RHTA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

RHTA - Threonine/homoserine exporter RhtA

UniProt:	P0AA67	Sequences: MPGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGVSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACWAIYILSGQRAGAEHGPATVAIGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGTLMSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12134
Length:	295 (268)
Sequences:	35168 (26116)
Seq/√Len:	1595.3

ECOLI - RHTA YIJE YICL YEDA YHBE EAMA YTFF YDDG RARD
BACSU - YWFM YXXF YBFH YVBV YCBK YETK YDED YDFC YCXC YRDR YOJE YDEK YYAM YOAV
HALSA - Q9HQ34 Q9HHP6 Q9HPI0
SULSO - Q97UE8 Q97UX3 Q97X73

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_S	153_A	3.431	1.00
16_I	228_I	2.844	1.00
228_I	232_R	2.757	1.00
99_I	150_C	2.745	1.00
253_G	259_E	2.649	1.00
52_T	184_L	2.580	1.00
90_L	152_L	2.527	1.00
30_L	213_A	2.429	1.00
67_A	70_Q	2.394	1.00
87_L	155_G	2.370	1.00
45_A	191_V	2.368	1.00
228_I	231_T	2.353	1.00
101_V	249_A	2.236	1.00
124_W	275_A	2.229	1.00
50_L	215_A	2.222	1.00
114_F	165_L	2.173	1.00
110_A	157_G	2.139	1.00
87_L	152_L	2.114	1.00
25_Q	248_L	2.111	1.00
32_K	259_E	2.086	1.00
31_A	89_Y	2.036	1.00
205_W	209_P	1.981	1.00
83_G	159_C	1.938	1.00
17_L	229_A	1.935	1.00
49_A	187_A	1.914	1.00
70_Q	173_E	1.849	1.00
56_I	180_A	1.820	1.00
118_R	121_D	1.794	1.00
25_Q	252_S	1.771	1.00
106_T	110_A	1.743	1.00
94_T	148_T	1.741	1.00
111_V	239_G	1.723	1.00
204_H	207_V	1.705	1.00
112_A	125_V	1.700	1.00
22_A	248_L	1.695	1.00
174_H	177_A	1.686	1.00
151_A	155_G	1.677	1.00
37_L	207_V	1.674	1.00
188_L	192_P	1.656	1.00
215_A	220_A	1.654	1.00
87_L	159_C	1.647	1.00
26_G	213_A	1.640	1.00
277_M	281_L	1.629	1.00
95_V	149_G	1.626	1.00
95_V	150_C	1.604	1.00
52_T	187_A	1.600	1.00
192_P	195_A	1.599	1.00
38_V	207_V	1.596	1.00
234_P	237_T	1.576	1.00
110_A	161_A	1.566	1.00
124_W	279_S	1.513	1.00
128_A	243_S	1.499	1.00
100_A	153_A	1.496	1.00
262_T	265_Q	1.481	1.00
68_K	72_L	1.472	1.00
90_L	94_T	1.462	1.00
34_L	43_V	1.439	1.00
167_G	227_M	1.434	1.00
110_A	158_A	1.428	1.00
72_L	76_F	1.392	1.00
147_L	150_C	1.390	1.00
263_P	267_L	1.387	1.00
45_A	187_A	1.384	1.00
90_L	93_Q	1.380	1.00
68_K	71_R	1.364	1.00
73_P	166_S	1.353	1.00
252_S	256_F	1.344	1.00
51_G	183_S	1.344	1.00
20_A	229_A	1.339	1.00
29_S	252_S	1.331	1.00
16_I	225_L	1.330	1.00
69_E	73_P	1.327	1.00
53_L	57_A	1.315	1.00
124_W	278_G	1.313	1.00
69_E	72_L	1.307	1.00
134_F	271_A	1.304	1.00
205_W	208_I	1.303	1.00
248_L	252_S	1.300	1.00
266_L	270_G	1.300	1.00
43_V	214_V	1.292	1.00
161_A	165_L	1.292	1.00
119_P	123_V	1.286	1.00
