00
215_S218_Q1.6511.00
226_G230_L1.6031.00
111_G172_V1.5991.00
21_A224_F1.5881.00
244_Q247_Q1.5801.00
32_V218_Q1.5791.00
17_I258_F1.5721.00
88_L170_V1.5691.00
70_R184_R1.5611.00
131_G297_S1.5501.00
135_L253_T1.5441.00
47_S199_T1.5361.00
280_N283_G1.5301.00
91_S95_Y1.4981.00
33_M218_Q1.4761.00
53_I57_K1.4731.00
101_S164_G1.4471.00
51_G55_A1.4341.00
111_G169_T1.4251.00
158_T161_V1.4101.00
178_Q237_A1.3961.00
40_F199_T1.3901.00
52_A56_V1.3621.00
29_V38_I1.3571.00
28_Q221_C1.3561.00
91_S94_Q1.3511.00
15_T239_A1.3451.00
115_A119_I1.3391.00
99_T260_L1.3231.00
19_W232_G1.3171.00
98_P263_S1.3161.00
69_P73_I1.3091.00
48_I52_A1.2841.00
116_S120_L1.2841.00
95_Y163_F1.2811.00
131_G296_Y1.2801.00
69_P72_L1.2781.00
281_L285_L1.2741.00
126_S130_V1.2731.00
258_F262_F1.2711.00
11_L235_A1.2661.00
46_A195_Y1.2661.00
24_I262_F1.2631.00
172_V176_V1.2611.00
97_S100_A1.2571.00
96_L100_A1.2541.00
262_F266_L1.2521.00
141_M289_V1.2521.00
9_I251_I1.2461.00
68_K72_L1.2451.00
68_K71_W1.2411.00
135_L293_G1.2381.00
72_L76_A1.2211.00
217_W220_A1.2191.00
38_I225_C1.2181.00
34_E37_T1.2141.00
284_Y288_F1.2081.00
138_G286_G1.1971.00
288_F292_A1.1961.00
217_W221_C1.1831.00
27_K31_E1.1831.00
49_G230_L1.1801.00
75_L78_A1.1791.00
93_L101_S1.1771.00
129_V133_L1.1641.00
254_L258_F1.1631.00
103_V287_A1.1621.00
70_R73_I1.1531.00
279_L284_Y1.1411.00
83_F201_A1.1401.00
36_P205_L1.1371.00
127_T296_Y1.1281.00
158_T162_I1.1281.00
201_A204_P1.1241.00
73_I77_V1.1211.00
216_H219_L1.1201.00
55_A59_R1.1201.00
220_A224_F1.1161.00
141_M282_L1.1121.00
159_W163_F1.1071.00
115_A173_S1.1071.00
14_T235_A1.1021.00
112_M245_A1.0951.00
179_K244_Q1.0921.00
133_L137_S1.0861.00
98_P275_A1.0851.00
138_G290_V1.0821.00
240_M248_V1.0721.00
96_L164_G1.0711.00
95_Y160_G1.0711.00
25_A221_C1.0711.00
73_I177_A1.0711.00
126_S129_V1.0651.00
44_L203_F1.0591.00
95_Y157_Y1.0581.00
180_V183_R1.0561.00
19_W236_L1.0551.00
179_K245_A1.0541.00
40_F44_L1.0471.00
21_A262_F1.0461.00
15_T235_A1.0411.00
120_L176_V1.0391.00
117_V123_K1.0381.00
72_L75_L1.0361.00
10_L14_T1.0331.00
81_G173_S1.0321.00
127_T300_G1.0321.00
18_C235_A1.0291.00
81_G174_Y1.0261.00
74_L78_A1.0231.00
179_K183_R1.0211.00
59_R186_A1.0171.00
124_M129_V1.0131.00
15_T19_W1.0131.00
32_V215_S1.0091.00
42_R229_T1.0081.00
40_F206_A1.0071.00
115_A172_V1.0061.00
112_M175_G1.0061.00
26_M93_L1.0031.00
159_W162_I1.0031.00
122_E128_Q0.9991.00
8_G239_A0.9961.00
83_F202_L0.9961.00
213_Q216_H0.9951.00
104_I168_A0.9881.00
47_S192_F0.9871.00
89_F93_L0.9851.00
104_I161_V0.9821.00
39_V90_S0.9811.00
142_F286_G0.9741.00
113_M124_M0.9741.00
