GREMLIN Database
THIO - Thioredoxin-1
UniProt: P0AA25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11031
Length: 109 (100)
Sequences: 11573 (7830)
Seq/√Len: 783.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_I68_A2.7841.00
45_E97_K2.4621.00
14_D70_K2.2731.00
8_L57_A2.2691.00
49_E101_K2.1531.00
10_D66_G2.1381.00
49_E97_K2.1181.00
80_L90_T2.0961.00
96_S99_Q2.0541.00
101_K105_D1.9731.00
60_N63_Q1.8471.00
10_D67_T1.8391.00
14_D19_K1.7991.00
50_Y101_K1.7761.00
22_G55_T1.7521.00
87_V90_T1.7411.00
33_C36_C1.7081.00
71_Y82_F1.7001.00
61_I76_I1.6941.00
80_L87_V1.6831.00
27_D58_K1.6541.00
24_I55_T1.6511.00
43_L56_V1.6161.00
99_Q102_E1.5761.00
10_D64_N1.5751.00
42_I45_E1.5721.00
9_T12_S1.5221.00
42_I97_K1.4831.00
91_K95_L1.4761.00
89_A103_F1.4701.00
50_Y105_D1.4651.00
23_A81_L1.4411.00
31_E60_N1.4191.00
25_L43_L1.4101.00
24_I57_A1.3611.00
17_V24_I1.3351.00
25_L79_L1.3321.00
91_K103_F1.3291.00
46_I56_V1.3221.00
94_A99_Q1.2711.00
46_I101_K1.2481.00
97_K101_K1.2421.00
39_I79_L1.1761.00
59_L67_T1.1541.00
46_I97_K1.1111.00
50_Y53_K1.0821.00
81_L103_F1.0611.00
9_T64_N1.0471.00
26_V82_F1.0381.00
29_W58_K1.0321.00
7_H58_K1.0251.00
65_P69_P1.0191.00
40_A44_D1.0121.00
95_L99_Q0.9961.00
83_K88_A0.9911.00
27_D40_A0.9761.00
40_A58_K0.9761.00
44_D58_K0.9711.00
79_L100_L0.9641.00
46_I50_Y0.9401.00
6_I55_T0.9221.00
39_I42_I0.9161.00
39_I100_L0.9151.00
15_T19_K0.9141.00
23_A83_K0.9111.00
28_F71_Y0.8761.00
86_E89_A0.8731.00
66_G70_K0.8681.00
14_D18_L0.8521.00
59_L68_A0.8521.00
95_L103_F0.8261.00
25_L56_V0.8231.00
7_H63_Q0.8141.00
53_K105_D0.8001.00
66_G69_P0.7981.00
81_L104_L0.7951.00
43_L79_L0.7951.00
38_M94_A0.7931.00
6_I17_V0.7881.00
29_W60_N0.7841.00
12_S57_A0.7781.00
46_I100_L0.7671.00
47_A56_V0.7611.00
34_G37_K0.7601.00
54_L104_L0.7431.00
42_I96_S0.7381.00
102_E105_D0.7321.00
50_Y54_L0.7291.00
21_D84_N0.7171.00
28_F61_I0.7151.00
103_F106_A0.7021.00
45_E48_D0.7001.00
31_E62_D0.6941.00
29_W76_I0.6901.00
67_T70_K0.6901.00
28_F73_I0.6721.00
98_G102_E0.6701.00
64_N67_T0.6631.00
89_A106_A0.6621.00
39_I95_L0.6541.00
82_F87_V0.6441.00
8_L17_V0.6361.00
48_D51_Q0.6361.00
27_D39_I0.6331.00
27_D35_P0.6311.00
22_G84_N0.6241.00
42_I46_I0.6221.00
8_L12_S0.6141.00
15_T20_A0.6111.00
13_F67_T0.6101.00
7_H31_E0.6081.00
74_R90_T0.6061.00
28_F80_L0.6041.00
21_D24_I0.6021.00
65_P68_A0.6011.00
13_F71_Y0.5971.00
35_P75_G0.5881.00
39_I94_A0.5861.00
25_L100_L0.5851.00
59_L64_N0.5841.00
6_I57_A0.5821.00
28_F59_L0.5821.00
22_G53_K0.5821.00
25_L104_L0.5731.00
13_F28_F0.5701.00
39_I43_L0.5651.00
32_W62_D0.5641.00
22_G52_G0.5631.00
79_L91_K0.5631.00
98_G101_K0.5621.00
12_S15_T0.5611.00
35_P38_M0.5601.00
13_F17_V0.5561.00
102_E106_A0.5541.00
73_I78_T0.5531.00
83_K86_E0.5471.00
32_W76_I0.5431.00
42_I94_A0.5421.00
31_E63_Q0.5361.00
7_H29_W0.5361.00
34_G38_M0.5341.00
30_A62_D0.5331.00
38_M42_I0.5321.00
26_V57_A0.5321.00
6_I24_I0.5251.00
23_A84_N0.5241.00
75_G92_V0.5211.00
20_A55_T0.5151.00
25_L81_L0.5101.00
13_F26_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f8uA 2 0.9725 99.8 0.144 Contact Map
2r2jA 2 0.945 99.8 0.148 Contact Map
3apoA 1 0.9174 99.8 0.16 Contact Map
2b5eA 1 0.9908 99.8 0.165 Contact Map
4ekzA 1 0.9908 99.8 0.188 Contact Map
3ed3A 1 1 99.8 0.193 Contact Map
1sjiA 2 0.9817 99.8 0.196 Contact Map
3us3A 2 0.9817 99.7 0.199 Contact Map
4kcaA 2 0.9633 99.7 0.203 Contact Map
3bj5A 1 0.9633 99.7 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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