97_L	253_G	1.282	1.00
39_G	42_G	1.279	1.00
206_S	209_P	1.277	1.00
14_I	241_L	1.266	1.00
33_S	210_L	1.264	1.00
54_I	220_A	1.258	1.00
95_V	99_I	1.251	1.00
169_R	172_A	1.251	1.00
102_A	269_L	1.249	1.00
120_V	278_G	1.246	1.00
76_F	166_S	1.245	1.00
126_V	130_L	1.240	1.00
56_I	60_K	1.230	1.00
128_A	275_A	1.222	1.00
61_P	64_L	1.218	1.00
206_S	210_L	1.215	1.00
134_F	264_I	1.211	1.00
168_Q	234_P	1.211	1.00
270_G	274_A	1.210	1.00
80_S	162_I	1.209	1.00
131_G	268_A	1.203	1.00
147_L	151_A	1.202	1.00
122_F	126_V	1.193	1.00
24_I	222_P	1.191	1.00
45_A	49_A	1.190	1.00
114_F	162_I	1.187	1.00
75_L	185_I	1.183	1.00
94_T	152_L	1.179	1.00
30_L	210_L	1.170	1.00
78_G	185_I	1.169	1.00
82_G	189_I	1.158	1.00
244_M	248_L	1.156	1.00
98_G	250_A	1.155	1.00
73_P	170_A	1.154	1.00
26_G	252_S	1.147	1.00
23_S	217_L	1.143	1.00
60_K	63_R	1.139	1.00
209_P	213_A	1.130	1.00
261_L	266_L	1.130	1.00
169_R	173_E	1.127	1.00
148_T	152_L	1.125	1.00
193_I	197_Q	1.123	1.00
37_L	204_H	1.122	1.00
45_A	194_G	1.118	1.00
94_T	146_D	1.107	1.00
15_V	19_V	1.103	1.00
92_I	100_A	1.100	1.00
120_V	281_L	1.096	1.00
57_A	60_K	1.093	1.00
189_I	192_P	1.092	1.00
95_V	153_A	1.092	1.00
20_A	225_L	1.091	1.00
79_V	189_I	1.084	1.00
88_F	92_I	1.082	1.00
24_I	226_E	1.079	1.00
96_P	99_I	1.077	1.00
94_T	149_G	1.075	1.00
32_K	36_P	1.072	1.00
82_G	190_F	1.069	1.00
52_T	180_A	1.053	1.00
119_P	122_F	1.050	1.00
103_L	157_G	1.047	1.00
120_V	282_T	1.043	1.00
47_R	219_T	1.041	1.00
41_P	193_I	1.041	1.00
168_Q	235_T	1.038	1.00
148_T	151_A	1.034	1.00
44_T	89_Y	1.030	1.00
41_P	86_Y	1.023	1.00
72_L	75_L	1.022	1.00
34_L	207_V	1.022	1.00
13_P	229_A	1.021	1.00
114_F	161_A	1.016	1.00
135_L	268_A	1.012	1.00
49_A	191_V	1.011	1.00
80_S	159_C	1.007	1.00
60_K	64_L	0.997	1.00
209_P	212_L	0.993	1.00
20_A	24_I	0.991	1.00
111_V	164_I	0.984	1.00
31_A	92_I	0.981	1.00
111_V	235_T	0.979	1.00
19_V	225_L	0.975	1.00
111_V	161_A	0.975	1.00
137_P	262_T	0.974	1.00
208_I	212_L	0.968	1.00
192_P	196_L	0.963	1.00
54_I	216_I	0.959	1.00
103_L	150_C	0.953	1.00
103_L	153_A	0.950	1.00
29_S	256_F	0.948	1.00
13_P	232_R	0.947	1.00
102_A	133_W	0.947	1.00
263_P	266_L	0.947	1.00
23_S	225_L	0.943	1.00
133_W	137_P	0.941	1.00
73_P	169_R	0.939	1.00
131_G	272_I	0.937	1.00
80_S	166_S	0.935	1.00
230_L	238_F	0.934	1.00
40_A	44_T	0.932	1.00
114_F	158_A	0.927	1.00
73_P	77_Y	0.927	1.00
127_L	275_A	0.926	1.00
71_R	185_I	0.925	1.00
247_A	269_L	0.925	1.00
34_L	210_L	0.925	1.00
157_G	161_A	0.918	1.00
234_P	238_F	0.901	1.00
146_D	150_C	0.899	1.00
118_R	122_F	0.899	1.00
86_Y	90_L	0.897	1.00
21_M	25_Q	0.891	1.00
202_L	205_W	0.888	1.00
