MREB - ECOLI - GREMLIN Contacts

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MREB - Rod shape-determining protein MreB

UniProt:	P0A9X4	Sequences: MLKKFRGMFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVAAVGHDAKQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDMHGGDLFSEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10608
Length:	347 (316)
Sequences:	11489 (6574)
Seq/√Len:	369.8

ECOLI - MREB DNAK HSCC HSCA YEGD EUTJ FTSA
BACSU - MREB MBL MREBH DNAK FTSA
HALSA - DNAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_R	136_R	3.480	1.00
164_V	267_I	3.230	1.00
186_S	266_G	3.192	1.00
223_G	227_P	3.023	1.00
197_A	262_E	2.965	1.00
205_N	255_E	2.915	1.00
272_M	310_E	2.901	1.00
233_E	250_T	2.881	1.00
320_D	323_T	2.596	1.00
75_P	78_D	2.458	1.00
261_Q	265_T	2.380	1.00
112_V	130_A	2.356	1.00
305_R	309_E	2.260	1.00
308_M	314_P	2.242	1.00
198_I	251_L	2.209	1.00
175_V	274_A	2.181	1.00
217_R	221_E	2.176	1.00
22_T	94_F	2.140	1.00
113_C	329_G	2.085	1.00
74_R	78_D	2.084	1.00
124_R	128_E	2.083	1.00
297_G	300_L	2.080	1.00
268_V	310_E	2.058	1.00
88_E	132_G	2.049	1.00
252_N	255_E	2.033	1.00
255_E	258_E	2.004	1.00
41_I	89_K	1.978	1.00
160_G	177_S	1.929	1.00
306_L	309_E	1.916	1.00
20_A	168_G	1.891	1.00
25_Y	330_G	1.860	1.00
89_K	92_Q	1.854	1.00
299_L	322_L	1.849	1.00
304_D	317_V	1.841	1.00
81_I	86_V	1.825	1.00
19_T	169_G	1.814	1.00
71_A	192_D	1.813	1.00
28_G	31_I	1.811	1.00
194_F	263_P	1.811	1.00
166_I	171_T	1.809	1.00
201_Y	205_N	1.792	1.00
268_V	306_L	1.779	1.00
127_R	131_Q	1.763	1.00
201_Y	259_A	1.742	1.00
235_E	250_T	1.738	1.00
264_L	302_N	1.728	1.00
22_T	37_S	1.693	1.00
175_V	278_C	1.693	1.00
260_L	300_L	1.688	1.00
256_I	300_L	1.679	1.00
57_H	61_Q	1.668	1.00
235_E	248_G	1.648	1.00
202_V	222_I	1.615	1.00
194_F	260_L	1.615	1.00
159_T	288_E	1.613	1.00
323_T	327_R	1.604	1.00
253_S	257_L	1.603	1.00
75_P	80_V	1.594	1.00
109_R	138_V	1.585	1.00
162_M	175_V	1.572	1.00
25_Y	326_A	1.571	1.00
197_A	200_N	1.567	1.00
202_V	249_F	1.563	1.00
225_A	236_V	1.559	1.00
260_L	264_L	1.536	1.00
166_I	194_F	1.519	1.00
261_Q	306_L	1.516	1.00
84_F	128_E	1.506	1.00
23_L	34_N	1.496	1.00
273_V	277_Q	1.495	1.00
128_E	131_Q	1.494	1.00
119_T	122_E	1.486	1.00
66_T	69_N	1.482	1.00
268_V	272_M	1.476	1.00
13_L	24_I	1.471	1.00
182_V	274_A	1.450	1.00
258_E	261_Q	1.444	1.00
281_E	284_S	1.437	1.00
74_R	77_K	1.428	1.00
