GREMLIN Database
YEDA - Uncharacterized inner membrane transporter YedA
UniProt: P0AA70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11141
Length: 306 (275)
Sequences: 38874 (28649)
Seq/√Len: 1727.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_A155_I3.3401.00
98_I152_A2.8941.00
12_A232_Y2.8601.00
232_Y236_N2.7051.00
257_G263_E2.6831.00
88_V154_L2.4741.00
128_G279_A2.3501.00
85_M157_I2.3131.00
41_G193_M2.3031.00
48_G186_L2.2991.00
232_Y235_R2.2811.00
26_V217_Y2.2801.00
119_I170_S2.2781.00
64_P67_P2.1951.00
109_F159_S2.1771.00
113_F167_V2.1361.00
28_R263_E2.1271.00
85_M154_L2.1101.00
100_A253_A2.0931.00
27_I87_T2.0231.00
46_A219_A2.0041.00
115_R121_T1.9971.00
209_L213_L1.9801.00
13_L233_L1.9611.00
21_G252_V1.9591.00
114_S119_I1.9301.00
81_V161_S1.8911.00
111_L129_I1.8821.00
45_L189_G1.8561.00
94_V152_A1.8041.00
67_P175_P1.7741.00
105_T109_F1.7621.00
53_A56_L1.7301.00
122_R125_E1.7291.00
110_T243_T1.7141.00
219_A224_I1.7141.00
94_V151_G1.6971.00
93_N150_W1.6931.00
21_G256_L1.6931.00
190_V194_I1.6921.00
153_I157_I1.6891.00
52_L182_A1.6871.00
238_S241_L1.6491.00
132_G247_Y1.6211.00
208_S211_G1.6181.00
85_M161_S1.6061.00
22_S217_Y1.5931.00
281_V285_L1.5401.00
109_F163_A1.5391.00
128_G283_V1.5391.00
266_S269_E1.5341.00
18_I252_V1.5111.00
194_I197_M1.4721.00
54_F58_R1.4651.00
99_A155_I1.4611.00
48_G189_G1.4051.00
66_R70_N1.4001.00
52_L56_L1.3961.00
30_G39_M1.3881.00
169_G231_M1.3881.00
135_G272_A1.3861.00
113_F117_F1.3821.00
20_W226_A1.3751.00
267_K271_L1.3641.00
16_L233_L1.3551.00
34_W211_G1.3501.00
65_L69_L1.3491.00
109_F160_I1.3411.00
70_N168_Y1.3391.00
132_G279_A1.3231.00
29_I214_A1.3161.00
88_V93_N1.3161.00
53_A57_L1.3151.00
128_G282_L1.3081.00
33_S211_G1.3081.00
50_L224_I1.3011.00
94_V98_I1.3001.00
97_G254_V1.2921.00
66_R69_L1.2901.00
96_S257_G1.2851.00
41_G189_G1.2841.00
88_V92_Q1.2841.00
93_N151_G1.2831.00
256_L260_L1.2831.00
69_L73_L1.2801.00
95_P98_I1.2621.00
138_M275_V1.2601.00
123_K127_V1.2601.00
12_A229_A1.2551.00
252_V256_L1.2521.00
171_R175_P1.2431.00
149_P152_A1.2421.00
56_L60_H1.2401.00
25_F256_L1.2381.00
47_A185_M1.2351.00
209_L212_F1.2341.00
10_F245_Y1.2311.00
65_L68_L1.2271.00
49_I53_A1.2271.00
101_V273_L1.2241.00
248_V252_V1.2211.00
270_W274_G1.2211.00
170_S238_S1.2211.00
39_M218_L1.2181.00
138_M268_I1.2081.00
163_A167_V1.1991.00
210_S213_L1.1941.00
126_W130_A1.1921.00
73_L168_Y1.1781.00
28_R32_E1.1771.00
265_L270_W1.1671.00
35_P38_M1.1661.00
93_N154_L1.1651.00
274_G278_F1.1631.00
191_V194_I1.1481.00
124_L282_L1.1421.00
90_E99_A1.1411.00
19_I221_F1.1321.00
149_P153_I1.1271.00
171_R174_L1.1141.00
139_L272_A1.1141.00
43_R223_S1.1091.00
78_L165_G1.1081.00
41_G45_L1.1081.00
110_T239_P1.1081.00
113_F164_F1.1011.00
130_A134_A1.1001.00
150_W154_L1.0881.00
213_L217_Y1.0851.00
26_V214_A1.0841.00
121_T126_W1.0821.00
135_G276_I1.0821.00
76_L191_V1.0791.00
11_G15_A1.0771.00
37_L195_A1.0751.00
72_A187_A1.0741.00
115_R120_K1.0611.00
