GREMLIN Database
ETTA - Energy-dependent translational throttle protein EttA
UniProt: P0A9W3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12343
Length: 555 (430)
Sequences: 916 (546)
Seq/√Len: 26.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_D245_S10.6541.00
273_L277_R5.1281.00
346_I352_V4.0981.00
332_S376_D3.9911.00
132_I137_G3.7611.00
103_R124_E3.6661.00
328_N343_S3.5741.00
289_A292_A3.3961.00
100_A103_R3.3281.00
402_K410_G3.2801.00
163_L171_V3.2581.00
526_N529_E3.0111.00
366_F497_I2.7420.99
231_E247_W2.7310.99
106_E110_L2.7110.99
291_L295_E2.6490.99
97_V101_L2.6010.99
429_G435_G2.5980.99
103_R107_V2.5740.99
276_V294_F2.5420.99
326_V344_F2.5070.99
287_G292_A2.4750.99
331_K376_D2.4330.99
440_K444_E2.3800.99
97_V100_A2.3660.98
136_D139_N2.3530.98
156_W163_L2.3420.98
280_T283_R2.3380.98
327_S379_T2.2640.98
230_L239_P2.2560.98
527_F530_Y2.2220.98
158_A162_N2.1880.97
230_L237_G2.1850.97
399_D402_K2.1530.97
104_L108_Y2.1500.97
223_D243_N2.1370.97
203_R206_H2.0980.97
265_R300_T2.0860.97
264_A283_R2.0740.96
100_A104_L2.0410.96
313_I316_G2.0370.96
292_A296_E1.9920.96
275_W290_R1.9770.95
467_L497_I1.9540.95
288_K291_L1.9470.95
326_V380_I1.9450.95
279_G282_G1.9430.95
266_R269_I1.9420.95
331_K368_M1.9160.94
352_V512_L1.8960.94
286_K290_R1.8700.94
289_A294_F1.8700.94
262_E266_R1.8600.93
350_A510_H1.8280.93
117_D120_K1.8270.93
286_K289_A1.8190.93
159_K162_N1.7680.92
487_L507_I1.7610.91
437_D440_K1.7600.91
105_D114_P1.7600.91
498_S504_L1.7520.91
368_M375_P1.7380.91
100_A107_V1.7320.91
272_E287_G1.7250.91
525_G530_Y1.7180.90
139_N143_Q1.7090.90
98_V102_K1.6940.90
104_L111_Y1.6910.90
279_G291_L1.6870.90
401_S443_G1.6630.89
432_N440_K1.6490.88
176_L184_L1.6400.88
231_E240_W1.6390.88
315_P491_P1.6310.88
171_V233_D1.6270.88
357_P360_A1.6260.88
107_V110_L1.6260.88
300_T303_Q1.6250.88
231_E251_K1.6070.87
110_L113_D1.5900.87
396_D403_T1.5850.86
339_I342_L1.5750.86
153_L167_E1.5640.86
442_V453_L1.5540.85
370_S467_L1.5180.84
97_V107_V1.5080.83
125_Q129_E1.4960.83
105_D108_Y1.4620.81
182_D487_L1.4440.81
353_G508_A1.4340.80
192_H197_S1.4290.80
110_L114_P1.4270.80
255_L259_A1.4200.79
340_D518_G1.4140.79
477_I480_L1.4070.79
429_G434_K1.4010.79
278_Q284_Q1.3960.78
125_Q132_I1.3810.78
289_A297_L1.3640.77
458_L465_M1.3550.76
290_R296_E1.3540.76
102_K105_D1.3540.76
166_G359_G1.3520.76
314_P428_V1.3500.76
289_A296_E1.3440.76
167_E394_F1.3390.75
361_G393_Q1.3380.75
106_E109_A1.3240.74
360_A518_G1.3230.74
516_D519_K1.3160.74
140_L144_L1.3130.74
297_L300_T1.3120.74
284_Q289_A1.3110.74
268_S272_E1.3040.73
408_V412_L1.2940.73
505_D528_T1.2920.73
192_H456_A1.2840.72
283_R287_G1.2770.72
359_G470_E1.2760.72
498_S503_F1.2690.71
128_L132_I1.2580.71
230_L272_E1.2550.70
284_Q288_K1.2540.70
268_S271_K1.2470.70
