SQUU - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

SQUU - 3-sulfolactaldehyde reductase

UniProt:	P0A9V8	Sequences: MAAIAFIGLGQMGSPMASNLLQQGHQLRVFDVNAEAVRHLVDKGATPAANPAQAAKDAEFIITMLPNGDLVRNVLFGENGVCEGLSTDALVIDMSTIHPLQTDKLIADMQAKGFSMMDVPVGRTSANAITGTLLLLAGGTAEQVERATPILMAMGSELINAGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALNLPFDVAVKVMSGTAAGKGHFTTSWPNKVLSGDLSPAFMIDLAHKDLGIALDVANQLHVPMPLGAASREVYSQARAAGRGRQDWSAILEQVRVSAGMTAKVKM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11847
Length:	298 (279)
Sequences:	11465 (7452)
Seq/√Len:	446.2

ECOLI - SQUU YGBJ GARR GLXR 6PGD
BACSU - YKWC YFJR YQEC 6PGDH 6PGD
HALSA - Q9HMG5
SULSO - Q97XZ7 Q97ZE5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
148_T	152_M	3.569	1.00
72_R	104_K	3.341	1.00
141_A	145_E	3.270	1.00
28_R	48_A	3.025	1.00
115_S	143_Q	2.866	1.00
3_A	26_Q	2.814	1.00
41_V	47_P	2.759	1.00
115_S	146_R	2.696	1.00
18_S	43_K	2.654	1.00
236_D	276_R	2.312	1.00
49_A	53_Q	2.208	1.00
37_V	47_P	2.201	1.00
38_R	42_D	2.179	1.00
145_E	148_T	2.175	1.00
109_M	114_F	2.126	1.00
5_A	54_A	2.061	1.00
90_L	147_A	2.033	1.00
21_L	45_A	1.987	1.00
212_G	217_T	1.960	1.00
14_S	39_H	1.937	1.00
25_H	153_A	1.914	1.00
141_A	160_N	1.903	1.00
50_N	53_Q	1.882	1.00
198_P	201_V	1.863	1.00
82_C	109_M	1.851	1.00
106_I	164_P	1.845	1.00
63_T	91_V	1.840	1.00
100_L	251_Q	1.816	1.00
115_S	140_T	1.789	1.00
26_Q	46_T	1.780	1.00
52_A	56_K	1.771	1.00
23_Q	153_A	1.770	1.00
3_A	28_R	1.763	1.00
19_N	22_Q	1.743	1.00
86_S	89_A	1.736	1.00
248_V	251_Q	1.734	1.00
33_N	36_A	1.724	1.00
107_A	111_A	1.696	1.00
110_Q	140_T	1.690	1.00
236_D	270_R	1.685	1.00
35_E	38_R	1.658	1.00
34_A	38_R	1.655	1.00
75_L	91_V	1.644	1.00
140_T	143_Q	1.641	1.00
192_C	202_A	1.623	1.00
135_L	154_M	1.620	1.00
28_R	57_D	1.600	1.00
274_R	277_Q	1.598	1.00
29_V	45_A	1.598	1.00
64_M	94_M	1.571	1.00
90_L	143_Q	1.561	1.00
117_M	139_G	1.558	1.00
106_I	110_Q	1.543	1.00
108_D	111_A	1.539	1.00
85_L	89_A	1.535	1.00
135_L	155_G	1.501	1.00
144_V	148_T	1.489	1.00
104_K	108_D	1.486	1.00
119_V	135_L	1.469	1.00
117_M	147_A	1.452	1.00
19_N	131_G	1.449	1.00
62_I	94_M	1.449	1.00
144_V	160_N	1.442	1.00
28_R	46_T	1.429	1.00
54_A	58_A	1.427	1.00
67_N	70_L	1.416	1.00
52_A	84_G	1.403	1.00
200_D	204_K	1.395	1.00
126_A	130_T	1.380	1.00
180_A	184_L	1.374	1.00
125_S	129_I	1.368	1.00
38_R	41_V	1.361	1.00
68_G	101_Q	1.349	1.00
235_I	269_A	1.344	1.00
161_A	170_V	1.341	1.00
34_A	49_A	1.326	1.00
236_D	275_G	1.326	1.00
263_R	267_S	1.325	1.00
59_E	86_S	1.324	1.00
172_L	244_I	1.323	1.00
260_A	264_E	1.310	1.00
22_Q	43_K	1.281	1.00
102_T	116_M	1.277	1.00
109_M	116_M	1.275	1.00
193_E	199_F	1.273	1.00
90_L	146_R	1.269	1.00
261_A	264_E	1.261	1.00
64_M	121_V	1.256	1.00
51_P	84_G	1.254	1.00
92_I	147_A	1.244	1.00