197_A	263_P	1.426	1.00
199_I	219_K	1.419	1.00
204_R	207_G	1.413	1.00
264_L	306_L	1.394	1.00
73_I	78_D	1.384	1.00
81_I	89_K	1.362	1.00
260_L	263_P	1.358	1.00
274_A	278_C	1.357	1.00
257_L	305_R	1.353	1.00
271_V	307_L	1.343	1.00
42_R	52_V	1.328	1.00
205_N	208_S	1.324	1.00
85_F	132_G	1.324	1.00
74_R	80_V	1.318	1.00
73_I	80_V	1.312	1.00
320_D	327_R	1.298	1.00
114_V	140_L	1.296	1.00
87_T	126_I	1.296	1.00
221_E	224_S	1.292	1.00
269_S	273_V	1.285	1.00
175_V	286_I	1.284	1.00
159_T	287_S	1.283	1.00
142_E	145_M	1.276	1.00
23_L	326_A	1.274	1.00
53_A	89_K	1.272	1.00
201_Y	255_E	1.270	1.00
173_V	274_A	1.264	1.00
162_M	173_V	1.264	1.00
196_E	200_N	1.263	1.00
12_D	333_L	1.260	1.00
185_S	273_V	1.259	1.00
73_I	77_K	1.255	1.00
224_S	228_G	1.254	1.00
93_H	97_Q	1.254	1.00
291_M	311_T	1.250	1.00
293_L	307_L	1.250	1.00
171_T	267_I	1.246	1.00
164_V	171_T	1.242	1.00
14_S	329_G	1.230	1.00
269_S	272_M	1.226	1.00
306_L	310_E	1.223	1.00
17_L	87_T	1.211	1.00
76_M	79_G	1.203	1.00
71_A	74_R	1.201	1.00
304_D	308_M	1.197	1.00
24_I	94_F	1.193	1.00
225_A	234_I	1.180	1.00
131_Q	136_R	1.179	1.00
198_I	222_I	1.179	1.00
123_R	142_E	1.175	1.00
302_N	305_R	1.173	1.00
17_L	126_I	1.171	1.00
261_Q	302_N	1.171	1.00
21_N	322_L	1.169	1.00
305_R	308_M	1.166	1.00
71_A	76_M	1.163	1.00
116_V	144_P	1.163	1.00
173_V	270_A	1.162	1.00
109_R	137_E	1.155	1.00
97_Q	101_N	1.151	1.00
202_V	236_V	1.150	1.00
166_I	303_L	1.146	1.00
162_M	271_V	1.144	1.00
194_F	300_L	1.135	1.00
39_V	86_V	1.132	1.00
27_K	334_E	1.130	1.00
237_R	248_G	1.123	1.00
197_A	260_L	1.121	1.00
71_A	75_P	1.115	1.00
11_N	105_R	1.112	1.00
96_K	100_S	1.111	1.00
265_T	269_S	1.106	1.00
141_I	332_A	1.106	1.00
143_E	172_E	1.103	1.00
67_P	70_I	1.093	1.00
14_S	326_A	1.081	1.00
41_I	81_I	1.073	1.00
302_N	306_L	1.072	1.00
160_G	280_P	1.072	1.00
194_F	256_I	1.072	1.00
194_F	297_G	1.071	1.00
272_M	276_E	1.069	1.00
88_E	92_Q	1.063	1.00
93_H	98_V	1.059	1.00
83_D	87_T	1.058	1.00
288_E	316_V	1.055	1.00
205_N	209_L	1.051	1.00
12_D	138_V	1.050	1.00
196_E	219_K	1.047	1.00
228_G	231_V	1.039	1.00
293_L	298_A	1.034	1.00
72_A	76_M	1.033	1.00
307_L	315_V	1.031	1.00
66_T	70_I	1.029	1.00
92_Q	96_K	1.027	1.00
77_K	80_V	1.021	1.00
169_G	172_E	1.019	1.00
281_E	285_D	1.016	1.00
44_D	52_V	1.011	1.00
12_D	109_R	1.008	1.00
199_I	222_I	1.005	1.00
120_Q	124_R	0.992	1.00
40_A	62_M	0.987	1.00
256_I	297_G	0.982	1.00
62_M	66_T	0.976	1.00