144_N280_N0.9701.00
29_V218_Q0.9671.00
79_T201_A0.9641.00
222_L226_G0.9631.00
75_L197_L0.9611.00
55_A58_K0.9511.00
35_P39_V0.9511.00
140_V144_N0.9501.00
29_V221_C0.9481.00
220_A223_I0.9451.00
8_G242_R0.9411.00
127_T299_I0.9391.00
107_L139_L0.9311.00
281_L284_Y0.9231.00
160_G164_G0.9211.00
240_M244_Q0.9201.00
115_A169_T0.9181.00
223_I226_G0.9171.00
75_L79_T0.9161.00
104_I164_G0.9151.00
204_P208_P0.9151.00
76_A177_A0.9131.00
244_Q248_V0.9111.00
168_A172_V0.9091.00
243_W248_V0.8951.00
134_M293_G0.8931.00
125_R129_V0.8911.00
24_I266_L0.8901.00
115_A118_F0.8901.00
112_M172_V0.8891.00
82_L174_Y0.8841.00
118_F121_K0.8841.00
49_G52_A0.8741.00
73_I181_L0.8711.00
36_P87_I0.8691.00
16_A20_G0.8681.00
74_L77_V0.8641.00
98_P277_P0.8541.00
43_F198_C0.8531.00
87_I91_S0.8501.00
205_L208_P0.8501.00
51_G196_T0.8421.00
49_G227_L0.8411.00
54_L58_K0.8401.00
103_V140_V0.8381.00
219_L223_I0.8341.00
71_W75_L0.8301.00
71_W197_L0.8291.00
243_W247_Q0.8231.00
16_A258_F0.8201.00
214_L219_L0.8201.00
266_L275_A0.8131.00
239_A248_V0.8111.00
37_T206_A0.8071.00
78_A197_L0.8051.00
56_V59_R0.8041.00
257_L287_A0.8041.00
123_K127_T0.8021.00
137_S289_V0.7991.00
157_Y161_V0.7981.00
24_I263_S0.7961.00
41_Y45_M0.7951.00
139_L143_F0.7901.00
221_C224_F0.7901.00
70_R185_L0.7891.00
196_T200_I0.7861.00
12_A251_I0.7831.00
164_G168_A0.7771.00
123_K126_S0.7731.00
141_M285_L0.7691.00
47_S51_G0.7661.00
264_D279_L0.7611.00
199_T203_F0.7581.00
173_S177_A0.7581.00
137_S141_M0.7551.00
260_L279_L0.7541.00
76_A79_T0.7461.00
197_L200_I0.7421.00
55_A60_L0.7421.00
37_T41_Y0.7391.00
282_L285_L0.7381.00
16_A254_L0.7361.00
13_L258_F0.7321.00
73_I180_V0.7301.00
114_V118_F0.7271.00
287_A291_V0.7261.00
56_V60_L0.7261.00
23_P89_F0.7241.00
83_F87_I0.7231.00
110_V135_L0.7231.00
81_G170_V0.7211.00
201_A205_L0.7211.00
260_L287_A0.7181.00
24_I98_P0.7151.00
9_I247_Q0.7151.00
130_V134_M0.7111.00
85_N170_V0.7071.00
231_V235_A0.7071.00
117_V121_K0.7071.00
54_L192_F0.7061.00
26_M30_L0.7051.00
155_T158_T0.7031.00
44_L48_I0.7011.00
84_G88_L0.7001.00
171_W175_G0.6981.00
112_M176_V0.6971.00
193_L197_L0.6941.00
96_L101_S0.6911.00
185_L190_I0.6891.00
74_L185_L0.6881.00
196_T199_T0.6861.00
33_M38_I0.6841.00
50_L230_L0.6821.00
215_S219_L0.6811.00
263_S275_A0.6811.00
254_L257_L0.6811.00
39_V202_L0.6801.00
104_I165_V0.6781.00
285_L289_V0.6761.00
113_M128_Q0.6761.00
191_L237_A0.6721.00
85_N174_Y0.6711.00
200_I203_F0.6711.00
293_G297_S0.6681.00
234_G238_E0.6671.00
33_M37_T0.6661.00
57_K60_L0.6631.00
49_G226_G0.6621.00
279_L283_G0.6591.00
278_M282_L0.6581.00
144_N147_L0.6561.00
264_D278_M0.6551.00