111_L121_T1.0611.00
20_W230_Y1.0561.00
210_S214_A1.0561.00
170_S174_L1.0531.00
80_A191_V1.0501.00
94_V155_I1.0471.00
9_L233_L1.0441.00
170_S239_P1.0441.00
110_T166_S1.0391.00
40_A87_T1.0381.00
16_L229_A1.0331.00
234_I242_A1.0331.00
16_L20_W1.0331.00
124_L286_G1.0321.00
123_K126_W1.0311.00
113_F163_A1.0301.00
15_A229_A1.0301.00
150_W153_I1.0291.00
93_N148_N1.0281.00
22_S256_L1.0181.00
41_G196_S1.0171.00
216_G219_A1.0161.00
27_I90_E1.0111.00
48_G182_A1.0051.00
19_I229_A1.0001.00
86_V90_E0.9961.00
194_I198_I0.9941.00
56_L59_G0.9931.00
102_V159_S0.9901.00
113_F116_L0.9901.00
119_I125_E0.9891.00
70_N172_I0.9871.00
80_A192_L0.9791.00
30_G211_G0.9791.00
124_L285_L0.9781.00
96_S261_G0.9761.00
213_L216_G0.9701.00
159_S163_A0.9681.00
105_T136_I0.9661.00
137_I141_S0.9641.00
267_K270_W0.9611.00
195_A199_A0.9591.00
77_L164_F0.9561.00
238_S242_A0.9501.00
36_P40_A0.9471.00
30_G214_A0.9441.00
151_G155_I0.9411.00
67_P176_V0.9411.00
113_F160_I0.9331.00
37_L84_G0.9281.00
146_S149_P0.9281.00
96_S263_E0.9251.00
122_R126_W0.9231.00
102_V152_A0.9211.00
234_I238_S0.9161.00
9_L236_N0.9111.00
75_G187_A0.9031.00
181_G184_E0.9011.00
45_L193_M0.8991.00
17_Y21_G0.8981.00
25_F260_L0.8911.00
77_L161_S0.8901.00
131_I279_A0.8851.00
50_L220_L0.8841.00
67_P70_N0.8841.00
141_S266_S0.8821.00
101_V137_I0.8811.00
64_P68_L0.8771.00
212_F216_G0.8771.00
195_A198_I0.8741.00
110_T163_A0.8741.00
102_V155_I0.8731.00
237_V242_A0.8681.00
74_I78_L0.8681.00
187_A190_V0.8611.00
69_L72_A0.8611.00
70_N171_R0.8541.00
17_Y252_V0.8481.00
55_L59_G0.8401.00
120_K124_L0.8391.00
50_L53_A0.8371.00
182_A186_L0.8361.00
33_S208_S0.8351.00
155_I159_S0.8251.00
233_L242_A0.8211.00
186_L190_V0.8131.00
38_M196_S0.8121.00
237_V241_L0.8121.00
134_A138_M0.8111.00
84_G88_V0.8101.00
162_W166_S0.8071.00
216_G220_L0.7991.00
115_R118_G0.7981.00
48_G52_L0.7961.00
208_S212_F0.7951.00
25_F257_G0.7941.00
206_L209_L0.7941.00
44_F188_A0.7931.00
136_I140_N0.7921.00
57_L60_H0.7911.00
68_L187_A0.7901.00
254_V265_L0.7901.00
197_M200_G0.7871.00
120_K123_K0.7821.00
70_N74_I0.7761.00
254_V273_L0.7751.00
183_I187_A0.7721.00
273_L277_V0.7721.00
251_V273_L0.7701.00
27_I31_V0.7681.00
179_M183_I0.7651.00
207_P211_G0.7651.00
148_N152_A0.7631.00
268_I271_L0.7631.00
77_L168_Y0.7601.00
164_F168_Y0.7601.00
258_T265_L0.7591.00
134_A275_V0.7561.00
138_M271_L0.7551.00
75_G80_A0.7541.00
271_L275_V0.7511.00
111_L125_E0.7491.00
14_F252_V0.7461.00
258_T264_T0.7441.00
108_L132_G0.7441.00
127_V131_I0.7411.00
73_L76_L0.7401.00
248_V251_V0.7341.00
215_V219_A0.7321.00
207_P212_F0.7321.00
51_L224_I0.7291.00
80_A84_G0.7281.00
68_L72_A0.7251.00
82_G161_S0.7251.00
75_G78_L0.7211.00
181_G185_M0.7211.00
214_A217_Y0.7161.00
198_I201_E0.7141.00
81_V85_M0.7141.00
13_L245_Y0.7131.00
105_T108_L0.7121.00
199_A202_K0.7101.00
54_F178_M0.7091.00
38_M42_V0.7051.00
244_S283_V0.7051.00
42_V46_A0.7051.00
187_A191_V0.7011.00
135_G279_A0.7001.00
279_A283_V0.6961.00