55_V	93_H	0.975	1.00
177_S	181_V	0.973	1.00
73_I	76_M	0.973	1.00
332_A	335_M	0.973	1.00
205_N	249_F	0.961	1.00
165_D	172_E	0.960	1.00
273_V	276_E	0.953	1.00
191_G	297_G	0.953	1.00
196_E	199_I	0.951	1.00
71_A	77_K	0.946	1.00
147_A	294_T	0.945	1.00
22_T	90_M	0.943	1.00
210_I	245_V	0.937	1.00
223_G	226_Y	0.935	1.00
40_A	70_I	0.934	1.00
127_R	140_L	0.933	1.00
40_A	54_A	0.932	1.00
147_A	325_V	0.932	1.00
254_N	257_L	0.928	1.00
265_T	306_L	0.927	1.00
294_T	324_C	0.927	1.00
141_I	146_A	0.922	1.00
175_V	280_P	0.921	1.00
95_I	99_H	0.917	1.00
165_D	169_G	0.917	1.00
215_A	219_K	0.911	1.00
225_A	251_L	0.903	1.00
260_L	302_N	0.903	1.00
111_L	333_L	0.903	1.00
128_E	132_G	0.897	1.00
95_I	110_V	0.892	1.00
257_L	302_N	0.887	1.00
265_T	268_V	0.878	1.00
195_D	223_G	0.873	1.00
151_A	292_V	0.864	1.00
255_E	259_A	0.864	1.00
232_R	253_S	0.862	1.00
114_V	142_E	0.860	1.00
42_R	51_S	0.848	1.00
124_R	127_R	0.847	1.00
270_A	274_A	0.847	1.00
165_D	170_T	0.845	1.00
84_F	125_A	0.838	1.00
112_V	126_I	0.838	1.00
148_A	176_I	0.837	1.00
166_I	297_G	0.835	1.00
327_R	331_K	0.831	1.00
95_I	135_A	0.830	1.00
99_H	103_F	0.828	1.00
57_H	60_K	0.828	1.00
120_Q	123_R	0.821	1.00
222_I	227_P	0.821	1.00
108_P	136_R	0.820	1.00
139_F	332_A	0.817	1.00
182_V	278_C	0.816	1.00
257_L	261_Q	0.815	1.00
240_N	247_R	0.810	1.00
114_V	123_R	0.809	1.00
71_A	80_V	0.808	1.00
38_V	60_K	0.807	1.00
168_G	172_E	0.803	1.00
13_L	110_V	0.802	1.00
90_M	94_F	0.800	1.00
150_G	324_C	0.799	1.00
194_F	264_L	0.795	1.00
201_Y	249_F	0.791	1.00
221_E	225_A	0.787	1.00
165_D	168_G	0.787	1.00
160_G	286_I	0.785	1.00
268_V	271_V	0.784	1.00
189_I	266_G	0.782	1.00
123_R	127_R	0.782	1.00
14_S	330_G	0.781	1.00
71_A	79_G	0.775	1.00
37_S	90_M	0.774	1.00
201_Y	251_L	0.773	1.00
308_M	315_V	0.770	1.00
76_M	80_V	0.769	1.00
233_E	252_N	0.766	1.00
160_G	287_S	0.761	1.00
15_I	91_L	0.759	1.00
166_I	267_I	0.758	1.00
251_L	256_I	0.756	1.00
62_M	65_R	0.755	1.00
54_A	58_D	0.754	1.00
115_P	118_A	0.753	1.00
228_G	234_I	0.751	1.00
123_R	140_L	0.751	1.00
88_E	129_S	0.750	1.00
280_P	285_D	0.749	1.00
95_I	98_V	0.749	1.00
41_I	86_V	0.747	1.00
87_T	91_L	0.746	1.00
149_I	332_A	0.744	1.00
186_S	189_I	0.743	1.00
17_L	91_L	0.742	1.00
256_I	260_L	0.741	1.00
254_N	258_E	0.740	1.00
150_G	327_R	0.740	1.00
82_A	85_F	0.737	1.00
184_S	270_A	0.737	1.00
266_G	269_S	0.737	1.00
200_N	204_R	0.733	1.00
72_A	80_V	0.731	1.00
