GREMLIN Database
SQUU - 3-sulfolactaldehyde reductase
UniProt: P0A9V8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11847
Length: 298 (279)
Sequences: 11465 (7452)
Seq/√Len: 446.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_T152_M3.5691.00
72_R104_K3.3411.00
141_A145_E3.2701.00
28_R48_A3.0251.00
115_S143_Q2.8661.00
3_A26_Q2.8141.00
41_V47_P2.7591.00
115_S146_R2.6961.00
18_S43_K2.6541.00
236_D276_R2.3121.00
49_A53_Q2.2081.00
37_V47_P2.2011.00
38_R42_D2.1791.00
145_E148_T2.1751.00
109_M114_F2.1261.00
5_A54_A2.0611.00
90_L147_A2.0331.00
21_L45_A1.9871.00
212_G217_T1.9601.00
14_S39_H1.9371.00
25_H153_A1.9141.00
141_A160_N1.9031.00
50_N53_Q1.8821.00
198_P201_V1.8631.00
82_C109_M1.8511.00
106_I164_P1.8451.00
63_T91_V1.8401.00
100_L251_Q1.8161.00
115_S140_T1.7891.00
26_Q46_T1.7801.00
52_A56_K1.7711.00
23_Q153_A1.7701.00
3_A28_R1.7631.00
19_N22_Q1.7431.00
86_S89_A1.7361.00
248_V251_Q1.7341.00
33_N36_A1.7241.00
107_A111_A1.6961.00
110_Q140_T1.6901.00
236_D270_R1.6851.00
35_E38_R1.6581.00
34_A38_R1.6551.00
75_L91_V1.6441.00
140_T143_Q1.6411.00
192_C202_A1.6231.00
135_L154_M1.6201.00
28_R57_D1.6001.00
274_R277_Q1.5981.00
29_V45_A1.5981.00
64_M94_M1.5711.00
90_L143_Q1.5611.00
117_M139_G1.5581.00
106_I110_Q1.5431.00
108_D111_A1.5391.00
85_L89_A1.5351.00
135_L155_G1.5011.00
144_V148_T1.4891.00
104_K108_D1.4861.00
119_V135_L1.4691.00
117_M147_A1.4521.00
19_N131_G1.4491.00
62_I94_M1.4491.00
144_V160_N1.4421.00
28_R46_T1.4291.00
54_A58_A1.4271.00
67_N70_L1.4161.00
52_A84_G1.4031.00
200_D204_K1.3951.00
126_A130_T1.3801.00
180_A184_L1.3741.00
125_S129_I1.3681.00
38_R41_V1.3611.00
68_G101_Q1.3491.00
235_I269_A1.3441.00
161_A170_V1.3411.00
34_A49_A1.3261.00
236_D275_G1.3261.00
263_R267_S1.3251.00
59_E86_S1.3241.00
172_L244_I1.3231.00
260_A264_E1.3101.00
22_Q43_K1.2811.00
102_T116_M1.2771.00
109_M116_M1.2751.00
193_E199_F1.2731.00
90_L146_R1.2691.00
261_A264_E1.2611.00
64_M121_V1.2561.00
51_P84_G1.2541.00
92_I147_A1.2441.00
69_D73_N1.2441.00
132_T156_S1.2411.00
117_M144_V1.2391.00
18_S129_I1.2361.00
277_Q284_E1.2261.00
15_P129_I1.2221.00
82_C112_K1.2161.00
80_G83_E1.2141.00
22_Q129_I1.2061.00
5_A58_A1.2061.00
147_A151_L1.1971.00
239_H270_R1.1911.00
140_T163_G1.1861.00
250_N260_A1.1811.00
17_A27_L1.1781.00
60_F90_L1.1711.00
249_A256_M1.1711.00
40_L45_A1.1691.00
190_V194_A1.1641.00
83_E112_K1.1591.00
39_H42_D1.1551.00
53_Q56_K1.1471.00
89_A114_F1.1451.00
179_I242_L1.1441.00
247_D251_Q1.1421.00
85_L114_F1.1401.00
55_A84_G1.1401.00
94_M135_L1.1371.00
60_F150_I1.1331.00
72_R108_D1.1241.00
103_D169_R1.1241.00
18_S22_Q1.1181.00
6_F16_M1.1181.00
179_I238_A1.1181.00
48_A54_A1.1171.00
195_L252_L1.1151.00
264_E267_S1.1151.00
255_P260_A1.0981.00
103_D164_P1.0951.00
6_F62_I1.0911.00
6_F17_A1.0861.00
98_H101_Q1.0791.00
65_L74_V1.0681.00
91_V109_M1.0631.00
246_L260_A1.0541.00
11_Q125_S1.0481.00
28_R58_A1.0471.00
207_S217_T1.0441.00
72_R101_Q1.0431.00
239_H267_S1.0411.00
68_G98_H1.0351.00
