GREMLIN Database
YFDV - Uncharacterized transporter YfdV
UniProt: P0AA49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14144
Length: 314 (295)
Sequences: 6529 (5090)
Seq/√Len: 296.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_F185_L5.2211.00
168_I172_K4.8551.00
249_G259_L4.3051.00
21_F25_R3.7251.00
44_A206_A3.2541.00
96_E284_Y3.0011.00
201_N205_K2.9861.00
270_P295_S2.9601.00
50_F181_L2.7931.00
14_V199_T2.5951.00
39_L206_A2.4771.00
238_L302_T2.3331.00
246_L250_M2.2471.00
22_S43_Y2.1671.00
113_G268_L2.1111.00
23_G217_L2.0951.00
253_H256_S2.0901.00
39_L44_A2.0501.00
33_A217_L2.0371.00
245_L266_G2.0321.00
23_G220_A2.0031.00
164_L168_I1.9671.00
51_V201_N1.9551.00
177_W181_L1.9521.00
51_V200_F1.9421.00
51_V204_A1.9391.00
38_K42_N1.9391.00
234_T238_L1.9371.00
51_V55_R1.9351.00
29_S32_Q1.9181.00
256_S259_L1.8951.00
185_L190_V1.8651.00
301_V304_P1.8621.00
234_T295_S1.8551.00
194_A198_P1.8491.00
29_S35_A1.8351.00
282_N285_T1.8331.00
51_V197_D1.8281.00
44_A207_N1.8251.00
103_I291_S1.8221.00
178_A182_A1.7721.00
34_R38_K1.7431.00
165_S168_I1.7181.00
184_I188_V1.6621.00
198_P201_N1.6601.00
267_A306_W1.6521.00
80_F84_F1.6271.00
47_A200_F1.6231.00
93_T96_E1.6181.00
246_L263_V1.6101.00
118_D123_D1.6101.00
22_S213_F1.6041.00
253_H259_L1.5951.00
24_R220_A1.5931.00
39_L213_F1.5751.00
197_D201_N1.5741.00
18_L199_T1.5681.00
49_L178_A1.5561.00
148_Y152_P1.5491.00
257_E261_M1.5241.00
38_K280_R1.5171.00
235_F239_I1.5161.00
169_S172_K1.5001.00
256_S260_Q1.4881.00
255_N258_H1.4841.00
71_S134_I1.4771.00
185_L191_K1.4681.00
15_I203_I1.4611.00
275_I292_L1.4601.00
218_T275_I1.4451.00
54_T185_L1.4321.00
233_N291_S1.4161.00
120_I307_I1.4161.00
39_L210_V1.4041.00
130_V258_H1.3861.00
182_A186_V1.3841.00
247_L250_M1.3781.00
32_Q35_A1.3781.00
99_V288_G1.3701.00
103_I270_P1.3681.00
86_C97_A1.3661.00
122_G125_V1.3571.00
116_V268_L1.3541.00
76_V80_F1.3491.00
65_T69_L1.3471.00
10_L14_V1.3451.00
10_L195_A1.3431.00
17_L21_F1.3401.00
18_L43_Y1.3331.00
57_N60_M1.3321.00
305_L308_Y1.3301.00
180_V184_I1.3241.00
53_I182_A1.3091.00
259_L263_V1.2971.00
131_V265_A1.2961.00
55_R197_D1.2891.00
278_A283_V1.2821.00
47_A178_A1.2821.00
297_L301_V1.2601.00
107_P268_L1.2601.00
15_I213_F1.2571.00
257_E260_Q1.2571.00
248_V251_A1.2391.00
104_A236_L1.2321.00
31_D35_A1.2201.00
82_S104_A1.2061.00
215_A272_F1.2061.00
243_L247_L1.2031.00
47_A203_I1.2001.00
54_T197_D1.1781.00
237_K241_M1.1751.00
250_M259_L1.1601.00
170_A176_V1.1561.00
143_I147_L1.1561.00
231_A235_F1.1561.00
40_V211_A1.1491.00
71_S75_I1.1471.00
15_I202_L1.1421.00
236_L240_L1.1401.00
100_C233_N1.1321.00
196_W199_T1.1261.00
36_F210_V1.1231.00
124_S257_E1.1221.00
106_S145_I1.1211.00
102_L106_S1.1191.00
263_V306_W1.1191.00
121_Y261_M1.1191.00
249_G254_L1.1151.00
87_Y91_K1.1141.00
117_L131_V1.1111.00
279_S285_T1.1061.00
58_R186_V1.1031.00
206_A210_V1.1021.00
44_A210_V1.1011.00
143_I146_G1.1011.00
185_L192_I1.1001.00
247_L251_A1.0991.00
234_T294_V1.0971.00
139_N143_I1.0941.00
14_V18_L1.0931.00
267_A303_A1.0921.00
18_L203_I1.0811.00
200_F204_A1.0681.00
121_Y260_Q1.0671.00
270_P291_S1.0611.00
230_I294_V1.0531.00
299_F303_A1.0471.00