166_G356_G1.2420.70
286_K292_A1.2410.69
205_L225_V1.2410.69
359_G393_Q1.2400.69
97_V103_R1.2360.69
358_N393_Q1.2340.69
219_R248_L1.2320.69
526_N530_Y1.2280.69
328_N341_D1.2210.68
282_G291_L1.2190.68
107_V112_A1.2180.68
105_D109_A1.2170.68
226_A243_N1.2090.67
195_A363_S1.2080.67
276_V291_L1.2070.67
96_E131_I1.2060.67
164_S358_N1.2020.67
372_Q490_F1.1950.66
158_A163_L1.1950.66
326_V329_L1.1940.66
151_L174_C1.1930.66
269_I297_L1.1900.66
290_R294_F1.1840.66
356_G362_K1.1810.66
311_L479_T1.1720.65
205_L429_G1.1720.65
101_L104_L1.1700.65
278_Q286_K1.1670.65
270_E374_Q1.1640.64
449_E464_N1.1630.64
127_R341_D1.1590.64
219_R500_D1.1590.64
284_Q291_L1.1580.64
159_K373_E1.1580.64
140_L178_L1.1550.64
241_E363_S1.1530.64
396_D400_N1.1500.63
109_A114_P1.1450.63
329_L375_P1.1400.63
237_G333_Y1.1380.63
367_R372_Q1.1370.63
484_E506_R1.1370.63
283_R297_L1.1360.62
419_N423_P1.1330.62
358_N361_G1.1230.62
329_L368_M1.1220.61
315_P408_V1.1150.61
144_L176_L1.1120.61
226_A229_I1.1100.61
183_M213_V1.1000.60
294_F298_N1.0990.60
433_F449_E1.0900.59
95_S98_V1.0880.59
362_K393_Q1.0870.59
199_A235_G1.0860.59
292_A295_E1.0860.59
99_N103_R1.0850.59
422_M426_A1.0750.58
164_S359_G1.0670.58
197_S429_G1.0640.57
403_T410_G1.0610.57
272_E293_R1.0580.57
430_R455_L1.0570.57
129_E198_V1.0560.57
290_R295_E1.0550.57
366_F467_L1.0530.57
406_E421_E1.0530.57
98_V101_L1.0470.56
356_G359_G1.0450.56
375_P380_I1.0440.56
96_E100_A1.0410.56
202_E224_N1.0400.56
387_K464_N1.0390.56
213_V309_N1.0380.55
403_T406_E1.0380.55
166_G361_G1.0330.55
182_D219_R1.0320.55
97_V105_D1.0250.54
327_S467_L1.0250.54
151_L512_L1.0250.54
283_R290_R1.0200.54
96_E102_K1.0160.54
102_K107_V1.0140.54
365_L514_Y1.0140.54
144_L178_L1.0130.54
430_R459_L1.0120.54
389_A458_L1.0100.53
111_Y114_P1.0080.53
180_K209_E1.0080.53
176_L331_K1.0030.53
314_P462_G1.0020.53
283_R289_A1.0020.53
268_S325_E0.9990.53
369_I382_L0.9880.52
215_I428_V0.9850.52
398_M407_E0.9840.51
108_Y113_D0.9840.51
402_K407_E0.9820.51
103_R110_L0.9810.51
169_R394_F0.9800.51
330_R340_D0.9730.51
109_A112_A0.9660.50
494_A507_I0.9660.50
405_W424_S0.9620.50
267_K379_T0.9540.49
287_G290_R0.9520.49
275_W288_K0.9520.49
274_E278_Q0.9500.49
395_R451_G0.9500.49
166_G393_Q0.9490.49
125_Q137_G0.9490.49
257_Q339_I0.9430.48
337_L340_D0.9430.48
229_I366_F0.9420.48
165_G492_G0.9420.48
97_V104_L0.9410.48
329_L514_Y0.9350.48
358_N362_K0.9350.48
152_R467_L0.9330.48
119_D122_A0.9330.48
104_L113_D0.9270.47
218_D447_G0.9260.47
100_A111_Y0.9220.47
205_L212_V0.9180.47
137_G140_L0.9170.46
490_F494_A0.9160.46
484_E502_W0.9110.46
165_G359_G0.9070.46
350_A493_C0.9070.46
198_V210_G0.9050.46
227_G458_L0.9050.46
206_H354_I0.9000.45
202_E313_I0.8990.45
140_L176_L0.8980.45
260_S264_A0.8950.45
110_L115_D0.8950.45
102_K106_E0.8940.45
