GREMLIN Database
RHTA - Threonine/homoserine exporter RhtA
UniProt: P0AA67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12134
Length: 295 (268)
Sequences: 35168 (26116)
Seq/√Len: 1595.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_S153_A3.4311.00
16_I228_I2.8441.00
228_I232_R2.7571.00
99_I150_C2.7451.00
253_G259_E2.6491.00
52_T184_L2.5801.00
90_L152_L2.5271.00
30_L213_A2.4291.00
67_A70_Q2.3941.00
87_L155_G2.3701.00
45_A191_V2.3681.00
228_I231_T2.3531.00
101_V249_A2.2361.00
124_W275_A2.2291.00
50_L215_A2.2221.00
114_F165_L2.1731.00
110_A157_G2.1391.00
87_L152_L2.1141.00
25_Q248_L2.1111.00
32_K259_E2.0861.00
31_A89_Y2.0361.00
205_W209_P1.9811.00
83_G159_C1.9381.00
17_L229_A1.9351.00
49_A187_A1.9141.00
70_Q173_E1.8491.00
56_I180_A1.8201.00
118_R121_D1.7941.00
25_Q252_S1.7711.00
106_T110_A1.7431.00
94_T148_T1.7411.00
111_V239_G1.7231.00
204_H207_V1.7051.00
112_A125_V1.7001.00
22_A248_L1.6951.00
174_H177_A1.6861.00
151_A155_G1.6771.00
37_L207_V1.6741.00
188_L192_P1.6561.00
215_A220_A1.6541.00
87_L159_C1.6471.00
26_G213_A1.6401.00
277_M281_L1.6291.00
95_V149_G1.6261.00
95_V150_C1.6041.00
52_T187_A1.6001.00
192_P195_A1.5991.00
38_V207_V1.5961.00
234_P237_T1.5761.00
110_A161_A1.5661.00
124_W279_S1.5131.00
128_A243_S1.4991.00
100_A153_A1.4961.00
262_T265_Q1.4811.00
68_K72_L1.4721.00
90_L94_T1.4621.00
34_L43_V1.4391.00
167_G227_M1.4341.00
110_A158_A1.4281.00
72_L76_F1.3921.00
147_L150_C1.3901.00
263_P267_L1.3871.00
45_A187_A1.3841.00
90_L93_Q1.3801.00
68_K71_R1.3641.00
73_P166_S1.3531.00
252_S256_F1.3441.00
51_G183_S1.3441.00
20_A229_A1.3391.00
29_S252_S1.3311.00
16_I225_L1.3301.00
69_E73_P1.3271.00
53_L57_A1.3151.00
124_W278_G1.3131.00
69_E72_L1.3071.00
134_F271_A1.3041.00
205_W208_I1.3031.00
248_L252_S1.3001.00
266_L270_G1.3001.00
43_V214_V1.2921.00
161_A165_L1.2921.00
119_P123_V1.2861.00
97_L253_G1.2821.00
39_G42_G1.2791.00
206_S209_P1.2771.00
14_I241_L1.2661.00
33_S210_L1.2641.00
54_I220_A1.2581.00
95_V99_I1.2511.00
169_R172_A1.2511.00
102_A269_L1.2491.00
120_V278_G1.2461.00
76_F166_S1.2451.00
126_V130_L1.2401.00
56_I60_K1.2301.00
128_A275_A1.2221.00
61_P64_L1.2181.00
206_S210_L1.2151.00
134_F264_I1.2111.00
168_Q234_P1.2111.00
270_G274_A1.2101.00
80_S162_I1.2091.00
131_G268_A1.2031.00
147_L151_A1.2021.00
122_F126_V1.1931.00
24_I222_P1.1911.00
45_A49_A1.1901.00
114_F162_I1.1871.00
75_L185_I1.1831.00
94_T152_L1.1791.00
30_L210_L1.1701.00
78_G185_I1.1691.00
82_G189_I1.1581.00
244_M248_L1.1561.00
98_G250_A1.1551.00
73_P170_A1.1541.00
26_G252_S1.1471.00
23_S217_L1.1431.00
60_K63_R1.1391.00
209_P213_A1.1301.00
261_L266_L1.1301.00
169_R173_E1.1271.00
148_T152_L1.1251.00
193_I197_Q1.1231.00
37_L204_H1.1221.00
45_A194_G1.1181.00
94_T146_D1.1071.00
15_V19_V1.1031.00
92_I100_A1.1001.00
120_V281_L1.0961.00
57_A60_K1.0931.00
189_I192_P1.0921.00
95_V153_A1.0921.00
