GREMLIN Database
ULAR - HTH-type transcriptional regulator UlaR
UniProt: P0A9W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12491
Length: 251 (243)
Sequences: 7679 (5640)
Seq/√Len: 361.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_E167_W3.3781.00
86_A89_Q3.1401.00
108_L204_L2.9971.00
137_S144_Q2.7701.00
168_M198_V2.6151.00
100_N191_E2.4501.00
13_M28_R2.3491.00
110_R129_Y2.2711.00
207_S230_G2.2551.00
195_L219_S2.2491.00
202_V226_M2.1061.00
161_S193_K2.1011.00
92_N95_E2.0911.00
167_W202_V2.0691.00
13_M17_L2.0481.00
9_I12_E2.0391.00
98_V165_G2.0301.00
85_K111_E1.9981.00
195_L201_L1.9931.00
81_V107_L1.9891.00
217_L220_R1.9461.00
99_I105_A1.9421.00
233_A238_L1.9311.00
167_W200_K1.8821.00
93_P115_K1.8771.00
98_V194_M1.8741.00
120_I165_G1.8151.00
107_L110_R1.8081.00
238_L242_E1.8011.00
200_K226_M1.7801.00
87_A169_F1.7201.00
165_G194_M1.7021.00
220_R223_Q1.7011.00
159_E162_L1.6881.00
87_A204_L1.6441.00
158_S189_M1.6171.00
140_I152_T1.5961.00
193_K196_S1.5751.00
141_M160_N1.5691.00
108_L169_F1.5661.00
166_H199_G1.5631.00
180_L224_I1.5551.00
127_A140_I1.5531.00
88_S111_E1.5311.00
76_N208_S1.5171.00
180_L203_V1.5021.00
31_I36_A1.5021.00
161_S196_S1.4941.00
239_Q243_A1.4911.00
25_V36_A1.4831.00
19_F57_E1.4701.00
157_G190_A1.4651.00
7_H46_S1.4631.00
141_M152_T1.4421.00
10_L25_V1.4411.00
84_A111_E1.4331.00
81_V111_E1.4321.00
119_I130_L1.4261.00
13_M20_V1.4251.00
193_K197_V1.4221.00
8_Q12_E1.4161.00
40_I56_A1.4061.00
17_L24_K1.4001.00
76_N79_E1.3941.00
9_I13_M1.3941.00
145_Y152_T1.3801.00
101_C151_I1.3791.00
207_S232_N1.3791.00
50_K59_I1.3731.00
90_L202_V1.3631.00
90_L228_I1.3631.00
203_V224_I1.3531.00
95_E166_H1.3511.00
79_E230_G1.3511.00
52_V55_G1.3491.00
15_A58_A1.3411.00
93_P116_P1.3401.00
23_E33_P1.3401.00
144_Q186_L1.3351.00
113_C133_Q1.3341.00
77_H107_L1.3111.00
11_L48_K1.3081.00
7_H42_K1.3081.00
235_P239_Q1.3001.00
234_N237_I1.2751.00
219_S223_Q1.2741.00
34_A38_R1.2721.00
175_L210_I1.2721.00
141_M157_G1.2691.00
21_T24_K1.2671.00
119_I136_D1.2641.00
80_K103_S1.2611.00
91_V112_M1.2601.00
200_K225_D1.2421.00
81_V110_R1.2341.00
94_G116_P1.2331.00
3_E7_H1.2201.00
9_I28_R1.2141.00
86_A90_L1.2081.00
196_S223_Q1.2001.00
98_V197_V1.1971.00
118_Q139_I1.1921.00
9_I29_L1.1751.00
239_Q242_E1.1681.00
109_G130_L1.1671.00
14_L49_L1.1611.00
172_G205_V1.1521.00
210_I233_A1.1501.00
169_F202_V1.1361.00
12_E16_Q1.1251.00
78_D81_V1.1221.00
77_H81_V1.1201.00
158_S190_A1.1201.00
92_N167_W1.1171.00
79_E207_S1.1171.00
41_N45_E1.1161.00
17_L28_R1.1121.00
156_Q160_N1.1101.00
11_L14_L1.1091.00
50_K57_E1.0941.00
118_Q137_S1.0941.00
226_M247_S1.0931.00