171_V435_G0.8880.44
260_S400_N0.8870.44
406_E410_G0.8860.44
290_R297_L0.8850.44
514_Y520_V0.8840.44
275_W284_Q0.8810.44
472_T486_A0.8800.44
199_A248_L0.8790.44
359_G364_T0.8780.44
95_S100_A0.8760.43
155_D516_D0.8750.43
192_H473_N0.8670.43
343_S377_S0.8660.43
108_Y114_P0.8640.43
99_N104_L0.8570.42
141_N341_D0.8560.42
95_S99_N0.8560.42
107_V114_P0.8530.42
102_K109_A0.8480.41
432_N437_D0.8480.41
269_I273_L0.8440.41
139_N497_I0.8440.41
359_G362_K0.8400.41
277_R281_K0.8380.41
288_K295_E0.8360.41
292_A297_L0.8330.40
228_W433_F0.8320.40
139_N355_I0.8280.40
121_L423_P0.8280.40
205_L313_I0.8280.40
243_N246_S0.8250.40
106_E112_A0.8240.40
407_E410_G0.8230.40
160_I169_R0.8230.40
404_V412_L0.8220.40
192_H429_G0.8220.40
293_R297_L0.8210.39
174_C512_L0.8180.39
132_I136_D0.8150.39
283_R286_K0.8140.39
109_A113_D0.8130.39
324_L346_I0.8090.39
275_W286_K0.8050.38
166_G364_T0.8040.38
250_Q253_Q0.8020.38
358_N470_E0.8010.38
358_N364_T0.7980.38
330_R376_D0.7970.38
212_V487_L0.7970.38
120_K124_E0.7960.38
247_W255_L0.7930.37
287_G297_L0.7920.37
382_L464_N0.7920.37
148_A170_R0.7920.37
365_L376_D0.7890.37
128_L478_E0.7890.37
101_L108_Y0.7870.37
321_D347_P0.7850.37
390_S433_F0.7850.37
280_T284_Q0.7850.37
106_E434_K0.7850.37
314_P317_P0.7850.37
266_R270_E0.7840.37
107_V115_D0.7840.37
240_W404_V0.7840.37
96_E101_L0.7820.37
393_Q470_E0.7800.37
397_S411_G0.7790.37
364_T393_Q0.7780.36
281_K296_E0.7770.36
123_A352_V0.7760.36
280_T395_R0.7750.36
480_L502_W0.7750.36
481_R493_C0.7740.36
251_K504_L0.7720.36
166_G486_A0.7710.36
170_R452_R0.7690.36
278_Q285_S0.7670.36
279_G295_E0.7670.36
510_H522_F0.7650.36
281_K284_Q0.7640.35
198_V345_S0.7640.35
407_E457_K0.7610.35
433_F437_D0.7610.35
118_F121_L0.7600.35
370_S390_S0.7600.35
354_I467_L0.7580.35
398_M404_V0.7580.35
361_G470_E0.7560.35
332_S369_I0.7520.35
286_K291_L0.7500.35
280_T292_A0.7490.34
228_W241_E0.7490.34
293_R296_E0.7480.34
279_G288_K0.7480.34
319_L322_K0.7470.34
112_A115_D0.7450.34
359_G497_I0.7440.34
151_L475_L0.7430.34
276_V292_A0.7420.34
131_I511_I0.7400.34
212_V274_E0.7380.34
427_Y456_A0.7360.34
449_E480_L0.7350.34
202_E278_Q0.7350.34
99_N109_A0.7320.33
219_R477_I0.7310.33
454_H504_L0.7300.33
225_V508_A0.7300.33
98_V103_R0.7300.33
447_G476_D0.7290.33
148_A156_W0.7290.33
494_A509_T0.7280.33
404_V407_E0.7280.33
256_A266_R0.7240.33
272_E283_R0.7240.33
332_S337_L0.7200.33
332_S424_S0.7170.32
128_L349_G0.7170.32
261_Q266_R0.7140.32
118_F122_A0.7130.32
168_R394_F0.7120.32
170_R351_I0.7100.32
190_T472_T0.7070.32
333_Y367_R0.7040.32
455_L477_I0.7040.32
355_I451_G0.7030.31
359_G492_G0.7030.31
161_A455_L0.7030.31
433_F453_L0.7020.31
357_P515_Q0.7020.31
103_R111_Y0.7010.31
211_T482_A0.6990.31
419_N424_S0.6990.31
279_G290_R0.6950.31
128_L190_T0.6940.31