72_A	86_V	0.729	1.00
151_A	324_C	0.728	1.00
72_A	78_D	0.728	1.00
162_M	286_I	0.726	1.00
87_T	90_M	0.725	1.00
72_A	75_P	0.723	1.00
201_Y	204_R	0.720	1.00
93_H	96_K	0.719	1.00
164_V	271_V	0.718	1.00
189_I	193_R	0.717	1.00
199_I	203_R	0.716	1.00
55_V	90_M	0.714	1.00
130_A	133_A	0.714	1.00
16_D	19_T	0.708	0.99
13_L	107_S	0.707	0.99
58_D	61_Q	0.705	0.99
71_A	78_D	0.705	0.99
199_I	215_A	0.705	0.99
205_N	247_R	0.702	0.99
144_P	147_A	0.700	0.99
130_A	140_L	0.700	0.99
82_A	90_M	0.699	0.99
110_V	135_A	0.698	0.99
40_A	66_T	0.697	0.99
86_V	89_K	0.697	0.99
143_E	170_T	0.695	0.99
143_E	168_G	0.695	0.99
21_N	34_N	0.691	0.99
271_V	310_E	0.691	0.99
15_I	110_V	0.688	0.99
316_V	324_C	0.687	0.99
251_L	259_A	0.687	0.99
216_E	220_H	0.686	0.99
100_S	106_P	0.685	0.99
68_G	212_E	0.682	0.99
160_G	181_V	0.680	0.99
143_E	325_V	0.677	0.99
293_L	317_V	0.674	0.99
144_P	172_E	0.674	0.99
221_E	234_I	0.674	0.99
72_A	77_K	0.671	0.99
265_T	310_E	0.666	0.99
138_V	336_I	0.665	0.99
74_R	79_G	0.663	0.99
43_Q	51_S	0.662	0.99
98_V	101_N	0.661	0.99
207_G	210_I	0.661	0.99
239_R	244_G	0.658	0.99
184_S	273_V	0.658	0.99
147_A	168_G	0.658	0.99
293_L	315_V	0.656	0.99
144_P	170_T	0.653	0.99
85_F	89_K	0.653	0.99
217_R	239_R	0.653	0.99
34_N	323_T	0.652	0.99
118_A	122_E	0.650	0.99
56_G	59_A	0.648	0.99
220_H	224_S	0.648	0.99
85_F	88_E	0.647	0.99
192_D	195_D	0.641	0.99
81_I	84_F	0.639	0.99
116_V	126_I	0.638	0.99
98_V	102_S	0.638	0.99
19_T	170_T	0.637	0.99
118_A	126_I	0.637	0.99
145_M	176_I	0.636	0.99
253_S	301_R	0.635	0.99
92_Q	97_Q	0.634	0.99
167_G	296_G	0.633	0.99
231_V	234_I	0.633	0.99
84_F	132_G	0.630	0.99
114_V	126_I	0.630	0.99
229_D	301_R	0.628	0.99
96_K	99_H	0.626	0.99
63_L	70_I	0.622	0.99
126_I	129_S	0.621	0.99
229_D	234_I	0.619	0.99
167_G	170_T	0.618	0.99
188_R	193_R	0.614	0.99
99_H	102_S	0.614	0.99
72_A	79_G	0.613	0.99
125_A	128_E	0.612	0.98
84_F	88_E	0.612	0.98
222_I	225_A	0.612	0.98
23_L	323_T	0.605	0.98
130_A	135_A	0.602	0.98
224_S	227_P	0.602	0.98
60_K	223_G	0.602	0.98
89_K	93_H	0.601	0.98
16_D	165_D	0.600	0.98
81_I	85_F	0.598	0.98
195_D	226_Y	0.598	0.98
72_A	90_M	0.597	0.98
206_Y	210_I	0.594	0.98
168_G	296_G	0.594	0.98
275_L	278_C	0.594	0.98
103_F	107_S	0.593	0.98
193_R	196_E	0.591	0.98
52_V	55_V	0.585	0.98
236_V	239_R	0.585	0.98
271_V	311_T	0.584	0.98
197_A	259_A	0.583	0.98
160_G	285_D	0.580	0.98
198_I	259_A	0.577	0.98
264_L	268_V	0.576	0.98