21_M	248_L	0.887	1.00
42_G	194_G	0.887	1.00
212_L	215_A	0.886	1.00
97_L	257_L	0.886	1.00
82_G	86_Y	0.882	1.00
193_I	196_L	0.874	1.00
230_L	234_P	0.870	1.00
149_G	153_A	0.868	1.00
59_F	63_R	0.865	1.00
233_L	238_F	0.864	1.00
21_M	244_M	0.862	1.00
106_T	132_L	0.857	1.00
81_L	163_Y	0.850	1.00
212_L	216_I	0.848	1.00
48_L	186_A	0.846	1.00
264_I	267_L	0.842	1.00
56_I	184_L	0.833	1.00
211_G	215_A	0.832	1.00
144_H	147_L	0.832	1.00
97_L	259_E	0.830	1.00
44_T	190_F	0.826	1.00
130_L	134_F	0.824	1.00
250_A	261_L	0.824	1.00
18_L	248_L	0.820	1.00
233_L	237_T	0.818	1.00
55_L	220_A	0.816	1.00
57_A	61_P	0.814	1.00
111_V	165_L	0.812	1.00
14_I	237_T	0.811	1.00
250_A	269_L	0.809	1.00
195_A	198_A	0.808	1.00
134_F	267_L	0.802	1.00
132_L	136_L	0.795	1.00
168_Q	172_A	0.782	1.00
28_A	88_F	0.779	1.00
54_I	57_A	0.776	1.00
84_M	159_C	0.775	1.00
64_L	174_H	0.773	1.00
58_F	62_W	0.772	1.00
254_M	260_T	0.772	1.00
180_A	184_L	0.772	1.00
29_S	253_G	0.771	1.00
203_W	208_I	0.768	1.00
130_L	271_A	0.768	1.00
71_R	75_L	0.767	1.00
67_A	71_R	0.766	1.00
52_T	56_I	0.763	1.00
123_V	127_L	0.755	1.00
117_R	120_V	0.754	1.00
91_S	100_A	0.751	1.00
49_A	53_L	0.749	1.00
181_I	185_I	0.747	1.00
70_Q	74_L	0.747	1.00
229_A	238_F	0.747	1.00
162_I	166_S	0.746	1.00
254_M	261_L	0.744	1.00
38_V	42_G	0.743	1.00
204_H	208_I	0.742	1.00
112_A	116_S	0.733	1.00
112_A	121_D	0.730	1.00
31_A	35_F	0.724	1.00
78_G	82_G	0.722	1.00
46_L	50_L	0.721	1.00
210_L	213_A	0.719	1.00
267_L	271_A	0.718	1.00
177_A	181_I	0.714	1.00
17_L	233_L	0.709	1.00
221_L	225_L	0.700	1.00
29_S	97_L	0.693	1.00
38_V	43_V	0.692	1.00
244_M	247_A	0.692	1.00
137_P	140_Q	0.690	1.00
42_G	46_L	0.689	1.00
28_A	101_V	0.688	1.00
103_L	154_L	0.687	1.00
253_G	257_L	0.687	1.00
153_A	157_G	0.683	1.00
73_P	76_F	0.683	1.00
109_L	128_A	0.682	1.00
269_L	273_I	0.680	1.00
185_I	188_L	0.678	1.00
95_V	100_A	0.676	1.00
54_I	215_A	0.673	1.00
39_G	198_A	0.672	1.00
207_V	210_L	0.671	1.00
187_A	191_V	0.667	1.00
160_W	164_I	0.667	1.00
91_S	149_G	0.662	1.00
27_G	218_S	0.661	1.00
194_G	198_A	0.659	1.00
213_A	217_L	0.658	1.00
185_I	189_I	0.657	1.00
50_L	54_I	0.651	1.00
250_A	254_M	0.649	1.00
184_L	188_L	0.648	1.00
81_L	223_Y	0.647	1.00
240_T	279_S	0.645	1.00
106_T	109_L	0.643	1.00
17_L	241_L	0.641	1.00
217_L	221_L	0.639	1.00
58_F	176_P	0.633	1.00
83_G	87_L	0.629	1.00
274_A	278_G	0.627	1.00
71_R	181_I	0.625	1.00
251_V	255_I	0.624	1.00
251_V	254_M	0.624	1.00
224_S	228_I	0.624	1.00
115_S	236_R	0.623	1.00
175_G	179_V	0.623	1.00
70_Q	73_P	0.623	1.00
260_T	264_I	0.621	1.00
74_L	178_T	0.620	1.00
121_D	234_P	0.620	1.00