20_A225_L1.0911.00
79_V189_I1.0841.00
88_F92_I1.0821.00
24_I226_E1.0791.00
96_P99_I1.0771.00
94_T149_G1.0751.00
32_K36_P1.0721.00
82_G190_F1.0691.00
52_T180_A1.0531.00
119_P122_F1.0501.00
103_L157_G1.0471.00
120_V282_T1.0431.00
47_R219_T1.0411.00
41_P193_I1.0411.00
168_Q235_T1.0381.00
148_T151_A1.0341.00
44_T89_Y1.0301.00
41_P86_Y1.0231.00
72_L75_L1.0221.00
34_L207_V1.0221.00
13_P229_A1.0211.00
114_F161_A1.0161.00
135_L268_A1.0121.00
49_A191_V1.0111.00
80_S159_C1.0071.00
60_K64_L0.9971.00
209_P212_L0.9931.00
20_A24_I0.9911.00
111_V164_I0.9841.00
31_A92_I0.9811.00
111_V235_T0.9791.00
19_V225_L0.9751.00
111_V161_A0.9751.00
137_P262_T0.9741.00
208_I212_L0.9681.00
192_P196_L0.9631.00
54_I216_I0.9591.00
103_L150_C0.9531.00
103_L153_A0.9501.00
29_S256_F0.9481.00
13_P232_R0.9471.00
102_A133_W0.9471.00
263_P266_L0.9471.00
23_S225_L0.9431.00
133_W137_P0.9411.00
73_P169_R0.9391.00
131_G272_I0.9371.00
80_S166_S0.9351.00
230_L238_F0.9341.00
40_A44_T0.9321.00
114_F158_A0.9271.00
73_P77_Y0.9271.00
127_L275_A0.9261.00
71_R185_I0.9251.00
247_A269_L0.9251.00
34_L210_L0.9251.00
157_G161_A0.9181.00
234_P238_F0.9011.00
146_D150_C0.8991.00
118_R122_F0.8991.00
86_Y90_L0.8971.00
21_M25_Q0.8911.00
202_L205_W0.8881.00
21_M248_L0.8871.00
42_G194_G0.8871.00
212_L215_A0.8861.00
97_L257_L0.8861.00
82_G86_Y0.8821.00
193_I196_L0.8741.00
230_L234_P0.8701.00
149_G153_A0.8681.00
59_F63_R0.8651.00
233_L238_F0.8641.00
21_M244_M0.8621.00
106_T132_L0.8571.00
81_L163_Y0.8501.00
212_L216_I0.8481.00
48_L186_A0.8461.00
264_I267_L0.8421.00
56_I184_L0.8331.00
211_G215_A0.8321.00
144_H147_L0.8321.00
97_L259_E0.8301.00
44_T190_F0.8261.00
130_L134_F0.8241.00
250_A261_L0.8241.00
18_L248_L0.8201.00
233_L237_T0.8181.00
55_L220_A0.8161.00
57_A61_P0.8141.00
111_V165_L0.8121.00
14_I237_T0.8111.00
250_A269_L0.8091.00
195_A198_A0.8081.00
134_F267_L0.8021.00
132_L136_L0.7951.00
168_Q172_A0.7821.00
28_A88_F0.7791.00
54_I57_A0.7761.00
84_M159_C0.7751.00
64_L174_H0.7731.00
58_F62_W0.7721.00
254_M260_T0.7721.00
180_A184_L0.7721.00
29_S253_G0.7711.00
203_W208_I0.7681.00
130_L271_A0.7681.00
71_R75_L0.7671.00
67_A71_R0.7661.00
52_T56_I0.7631.00
123_V127_L0.7551.00
117_R120_V0.7541.00
91_S100_A0.7511.00
49_A53_L0.7491.00
181_I185_I0.7471.00
70_Q74_L0.7471.00
229_A238_F0.7471.00
162_I166_S0.7461.00
254_M261_L0.7441.00
38_V42_G0.7431.00
204_H208_I0.7421.00
112_A116_S0.7331.00
112_A121_D0.7301.00
31_A35_F0.7241.00
78_G82_G0.7221.00
46_L50_L0.7211.00
210_L213_A0.7191.00
267_L271_A0.7181.00
177_A181_I0.7141.00
17_L233_L0.7091.00
221_L225_L0.7001.00
29_S97_L0.6931.00
38_V43_V0.6921.00
244_M247_A0.6921.00
137_P140_Q0.6901.00
42_G46_L0.6891.00
28_A101_V0.6881.00
103_L154_L0.6871.00
253_G257_L0.6871.00
153_A157_G0.6831.00
73_P76_F0.6831.00
109_L128_A0.6821.00
269_L273_I0.6801.00
185_I188_L0.6781.00
95_V100_A0.6761.00
54_I215_A0.6731.00
39_G198_A0.6721.00
