GREMLIN Database
QMCA - Protein QmcA
UniProt: P0AA53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13258
Length: 305 (258)
Sequences: 6082 (3471)
Seq/√Len: 216.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R53_D5.3731.00
37_Y40_T4.0491.00
93_D96_R3.6621.00
201_E205_Q2.9561.00
90_Q153_K2.6761.00
230_E234_R2.6571.00
212_E216_Q2.5901.00
39_K53_D2.5701.00
194_Q197_I2.5341.00
195_A199_K2.4661.00
223_E227_R2.4501.00
217_S221_Q2.3851.00
215_R219_F2.3831.00
216_Q219_F2.3551.00
23_V29_W2.2871.00
134_S138_R2.2571.00
227_R230_E2.2541.00
216_Q220_L2.1701.00
131_Q134_S2.1351.00
258_K261_E2.0681.00
199_K203_E2.0501.00
6_P10_F2.0011.00
24_P27_Y1.9881.00
27_Y58_K1.9681.00
234_R238_M1.9471.00
241_E245_S1.9311.00
221_Q225_R1.9301.00
188_E192_I1.9301.00
111_L143_V1.9061.00
203_E210_K1.8531.00
92_I153_K1.8371.00
76_K124_E1.8161.00
127_E131_Q1.7971.00
214_E218_A1.7931.00
33_R38_T1.7341.00
220_L223_E1.7231.00
252_N256_A1.7111.00
239_V242_A1.7081.00
219_F223_E1.6891.00
138_R141_R1.6791.00
96_R100_E1.6701.00
137_S141_R1.6651.00
208_I212_E1.6451.00
28_Q61_M1.6181.00
87_C112_T1.6161.00
19_G47_L1.6081.00
141_R145_E1.5591.00
229_A239_V1.5501.00
209_L212_E1.5481.00
21_K41_L1.5461.00
214_E221_Q1.5401.00
28_Q94_A1.5361.00
170_S174_A1.5321.00
206_S210_K1.5321.00
38_T53_D1.5281.00
119_V138_R1.5191.00
229_A232_E1.5021.00
32_E99_Y1.4811.00
186_I190_E1.4551.00
192_I196_E1.4531.00
234_R237_K1.4391.00
29_W55_I1.4351.00
201_E204_K1.4321.00
122_S138_R1.4301.00
218_A221_Q1.4281.00
124_E127_E1.4281.00
96_R99_Y1.4231.00
30_T98_A1.4001.00
166_A170_S1.3881.00
90_Q155_T1.3831.00
210_K214_E1.3811.00
182_K186_I1.3761.00
176_M180_R1.3701.00
15_I19_G1.3691.00
212_E215_R1.3531.00
83_I120_L1.3431.00
181_T185_Y1.3391.00
120_L128_M1.3371.00
236_T240_S1.3321.00
254_F257_Q1.2921.00
233_A237_K1.2811.00
205_Q208_I1.2811.00
227_R231_A1.2661.00
29_W58_K1.2541.00
190_E193_R1.2341.00
41_L46_S1.2321.00
196_E199_K1.2321.00
263_L266_I1.2281.00
144_D148_N1.2271.00
14_V18_A1.2211.00
97_A101_V1.2011.00
5_I9_I1.1921.00
59_I98_A1.1881.00
63_E155_T1.1861.00
240_S243_I1.1861.00
235_A238_M1.1821.00
184_A188_E1.1801.00
20_V47_L1.1611.00
4_F8_L1.1581.00
13_L17_G1.1481.00
37_Y95_P1.1351.00
21_K48_V1.1321.00
28_Q40_T1.1311.00
194_Q198_L1.1291.00
174_A177_K1.1271.00
85_A116_I1.1141.00
205_Q209_L1.1131.00
189_A198_L1.0981.00
177_K181_T1.0961.00
232_E239_V1.0831.00
108_I147_T1.0711.00
133_D137_S1.0711.00
204_K208_I1.0661.00
163_R169_I1.0661.00
255_V259_Y1.0631.00
229_A236_T1.0611.00
31_V53_D1.0571.00
49_V53_D1.0541.00
202_G206_S1.0541.00
19_G48_V1.0531.00
213_G217_S1.0511.00
12_A16_V1.0481.00
10_F14_V1.0471.00
256_A259_Y1.0431.00
225_R228_S1.0391.00
112_T143_V1.0371.00
203_E207_Q1.0351.00
22_I45_L1.0341.00
243_I246_G1.0321.00
138_R142_I1.0321.00