201_L224_I1.0911.00
172_G218_F1.0901.00
174_G181_Y1.0891.00
139_I144_Q1.0461.00
14_L58_A1.0451.00
202_V228_I1.0431.00
22_V40_I1.0421.00
49_L56_A1.0361.00
88_S91_V1.0331.00
42_K46_S1.0201.00
91_V169_F1.0201.00
87_A108_L1.0181.00
156_Q163_Y1.0071.00
3_E42_K1.0041.00
120_I163_Y1.0021.00
26_V33_P1.0011.00
90_L226_M0.9981.00
99_I108_L0.9941.00
69_M103_S0.9921.00
88_S108_L0.9881.00
79_E83_I0.9801.00
173_K182_K0.9801.00
109_G129_Y0.9791.00
5_Q9_I0.9791.00
237_I240_Q0.9781.00
210_I227_L0.9771.00
102_G105_A0.9601.00
175_L205_V0.9491.00
158_S193_K0.9411.00
168_M194_M0.9401.00
105_A126_L0.9361.00
80_K209_K0.9331.00
41_N44_D0.9321.00
84_A88_S0.9321.00
81_V85_K0.9321.00
189_M192_Q0.9311.00
13_M16_Q0.9261.00
80_K104_T0.9231.00
188_A216_M0.9231.00
104_T206_D0.9221.00
222_D244_Q0.9161.00
172_G203_V0.9151.00
108_L111_E0.9091.00
42_K45_E0.9081.00
24_K28_R0.9081.00
162_L192_Q0.9051.00
83_I104_T0.9011.00
26_V36_A0.8991.00
176_T213_R0.8991.00
125_P150_S0.8941.00
164_A199_G0.8861.00
105_A108_L0.8851.00
76_N206_D0.8821.00
138_V145_Y0.8821.00
20_V25_V0.8771.00
104_T209_K0.8771.00
84_A108_L0.8701.00
20_V56_A0.8681.00
43_L48_K0.8651.00
84_A107_L0.8631.00
156_Q162_L0.8601.00
199_G213_R0.8461.00
123_Y126_L0.8431.00
240_Q243_A0.8391.00
131_I150_S0.8381.00
11_L15_A0.8311.00
113_C129_Y0.8311.00
116_P135_H0.8301.00
164_A217_L0.8281.00
169_F204_L0.8261.00
182_K188_A0.8191.00
163_Y185_M0.8181.00
109_G126_L0.8181.00
201_L225_D0.8141.00
149_Q173_K0.8081.00
87_A228_I0.8081.00
5_Q8_Q0.8071.00
82_R85_K0.8011.00
12_E15_A0.7931.00
24_K27_E0.7911.00
129_Y132_D0.7871.00
41_N51_K0.7861.00
76_N207_S0.7851.00
164_A213_R0.7841.00
185_M216_M0.7841.00
133_Q136_D0.7791.00
175_L180_L0.7741.00
172_G180_L0.7721.00
72_H173_K0.7711.00
181_Y213_R0.7711.00
105_A204_L0.7701.00
99_I119_I0.7561.00
5_Q19_F0.7421.00
233_A237_I0.7421.00
128_N150_S0.7401.00
78_D82_R0.7371.00
146_N187_T0.7371.00
99_I109_G0.7361.00
68_P71_L0.7351.00
162_L217_L0.7341.00
182_K218_F0.7281.00
106_F129_Y0.7281.00
103_S209_K0.7271.00
18_G58_A0.7221.00
7_H11_L0.7200.99
195_L218_F0.7190.99
66_W72_H0.7170.99
164_A197_V0.7130.99
180_L218_F0.7100.99
127_A152_T0.7030.99
101_C149_Q0.7000.99
146_N153_L0.7000.99
107_L111_E0.7000.99
165_G198_V0.7000.99
142_G157_G0.7000.99
127_A145_Y0.6980.99
142_G160_N0.6960.99
154_S157_G0.6960.99
175_L221_A0.6890.99
168_M201_L0.6890.99
177_A240_Q0.6880.99
182_K187_T0.6870.99
40_I51_K0.6870.99
52_V57_E0.6850.99
205_V227_L0.6850.99
31_I34_A0.6840.99
206_D209_K0.6770.99
23_E27_E0.6770.99
11_L43_L0.6730.99
44_D51_K0.6710.99
82_R86_A0.6690.99
202_V225_D0.6690.99
132_D150_S0.6670.99
25_V40_I0.6640.99