69_D	73_N	1.244	1.00
132_T	156_S	1.241	1.00
117_M	144_V	1.239	1.00
18_S	129_I	1.236	1.00
277_Q	284_E	1.226	1.00
15_P	129_I	1.222	1.00
82_C	112_K	1.216	1.00
80_G	83_E	1.214	1.00
22_Q	129_I	1.206	1.00
5_A	58_A	1.206	1.00
147_A	151_L	1.197	1.00
239_H	270_R	1.191	1.00
140_T	163_G	1.186	1.00
250_N	260_A	1.181	1.00
17_A	27_L	1.178	1.00
60_F	90_L	1.171	1.00
249_A	256_M	1.171	1.00
40_L	45_A	1.169	1.00
190_V	194_A	1.164	1.00
83_E	112_K	1.159	1.00
39_H	42_D	1.155	1.00
53_Q	56_K	1.147	1.00
89_A	114_F	1.145	1.00
179_I	242_L	1.144	1.00
247_D	251_Q	1.142	1.00
85_L	114_F	1.140	1.00
55_A	84_G	1.140	1.00
94_M	135_L	1.137	1.00
60_F	150_I	1.133	1.00
72_R	108_D	1.124	1.00
103_D	169_R	1.124	1.00
18_S	22_Q	1.118	1.00
6_F	16_M	1.118	1.00
179_I	238_A	1.118	1.00
48_A	54_A	1.117	1.00
195_L	252_L	1.115	1.00
264_E	267_S	1.115	1.00
255_P	260_A	1.098	1.00
103_D	164_P	1.095	1.00
6_F	62_I	1.091	1.00
6_F	17_A	1.086	1.00
98_H	101_Q	1.079	1.00
65_L	74_V	1.068	1.00
91_V	109_M	1.063	1.00
246_L	260_A	1.054	1.00
11_Q	125_S	1.048	1.00
28_R	58_A	1.047	1.00
207_S	217_T	1.044	1.00
72_R	101_Q	1.043	1.00
239_H	267_S	1.041	1.00
68_G	98_H	1.035	1.00
94_M	154_M	1.027	1.00
62_I	150_I	1.025	1.00
163_G	166_M	1.025	1.00
221_P	226_S	1.023	1.00
31_D	36_A	1.023	1.00
137_A	144_V	1.022	1.00
103_D	107_A	1.020	1.00
48_A	53_Q	1.017	1.00
243_G	263_R	1.015	1.00
108_D	112_K	1.008	1.00
106_I	140_T	1.003	1.00
107_A	110_Q	0.995	1.00
152_M	158_L	0.994	1.00
160_N	163_G	0.989	1.00
247_D	250_N	0.988	1.00
57_D	86_S	0.986	1.00
177_M	188_A	0.984	1.00
235_I	270_R	0.974	1.00
52_A	80_G	0.973	1.00
201_V	204_K	0.972	1.00
21_L	44_G	0.968	1.00
118_D	165_G	0.962	1.00
3_A	59_E	0.961	1.00
117_M	137_A	0.954	1.00
85_L	91_V	0.953	1.00
39_H	43_K	0.950	1.00
46_T	57_D	0.942	1.00
53_Q	57_D	0.941	1.00
79_N	83_E	0.940	1.00
79_N	108_D	0.936	1.00
34_A	47_P	0.935	1.00
128_A	133_L	0.932	1.00
62_I	92_I	0.930	1.00
70_L	73_N	0.927	1.00
173_I	188_A	0.922	1.00
71_V	97_I	0.922	1.00
161_A	166_M	0.922	1.00
173_I	192_C	0.920	1.00
145_E	160_N	0.918	1.00
267_S	271_A	0.916	1.00
189_A	203_V	0.916	1.00
214_G	218_T	0.915	1.00
122_G	174_N	0.912	1.00
203_V	220_W	0.912	1.00
9_L	40_L	0.906	1.00
243_G	247_D	0.906	1.00
72_R	105_L	0.902	1.00
98_H	247_D	0.902	1.00
35_E	39_H	0.902	1.00
87_T	113_G	0.901	1.00
75_L	109_M	0.900	1.00
180_A	258_L	0.900	1.00
207_S	216_F	0.895	1.00
32_V	70_L	0.893	1.00
136_L	205_V	0.885	1.00
122_G	136_L	0.884	1.00
277_Q	281_A	0.882	1.00
207_S	212_G	0.880	1.00
139_G	144_V	0.880	1.00
233_F	237_L	0.880	1.00
161_A	205_V	0.879	1.00
102_T	168_I	0.879	1.00
270_R	275_G	0.878	1.00
19_N	154_M	0.876	1.00
101_Q	104_K	0.872	1.00
75_L	81_V	0.872	1.00
90_L	115_S	0.864	1.00
194_A	254_V	0.860	1.00
60_F	146_R	0.860	1.00
149_P	152_M	0.852	1.00