206_Y	255_E	0.576	0.98
270_A	273_V	0.570	0.98
24_I	98_V	0.566	0.97
263_P	266_G	0.565	0.97
231_V	254_N	0.562	0.97
166_I	298_A	0.561	0.97
163_V	294_T	0.559	0.97
204_R	208_S	0.557	0.97
264_L	300_L	0.555	0.97
129_S	133_A	0.554	0.97
184_S	274_A	0.553	0.97
272_M	311_T	0.552	0.97
115_P	143_E	0.552	0.97
164_V	173_V	0.552	0.97
214_T	218_I	0.551	0.97
200_N	203_R	0.550	0.97
226_Y	297_G	0.548	0.97
291_M	307_L	0.548	0.97
160_G	175_V	0.547	0.97
35_E	93_H	0.546	0.97
182_V	279_P	0.546	0.97
161_S	288_E	0.546	0.97
86_V	93_H	0.544	0.97
253_S	256_I	0.544	0.97
219_K	222_I	0.543	0.97
16_D	169_G	0.542	0.97
231_V	253_S	0.542	0.97
216_E	219_K	0.542	0.97
162_M	311_T	0.541	0.97
143_E	169_G	0.541	0.97
54_A	57_H	0.541	0.97
44_D	51_S	0.540	0.97
212_E	216_E	0.537	0.97
150_G	153_L	0.537	0.97
38_V	59_A	0.536	0.97
37_S	56_G	0.532	0.96
184_S	187_V	0.532	0.96
131_Q	137_E	0.531	0.96
268_V	303_L	0.531	0.96
182_V	186_S	0.531	0.96
181_V	280_P	0.530	0.96
294_T	325_V	0.530	0.96
54_A	62_M	0.529	0.96
113_C	325_V	0.526	0.96
266_G	270_A	0.526	0.96
240_N	243_E	0.525	0.96
244_G	247_R	0.525	0.96
173_V	184_S	0.525	0.96
234_I	239_R	0.524	0.96
168_G	191_G	0.523	0.96
184_S	277_Q	0.522	0.96
259_A	262_E	0.520	0.96
260_L	297_G	0.519	0.96
233_E	237_R	0.518	0.96
72_A	87_T	0.518	0.96
170_T	190_G	0.518	0.96
126_I	140_L	0.517	0.96
257_L	300_L	0.517	0.96
17_L	90_M	0.516	0.96
14_S	333_L	0.515	0.96
226_Y	309_E	0.514	0.96
307_L	311_T	0.513	0.96
91_L	126_I	0.513	0.96
332_A	336_I	0.511	0.95
117_G	172_E	0.510	0.95
150_G	292_V	0.510	0.95
202_V	206_Y	0.510	0.95
163_V	292_V	0.509	0.95
11_N	108_P	0.506	0.95
256_I	259_A	0.506	0.95
53_A	92_Q	0.506	0.95
186_S	190_G	0.503	0.95
39_V	90_M	0.503	0.95
206_Y	214_T	0.503	0.95
116_V	172_E	0.501	0.95
267_I	303_L	0.501	0.95
173_V	271_V	0.501	0.95
217_R	246_P	0.501	0.95
91_L	130_A	0.500	0.95
35_E	57_H	0.500	0.95
206_Y	242_A	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4jneA	2	0.9481	100	0.258	Contact Map
4fl9A	1	0.9193	100	0.262	Contact Map
3d2fA	1	0.9366	100	0.271	Contact Map
2v7yA	1	0.9452	100	0.272	Contact Map
4rtfD	1	0.9078	100	0.281	Contact Map
3i33A	1	0.9107	100	0.297	Contact Map
4kboA	1	0.9135	100	0.306	Contact Map
4j8fA	2	0.9539	100	0.323	Contact Map
4gniA	2	0.9107	100	0.333	Contact Map
1jceA	1	0.9251	100	0.373	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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