114_G133_Q0.6640.99
192_Q196_S0.6640.99
240_Q244_Q0.6630.99
22_V36_A0.6630.99
122_N194_M0.6630.99
73_Q106_F0.6620.99
236_E240_Q0.6610.99
96_S120_I0.6610.99
85_K89_Q0.6590.99
97_V119_I0.6530.99
34_A123_Y0.6520.99
170_T198_V0.6500.99
161_S197_V0.6490.99
83_I204_L0.6380.99
235_P238_L0.6360.99
14_L20_V0.6300.99
115_K135_H0.6270.99
97_V167_W0.6260.99
155_P159_E0.6260.99
106_F125_P0.6240.99
44_D49_L0.6200.99
173_K214_A0.6170.98
6_R39_D0.6170.98
219_S224_I0.6140.98
159_E189_M0.6130.98
4_A7_H0.6120.98
121_T127_A0.6100.98
91_V108_L0.6100.98
124_L152_T0.6080.98
163_Y216_M0.6080.98
155_P189_M0.6080.98
198_V201_L0.6060.98
100_N105_A0.6060.98
120_I215_G0.6050.98
124_L128_N0.6050.98
237_I241_L0.6050.98
79_E232_N0.5990.98
123_Y187_T0.5970.98
124_L140_I0.5960.98
102_G171_S0.5950.98
188_A218_F0.5950.98
200_K247_S0.5940.98
29_L36_A0.5900.98
157_G160_N0.5880.98
183_T214_A0.5870.98
155_P158_S0.5860.98
173_K187_T0.5860.98
72_H187_T0.5860.98
34_A173_K0.5840.98
186_L189_M0.5840.98
97_V169_F0.5820.98
73_Q107_L0.5790.98
125_P128_N0.5790.98
191_E218_F0.5790.98
116_P137_S0.5760.98
82_R231_K0.5760.98
70_N73_Q0.5720.97
170_T218_F0.5720.97
156_Q159_E0.5710.97
179_G220_R0.5690.97
155_P186_L0.5690.97
190_A193_K0.5680.97
173_K183_T0.5670.97
182_K191_E0.5670.97
102_G173_K0.5630.97
120_I139_I0.5620.97
80_K206_D0.5610.97
158_S161_S0.5610.97
146_N184_D0.5600.97
173_K191_E0.5590.97
171_S182_K0.5580.97
38_R175_L0.5580.97
96_S215_G0.5550.97
176_T181_Y0.5520.97
98_V168_M0.5520.97
97_V108_L0.5510.97
207_S233_A0.5440.97
210_I229_T0.5430.97
102_G123_Y0.5420.97
232_N238_L0.5420.97
170_T195_L0.5420.97
180_L219_S0.5400.96
27_E30_G0.5330.96
151_I187_T0.5320.96
66_W146_N0.5290.96
177_A237_I0.5220.96
235_P242_E0.5220.96
201_L223_Q0.5200.96
26_V32_S0.5190.96
242_E247_S0.5170.95
72_H100_N0.5150.95
238_L241_L0.5140.95
130_L136_D0.5140.95
174_G212_E0.5130.95
159_E192_Q0.5120.95
137_S147_K0.5120.95
210_I237_I0.5110.95
174_G214_A0.5090.95
69_M150_S0.5080.95
72_H103_S0.5070.95
22_V26_V0.5060.95
170_T201_L0.5060.95
152_T160_N0.5050.95
98_V120_I0.5030.95
139_I156_Q0.5030.95
29_L35_T0.5030.95
20_V52_V0.5010.95
83_I229_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9283 100 0.53 Contact Map
3rrlB 1 0.6653 100 0.543 Contact Map
2w48A 3 0.9243 100 0.591 Contact Map
3l7oA 2 0.5976 100 0.612 Contact Map
2o0mA 1 0.6972 100 0.616 Contact Map
1o8bA 2 0.5857 100 0.619 Contact Map
1m0sA 2 0.6096 100 0.624 Contact Map
1uj6A 2 0.6056 100 0.625 Contact Map
1lk5A 4 0.6096 100 0.626 Contact Map
4io1A 2 0.6096 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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