GREMLIN Database
MREB - Rod shape-determining protein MreB
UniProt: P0A9X4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10608
Length: 347 (316)
Sequences: 11489 (6574)
Seq/√Len: 369.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_R136_R3.4801.00
164_V267_I3.2301.00
186_S266_G3.1921.00
223_G227_P3.0231.00
197_A262_E2.9651.00
205_N255_E2.9151.00
272_M310_E2.9011.00
233_E250_T2.8811.00
320_D323_T2.5961.00
75_P78_D2.4581.00
261_Q265_T2.3801.00
112_V130_A2.3561.00
305_R309_E2.2601.00
308_M314_P2.2421.00
198_I251_L2.2091.00
175_V274_A2.1811.00
217_R221_E2.1761.00
22_T94_F2.1401.00
113_C329_G2.0851.00
74_R78_D2.0841.00
124_R128_E2.0831.00
297_G300_L2.0801.00
268_V310_E2.0581.00
88_E132_G2.0491.00
252_N255_E2.0331.00
255_E258_E2.0041.00
41_I89_K1.9781.00
160_G177_S1.9291.00
306_L309_E1.9161.00
20_A168_G1.8911.00
25_Y330_G1.8601.00
89_K92_Q1.8541.00
299_L322_L1.8491.00
304_D317_V1.8411.00
81_I86_V1.8251.00
19_T169_G1.8141.00
71_A192_D1.8131.00
28_G31_I1.8111.00
194_F263_P1.8111.00
166_I171_T1.8091.00
201_Y205_N1.7921.00
268_V306_L1.7791.00
127_R131_Q1.7631.00
201_Y259_A1.7421.00
235_E250_T1.7381.00
264_L302_N1.7281.00
22_T37_S1.6931.00
175_V278_C1.6931.00
260_L300_L1.6881.00
256_I300_L1.6791.00
57_H61_Q1.6681.00
235_E248_G1.6481.00
202_V222_I1.6151.00
194_F260_L1.6151.00
159_T288_E1.6131.00
323_T327_R1.6041.00
253_S257_L1.6031.00
75_P80_V1.5941.00
109_R138_V1.5851.00
162_M175_V1.5721.00
25_Y326_A1.5711.00
197_A200_N1.5671.00
202_V249_F1.5631.00
225_A236_V1.5591.00
260_L264_L1.5361.00
166_I194_F1.5191.00
261_Q306_L1.5161.00
84_F128_E1.5061.00
23_L34_N1.4961.00
273_V277_Q1.4951.00
128_E131_Q1.4941.00
119_T122_E1.4861.00
66_T69_N1.4821.00
268_V272_M1.4761.00
13_L24_I1.4711.00
182_V274_A1.4501.00
258_E261_Q1.4441.00
281_E284_S1.4371.00
74_R77_K1.4281.00
197_A263_P1.4261.00
199_I219_K1.4191.00
204_R207_G1.4131.00
264_L306_L1.3941.00
73_I78_D1.3841.00
81_I89_K1.3621.00
260_L263_P1.3581.00
274_A278_C1.3571.00
257_L305_R1.3531.00
271_V307_L1.3431.00
42_R52_V1.3281.00
205_N208_S1.3241.00
85_F132_G1.3241.00
74_R80_V1.3181.00
73_I80_V1.3121.00
320_D327_R1.2981.00
114_V140_L1.2961.00
87_T126_I1.2961.00
221_E224_S1.2921.00
269_S273_V1.2851.00
175_V286_I1.2841.00
159_T287_S1.2831.00
142_E145_M1.2761.00
23_L326_A1.2741.00
53_A89_K1.2721.00
201_Y255_E1.2701.00
173_V274_A1.2641.00
162_M173_V1.2641.00
196_E200_N1.2631.00
12_D333_L1.2601.00
185_S273_V1.2591.00
73_I77_K1.2551.00
224_S228_G1.2541.00
93_H97_Q1.2541.00
291_M311_T1.2501.00
293_L307_L1.2501.00