92_R96_E1.0461.00
65_T68_T1.0431.00
42_N280_R1.0411.00
117_L121_Y1.0391.00
243_L306_W1.0371.00
128_G132_A1.0341.00
250_M255_N1.0291.00
172_K177_W1.0161.00
255_N259_L1.0151.00
83_W87_Y1.0101.00
31_D34_R1.0091.00
195_A199_T1.0051.00
40_V44_A0.9911.00
70_V74_V0.9851.00
43_Y213_F0.9851.00
32_Q36_F0.9811.00
74_V245_L0.9801.00
87_Y97_A0.9791.00
20_Y24_R0.9791.00
270_P274_G0.9771.00
20_Y220_A0.9771.00
234_T298_G0.9721.00
85_G89_F0.9711.00
94_H97_A0.9691.00
103_I274_G0.9681.00
132_A135_S0.9641.00
74_V78_C0.9641.00
98_A150_L0.9581.00
136_I140_A0.9561.00
37_N214_A0.9541.00
79_F105_G0.9511.00
13_I16_M0.9481.00
121_Y125_V0.9481.00
206_A209_G0.9441.00
85_G90_F0.9431.00
97_A101_A0.9421.00
238_L298_G0.9421.00
208_S211_A0.9401.00
185_L188_V0.9391.00
150_L278_A0.9361.00
103_I288_G0.9241.00
23_G221_A0.9231.00
140_A143_I0.9211.00
299_F302_T0.9201.00
125_V129_L0.9151.00
254_L259_L0.9011.00
181_L185_L0.9001.00
230_I234_T0.8911.00
54_T182_A0.8891.00
147_L281_F0.8881.00
102_L146_G0.8851.00
40_V207_N0.8841.00
263_V310_S0.8761.00
114_F128_G0.8711.00
188_V191_K0.8691.00
107_P237_K0.8661.00
284_Y287_T0.8661.00
260_Q310_S0.8551.00
184_I187_L0.8421.00
23_G30_E0.8391.00
249_G263_V0.8361.00
102_L150_L0.8331.00
82_S236_L0.8321.00
23_G26_E0.8291.00
22_S27_T0.8281.00
64_D67_L0.8251.00
228_A231_A0.8251.00
8_D11_P0.8231.00
92_R229_E0.8201.00
26_E29_S0.8181.00
48_A207_N0.8171.00
231_A234_T0.8061.00
201_N204_A0.8041.00
183_T187_L0.8041.00
96_E229_E0.7991.00
130_V133_I0.7950.99
112_L116_V0.7920.99
109_I134_I0.7900.99
72_L75_I0.7870.99
114_F135_S0.7830.99
41_L111_F0.7820.99
118_D125_V0.7770.99
267_A302_T0.7760.99
137_I148_Y0.7740.99
85_G232_Y0.7730.99
214_A275_I0.7730.99
244_A247_L0.7710.99
66_R69_L0.7670.99
116_V264_L0.7630.99
54_T186_V0.7600.99
13_I17_L0.7590.99
78_C82_S0.7570.99
177_W180_V0.7560.99
144_P147_L0.7540.99
43_Y203_I0.7530.99
239_I242_P0.7510.99
194_A197_D0.7500.99
128_G131_V0.7490.99
167_L170_A0.7490.99
138_V141_I0.7480.99
190_V193_P0.7450.99
54_T192_I0.7360.99
163_N167_L0.7360.99
96_E287_T0.7340.99
64_D68_T0.7290.99
202_L205_K0.7280.99
235_F240_L0.7270.99
270_P292_L0.7260.99
242_P267_A0.7240.99
161_N164_L0.7220.99
301_V305_L0.7210.99
34_R282_N0.7190.99
298_G301_V0.7180.99
7_G195_A0.7180.99
82_S86_C0.7180.99
150_L283_V0.7170.99
250_M253_H0.7130.99
86_C90_F0.7110.99
72_L137_I0.7110.99
19_G217_L0.7080.99
77_G244_A0.7080.99
80_F83_W0.7050.99
175_V178_A0.7040.99
106_S110_G0.7030.99
117_L261_M0.7030.99
278_A288_G0.7010.99
274_G288_G0.7000.99
181_L184_I0.6900.99
84_F87_Y0.6900.99
28_F217_L0.6850.98
238_L295_S0.6840.98
117_L125_V0.6800.98
264_L310_S0.6790.98
150_L277_I0.6740.98
244_A248_V0.6720.98
129_L132_A0.6710.98
47_A204_A0.6690.98
198_P202_L0.6690.98
173_E177_W0.6690.98
83_W101_A0.6670.98
73_V77_G0.6650.98
12_I40_V0.6650.98
113_G265_A0.6640.98
263_V267_A0.6640.98
50_F200_F0.6630.98
86_C101_A0.6620.98
164_L167_L0.6600.98
110_G132_A0.6590.98
30_E221_A0.6580.98
305_L309_V0.6580.98
131_V135_S0.6580.98
78_C241_M0.6560.98
28_F32_Q0.6550.98
22_S25_R0.6510.98
64_D79_F0.6510.98
240_L282_N0.6490.98
229_E287_T0.6490.98
79_F83_W0.6460.98
192_I197_D0.6450.98
196_W200_F0.6440.98