94_M154_M1.0271.00
62_I150_I1.0251.00
163_G166_M1.0251.00
221_P226_S1.0231.00
31_D36_A1.0231.00
137_A144_V1.0221.00
103_D107_A1.0201.00
48_A53_Q1.0171.00
243_G263_R1.0151.00
108_D112_K1.0081.00
106_I140_T1.0031.00
107_A110_Q0.9951.00
152_M158_L0.9941.00
160_N163_G0.9891.00
247_D250_N0.9881.00
57_D86_S0.9861.00
177_M188_A0.9841.00
235_I270_R0.9741.00
52_A80_G0.9731.00
201_V204_K0.9721.00
21_L44_G0.9681.00
118_D165_G0.9621.00
3_A59_E0.9611.00
117_M137_A0.9541.00
85_L91_V0.9531.00
39_H43_K0.9501.00
46_T57_D0.9421.00
53_Q57_D0.9411.00
79_N83_E0.9401.00
79_N108_D0.9361.00
34_A47_P0.9351.00
128_A133_L0.9321.00
62_I92_I0.9301.00
70_L73_N0.9271.00
173_I188_A0.9221.00
71_V97_I0.9221.00
161_A166_M0.9221.00
173_I192_C0.9201.00
145_E160_N0.9181.00
267_S271_A0.9161.00
189_A203_V0.9161.00
214_G218_T0.9151.00
122_G174_N0.9121.00
203_V220_W0.9121.00
9_L40_L0.9061.00
243_G247_D0.9061.00
72_R105_L0.9021.00
98_H247_D0.9021.00
35_E39_H0.9021.00
87_T113_G0.9011.00
75_L109_M0.9001.00
180_A258_L0.9001.00
207_S216_F0.8951.00
32_V70_L0.8931.00
136_L205_V0.8851.00
122_G136_L0.8841.00
277_Q281_A0.8821.00
207_S212_G0.8801.00
139_G144_V0.8801.00
233_F237_L0.8801.00
161_A205_V0.8791.00
102_T168_I0.8791.00
270_R275_G0.8781.00
19_N154_M0.8761.00
101_Q104_K0.8721.00
75_L81_V0.8721.00
90_L115_S0.8641.00
194_A254_V0.8601.00
60_F146_R0.8601.00
149_P152_M0.8521.00
169_R248_V0.8511.00
243_G267_S0.8491.00
239_H263_R0.8481.00
36_A39_H0.8471.00
230_S277_Q0.8461.00
203_V207_S0.8461.00
16_M154_M0.8421.00
6_F27_L0.8411.00
14_S18_S0.8411.00
54_A57_D0.8381.00
92_I119_V0.8351.00
143_Q146_R0.8321.00
97_I101_Q0.8291.00
169_R195_L0.8291.00
9_L29_V0.8261.00
20_L62_I0.8241.00
220_W224_V0.8241.00
61_I81_V0.8211.00
51_P55_A0.8181.00
104_K107_A0.8181.00
274_R284_E0.8151.00
232_A235_I0.8121.00
63_T71_V0.8061.00
118_D167_G0.8061.00
4_I25_H0.7991.00
183_A258_L0.7991.00
200_D226_S0.7951.00
170_V197_L0.7921.00
141_A163_G0.7901.00
268_Q271_A0.7881.00
181_L185_S0.7851.00
3_A57_D0.7841.00
100_L103_D0.7791.00
21_L43_K0.7721.00
144_V158_L0.7711.00
16_M94_M0.7671.00
138_G167_G0.7661.00
115_S142_E0.7651.00
176_Y259_G0.7621.00
194_A252_L0.7621.00
66_P70_L0.7611.00
103_D165_G0.7581.00
234_M276_R0.7541.00
269_A281_A0.7531.00
96_T244_I0.7511.00
93_D116_M0.7471.00
258_L262_S0.7461.00
186_A282_I0.7421.00
268_Q285_Q0.7421.00
192_C197_L0.7421.00
234_M237_L0.7381.00
181_L213_K0.7361.00
248_V252_L0.7311.00
16_M133_L0.7311.00
117_M143_Q0.7311.00
264_E268_Q0.7301.00
60_F92_I0.7291.00
29_V37_V0.7281.00
65_L70_L0.7281.00
223_K228_D0.7271.00
82_C108_D0.7271.00
143_Q147_A0.7261.00
20_L27_L0.7261.00
56_K84_G0.7241.00
151_L158_L0.7231.00
176_Y245_A0.7221.00
177_M185_S0.7221.00
200_D225_L0.7201.00
124_T127_N0.7191.00
7_I51_P0.7181.00
63_T75_L0.7181.00
14_S43_K0.7161.00
32_V36_A0.7151.00
229_L284_E0.7141.00
16_M64_M0.7131.00
148_T158_L0.7111.00
142_E145_E0.7101.00
28_R54_A0.7081.00
34_A37_V0.7081.00
4_I20_L0.7001.00
105_L116_M0.6991.00