171_T267_I1.2461.00
164_V171_T1.2421.00
14_S329_G1.2301.00
269_S272_M1.2261.00
306_L310_E1.2231.00
17_L87_T1.2111.00
76_M79_G1.2031.00
71_A74_R1.2011.00
304_D308_M1.1971.00
24_I94_F1.1931.00
225_A234_I1.1801.00
131_Q136_R1.1791.00
198_I222_I1.1791.00
123_R142_E1.1751.00
302_N305_R1.1731.00
17_L126_I1.1711.00
261_Q302_N1.1711.00
21_N322_L1.1691.00
305_R308_M1.1661.00
71_A76_M1.1631.00
116_V144_P1.1631.00
173_V270_A1.1621.00
109_R137_E1.1551.00
97_Q101_N1.1511.00
202_V236_V1.1501.00
166_I303_L1.1461.00
162_M271_V1.1441.00
194_F300_L1.1351.00
39_V86_V1.1321.00
27_K334_E1.1301.00
237_R248_G1.1231.00
197_A260_L1.1211.00
71_A75_P1.1151.00
11_N105_R1.1121.00
96_K100_S1.1111.00
265_T269_S1.1061.00
141_I332_A1.1061.00
143_E172_E1.1031.00
67_P70_I1.0931.00
14_S326_A1.0811.00
41_I81_I1.0731.00
302_N306_L1.0721.00
160_G280_P1.0721.00
194_F256_I1.0721.00
194_F297_G1.0711.00
272_M276_E1.0691.00
88_E92_Q1.0631.00
93_H98_V1.0591.00
83_D87_T1.0581.00
288_E316_V1.0551.00
205_N209_L1.0511.00
12_D138_V1.0501.00
196_E219_K1.0471.00
228_G231_V1.0391.00
293_L298_A1.0341.00
72_A76_M1.0331.00
307_L315_V1.0311.00
66_T70_I1.0291.00
92_Q96_K1.0271.00
77_K80_V1.0211.00
169_G172_E1.0191.00
281_E285_D1.0161.00
44_D52_V1.0111.00
12_D109_R1.0081.00
199_I222_I1.0051.00
120_Q124_R0.9921.00
40_A62_M0.9871.00
256_I297_G0.9821.00
62_M66_T0.9761.00
55_V93_H0.9751.00
177_S181_V0.9731.00
73_I76_M0.9731.00
332_A335_M0.9731.00
205_N249_F0.9611.00
165_D172_E0.9601.00
273_V276_E0.9531.00
191_G297_G0.9531.00
196_E199_I0.9511.00
71_A77_K0.9461.00
147_A294_T0.9451.00
22_T90_M0.9431.00
210_I245_V0.9371.00
223_G226_Y0.9351.00
40_A70_I0.9341.00
127_R140_L0.9331.00
40_A54_A0.9321.00
147_A325_V0.9321.00
254_N257_L0.9281.00
265_T306_L0.9271.00
294_T324_C0.9271.00
141_I146_A0.9221.00
175_V280_P0.9211.00
95_I99_H0.9171.00
165_D169_G0.9171.00
215_A219_K0.9111.00
225_A251_L0.9031.00
260_L302_N0.9031.00
111_L333_L0.9031.00
128_E132_G0.8971.00
95_I110_V0.8921.00
257_L302_N0.8871.00
265_T268_V0.8781.00
195_D223_G0.8731.00
151_A292_V0.8641.00
255_E259_A0.8641.00
232_R253_S0.8621.00
114_V142_E0.8601.00
42_R51_S0.8481.00
124_R127_R0.8471.00
270_A274_A0.8471.00
165_D170_T0.8451.00
84_F125_A0.8381.00
112_V126_I0.8381.00
148_A176_I0.8371.00
166_I297_G0.8351.00
327_R331_K0.8311.00
95_I135_A0.8301.00
99_H103_F0.8281.00
57_H60_K0.8281.00
120_Q123_R0.8211.00
222_I227_P0.8211.00
108_P136_R0.8201.00
139_F332_A0.8171.00
182_V278_C0.8161.00
257_L261_Q0.8151.00
240_N247_R0.8101.00
114_V123_R0.8091.00
71_A80_V0.8081.00
