GREMLIN Database
PLAP - Low-affinity putrescine importer PlaP
UniProt: P0AA47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11896
Length: 452 (419)
Sequences: 24865 (16359)
Seq/√Len: 799.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_T344_G4.3031.00
325_F338_M3.9251.00
59_L246_G3.2051.00
379_S383_I3.1171.00
328_Y338_M3.0491.00
232_R236_R3.0111.00
19_T228_K2.8991.00
330_H333_W2.8901.00
83_Y318_D2.8081.00
227_T233_V2.7381.00
174_V255_F2.6941.00
99_G315_M2.6901.00
316_G327_G2.5801.00
229_D232_R2.5591.00
330_H337_A2.4651.00
225_E317_R2.4331.00
24_V240_L2.4101.00
371_T405_A2.4011.00
172_G176_Y2.3851.00
135_V348_L2.3611.00
71_K381_F2.3381.00
20_L240_L2.3341.00
87_Q95_G2.3181.00
341_I345_A2.2441.00
226_E310_R2.1951.00
397_Y401_P2.1421.00
20_L233_V2.1401.00
402_M406_L2.1181.00
313_Y317_R2.1021.00
20_L24_V2.0961.00
143_A147_R2.0631.00
23_V227_T2.0571.00
150_K154_N2.0531.00
142_T340_I2.0441.00
319_G323_K1.9971.00
139_A348_L1.9791.00
284_A288_G1.9771.00
90_I379_S1.9701.00
146_L337_A1.9631.00
275_E278_L1.9511.00
236_R240_L1.9471.00
134_V351_I1.9461.00
391_L394_H1.9391.00
14_L329_V1.9361.00
103_L343_V1.9241.00
87_Q92_P1.9221.00
19_T22_P1.9171.00
135_V351_I1.9131.00
432_I436_C1.8991.00
161_V165_V1.8881.00
60_I64_F1.8731.00
399_F403_C1.8321.00
68_S374_N1.8151.00
374_N404_G1.7981.00
330_H335_T1.7981.00
326_F342_L1.7891.00
90_I375_L1.7851.00
43_V51_V1.7851.00
229_D233_V1.7491.00
388_N391_L1.7451.00
239_F243_L1.7271.00
145_N302_M1.7251.00
100_W430_G1.7121.00
54_A206_G1.7011.00
22_P157_T1.6971.00
98_V372_F1.6711.00
114_I301_G1.6521.00
146_L341_I1.6441.00
86_A98_V1.6381.00
333_W337_A1.6341.00
379_S382_W1.6331.00
406_L410_A1.6231.00
27_G241_T1.6171.00
275_E279_Y1.6111.00
265_R279_Y1.6101.00
165_V169_V1.6081.00
24_V244_I1.6031.00
139_A344_G1.5971.00
129_P132_M1.5891.00
138_V347_A1.5861.00
110_P347_A1.5791.00
426_W430_G1.5521.00
18_L22_P1.5521.00
189_S195_S1.5301.00
243_L247_M1.5241.00
338_M342_L1.5191.00
121_F133_F1.5151.00
229_D236_R1.5131.00
164_V168_A1.5121.00
91_S94_V1.5021.00
192_P195_S1.4911.00
58_A210_L1.4831.00
223_L306_A1.4751.00
389_K393_D1.4731.00
117_A294_T1.4731.00
424_L428_A1.4681.00
408_V411_L1.4551.00
128_I132_M1.4491.00
114_I138_V1.4451.00
79_A225_E1.4351.00
313_Y329_V1.4351.00
189_S192_P1.4311.00
147_R333_W1.4291.00
47_T50_H1.4281.00
66_A242_A1.4271.00
391_L395_F1.4221.00
308_V343_V1.4181.00
166_L292_F1.4131.00
192_P196_G1.3961.00
436_C439_K1.3901.00
14_L313_Y1.3821.00
401_P405_A1.3821.00
312_M339_N1.3801.00
417_E420_M1.3781.00
230_A235_P1.3761.00
382_W385_E1.3741.00
431_L435_A1.3741.00
142_T341_I1.3671.00
175_V255_F1.3611.00
22_P153_A1.3571.00
138_V344_G1.3541.00