55_I58_K1.0281.00
59_I91_V1.0261.00
251_V256_A1.0241.00
238_M241_E1.0241.00
217_S224_A1.0111.00
253_Y257_Q1.0051.00
261_E264_Q1.0031.00
103_N106_L1.0001.00
226_E230_E0.9981.00
15_I51_F0.9951.00
54_R57_R0.9911.00
240_S244_A0.9861.00
114_T118_T0.9831.00
236_T239_V0.9821.00
192_I199_K0.9711.00
181_T184_A0.9661.00
32_E57_R0.9631.00
48_V53_D0.9631.00
224_A228_S0.9561.00
42_Q46_S0.9551.00
214_E217_S0.9541.00
242_A245_S0.9531.00
192_I195_A0.9521.00
193_R197_I0.9511.00
229_A233_A0.9491.00
218_A224_A0.9491.00
229_A242_A0.9461.00
183_R186_I0.9461.00
134_S137_S0.9431.00
26_G62_M0.9360.99
146_A150_W0.9340.99
32_E54_R0.9310.99
253_Y256_A0.9310.99
211_A220_L0.9290.99
174_A181_T0.9270.99
20_V45_L0.9260.99
260_T266_I0.9250.99
198_L201_E0.9160.99
7_I11_V0.9160.99
9_I13_L0.9140.99
142_I145_E0.9110.99
252_N255_V0.9100.99
73_V120_L0.9070.99
18_A48_V0.8950.99
241_E244_A0.8940.99
251_V254_F0.8860.99
65_V88_F0.8790.99
34_F38_T0.8740.99
18_A21_K0.8720.99
240_S246_G0.8720.99
191_G195_A0.8690.99
179_E183_R0.8640.99
140_L144_D0.8610.99
34_F52_M0.8600.99
232_E236_T0.8600.99
231_A235_A0.8580.99
221_Q224_A0.8530.99
89_I152_I0.8530.99
49_V52_M0.8520.99
94_A101_V0.8490.99
203_E206_S0.8450.99
231_A239_V0.8380.99
119_V122_S0.8380.99
77_D126_D0.8330.99
104_L152_I0.8250.99
166_A169_I0.8240.99
123_M131_Q0.8100.99
117_R121_G0.8080.99
26_G61_M0.8060.98
145_E148_N0.8060.98
207_Q210_K0.8040.98
26_G60_N0.8030.98
123_M135_I0.8000.98
75_S81_V0.8000.98
5_I8_L0.8000.98
176_M179_E0.7990.98
215_R224_A0.7930.98
232_E242_A0.7890.98
63_E88_F0.7860.98
237_K240_S0.7860.98
200_A204_K0.7850.98
21_K29_W0.7830.98
87_C154_V0.7790.98
95_P99_Y0.7770.98
251_V255_V0.7760.98
174_A178_A0.7760.98
139_L143_V0.7670.98
200_A209_L0.7610.98
98_A101_V0.7600.98
59_I94_A0.7590.98
118_T142_I0.7530.98
169_I173_N0.7530.98
237_K241_E0.7510.98
252_N259_Y0.7480.98
33_R49_V0.7470.98
146_A149_P0.7470.98
19_G49_V0.7440.97
31_V55_I0.7430.97
231_A234_R0.7420.97
97_A100_E0.7420.97
179_E182_K0.7380.97
15_I49_V0.7360.97
242_A246_G0.7340.97
111_L146_A0.7290.97
72_E82_T0.7280.97
147_T154_V0.7250.97
94_A97_A0.7210.97
94_A98_A0.7170.97
215_R220_L0.7160.97
225_R229_A0.7140.97
79_A164_P0.7140.97
222_A226_E0.7110.97
11_V15_I0.7090.97
67_D84_D0.7090.97
28_Q42_Q0.7020.96
235_A239_V0.7000.96
28_Q32_E0.6940.96
229_A240_S0.6920.96
136_N156_R0.6900.96
87_C168_L0.6880.96
115_N146_A0.6870.96
115_N142_I0.6810.96
197_I201_E0.6780.96
175_Q179_E0.6760.96
127_E130_S0.6720.95
262_A265_Q0.6670.95
116_I139_L0.6650.95
108_I152_I0.6640.95
75_S125_L0.6640.95
67_D160_R0.6610.95
220_L224_A0.6600.95
127_E134_S0.6580.95
231_A242_A0.6570.95
256_A260_T0.6560.95
180_R183_R0.6550.95
39_K46_S0.6530.95
8_L12_A0.6490.94
229_A235_A0.6490.94
190_E194_Q0.6480.94
31_V39_K0.6460.94
231_A236_T0.6440.94
225_R232_E0.6420.94