10_F241_L0.6951.00
225_I229_A0.6941.00
40_A192_L0.6941.00
70_N73_L0.6921.00
190_V193_M0.6901.00
17_Y248_V0.6891.00
189_G193_M0.6881.00
89_A99_A0.6861.00
265_L269_E0.6861.00
110_T167_V0.6861.00
211_G214_A0.6861.00
109_F156_L0.6851.00
121_T125_E0.6821.00
112_C116_L0.6811.00
183_I186_L0.6791.00
24_Y86_V0.6731.00
52_L186_L0.6721.00
25_F96_S0.6681.00
34_W39_M0.6661.00
72_A76_L0.6631.00
45_L49_I0.6631.00
82_G165_G0.6601.00
94_V99_A0.6601.00
19_I226_A0.6581.00
104_A136_I0.6571.00
257_G261_G0.6511.00
54_F57_L0.6491.00
102_V156_L0.6471.00
119_I240_A0.6471.00
278_F282_L0.6441.00
89_A151_G0.6431.00
71_A180_A0.6431.00
228_N232_Y0.6411.00
162_W230_Y0.6391.00
13_L237_V0.6391.00
71_A176_V0.6371.00
86_V99_A0.6331.00
264_T268_I0.6331.00
29_I261_G0.6281.00
196_S200_G0.6281.00
107_P247_Y0.6271.00
105_T159_S0.6251.00
50_L219_A0.6211.00
208_S213_L0.6201.00
104_A107_P0.6161.00
19_I222_G0.6151.00
47_A224_I0.6151.00
269_E273_L0.6131.00
24_Y100_A0.6121.00
254_V258_T0.6111.00
34_W38_M0.6111.00
86_V158_G0.6111.00
111_L115_R0.6111.00
64_P69_L0.6101.00
180_A183_I0.6061.00
55_L182_A0.6041.00
180_A184_E0.6041.00
188_A192_L0.6021.00
186_L189_G0.5991.00
82_G86_V0.5961.00
46_A50_L0.5951.00
17_Y249_N0.5951.00
23_T222_G0.5941.00
165_G231_M0.5941.00
181_G231_M0.5931.00
24_Y28_R0.5921.00
131_I282_L0.5861.00
256_L259_G0.5821.00
154_L157_I0.5741.00
144_N147_G0.5731.00
166_S243_T0.5701.00
166_S230_Y0.5661.00
25_F253_A0.5641.00
140_N152_A0.5611.00
80_A195_A0.5601.00
53_A58_R0.5591.00
217_Y221_F0.5571.00
68_L183_I0.5561.00
9_L237_V0.5561.00
247_Y280_V0.5551.00
15_A19_I0.5491.00
101_V140_N0.5481.00
42_V215_V0.5471.00
104_A159_S0.5471.00
35_P200_G0.5461.00
246_A249_N0.5461.00
125_E238_S0.5461.00
31_V90_E0.5441.00
185_M189_G0.5431.00
259_G262_G0.5411.00
117_F164_F0.5391.00
184_E187_A0.5391.00
101_V139_L0.5381.00
221_F225_I0.5351.00
68_L71_A0.5321.00
266_S270_W0.5311.00
114_S240_A0.5301.00
142_G268_I0.5281.00
105_T132_G0.5271.00
125_E287_K0.5251.00
21_G249_N0.5231.00
23_T87_T0.5231.00
178_M181_G0.5211.00
22_S222_G0.5201.00
14_F17_Y0.5201.00
70_N175_P0.5191.00
145_L148_N0.5191.00
165_G169_G0.5171.00
280_V283_V0.5171.00
205_A209_L0.5161.00
255_L259_G0.5161.00
13_L230_Y0.5151.00
49_I52_L0.5151.00
146_S150_W0.5141.00
60_H177_G0.5141.00
233_L237_V0.5141.00
85_M158_G0.5121.00
127_V134_A0.5101.00
193_M197_M0.5091.00
255_L258_T0.5081.00
82_G162_W0.5071.00
55_L58_R0.5071.00
264_T269_E0.5061.00
258_T270_W0.5001.00
147_G150_W0.5001.00
106_V159_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2516 98.9 0.755 Contact Map
3b5dA 2 0.3301 98 0.813 Contact Map
2cfqA 1 0.6078 75 0.909 Contact Map
4j05A 3 0.9248 73.3 0.91 Contact Map
4pypA 1 0.7843 72.2 0.911 Contact Map
3l1lA 2 0.8595 66.5 0.914 Contact Map
1pw4A 1 0.8137 60.8 0.917 Contact Map
4he8J 1 0.5131 60.7 0.917 Contact Map
3zuxA 1 0.8987 56.7 0.919 Contact Map
4czbA 2 0.9346 52.9 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.