90_I94_V1.3471.00
135_V139_A1.3451.00
15_R334_R1.3321.00
309_A340_I1.3251.00
60_I403_C1.3131.00
66_A238_I1.3131.00
18_L23_V1.3051.00
375_L379_S1.2951.00
38_D116_L1.2901.00
381_F385_E1.2831.00
76_Y88_K1.2791.00
18_L153_A1.2761.00
261_P265_R1.2721.00
190_T195_S1.2711.00
323_K327_G1.2711.00
398_L402_M1.2701.00
328_Y337_A1.2681.00
312_M321_F1.2661.00
65_T374_N1.2651.00
86_A372_F1.2641.00
278_L286_Q1.2631.00
401_P408_V1.2621.00
171_L251_F1.2501.00
435_A439_K1.2461.00
384_R387_R1.2451.00
269_P275_E1.2431.00
247_M251_F1.2411.00
404_G408_V1.2401.00
278_L283_K1.2271.00
52_P254_Y1.2271.00
420_M423_G1.2271.00
189_S194_W1.2261.00
117_A137_L1.2221.00
61_A407_T1.2211.00
404_G407_T1.2211.00
64_F403_C1.2161.00
416_E419_S1.2141.00
178_V258_L1.2131.00
113_N300_S1.2071.00
67_L239_F1.2061.00
425_I429_I1.2051.00
233_V236_R1.2021.00
389_K392_K1.1981.00
84_T88_K1.1961.00
21_V25_M1.1941.00
417_E421_V1.1881.00
31_M245_G1.1861.00
261_P264_S1.1791.00
131_W135_V1.1711.00
103_L312_M1.1701.00
174_V259_Y1.1701.00
20_L236_R1.1691.00
193_F196_G1.1601.00
430_G433_Y1.1591.00
144_F155_F1.1591.00
176_Y181_G1.1531.00
323_K328_Y1.1501.00
69_Y82_A1.1501.00
141_M301_G1.1441.00
428_A432_I1.1441.00
433_Y436_C1.1411.00
329_V334_R1.1411.00
93_T437_V1.1401.00
170_I174_V1.1301.00
338_M341_I1.1221.00
179_F182_E1.1211.00
132_M136_A1.1181.00
146_L335_T1.1151.00
73_V85_Y1.1151.00
169_V173_M1.1111.00
71_K74_R1.1061.00
28_L244_I1.1051.00
281_A285_F1.1021.00
156_N302_M1.1011.00
96_F100_W1.1001.00
136_A140_F1.0951.00
86_A94_V1.0921.00
401_P407_T1.0881.00
27_G220_I1.0871.00
409_G413_V1.0871.00
23_V237_A1.0831.00
89_S376_S1.0771.00
78_S84_T1.0761.00
375_L405_A1.0761.00
287_V291_I1.0741.00
44_S51_V1.0711.00
418_S422_L1.0681.00
83_Y314_V1.0671.00
168_A172_G1.0601.00
121_F125_V1.0521.00
261_P279_Y1.0481.00
155_F159_I1.0471.00
175_V179_F1.0461.00
408_V412_W1.0441.00
228_K233_V1.0411.00
17_T228_K1.0341.00
282_G285_F1.0341.00
422_L425_I1.0311.00
26_M223_L1.0281.00
418_S421_V1.0261.00
142_T146_L1.0181.00
399_F402_M1.0171.00
88_K384_R1.0141.00
154_N158_V1.0141.00
269_P272_S1.0091.00
68_S401_P1.0091.00
410_A413_V1.0081.00
345_A349_L1.0081.00
371_T375_L1.0071.00
317_R327_G1.0061.00
190_T193_F1.0031.00
199_H202_P1.0021.00
75_R387_R0.9981.00
188_A191_R0.9951.00
56_A250_I0.9891.00
28_L245_G0.9881.00
139_A143_A0.9871.00
170_I277_M0.9861.00
390_T394_H0.9741.00
397_Y400_L0.9701.00
146_L330_H0.9691.00
176_Y180_E0.9601.00
407_T411_L0.9591.00
398_L401_P0.9551.00
433_Y437_V0.9541.00
421_V425_I0.9531.00
121_F294_T0.9531.00
200_V203_M0.9511.00
430_G434_L0.9481.00
118_K133_F0.9441.00
325_F328_Y0.9431.00
118_K134_V0.9401.00
188_A192_P0.9371.00
