GREMLIN Database
OMPR - Transcriptional regulatory protein OmpR
UniProt: P0AA16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10672
Length: 239 (207)
Sequences: 74368 (52195)
Seq/√Len: 3627.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_R33_S3.7261.00
17_R35_A3.2501.00
21_E33_S3.1961.00
10_V40_M2.7331.00
41_D69_R2.6691.00
38_E60_G2.5481.00
32_R49_F2.3991.00
37_A61_E2.3861.00
61_E69_R2.3401.00
36_N60_G2.3371.00
45_T73_Q2.3011.00
6_K32_R2.1751.00
6_K30_Q2.1161.00
23_Y109_P2.0841.00
21_E25_T2.0791.00
27_Q113_L2.0581.00
34_V43_L2.0341.00
57_M85_K1.8951.00
35_A39_Q1.8601.00
91_R111_E1.8461.00
54_L66_I1.7951.00
32_R43_L1.7701.00
36_N39_Q1.7661.00
199_R202_D1.7541.00
164_G167_A1.7431.00
81_M94_G1.7401.00
71_R100_D1.7171.00
67_C79_I1.6911.00
8_L34_V1.6811.00
43_L47_E1.6351.00
69_R73_Q1.6341.00
88_E108_N1.6301.00
182_R202_D1.6131.00
32_R47_E1.6031.00
5_Y120_L1.5751.00
170_K174_S1.5651.00
61_E65_S1.5601.00
81_M99_A1.5581.00
171_A188_L1.5451.00
37_A66_I1.5371.00
180_L188_L1.5241.00
24_L116_I1.5141.00
85_K90_D1.5111.00
68_R97_I1.5071.00
101_D115_R1.4981.00
43_L46_R1.4911.00
62_D65_S1.4891.00
181_S184_K1.4541.00
44_L70_L1.4381.00
52_M77_M1.4371.00
204_Q207_R1.4331.00
139_A144_K1.4291.00
69_R72_S1.4211.00
142_K155_E1.4121.00
38_E61_E1.4011.00
14_M35_A1.3741.00
80_I119_V1.3501.00
51_L116_I1.3501.00
67_C81_M1.3371.00
65_S68_R1.3231.00
41_D66_I1.3081.00
165_E211_M1.2921.00
29_F117_R1.2551.00
6_K47_E1.2491.00
137_V144_K1.2421.00
56_L64_L1.2411.00
100_D122_R1.2281.00
43_L49_F1.2271.00
10_V58_L1.2201.00
11_D17_R1.2131.00
42_R46_R1.2091.00
41_D61_E1.2001.00
64_L94_G1.1941.00
54_L67_C1.1901.00
171_A175_H1.1781.00
39_Q42_R1.1741.00
39_Q43_L1.1691.00
56_L81_M1.1611.00
113_L117_R1.1611.00
184_K188_L1.1591.00
34_V40_M1.1571.00
28_G117_R1.1541.00
12_D55_D1.1541.00
100_D119_V1.1511.00
8_L49_F1.1471.00
144_K153_F1.1441.00
87_E90_D1.1431.00
88_E92_I1.1351.00
166_F170_K1.1261.00
151_E158_P1.1181.00
146_N149_T1.1161.00
64_L93_V1.1151.00
27_Q117_R1.1041.00
38_E42_R1.1021.00
93_V97_I1.0931.00
8_L40_M1.0911.00
183_D198_E1.0871.00
171_A180_L1.0791.00
7_I29_F1.0731.00
74_S77_M1.0731.00
51_L120_L1.0601.00
203_V206_S1.0541.00
5_Y29_F1.0511.00
96_E117_R1.0461.00
114_A118_A1.0321.00
8_L43_L1.0241.00
111_E114_A1.0221.00
34_V39_Q1.0211.00
145_L173_V1.0171.00
147_L170_K1.0151.00
136_A148_G1.0131.00
89_V93_V1.0111.00
163_S167_A0.9981.00
199_R203_V0.9961.00
21_E31_V0.9891.00
92_I96_E0.9811.00
41_D45_T0.9791.00
40_M66_I0.9761.00
167_A170_K0.9701.00
18_A33_S0.9651.00
214_E224_T0.9631.00
91_R104_P0.9581.00
15_R19_L0.9581.00
153_F158_P0.9561.00
68_R93_V0.9541.00
40_M44_L0.9461.00
52_M70_L0.9441.00
9_V20_L0.9421.00
10_V34_V0.9401.00
14_M18_A0.9331.00
145_L166_F0.9301.00
54_L79_I0.9271.00
56_L62_D0.9251.00
64_L97_I0.9221.00
164_G190_R0.9151.00
20_L82_V0.9151.00
180_L184_K0.9061.00
171_A185_L0.9041.00
10_V52_M0.8981.00
200_S204_Q0.8981.00
8_L44_L0.8831.00
119_V122_R0.8811.00
44_L74_S0.8781.00
6_K50_H0.8731.00
215_D218_H0.8681.00
65_S69_R0.8651.00
14_M17_R0.8611.00
54_L81_M0.8601.00
198_E202_D0.8561.00
67_C97_I0.8511.00
29_F113_L0.8501.00
42_R45_T0.8501.00
199_R206_S0.8431.00
214_E220_R0.8421.00
53_V112_L0.8371.00
139_A142_K0.8331.00
9_V31_V0.8321.00
93_V96_E0.8321.00
5_Y124_A0.8301.00
86_G104_P0.8291.00
67_C99_A0.8251.00
88_E91_R0.8251.00
22_R26_E0.8221.00