85_A112_T0.6410.94
237_K242_A0.6390.94
16_V20_V0.6360.94
67_D70_S0.6350.94
167_E170_S0.6340.94
75_S128_M0.6320.94
215_R228_S0.6260.93
125_L162_V0.6250.93
239_V246_G0.6240.93
48_V55_I0.6220.93
229_A237_K0.6180.93
18_A22_I0.6140.93
41_L48_V0.6140.93
74_I80_N0.6130.93
107_A150_W0.6090.92
27_Y60_N0.6060.92
171_S174_A0.6050.92
260_T265_Q0.6000.92
239_V243_I0.6000.92
144_D154_V0.6000.92
118_T122_S0.5950.92
6_P9_I0.5940.91
136_N158_E0.5940.91
82_T87_C0.5930.91
223_E226_E0.5900.91
23_V44_G0.5900.91
206_S214_E0.5900.91
188_E191_G0.5880.91
220_L227_R0.5880.91
72_E80_N0.5870.91
184_A191_G0.5820.91
92_I148_N0.5820.91
230_E236_T0.5820.91
86_V158_E0.5810.91
164_P168_L0.5810.91
175_Q180_R0.5790.90
185_Y188_E0.5790.90
243_I251_V0.5770.90
106_L110_N0.5770.90
15_I48_V0.5770.90
135_I159_I0.5740.90
64_Q105_E0.5730.90
232_E235_A0.5710.90
230_E242_A0.5700.90
25_Q43_P0.5700.90
222_A228_S0.5680.90
236_T243_I0.5680.90
23_V55_I0.5670.89
211_A224_A0.5670.89
97_A104_L0.5660.89
33_R52_M0.5650.89
251_V257_Q0.5630.89
237_K245_S0.5620.89
79_A168_L0.5610.89
236_T246_G0.5610.89
231_A238_M0.5600.89
251_V259_Y0.5590.89
103_N107_A0.5580.89
199_K202_G0.5580.89
258_K262_A0.5570.89
172_M175_Q0.5560.89
123_M127_E0.5540.88
130_S160_R0.5530.88
219_F222_A0.5510.88
111_L150_W0.5500.88
86_V160_R0.5480.88
179_E187_L0.5480.88
238_M242_A0.5460.88
110_N143_V0.5460.88
254_F258_K0.5450.88
224_A253_Y0.5440.87
117_R132_R0.5420.87
259_Y262_A0.5410.87
196_E200_A0.5380.87
10_F13_L0.5380.87
101_V107_A0.5370.87
218_A225_R0.5370.87
8_L15_I0.5330.86
189_A193_R0.5320.86
173_N176_M0.5320.86
31_V48_V0.5320.86
84_D160_R0.5320.86
219_F227_R0.5310.86
252_N257_Q0.5300.86
213_G218_A0.5300.86
111_L114_T0.5290.86
262_A266_I0.5280.86
173_N180_R0.5280.86
91_V104_L0.5250.86
125_L180_R0.5250.86
123_M138_R0.5230.85
254_F259_Y0.5220.85
181_T188_E0.5220.85
30_T40_T0.5210.85
167_E181_T0.5190.85
16_V19_G0.5190.85
48_V52_M0.5150.84
23_V58_K0.5150.84
236_T254_F0.5150.84
21_K39_K0.5140.84
132_R173_N0.5130.84
252_N265_Q0.5110.84
143_V146_A0.5100.84
208_I224_A0.5070.84
123_M134_S0.5070.84
107_A111_L0.5060.83
174_A188_E0.5050.83
12_A15_I0.5050.83
236_T242_A0.5040.83
255_V258_K0.5030.83
39_K95_P0.5020.83
215_R218_A0.5020.83
144_D153_K0.5010.83
258_K263_L0.5010.83
25_Q78_N0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.5574 100 0.544 Contact Map
4fvgA 2 0.3574 99.9 0.585 Contact Map
1winA 1 0.4393 99.9 0.605 Contact Map
2rpbA 1 0.3705 99.8 0.667 Contact Map
2zuoA 7 0.9705 97.1 0.878 Contact Map
2marA 1 0.4 23.3 0.95 Contact Map
3v6iB 1 0.2918 17.1 0.953 Contact Map
4efaG 1 0.3115 13.6 0.955 Contact Map
2dm9A 2 0.2295 13.6 0.955 Contact Map
3ioxA 1 0.4754 9.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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