38_V60_K0.8071.00
168_G172_E0.8031.00
13_L110_V0.8021.00
90_M94_F0.8001.00
150_G324_C0.7991.00
194_F264_L0.7951.00
201_Y249_F0.7911.00
221_E225_A0.7871.00
165_D168_G0.7871.00
160_G286_I0.7851.00
268_V271_V0.7841.00
189_I266_G0.7821.00
123_R127_R0.7821.00
14_S330_G0.7811.00
71_A79_G0.7751.00
37_S90_M0.7741.00
201_Y251_L0.7731.00
308_M315_V0.7701.00
76_M80_V0.7691.00
233_E252_N0.7661.00
160_G287_S0.7611.00
15_I91_L0.7591.00
166_I267_I0.7581.00
251_L256_I0.7561.00
62_M65_R0.7551.00
54_A58_D0.7541.00
115_P118_A0.7531.00
228_G234_I0.7511.00
123_R140_L0.7511.00
88_E129_S0.7501.00
280_P285_D0.7491.00
95_I98_V0.7491.00
41_I86_V0.7471.00
87_T91_L0.7461.00
149_I332_A0.7441.00
186_S189_I0.7431.00
17_L91_L0.7421.00
256_I260_L0.7411.00
254_N258_E0.7401.00
150_G327_R0.7401.00
82_A85_F0.7371.00
184_S270_A0.7371.00
266_G269_S0.7371.00
200_N204_R0.7331.00
72_A80_V0.7311.00
72_A86_V0.7291.00
151_A324_C0.7281.00
72_A78_D0.7281.00
162_M286_I0.7261.00
87_T90_M0.7251.00
72_A75_P0.7231.00
201_Y204_R0.7201.00
93_H96_K0.7191.00
164_V271_V0.7181.00
189_I193_R0.7171.00
199_I203_R0.7161.00
55_V90_M0.7141.00
130_A133_A0.7141.00
16_D19_T0.7080.99
13_L107_S0.7070.99
58_D61_Q0.7050.99
71_A78_D0.7050.99
199_I215_A0.7050.99
205_N247_R0.7020.99
144_P147_A0.7000.99
130_A140_L0.7000.99
82_A90_M0.6990.99
110_V135_A0.6980.99
40_A66_T0.6970.99
86_V89_K0.6970.99
143_E170_T0.6950.99
143_E168_G0.6950.99
21_N34_N0.6910.99
271_V310_E0.6910.99
15_I110_V0.6880.99
316_V324_C0.6870.99
251_L259_A0.6870.99
216_E220_H0.6860.99
100_S106_P0.6850.99
68_G212_E0.6820.99
160_G181_V0.6800.99
143_E325_V0.6770.99
293_L317_V0.6740.99
144_P172_E0.6740.99
221_E234_I0.6740.99
72_A77_K0.6710.99
265_T310_E0.6660.99
138_V336_I0.6650.99
74_R79_G0.6630.99
43_Q51_S0.6620.99
98_V101_N0.6610.99
207_G210_I0.6610.99
239_R244_G0.6580.99
184_S273_V0.6580.99
147_A168_G0.6580.99
293_L315_V0.6560.99
144_P170_T0.6530.99
85_F89_K0.6530.99
217_R239_R0.6530.99
34_N323_T0.6520.99
118_A122_E0.6500.99
56_G59_A0.6480.99
220_H224_S0.6480.99
85_F88_E0.6470.99
192_D195_D0.6410.99
81_I84_F0.6390.99
116_V126_I0.6380.99
98_V102_S0.6380.99
19_T170_T0.6370.99
118_A126_I0.6370.99
145_M176_I0.6360.99
253_S301_R0.6350.99
92_Q97_Q0.6340.99
167_G296_G0.6330.99
231_V234_I0.6330.99
84_F132_G0.6300.99
114_V126_I0.6300.99
229_D301_R0.6280.99
96_K99_H0.6260.99
63_L70_I0.6220.99
126_I129_S0.6210.99
229_D234_I0.6190.99
167_G170_T0.6180.99
188_R193_R0.6140.99
99_H102_S0.6140.99
72_A79_G0.6130.99
125_A128_E0.6120.98
84_F88_E0.6120.98
222_I225_A0.6120.98