207_V210_L0.6711.00
187_A191_V0.6671.00
160_W164_I0.6671.00
91_S149_G0.6621.00
27_G218_S0.6611.00
194_G198_A0.6591.00
213_A217_L0.6581.00
185_I189_I0.6571.00
50_L54_I0.6511.00
250_A254_M0.6491.00
184_L188_L0.6481.00
81_L223_Y0.6471.00
240_T279_S0.6451.00
106_T109_L0.6431.00
17_L241_L0.6411.00
217_L221_L0.6391.00
58_F176_P0.6331.00
83_G87_L0.6291.00
274_A278_G0.6271.00
71_R181_I0.6251.00
251_V255_I0.6241.00
251_V254_M0.6241.00
224_S228_I0.6241.00
115_S236_R0.6231.00
175_G179_V0.6231.00
70_Q73_P0.6231.00
260_T264_I0.6211.00
74_L178_T0.6201.00
121_D234_P0.6201.00
265_Q269_L0.6171.00
110_A154_L0.6171.00
41_P197_Q0.6161.00
276_S279_S0.6151.00
179_V182_G0.6151.00
163_Y227_M0.6141.00
46_L211_G0.6131.00
261_L265_Q0.6121.00
62_W174_H0.6061.00
113_L125_V0.6061.00
123_V130_L0.6031.00
184_L187_A0.6031.00
33_S257_L0.6021.00
144_H148_T0.6011.00
35_F92_I0.6001.00
262_T266_L0.5991.00
203_W207_V0.5991.00
179_V227_M0.5941.00
160_W226_E0.5931.00
81_L182_G0.5921.00
181_I184_L0.5911.00
121_D125_V0.5911.00
75_L79_V0.5891.00
50_L211_G0.5861.00
254_M266_L0.5851.00
106_T157_G0.5851.00
23_S222_P0.5821.00
152_L155_G0.5801.00
275_A279_S0.5791.00
14_I18_L0.5771.00
88_F100_A0.5751.00
13_P233_L0.5741.00
252_S255_I0.5741.00
82_G193_I0.5731.00
102_A136_L0.5711.00
158_A162_I0.5711.00
204_H209_P0.5701.00
35_F93_Q0.5701.00
77_Y80_S0.5671.00
51_G215_A0.5651.00
74_L185_I0.5651.00
260_T265_Q0.5641.00
18_L21_M0.5611.00
127_L278_G0.5601.00
67_A72_L0.5581.00
29_S249_A0.5571.00
84_M163_Y0.5541.00
163_Y167_G0.5521.00
164_I226_E0.5521.00
84_M88_F0.5501.00
186_A190_F0.5481.00
243_S276_S0.5481.00
136_L150_C0.5471.00
129_V243_S0.5461.00
188_L191_V0.5451.00
229_A233_L0.5441.00
69_E173_E0.5421.00
88_F156_A0.5411.00
21_M245_E0.5401.00
41_P190_F0.5391.00
53_L56_I0.5381.00
191_V195_A0.5371.00
89_Y93_Q0.5351.00
76_F79_V0.5341.00
105_F132_L0.5341.00
27_G89_Y0.5321.00
131_G275_A0.5311.00
164_I239_G0.5301.00
75_L189_I0.5301.00
130_L133_W0.5291.00
108_P243_S0.5251.00
109_L125_V0.5241.00
111_V115_S0.5201.00
19_V23_S0.5191.00
155_G159_C0.5161.00
33_S37_L0.5151.00
87_L156_A0.5131.00
115_S165_L0.5131.00
101_V105_F0.5111.00
118_R282_T0.5111.00
81_L85_N0.5091.00
39_G197_Q0.5091.00
14_I233_L0.5081.00
81_L186_A0.5071.00
51_G220_A0.5061.00
266_L269_L0.5061.00
202_L208_I0.5051.00
25_Q249_A0.5031.00
25_Q245_E0.5031.00
199_G202_L0.5021.00
77_Y167_G0.5021.00
102_A135_L0.5011.00
33_S36_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.261 98.9 0.757 Contact Map
3b5dA 2 0.3424 98.2 0.809 Contact Map
1pw4A 1 0.8983 41.1 0.928 Contact Map
2cfqA 1 0.6 21.9 0.937 Contact Map
2kluA 1 0.1525 21 0.938 Contact Map
4pypA 1 0.9356 19.3 0.939 Contact Map
4he8J 1 0.5186 16.6 0.941 Contact Map
3mktA 1 0.8814 16.4 0.941 Contact Map
3o7qA 1 0.8407 15.7 0.942 Contact Map
2rddB 1 0.1186 15.3 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.