124_E374_Q0.6940.31
145_E157_D0.6940.31
229_I494_A0.6910.31
166_G358_N0.6900.31
339_I506_R0.6830.30
496_V503_F0.6820.30
282_G496_V0.6790.30
131_I135_H0.6760.30
275_W295_E0.6730.30
361_G364_T0.6720.30
171_V254_R0.6710.29
107_V353_G0.6700.29
135_H229_I0.6700.29
99_N111_Y0.6700.29
136_D405_W0.6680.29
168_R350_A0.6670.29
358_N499_H0.6670.29
361_G497_I0.6660.29
472_T496_V0.6650.29
128_L137_G0.6650.29
406_E409_S0.6650.29
367_R467_L0.6650.29
391_V441_R0.6640.29
501_R505_D0.6630.29
342_L521_E0.6620.29
275_W294_F0.6610.29
334_G376_D0.6600.29
138_H342_L0.6590.29
219_R502_W0.6570.29
148_A153_L0.6570.29
185_L213_V0.6560.29
99_N102_K0.6540.28
325_E328_N0.6540.28
203_R363_S0.6540.28
243_N346_I0.6510.28
96_E99_N0.6510.28
371_G374_Q0.6490.28
172_A394_F0.6490.28
259_A263_A0.6490.28
215_I325_E0.6490.28
275_W279_G0.6490.28
253_Q257_Q0.6480.28
329_L463_G0.6460.28
331_K350_A0.6450.28
275_W280_T0.6430.28
107_V113_D0.6430.28
139_N264_A0.6420.28
405_W408_V0.6420.28
207_D461_V0.6400.28
339_I474_D0.6400.28
164_S361_G0.6400.28
143_Q494_A0.6400.28
96_E103_R0.6380.27
193_L366_F0.6380.27
287_G294_F0.6370.27
405_W438_Q0.6360.27
218_D501_R0.6360.27
163_L169_R0.6350.27
288_K303_Q0.6350.27
515_Q521_E0.6350.27
391_V483_L0.6340.27
274_E277_R0.6330.27
124_E127_R0.6330.27
98_V105_D0.6290.27
524_E530_Y0.6270.27
400_N404_V0.6270.27
100_A105_D0.6260.27
407_E411_G0.6240.27
359_G499_H0.6230.27
195_A198_V0.6220.27
273_L291_L0.6220.27
262_E265_R0.6210.26
232_L299_S0.6180.26
275_W289_A0.6170.26
99_N106_E0.6160.26
117_D121_L0.6160.26
164_S393_Q0.6160.26
215_I453_L0.6160.26
166_G362_K0.6150.26
190_T503_F0.6150.26
188_E191_N0.6140.26
384_E487_L0.6130.26
144_L170_R0.6130.26
124_E373_E0.6120.26
363_S367_R0.6110.26
111_Y115_D0.6110.26
333_Y497_I0.6110.26
371_G494_A0.6100.26
348_K383_G0.6100.26
444_E464_N0.6080.26
140_L504_L0.6080.26
351_I493_C0.6060.26
246_S249_E0.6060.26
230_L365_L0.6050.26
404_V410_G0.6050.26
290_R300_T0.6030.25
295_E450_R0.6020.25
474_D508_A0.6020.25
162_N171_V0.6020.25
278_Q287_G0.6020.25
356_G393_Q0.6000.25
280_T291_L0.5990.25
279_G283_R0.5980.25
108_Y111_Y0.5980.25
130_E409_S0.5970.25
166_G472_T0.5970.25
157_D328_N0.5970.25
97_V102_K0.5970.25
291_L300_T0.5960.25
277_R288_K0.5950.25
388_L465_M0.5950.25
431_F456_A0.5940.25
104_L107_V0.5940.25
106_E115_D0.5940.25
383_G435_G0.5920.25
339_I370_S0.5910.25
167_E170_R0.5910.25
293_R350_A0.5900.25
142_V271_K0.5880.25
275_W291_L0.5860.24
358_N497_I0.5850.24
219_R501_R0.5840.24
163_L167_E0.5830.24
238_I254_R0.5820.24
127_R273_L0.5820.24
293_R523_F0.5820.24
126_G390_S0.5800.24
228_W453_L0.5790.24
324_L374_Q0.5760.24
109_A335_D0.5750.24
152_R367_R0.5750.24
324_L402_K0.5750.24
290_R293_R0.5710.24
293_R298_N0.5710.24
436_V450_R0.5710.24
95_S102_K0.5700.24
195_A391_V0.5690.24