23_L323_T0.6050.98
130_A135_A0.6020.98
224_S227_P0.6020.98
60_K223_G0.6020.98
89_K93_H0.6010.98
16_D165_D0.6000.98
81_I85_F0.5980.98
195_D226_Y0.5980.98
72_A90_M0.5970.98
206_Y210_I0.5940.98
168_G296_G0.5940.98
275_L278_C0.5940.98
103_F107_S0.5930.98
193_R196_E0.5910.98
52_V55_V0.5850.98
236_V239_R0.5850.98
271_V311_T0.5840.98
197_A259_A0.5830.98
160_G285_D0.5800.98
198_I259_A0.5770.98
264_L268_V0.5760.98
206_Y255_E0.5760.98
270_A273_V0.5700.98
24_I98_V0.5660.97
263_P266_G0.5650.97
231_V254_N0.5620.97
166_I298_A0.5610.97
163_V294_T0.5590.97
204_R208_S0.5570.97
264_L300_L0.5550.97
129_S133_A0.5540.97
184_S274_A0.5530.97
272_M311_T0.5520.97
115_P143_E0.5520.97
164_V173_V0.5520.97
214_T218_I0.5510.97
200_N203_R0.5500.97
226_Y297_G0.5480.97
291_M307_L0.5480.97
160_G175_V0.5470.97
35_E93_H0.5460.97
182_V279_P0.5460.97
161_S288_E0.5460.97
86_V93_H0.5440.97
253_S256_I0.5440.97
219_K222_I0.5430.97
16_D169_G0.5420.97
231_V253_S0.5420.97
216_E219_K0.5420.97
162_M311_T0.5410.97
143_E169_G0.5410.97
54_A57_H0.5410.97
44_D51_S0.5400.97
212_E216_E0.5370.97
150_G153_L0.5370.97
38_V59_A0.5360.97
37_S56_G0.5320.96
184_S187_V0.5320.96
131_Q137_E0.5310.96
268_V303_L0.5310.96
182_V186_S0.5310.96
181_V280_P0.5300.96
294_T325_V0.5300.96
54_A62_M0.5290.96
113_C325_V0.5260.96
266_G270_A0.5260.96
240_N243_E0.5250.96
244_G247_R0.5250.96
173_V184_S0.5250.96
234_I239_R0.5240.96
168_G191_G0.5230.96
184_S277_Q0.5220.96
259_A262_E0.5200.96
260_L297_G0.5190.96
233_E237_R0.5180.96
72_A87_T0.5180.96
170_T190_G0.5180.96
126_I140_L0.5170.96
257_L300_L0.5170.96
17_L90_M0.5160.96
14_S333_L0.5150.96
226_Y309_E0.5140.96
307_L311_T0.5130.96
91_L126_I0.5130.96
332_A336_I0.5110.95
117_G172_E0.5100.95
150_G292_V0.5100.95
202_V206_Y0.5100.95
163_V292_V0.5090.95
11_N108_P0.5060.95
256_I259_A0.5060.95
53_A92_Q0.5060.95
186_S190_G0.5030.95
39_V90_M0.5030.95
206_Y214_T0.5030.95
116_V172_E0.5010.95
267_I303_L0.5010.95
173_V271_V0.5010.95
217_R246_P0.5010.95
91_L130_A0.5000.95
35_E57_H0.5000.95
206_Y242_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jneA 2 0.9481 100 0.258 Contact Map
4fl9A 1 0.9193 100 0.262 Contact Map
3d2fA 1 0.9366 100 0.271 Contact Map
2v7yA 1 0.9452 100 0.272 Contact Map
4rtfD 1 0.9078 100 0.281 Contact Map
3i33A 1 0.9107 100 0.297 Contact Map
4kboA 1 0.9135 100 0.306 Contact Map
4j8fA 2 0.9539 100 0.323 Contact Map
4gniA 2 0.9107 100 0.333 Contact Map
1jceA 1 0.9251 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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