5_F9_L0.6430.98
131_V134_I0.6420.98
167_L171_A0.6420.98
50_F178_A0.6410.98
18_L213_F0.6370.98
268_L274_G0.6370.98
50_F54_T0.6320.97
85_G236_L0.6290.97
74_V79_F0.6280.97
146_G150_L0.6270.97
53_I184_I0.6250.97
40_V210_V0.6240.97
109_I138_V0.6220.97
67_L262_M0.6200.97
27_T42_N0.6190.97
163_N166_A0.6160.97
45_L211_A0.6150.97
140_A144_P0.6130.97
33_A214_A0.6110.97
202_L206_A0.6110.97
279_S282_N0.6110.97
242_P302_T0.6090.97
22_S26_E0.6080.97
191_K194_A0.6070.97
138_V142_T0.6050.97
101_A105_G0.6050.97
140_A146_G0.6040.97
64_D258_H0.6030.97
69_L73_V0.6030.97
41_L273_S0.6030.97
14_V17_L0.6010.97
106_S141_I0.6010.97
98_A101_A0.5990.96
83_W97_A0.5990.96
25_R28_F0.5980.96
298_G302_T0.5970.96
75_I86_C0.5970.96
278_A285_T0.5950.96
77_G81_F0.5950.96
41_L173_E0.5920.96
131_V142_T0.5910.96
141_I144_P0.5900.96
42_N111_F0.5890.96
139_N142_T0.5880.96
73_V248_V0.5880.96
28_F35_A0.5880.96
199_T202_L0.5870.96
110_G139_N0.5860.96
6_I9_L0.5830.96
110_G271_A0.5820.96
13_I297_L0.5810.96
45_L175_V0.5780.96
99_V150_L0.5780.96
70_V248_V0.5780.96
94_H152_P0.5780.96
67_L71_S0.5770.96
135_S139_N0.5740.96
19_G213_F0.5740.96
107_P113_G0.5720.95
111_F208_S0.5710.95
82_S105_G0.5670.95
215_A275_I0.5660.95
162_S165_S0.5650.95
245_L263_V0.5620.95
70_V262_M0.5620.95
125_V131_V0.5610.95
102_L274_G0.5610.95
246_L306_W0.5610.95
302_T306_W0.5610.95
19_G212_V0.5590.95
37_N211_A0.5580.95
219_L293_A0.5540.95
86_C100_C0.5540.95
48_A209_G0.5520.94
25_R29_S0.5520.94
227_S290_A0.5480.94
32_Q217_L0.5480.94
69_L252_C0.5470.94
105_G146_G0.5470.94
249_G262_M0.5460.94
136_I139_N0.5450.94
47_A181_L0.5440.94
124_S129_L0.5420.94
71_S82_S0.5400.94
75_I78_C0.5400.94
109_I265_A0.5390.94
233_N270_P0.5390.94
56_A186_V0.5370.94
254_L258_H0.5370.94
239_I305_L0.5360.94
87_Y90_F0.5340.93
265_A293_A0.5330.93
232_Y235_F0.5330.93
292_L296_V0.5320.93
285_T289_T0.5320.93
98_A153_S0.5320.93
235_F238_L0.5310.93
48_A237_K0.5300.93
274_G292_L0.5300.93
165_S169_S0.5300.93
79_F101_A0.5290.93
125_V130_V0.5270.93
108_T114_F0.5260.93
271_A274_G0.5250.93
103_I107_P0.5240.93
130_V261_M0.5240.93
23_G28_F0.5230.93
215_A292_L0.5230.93
114_F136_I0.5220.93
71_S137_I0.5180.92
222_H293_A0.5180.92
108_T115_A0.5180.92
7_G194_A0.5150.92
84_F89_F0.5140.92
125_V257_E0.5140.92
230_I291_S0.5130.92
151_N170_A0.5130.92
64_D69_L0.5130.92
245_L249_G0.5100.92
232_Y236_L0.5070.92
215_A293_A0.5060.92
98_A149_L0.5060.92
230_I290_A0.5060.92
111_F215_A0.5060.92
111_F131_V0.5060.92
93_T284_Y0.5060.92
34_R279_S0.5050.91
214_A217_L0.5050.91
57_N61_I0.5040.91
239_I243_L0.5040.91
227_S230_I0.5030.91
306_W309_V0.5010.91
83_W94_H0.5010.91
52_S132_A0.5010.91
96_E283_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.4745 99.7 0.687 Contact Map
4n7wA 2 0.4586 99.7 0.695 Contact Map
4czbA 2 0.535 74.4 0.926 Contact Map
4cz8A 2 0.535 73.5 0.927 Contact Map
2cfqA 1 0.9554 62.9 0.932 Contact Map
4bwzA 2 0.5287 58 0.934 Contact Map
2gfpA 2 0.9268 56.1 0.935 Contact Map
4m64A 1 0.949 21.2 0.948 Contact Map
3o7qA 1 0.9395 18.1 0.95 Contact Map
1zcdA 1 0.4904 15.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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