14_L226_E0.9351.00
218_D222_N0.9351.00
78_S88_K0.9341.00
59_L214_F0.9331.00
429_I433_Y0.9271.00
224_S234_I0.9261.00
171_L255_F0.9231.00
149_L306_A0.9231.00
189_S196_G0.9211.00
385_E389_K0.9201.00
14_L310_R0.9191.00
164_V248_I0.9161.00
420_M424_L0.9161.00
141_M302_M0.9111.00
191_R195_S0.9101.00
259_Y276_I0.9091.00
401_P413_V0.9061.00
93_T97_M0.9061.00
405_A408_V0.8971.00
401_P412_W0.8961.00
159_I299_A0.8951.00
112_I212_F0.8911.00
80_G83_Y0.8871.00
215_T366_A0.8871.00
163_Q296_T0.8851.00
87_Q318_D0.8841.00
52_P257_Q0.8841.00
140_F298_L0.8821.00
188_A195_S0.8811.00
405_A409_G0.8801.00
371_T409_G0.8761.00
321_F326_F0.8751.00
401_P404_G0.8751.00
246_G250_I0.8721.00
75_R389_K0.8721.00
100_W321_F0.8681.00
337_A341_I0.8661.00
305_H344_G0.8661.00
417_E423_G0.8621.00
80_G84_T0.8601.00
419_S423_G0.8591.00
22_P154_N0.8571.00
254_Y258_L0.8551.00
204_I410_A0.8531.00
330_H334_R0.8521.00
361_L365_G0.8491.00
93_T431_L0.8491.00
271_A275_E0.8471.00
56_A60_I0.8461.00
326_F338_M0.8441.00
17_T150_K0.8371.00
171_L175_V0.8371.00
376_S380_Q0.8371.00
20_L237_A0.8341.00
344_G348_L0.8321.00
354_D357_M0.8311.00
50_H194_W0.8241.00
425_I428_A0.8211.00
401_P411_L0.8211.00
283_K287_V0.8181.00
419_S422_L0.8171.00
74_R390_T0.8161.00
240_L244_I0.8151.00
418_S423_G0.8131.00
53_T203_M0.8121.00
32_Q35_T0.8111.00
117_A297_V0.8081.00
133_F136_A0.8081.00
118_K130_S0.8071.00
205_T209_I0.8051.00
25_M157_T0.8031.00
364_F423_G0.8011.00
215_T370_F0.7991.00
219_G307_G0.7991.00
21_V157_T0.7981.00
373_V376_S0.7971.00
427_A430_G0.7961.00
36_L252_A0.7961.00
175_V251_F0.7961.00
117_A298_L0.7951.00
32_Q163_Q0.7941.00
423_G427_A0.7931.00
141_M305_H0.7921.00
138_V351_I0.7901.00
415_L420_M0.7881.00
63_L67_L0.7871.00
378_I402_M0.7851.00
131_W351_I0.7791.00
86_A376_S0.7771.00
50_H203_M0.7751.00
176_Y179_F0.7741.00
154_N157_T0.7731.00
122_E130_S0.7721.00
115_L358_A0.7711.00
397_Y402_M0.7711.00
107_L346_I0.7661.00
264_S268_D0.7661.00
194_W203_M0.7661.00
64_F68_S0.7641.00
63_L239_F0.7621.00
191_R194_W0.7621.00
179_F183_G0.7581.00
414_N417_E0.7491.00
181_G184_A0.7491.00
235_P238_I0.7461.00
389_K395_F0.7441.00
75_R385_E0.7411.00
229_D235_P0.7401.00
378_I382_W0.7381.00
31_M241_T0.7371.00
200_V204_I0.7351.00
143_A146_L0.7341.00
417_E424_L0.7331.00
112_I359_T0.7331.00
429_I432_I0.7301.00
91_S438_T0.7271.00
387_R390_T0.7261.00
184_A187_L0.7241.00
147_R151_S0.7241.00
432_I435_A0.7211.00
402_M405_A0.7201.00
102_S106_Y0.7181.00
43_V47_T0.7161.00
53_T56_A0.7161.00
377_V381_F0.7161.00
17_T149_L0.7151.00
365_G369_A0.7141.00
400_L404_G0.7131.00
416_E420_M0.7131.00
131_W134_V0.7131.00
188_A196_G0.7111.00
178_V181_G0.7111.00
305_H309_A0.7091.00