297_L390_S0.5690.24
423_P426_A0.5690.24
282_G286_K0.5690.24
429_G467_L0.5680.23
389_A463_G0.5680.23
395_R454_H0.5660.23
321_D432_N0.5660.23
153_L398_M0.5660.23
356_G361_G0.5660.23
169_R172_A0.5650.23
326_V369_I0.5650.23
259_A262_E0.5630.23
258_E263_A0.5620.23
286_K294_F0.5610.23
269_I277_R0.5610.23
170_R463_G0.5600.23
261_Q265_R0.5600.23
221_F243_N0.5590.23
212_V429_G0.5580.23
266_R406_E0.5570.23
393_Q499_H0.5560.23
269_I299_S0.5540.23
146_R389_A0.5540.23
185_L245_S0.5530.23
496_V512_L0.5530.23
347_P468_L0.5520.23
271_K275_W0.5510.23
518_G524_E0.5480.22
431_F504_L0.5480.22
159_K490_F0.5460.22
148_A181_P0.5460.22
127_R528_T0.5450.22
213_V222_L0.5450.22
332_S338_L0.5440.22
389_A513_D0.5440.22
147_A179_E0.5440.22
286_K296_E0.5410.22
168_R198_V0.5390.22
343_S381_T0.5370.22
164_S499_H0.5370.22
273_L295_E0.5360.22
316_G431_F0.5360.22
153_L169_R0.5350.22
138_H233_D0.5340.22
364_T367_R0.5340.22
126_G411_G0.5320.22
370_S518_G0.5320.22
364_T497_I0.5310.22
173_L200_W0.5310.22
276_V289_A0.5300.22
279_G284_Q0.5290.21
245_S511_I0.5280.21
262_E302_Y0.5280.21
129_E282_G0.5280.21
470_E492_G0.5280.21
166_G492_G0.5280.21
405_W413_D0.5270.21
165_G470_E0.5270.21
492_G497_I0.5260.21
167_E398_M0.5260.21
320_G383_G0.5260.21
307_E311_L0.5260.21
378_G452_R0.5250.21
134_A227_G0.5250.21
213_V300_T0.5250.21
147_A309_N0.5250.21
315_P428_V0.5250.21
301_E311_L0.5240.21
276_V383_G0.5240.21
389_A466_L0.5230.21
152_R163_L0.5230.21
204_F210_G0.5230.21
288_K301_E0.5220.21
183_M265_R0.5200.21
470_E483_L0.5200.21
283_R295_E0.5200.21
443_G495_M0.5190.21
172_A443_G0.5190.21
208_F490_F0.5190.21
433_F458_L0.5180.21
295_E298_N0.5170.21
511_I515_Q0.5170.21
334_G337_L0.5170.21
405_W409_S0.5170.21
404_V442_V0.5160.21
163_L423_P0.5160.21
477_I503_F0.5160.21
287_G431_F0.5160.21
366_F458_L0.5160.21
162_N363_S0.5160.21
361_G499_H0.5150.21
356_G486_A0.5150.21
95_S109_A0.5140.21
165_G192_H0.5130.21
107_V121_L0.5130.21
232_L461_V0.5120.21
221_F225_V0.5110.21
192_H210_G0.5110.21
393_Q483_L0.5100.21
214_A420_T0.5080.20
346_I461_V0.5080.20
433_F440_K0.5060.20
102_K127_R0.5050.20
103_R108_Y0.5050.20
122_A135_H0.5040.20
270_E421_E0.5040.20
291_L367_R0.5030.20
323_V466_L0.5030.20
429_G458_L0.5020.20
286_K293_R0.5010.20
151_L168_R0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4finA 2 0.9748 100 0.471 Contact Map
2iw3A 2 0.7802 100 0.556 Contact Map
3bk7A 1 0.8811 100 0.6 Contact Map
1yqtA 1 0.8667 100 0.608 Contact Map
3ozxA 1 0.8613 100 0.613 Contact Map
4q9hA 1 0.8937 100 0.622 Contact Map
3j16B 1 0.8847 100 0.623 Contact Map
4f4cA 1 0.8486 100 0.634 Contact Map
3ux8A 2 0.7495 100 0.647 Contact Map
2vf7A 2 0.8667 100 0.653 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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