265_Q	269_L	0.617	1.00
110_A	154_L	0.617	1.00
41_P	197_Q	0.616	1.00
276_S	279_S	0.615	1.00
179_V	182_G	0.615	1.00
163_Y	227_M	0.614	1.00
46_L	211_G	0.613	1.00
261_L	265_Q	0.612	1.00
62_W	174_H	0.606	1.00
113_L	125_V	0.606	1.00
123_V	130_L	0.603	1.00
184_L	187_A	0.603	1.00
33_S	257_L	0.602	1.00
144_H	148_T	0.601	1.00
35_F	92_I	0.600	1.00
262_T	266_L	0.599	1.00
203_W	207_V	0.599	1.00
179_V	227_M	0.594	1.00
160_W	226_E	0.593	1.00
81_L	182_G	0.592	1.00
181_I	184_L	0.591	1.00
121_D	125_V	0.591	1.00
75_L	79_V	0.589	1.00
50_L	211_G	0.586	1.00
254_M	266_L	0.585	1.00
106_T	157_G	0.585	1.00
23_S	222_P	0.582	1.00
152_L	155_G	0.580	1.00
275_A	279_S	0.579	1.00
14_I	18_L	0.577	1.00
88_F	100_A	0.575	1.00
13_P	233_L	0.574	1.00
252_S	255_I	0.574	1.00
82_G	193_I	0.573	1.00
102_A	136_L	0.571	1.00
158_A	162_I	0.571	1.00
204_H	209_P	0.570	1.00
35_F	93_Q	0.570	1.00
77_Y	80_S	0.567	1.00
51_G	215_A	0.565	1.00
74_L	185_I	0.565	1.00
260_T	265_Q	0.564	1.00
18_L	21_M	0.561	1.00
127_L	278_G	0.560	1.00
67_A	72_L	0.558	1.00
29_S	249_A	0.557	1.00
84_M	163_Y	0.554	1.00
163_Y	167_G	0.552	1.00
164_I	226_E	0.552	1.00
84_M	88_F	0.550	1.00
186_A	190_F	0.548	1.00
243_S	276_S	0.548	1.00
136_L	150_C	0.547	1.00
129_V	243_S	0.546	1.00
188_L	191_V	0.545	1.00
229_A	233_L	0.544	1.00
69_E	173_E	0.542	1.00
88_F	156_A	0.541	1.00
21_M	245_E	0.540	1.00
41_P	190_F	0.539	1.00
53_L	56_I	0.538	1.00
191_V	195_A	0.537	1.00
89_Y	93_Q	0.535	1.00
76_F	79_V	0.534	1.00
105_F	132_L	0.534	1.00
27_G	89_Y	0.532	1.00
131_G	275_A	0.531	1.00
164_I	239_G	0.530	1.00
75_L	189_I	0.530	1.00
130_L	133_W	0.529	1.00
108_P	243_S	0.525	1.00
109_L	125_V	0.524	1.00
111_V	115_S	0.520	1.00
19_V	23_S	0.519	1.00
155_G	159_C	0.516	1.00
33_S	37_L	0.515	1.00
87_L	156_A	0.513	1.00
115_S	165_L	0.513	1.00
101_V	105_F	0.511	1.00
118_R	282_T	0.511	1.00
81_L	85_N	0.509	1.00
39_G	197_Q	0.509	1.00
14_I	233_L	0.508	1.00
81_L	186_A	0.507	1.00
51_G	220_A	0.506	1.00
266_L	269_L	0.506	1.00
202_L	208_I	0.505	1.00
25_Q	249_A	0.503	1.00
25_Q	245_E	0.503	1.00
199_G	202_L	0.502	1.00
77_Y	167_G	0.502	1.00
102_A	135_L	0.501	1.00
33_S	36_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.261	98.9	0.757	Contact Map
3b5dA	2	0.3424	98.2	0.809	Contact Map
1pw4A	1	0.8983	41.1	0.928	Contact Map
2cfqA	1	0.6	21.9	0.937	Contact Map
2kluA	1	0.1525	21	0.938	Contact Map
4pypA	1	0.9356	19.3	0.939	Contact Map
4he8J	1	0.5186	16.6	0.941	Contact Map
3mktA	1	0.8814	16.4	0.941	Contact Map
3o7qA	1	0.8407	15.7	0.942	Contact Map
2rddB	1	0.1186	15.3	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.