145_N306_A0.7071.00
356_V359_T0.7051.00
83_Y87_Q0.7041.00
380_Q384_R0.7011.00
146_L333_W0.7011.00
145_N340_I0.7011.00
271_A274_P0.6991.00
369_A373_V0.6981.00
355_L359_T0.6941.00
382_W386_K0.6931.00
325_F342_L0.6911.00
94_V372_F0.6901.00
24_V237_A0.6891.00
372_F376_S0.6881.00
72_L85_Y0.6881.00
146_L340_I0.6861.00
426_W434_L0.6861.00
386_K389_K0.6841.00
202_P205_T0.6791.00
196_G199_H0.6781.00
397_Y405_A0.6741.00
417_E430_G0.6741.00
124_L291_I0.6731.00
24_V27_G0.6721.00
426_W429_I0.6711.00
312_M342_L0.6711.00
141_M298_L0.6711.00
345_A348_L0.6691.00
265_R268_D0.6651.00
53_T57_F0.6651.00
32_Q248_I0.6631.00
135_V352_N0.6631.00
374_N377_V0.6621.00
153_A157_T0.6621.00
316_G326_F0.6611.00
72_L377_V0.6611.00
244_I248_I0.6611.00
310_R313_Y0.6601.00
309_A339_N0.6591.00
240_L243_L0.6571.00
62_I217_F0.6571.00
139_A142_T0.6571.00
21_V154_N0.6571.00
83_Y99_G0.6551.00
395_F400_L0.6551.00
73_V234_I0.6531.00
178_V255_F0.6531.00
171_L252_A0.6521.00
43_V210_L0.6521.00
377_V401_P0.6481.00
153_A302_M0.6451.00
403_C406_L0.6431.00
14_L17_T0.6411.00
65_T408_V0.6401.00
179_F187_L0.6381.00
395_F398_L0.6371.00
363_N366_A0.6371.00
113_N301_G0.6351.00
378_I398_L0.6351.00
101_S369_A0.6351.00
29_A160_V0.6341.00
180_E183_G0.6341.00
399_F413_V0.6321.00
284_A287_V0.6311.00
215_T218_D0.6291.00
374_N405_A0.6261.00
52_P56_A0.6261.00
190_T194_W0.6251.00
189_S193_F0.6241.00
162_L292_F0.6201.00
366_A369_A0.6181.00
427_A431_L0.6141.00
221_S238_I0.6131.00
118_K121_F0.6121.00
389_K394_H0.6121.00
83_Y95_G0.6101.00
403_C407_T0.6091.00
149_L223_L0.6091.00
109_A113_N0.6081.00
188_A194_W0.6071.00
82_A222_N0.6061.00
225_E313_Y0.6061.00
89_S379_S0.6061.00
52_P250_I0.6061.00
55_Y213_S0.6061.00
137_L301_G0.6041.00
40_F253_T0.6041.00
385_E388_N0.6031.00
120_Y293_S0.6021.00
105_D366_A0.6011.00
421_V424_L0.6011.00
70_G74_R0.6011.00
69_Y373_V0.6001.00
342_L346_I0.6001.00
251_F255_F0.5991.00
124_L290_L0.5991.00
49_G257_Q0.5981.00
332_K337_A0.5981.00
79_A313_Y0.5971.00
433_Y439_K0.5931.00
226_E336_P0.5921.00
308_V312_M0.5911.00
82_A218_D0.5911.00
173_M281_A0.5911.00
291_I295_I0.5901.00
17_T21_V0.5871.00
370_F374_N0.5871.00
151_S154_N0.5851.00
123_A290_L0.5851.00
277_M285_F0.5851.00
409_G412_W0.5841.00
400_L403_C0.5841.00
58_A214_F0.5841.00
252_A256_L0.5841.00
399_F407_T0.5841.00
392_K395_F0.5841.00
51_V253_T0.5831.00
28_L160_V0.5831.00
91_S95_G0.5821.00
111_M350_A0.5821.00
66_A217_F0.5811.00
336_P339_N0.5811.00
140_F144_F0.5811.00
178_V259_Y0.5771.00
388_N393_D0.5771.00
106_Y304_A0.5771.00
108_F361_L0.5771.00
425_I432_I0.5761.00
296_T299_A0.5761.00
30_Y304_A0.5751.00
21_V24_V0.5751.00
419_S426_W0.5741.00
183_G187_L0.5731.00