53_I188_P0.6541.00
81_G177_A0.6541.00
124_M128_Q0.6541.00
192_F196_T0.6531.00
107_L110_V0.6531.00
198_C202_L0.6511.00
82_L233_Y0.6461.00
18_C228_N0.6431.00
53_I56_V0.6431.00
111_G165_V0.6421.00
89_F101_S0.6411.00
92_S101_S0.6381.00
180_V184_R0.6381.00
12_A243_W0.6371.00
212_A215_S0.6351.00
292_A296_Y0.6331.00
122_E246_A0.6321.00
197_L201_A0.6301.00
250_A297_S0.6261.00
113_M117_V0.6241.00
120_L180_V0.6211.00
28_Q275_A0.6211.00
218_Q221_C0.6211.00
156_D159_W0.6201.00
46_A230_L0.6191.00
261_F265_L0.6171.00
57_K186_A0.6151.00
106_Q139_L0.6141.00
23_P102_Q0.6141.00
215_S220_A0.6131.00
18_C232_G0.6121.00
73_I76_A0.6101.00
260_L264_D0.6101.00
189_Q193_L0.6081.00
90_S94_Q0.6071.00
174_Y237_A0.6071.00
214_L218_Q0.6021.00
283_G287_A0.5991.00
212_A216_H0.5981.00
138_G293_G0.5971.00
155_T159_W0.5931.00
71_W74_L0.5921.00
109_P253_T0.5911.00
119_I173_S0.5891.00
223_I227_L0.5871.00
9_I13_L0.5821.00
203_F207_K0.5811.00
73_I78_A0.5781.00
57_K188_P0.5781.00
14_T18_C0.5761.00
106_Q109_P0.5731.00
92_S160_G0.5711.00
193_L196_T0.5701.00
143_F161_V0.5691.00
191_L194_L0.5671.00
294_A297_S0.5661.00
21_A228_N0.5641.00
171_W236_L0.5621.00
103_V142_F0.5601.00
8_G243_W0.5591.00
107_L168_A0.5591.00
89_F167_A0.5591.00
134_M296_Y0.5581.00
41_Y222_L0.5531.00
88_L167_A0.5491.00
78_A83_F0.5491.00
102_Q106_Q0.5491.00
187_S191_L0.5481.00
252_I255_T0.5451.00
82_L194_L0.5421.00
16_A255_T0.5401.00
163_F166_G0.5401.00
253_T294_A0.5391.00
30_L93_L0.5381.00
280_N284_Y0.5371.00
128_Q244_Q0.5371.00
34_E209_G0.5371.00
262_F265_L0.5361.00
13_L16_A0.5361.00
145_T282_L0.5341.00
106_Q168_A0.5291.00
48_I51_G0.5271.00
235_A238_E0.5261.00
175_G249_S0.5251.00
22_L228_N0.5241.00
116_S246_A0.5231.00
70_R74_L0.5221.00
239_A243_W0.5221.00
130_V137_S0.5221.00
74_L190_I0.5201.00
67_R71_W0.5171.00
71_W78_A0.5161.00
12_A236_L0.5151.00
24_I259_T0.5151.00
284_Y287_A0.5141.00
103_V143_F0.5131.00
278_M283_G0.5131.00
175_G236_L0.5121.00
85_N89_F0.5091.00
174_Y178_Q0.5081.00
178_Q190_I0.5081.00
261_F264_D0.5071.00
71_W193_L0.5021.00
20_G255_T0.5001.00
138_G289_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2399 98.9 0.767 Contact Map
3b5dA 2 0.3146 97.9 0.825 Contact Map
4j05A 3 0.9346 92.5 0.888 Contact Map
2cfqA 1 0.5981 85.8 0.902 Contact Map
4pypA 1 0.9097 85.5 0.903 Contact Map
3wdoA 1 0.9315 85.4 0.903 Contact Map
4tphA 2 0.8692 73 0.914 Contact Map
4he8J 1 0.4829 71.4 0.915 Contact Map
1pw4A 1 0.9502 70.8 0.915 Contact Map
4zw9A 1 0.9283 69.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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