GREMLIN Database
PTHP - Phosphocarrier protein HPr
UniProt: P0AA04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10788
Length: 85 (81)
Sequences: 2949 (1964)
Seq/√Len: 218.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_E60_V2.8341.00
65_A74_V2.6961.00
30_T68_E2.3511.00
4_Q78_V2.2841.00
3_Q62_T2.2801.00
6_V78_V2.2111.00
36_T64_S2.0961.00
25_E28_G2.0411.00
31_S69_D2.0281.00
34_T41_S2.0261.00
29_F76_H1.9971.00
36_T62_T1.9711.00
41_S64_S1.9511.00
36_T41_S1.9431.00
5_E62_T1.8501.00
78_V82_A1.8421.00
3_Q64_S1.7471.00
37_S59_T1.7321.00
71_Q75_E1.6781.00
2_F74_V1.6231.00
7_T60_V1.6231.00
30_T69_D1.5391.00
22_F44_A1.4501.00
25_E76_H1.4481.00
9_T82_A1.4211.00
2_F71_Q1.3921.00
26_A77_L1.3851.00
22_F77_L1.3351.00
2_F70_E1.3081.00
75_E79_K1.3011.00
72_K76_H1.2841.00
32_E66_E1.2251.00
4_Q75_E1.1761.00
29_F73_A1.1671.00
11_P57_Q1.1091.00
22_F81_M1.0561.00
56_T59_T1.0171.00
42_A53_L1.0141.00
14_L22_F0.9961.00
31_S65_A0.9841.00
55_L61_V0.9811.00
72_K75_E0.9461.00
36_T39_G0.9461.00
33_I73_A0.9320.99
8_I55_L0.9160.99
69_D72_K0.9120.99
32_E43_S0.9110.99
43_S46_S0.9080.99
21_Q25_E0.8900.99
22_F35_V0.8690.99
2_F65_A0.8540.99
21_Q24_K0.8350.99
34_T64_S0.8270.99
33_I65_A0.8120.99
46_S49_K0.8110.99
4_Q82_A0.8100.99
16_T20_A0.8000.98
26_A33_I0.7860.98
20_A51_Q0.7850.98
23_V47_L0.7850.98
76_H79_K0.7810.98
12_N18_P0.7780.98
10_A80_L0.7760.98
61_V81_M0.7690.98
25_E80_L0.7660.98
6_V63_I0.7660.98
48_F52_T0.7530.98
26_A45_K0.7450.98
42_A48_F0.7370.97
18_P21_Q0.7340.97
21_Q80_L0.7310.97
42_A49_K0.7120.97
33_I44_A0.7030.97
29_F69_D0.6960.96
43_S48_F0.6960.96
63_I81_M0.6820.96
22_F63_I0.6810.96
27_K49_K0.6770.96
24_K28_G0.6760.96
47_L51_Q0.6670.95
20_A24_K0.6600.95
19_A50_L0.6590.95
35_V50_L0.6570.95
23_V50_L0.6550.95
26_A73_A0.6540.95
63_I74_V0.6460.94
63_I77_L0.6360.94
20_A46_S0.6340.94
37_S55_L0.6310.94
6_V14_L0.6200.93
15_H80_L0.6170.93
34_T43_S0.6120.93
74_V78_V0.6090.93
48_F51_Q0.5960.92
16_T47_L0.5790.91
38_N59_T0.5770.90
16_T48_F0.5730.90
13_G19_A0.5700.90
47_L54_G0.5670.90
4_Q74_V0.5660.90
10_A81_M0.5420.88
12_N81_M0.5420.88
6_V81_M0.5400.87
23_V45_K0.5340.87
19_A47_L0.5330.87
20_A52_T0.5300.86
13_G17_R0.5260.86
16_T49_K0.5250.86
11_P37_S0.5200.85
52_T55_L0.5190.85
27_K48_F0.5170.85
28_G76_H0.5160.85
12_N48_F0.5150.85
32_E45_K0.5140.85
27_K47_L0.5120.84
69_D73_A0.5120.84
8_I81_M0.5090.84
15_H18_P0.5070.84
19_A49_K0.5060.84
10_A51_Q0.5060.84
31_S70_E0.5030.83
2_F66_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ccdA 2 1 100 0.111 Contact Map
3ihsA 1 0.9647 100 0.131 Contact Map
1kklH 1 0.9765 100 0.134 Contact Map
1ka5A 1 1 100 0.136 Contact Map
1ptfA 1 1 100 0.139 Contact Map
1sphA 2 0.9882 100 0.14 Contact Map
1y51A 1 0.9882 100 0.14 Contact Map
3le1A 1 1 100 0.148 Contact Map
1pchA 1 0.9882 99.9 0.166 Contact Map
2jpiA 1 0.8941 63 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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