90_I376_S0.5731.00
148_S151_S0.5721.00
109_A112_I0.5711.00
116_L120_Y0.5711.00
406_L409_G0.5691.00
152_V306_A0.5681.00
128_I133_F0.5681.00
178_V182_E0.5681.00
234_I238_I0.5671.00
73_V221_S0.5661.00
191_R196_G0.5661.00
121_F137_L0.5651.00
255_F258_L0.5621.00
114_I118_K0.5621.00
66_A70_G0.5621.00
400_L408_V0.5611.00
310_R336_P0.5611.00
348_L351_I0.5601.00
244_I247_M0.5601.00
64_F400_L0.5591.00
260_F275_E0.5581.00
139_A341_I0.5571.00
326_F339_N0.5571.00
407_T410_A0.5571.00
426_W433_Y0.5561.00
252_A273_Q0.5551.00
322_P325_F0.5551.00
256_L273_Q0.5551.00
72_L89_S0.5541.00
111_M358_A0.5531.00
433_Y438_T0.5521.00
70_G238_I0.5521.00
376_S379_S0.5511.00
136_A139_A0.5501.00
305_H340_I0.5491.00
380_Q385_E0.5491.00
378_I401_P0.5481.00
337_A340_I0.5461.00
397_Y412_W0.5451.00
52_P55_Y0.5441.00
188_A193_F0.5441.00
227_T234_I0.5441.00
30_Y303_A0.5431.00
156_N299_A0.5431.00
187_L190_T0.5411.00
230_A233_V0.5411.00
142_T305_H0.5411.00
138_V348_L0.5401.00
162_L166_L0.5401.00
151_S155_F0.5401.00
113_N116_L0.5391.00
424_L427_A0.5391.00
157_T161_V0.5391.00
227_T237_A0.5381.00
109_A362_I0.5381.00
33_P249_F0.5371.00
405_A412_W0.5371.00
381_F384_R0.5361.00
405_A413_V0.5331.00
264_S267_K0.5321.00
383_I387_R0.5321.00
231_E388_N0.5311.00
105_D365_G0.5311.00
404_G412_W0.5311.00
30_Y219_G0.5301.00
158_V161_V0.5301.00
57_F207_A0.5291.00
58_A211_C0.5281.00
431_L434_L0.5281.00
65_T218_D0.5271.00
349_L352_N0.5271.00
89_S380_Q0.5261.00
415_L419_S0.5261.00
107_L343_V0.5251.00
400_L407_T0.5241.00
397_Y411_L0.5241.00
417_E434_L0.5241.00
36_L167_I0.5241.00
14_L79_A0.5231.00
310_R329_V0.5231.00
382_W398_L0.5211.00
222_N307_G0.5201.00
226_E329_V0.5201.00
23_V233_V0.5191.00
28_L31_M0.5191.00
414_N420_M0.5191.00
55_Y253_T0.5181.00
27_G31_M0.5151.00
13_E16_K0.5151.00
173_M282_G0.5141.00
37_F167_I0.5141.00
93_T434_L0.5131.00
429_I437_V0.5131.00
220_I234_I0.5131.00
407_T412_W0.5111.00
42_I356_V0.5101.00
86_A95_G0.5101.00
402_M412_W0.5091.00
231_E236_R0.5081.00
71_K75_R0.5051.00
33_P37_F0.5031.00
81_S221_S0.5031.00
369_A376_S0.5031.00
265_R269_P0.5031.00
230_A234_I0.5021.00
32_Q37_F0.5021.00
213_S249_F0.5001.00
201_I204_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9093 100 0.284 Contact Map
3giaA 1 0.9314 100 0.362 Contact Map
4djkA 2 0.885 100 0.366 Contact Map
3dh4A 3 0.927 99 0.852 Contact Map
2xq2A 2 0.9314 98.9 0.858 Contact Map
2jlnA 1 0.9093 98.8 0.861 Contact Map
4wgvA 2 0.8053 98.1 0.888 Contact Map
2a65A 2 0.9137 97.3 0.906 Contact Map
4xp4A 1 0.9314 96.7 0.913 Contact Map
4us3A 1 0.8695 96 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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