118_A123_Q0.8221.00
111_E115_R0.8191.00
137_V146_N0.8161.00
48_S74_S0.8081.00
78_P100_D0.8081.00
205_I209_R0.8041.00
56_L90_D0.8041.00
53_V82_V0.8021.00
150_R167_A0.7941.00
207_R210_R0.7941.00
80_I115_R0.7931.00
18_A21_E0.7931.00
66_I70_L0.7921.00
58_L66_I0.7821.00
92_I110_R0.7761.00
52_M79_I0.7751.00
182_R198_E0.7741.00
68_R72_S0.7731.00
6_K49_F0.7671.00
162_T211_M0.7621.00
109_P113_L0.7621.00
61_E66_I0.7591.00
183_D187_N0.7591.00
20_L112_L0.7591.00
16_L107_F0.7591.00
70_L75_N0.7571.00
82_V107_F0.7571.00
56_L85_K0.7541.00
171_A174_S0.7541.00
118_A121_R0.7481.00
90_D93_V0.7471.00
44_L77_M0.7461.00
89_V110_R0.7441.00
206_S210_R0.7441.00
213_E216_P0.7421.00
44_L49_F0.7361.00
168_V172_L0.7331.00
203_V207_R0.7331.00
108_N111_E0.7271.00
53_V116_I0.7261.00
37_A41_D0.7221.00
184_K187_N0.7181.00
10_V66_I0.7181.00
23_Y113_L0.7181.00
220_R223_Q0.7181.00
57_M84_A0.7171.00
18_A22_R0.7011.00
209_R214_E0.6961.00
95_L115_R0.6951.00
120_L123_Q0.6891.00
37_A60_G0.6801.00
41_D44_L0.6781.00
213_E220_R0.6731.00
167_A171_A0.6671.00
215_D220_R0.6641.00
19_L23_Y0.6631.00
80_I101_D0.6611.00
45_T74_S0.6611.00
107_F112_L0.6601.00
78_P120_L0.6601.00
44_L52_M0.6591.00
96_E114_A0.6581.00
143_F154_R0.6561.00
187_N190_R0.6531.00
55_D105_K0.6531.00
94_G99_A0.6481.00
7_I51_L0.6471.00
123_Q127_L0.6471.00
196_A201_I0.6471.00
9_V33_S0.6461.00
76_P125_N0.6431.00
11_D58_L0.6411.00
17_R21_E0.6411.00
45_T69_R0.6401.00
88_E110_R0.6401.00
24_L29_F0.6391.00
145_L152_M0.6371.00
25_T31_V0.6371.00
7_I24_L0.6361.00
153_F156_D0.6351.00
41_D73_Q0.6311.00
174_S180_L0.6301.00
150_R166_F0.6291.00
174_S188_L0.6241.00
9_V21_E0.6231.00
172_L205_I0.6231.00
110_R114_A0.6131.00
91_R108_N0.6111.00
147_L174_S0.6071.00
154_R157_E0.6071.00
145_L170_K0.6071.00
13_D84_A0.6061.00
76_P126_E0.6061.00
37_A58_L0.6061.00
164_G204_Q0.6051.00
107_F111_E0.6001.00
71_R78_P0.5991.00
64_L90_D0.5991.00
202_D205_I0.5971.00
5_Y50_H0.5941.00
142_K154_R0.5871.00
53_V80_I0.5821.00
162_T165_E0.5781.00
71_R77_M0.5771.00
220_R224_T0.5761.00
217_A220_R0.5761.00
205_I217_A0.5721.00
115_R119_V0.5691.00
92_I95_L0.5661.00
70_L79_I0.5621.00
101_D118_A0.5621.00
154_R215_D0.5611.00
83_T105_K0.5611.00
25_T30_Q0.5601.00
12_D83_T0.5591.00
114_A117_R0.5581.00
140_F144_K0.5571.00
23_Y27_Q0.5571.00
13_D16_L0.5551.00
117_R121_R0.5531.00
56_L94_G0.5501.00
197_M200_S0.5471.00
39_Q60_G0.5461.00
216_P220_R0.5461.00
136_A147_L0.5421.00
86_G106_P0.5381.00
54_L58_L0.5351.00
83_T102_Y0.5341.00
146_N151_E0.5341.00
186_M190_R0.5321.00
19_L22_R0.5301.00
154_R213_E0.5261.00
8_L47_E0.5241.00
154_R214_E0.5241.00
78_P122_R0.5231.00
89_V92_I0.5231.00
138_I147_L0.5191.00
67_C71_R0.5171.00
83_T91_R0.5161.00
51_L119_V0.5071.00
54_L70_L0.5071.00
16_L19_L0.5061.00
94_G102_Y0.5041.00
136_A140_F0.5031.00
78_P123_Q0.5031.00
36_N58_L0.5031.00
70_L77_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.9456 100 0.201 Contact Map
3r0jA 2 0.9331 100 0.201 Contact Map
2gwrA 1 0.9372 100 0.202 Contact Map
1kgsA 1 0.9163 100 0.22 Contact Map
4b09A 2 0.8996 100 0.221 Contact Map
2oqrA 2 0.9456 100 0.222 Contact Map
4kfcA 2 0.9372 100 0.229 Contact Map
2hqrA 2 0.9205 100 0.249 Contact Map
1p2fA 1 0.9079 100 0.253 Contact Map
3q9sA 1 0.8787 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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