82_C114_F0.6941.00
250_N263_R0.6941.00
269_A285_Q0.6931.00
6_F64_M0.6911.00
25_H150_I0.6911.00
268_Q272_A0.6871.00
7_I30_F0.6871.00
246_L263_R0.6801.00
235_I281_A0.6741.00
190_V193_E0.6731.00
4_I150_I0.6711.00
116_M164_P0.6681.00
65_L71_V0.6671.00
51_P54_A0.6661.00
272_A285_Q0.6651.00
177_M184_L0.6641.00
48_A57_D0.6581.00
61_I85_L0.6551.00
169_R197_L0.6541.00
71_V95_S0.6531.00
52_A55_A0.6531.00
267_S270_R0.6531.00
37_V41_V0.6501.00
138_G160_N0.6501.00
281_A284_E0.6491.00
159_I205_V0.6481.00
173_I191_L0.6460.99
101_Q105_L0.6450.99
14_S40_L0.6420.99
38_R47_P0.6390.99
21_L27_L0.6380.99
177_M181_L0.6380.99
265_V268_Q0.6340.99
119_V137_A0.6330.99
157_E208_G0.6300.99
17_A29_V0.6260.99
87_T112_K0.6220.99
172_L245_A0.6220.99
185_S216_F0.6210.99
170_V202_A0.6190.99
31_D34_A0.6190.99
81_V85_L0.6160.99
74_V80_G0.6160.99
127_N132_T0.6150.99
191_L256_M0.6140.99
71_V93_D0.6140.99
119_V151_L0.6140.99
137_A151_L0.6140.99
214_G217_T0.6130.99
137_A158_L0.6130.99
73_N80_G0.6130.99
86_S114_F0.6110.99
180_A262_S0.6100.99
148_T160_N0.6090.99
157_E204_K0.6090.99
177_M206_M0.6080.99
182_N279_W0.6070.99
197_L202_A0.6060.99
151_L155_G0.6010.99
73_N79_N0.6010.99
69_D72_R0.6000.99
71_V101_Q0.5980.99
10_G66_P0.5970.99
243_G250_N0.5960.99
58_A61_I0.5950.99
98_H244_I0.5920.99
60_F147_A0.5920.99
215_H219_S0.5910.99
97_I102_T0.5900.99
181_L215_H0.5900.99
239_H243_G0.5880.99
97_I168_I0.5830.99
246_L250_N0.5770.99
63_T93_D0.5750.99
52_A79_N0.5740.99
269_A274_R0.5730.99
220_W225_L0.5730.99
52_A83_E0.5730.99
31_D70_L0.5720.99
12_M16_M0.5720.99
206_M211_A0.5700.99
264_E271_A0.5700.99
15_P125_S0.5650.99
174_N209_T0.5630.99
203_V225_L0.5570.99
18_S21_L0.5570.99
7_I54_A0.5570.99
141_A144_V0.5530.98
102_T164_P0.5520.98
9_L17_A0.5520.98
189_A220_W0.5510.98
30_F51_P0.5500.98
150_I153_A0.5490.98
61_I89_A0.5470.98
127_N130_T0.5420.98
255_P268_Q0.5410.98
18_S39_H0.5380.98
190_V254_V0.5370.98
156_S208_G0.5350.98
75_L105_L0.5330.98
71_V105_L0.5310.98
92_I151_L0.5300.98
5_A28_R0.5290.98
19_N23_Q0.5290.98
62_I154_M0.5260.98
37_V40_L0.5250.98
99_P169_R0.5210.98
15_P131_G0.5210.98
210_A215_H0.5200.98
141_A148_T0.5190.98
166_M169_R0.5180.98
176_Y191_L0.5160.98
146_R149_P0.5150.98
161_A201_V0.5120.97
56_K86_S0.5120.97
242_L266_Y0.5110.97
3_A58_A0.5090.97
100_L104_K0.5080.97
32_V73_N0.5080.97
149_P153_A0.5080.97
62_I151_L0.5070.97
258_L261_A0.5060.97
159_I201_V0.5020.97
255_P271_A0.5020.97
139_G143_Q0.5020.97
59_E89_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ckyA 4 0.9933 100 0.359 Contact Map
1vpdA 1 0.9866 100 0.36 Contact Map
3pduA 4 0.9631 100 0.36 Contact Map
3dojA 3 0.9698 100 0.363 Contact Map
3pefA 5 0.9631 100 0.364 Contact Map
3obbA 4 0.9698 100 0.365 Contact Map
1yb4A 4 0.9765 100 0.372 Contact Map
3ws7A 2 0.943 100 0.377 Contact Map
3g0oA 3 0.9497 100 0.377 Contact Map
2uyyA 3 0.9631 100 0.377 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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