GREMLIN Database
CSPA - Cold shock protein CspA
UniProt: P0A9X9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10166
Length: 70 (63)
Sequences: 3981 (1578)
Seq/√Len: 198.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V67_V3.8611.00
56_E65_G3.4101.00
54_T66_N2.7971.00
14_A46_D2.3851.00
52_S68_T2.3621.00
38_Q68_T2.0981.00
8_I50_K2.0471.00
5_M23_P1.9711.00
24_D50_K1.9461.00
6_T52_S1.9221.00
58_G61_G1.7641.00
6_T50_K1.7331.00
46_D49_Q1.7071.00
57_S62_P1.6581.00
38_Q66_N1.6481.00
23_P28_K1.6471.00
36_A65_G1.5951.00
58_G63_A1.5601.00
14_A42_Y1.5001.00
28_K62_P1.4221.00
23_P26_G1.3291.00
32_V45_L1.2811.00
23_P53_F1.2641.00
14_A44_S1.2611.00
55_I62_P1.2251.00
8_I22_T1.1201.00
30_V55_I1.0511.00
37_I42_Y1.0291.00
6_T24_D1.0251.00
34_F43_K1.0071.00
36_A56_E1.0071.00
37_I43_K1.0051.00
7_G21_I0.9951.00
21_I53_F0.9230.99
10_K29_D0.8990.99
10_K16_K0.8740.99
7_G64_A0.8620.99
21_I51_V0.8430.99
11_W16_K0.8390.98
56_E63_A0.8280.98
37_I40_D0.8160.98
45_L51_V0.8080.98
5_M25_D0.8060.98
53_F64_A0.7720.97
36_A66_N0.7710.97
12_F34_F0.7480.97
34_F37_I0.7390.97
12_F16_K0.7210.96
21_I64_A0.6930.95
13_N31_F0.6890.95
8_I24_D0.6630.94
34_F60_K0.6510.93
5_M54_T0.6370.92
20_F33_H0.6260.92
15_D63_A0.6190.91
5_M68_T0.6160.91
15_D49_Q0.6140.91
18_F30_V0.6110.91
12_F17_G0.6080.91
16_K29_D0.6060.90
23_P55_I0.6030.90
5_M53_F0.6020.90
35_S60_K0.6000.90
58_G62_P0.5970.90
11_W29_D0.5860.89
19_G32_V0.5820.89
39_N43_K0.5770.88
47_E63_A0.5760.88
9_V45_L0.5750.88
28_K57_S0.5730.88
10_K17_G0.5690.88
40_D68_T0.5670.87
57_S60_K0.5670.87
30_V36_A0.5620.87
11_W17_G0.5510.86
21_I32_V0.5510.86
30_V56_E0.5420.85
39_N42_Y0.5310.84
5_M55_I0.5290.84
12_F42_Y0.5260.83
22_T48_G0.5220.83
20_F48_G0.5190.82
30_V64_A0.5180.82
54_T65_G0.5180.82
11_W32_V0.5140.82
17_G29_D0.5090.81
17_G37_I0.5090.81
22_T30_V0.5040.81
56_E62_P0.5030.80
31_F49_Q0.5020.80
18_F29_D0.5020.80
39_N44_S0.5020.80
11_W47_E0.5020.80
17_G61_G0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lssA 1 1 99.7 0.162 Contact Map
3i2zB 2 1 99.7 0.175 Contact Map
1h95A 1 1 99.7 0.177 Contact Map
3camA 2 0.9571 99.7 0.197 Contact Map
2mqhA 1 0.9714 99.7 0.199 Contact Map
1wfqA 1 0.9571 99.7 0.21 Contact Map
2ytyA 1 0.9571 99.7 0.21 Contact Map
1g6pA 1 0.9286 99.6 0.213 Contact Map
1x65A 1 0.9429 99.6 0.216 Contact Map
1c9oA 2 0.9429 99.6 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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