169_R	248_V	0.851	1.00
243_G	267_S	0.849	1.00
239_H	263_R	0.848	1.00
36_A	39_H	0.847	1.00
230_S	277_Q	0.846	1.00
203_V	207_S	0.846	1.00
16_M	154_M	0.842	1.00
6_F	27_L	0.841	1.00
14_S	18_S	0.841	1.00
54_A	57_D	0.838	1.00
92_I	119_V	0.835	1.00
143_Q	146_R	0.832	1.00
97_I	101_Q	0.829	1.00
169_R	195_L	0.829	1.00
9_L	29_V	0.826	1.00
20_L	62_I	0.824	1.00
220_W	224_V	0.824	1.00
61_I	81_V	0.821	1.00
51_P	55_A	0.818	1.00
104_K	107_A	0.818	1.00
274_R	284_E	0.815	1.00
232_A	235_I	0.812	1.00
63_T	71_V	0.806	1.00
118_D	167_G	0.806	1.00
4_I	25_H	0.799	1.00
183_A	258_L	0.799	1.00
200_D	226_S	0.795	1.00
170_V	197_L	0.792	1.00
141_A	163_G	0.790	1.00
268_Q	271_A	0.788	1.00
181_L	185_S	0.785	1.00
3_A	57_D	0.784	1.00
100_L	103_D	0.779	1.00
21_L	43_K	0.772	1.00
144_V	158_L	0.771	1.00
16_M	94_M	0.767	1.00
138_G	167_G	0.766	1.00
115_S	142_E	0.765	1.00
176_Y	259_G	0.762	1.00
194_A	252_L	0.762	1.00
66_P	70_L	0.761	1.00
103_D	165_G	0.758	1.00
234_M	276_R	0.754	1.00
269_A	281_A	0.753	1.00
96_T	244_I	0.751	1.00
93_D	116_M	0.747	1.00
258_L	262_S	0.746	1.00
186_A	282_I	0.742	1.00
268_Q	285_Q	0.742	1.00
192_C	197_L	0.742	1.00
234_M	237_L	0.738	1.00
181_L	213_K	0.736	1.00
248_V	252_L	0.731	1.00
16_M	133_L	0.731	1.00
117_M	143_Q	0.731	1.00
264_E	268_Q	0.730	1.00
60_F	92_I	0.729	1.00
29_V	37_V	0.728	1.00
65_L	70_L	0.728	1.00
223_K	228_D	0.727	1.00
82_C	108_D	0.727	1.00
143_Q	147_A	0.726	1.00
20_L	27_L	0.726	1.00
56_K	84_G	0.724	1.00
151_L	158_L	0.723	1.00
176_Y	245_A	0.722	1.00
177_M	185_S	0.722	1.00
200_D	225_L	0.720	1.00
124_T	127_N	0.719	1.00
7_I	51_P	0.718	1.00
63_T	75_L	0.718	1.00
14_S	43_K	0.716	1.00
32_V	36_A	0.715	1.00
229_L	284_E	0.714	1.00
16_M	64_M	0.713	1.00
148_T	158_L	0.711	1.00
142_E	145_E	0.710	1.00
28_R	54_A	0.708	1.00
34_A	37_V	0.708	1.00
4_I	20_L	0.700	1.00
105_L	116_M	0.699	1.00
82_C	114_F	0.694	1.00
250_N	263_R	0.694	1.00
269_A	285_Q	0.693	1.00
6_F	64_M	0.691	1.00
25_H	150_I	0.691	1.00
268_Q	272_A	0.687	1.00
7_I	30_F	0.687	1.00
246_L	263_R	0.680	1.00
235_I	281_A	0.674	1.00
190_V	193_E	0.673	1.00
4_I	150_I	0.671	1.00
116_M	164_P	0.668	1.00
65_L	71_V	0.667	1.00
51_P	54_A	0.666	1.00
272_A	285_Q	0.665	1.00
177_M	184_L	0.664	1.00
48_A	57_D	0.658	1.00
61_I	85_L	0.655	1.00
169_R	197_L	0.654	1.00
71_V	95_S	0.653	1.00
52_A	55_A	0.653	1.00
267_S	270_R	0.653	1.00
37_V	41_V	0.650	1.00
138_G	160_N	0.650	1.00
281_A	284_E	0.649	1.00
159_I	205_V	0.648	1.00
173_I	191_L	0.646	0.99
101_Q	105_L	0.645	0.99
14_S	40_L	0.642	0.99
38_R	47_P	0.639	0.99
21_L	27_L	0.638	0.99
177_M	181_L	0.638	0.99
265_V	268_Q	0.634	0.99
119_V	137_A	0.633	0.99
157_E	208_G	0.630	0.99
17_A	29_V	0.626	0.99
87_T	112_K	0.622	0.99
172_L	245_A	0.622	0.99
185_S	216_F	0.621	0.99
170_V	202_A	0.619	0.99
31_D	34_A	0.619	0.99
81_V	85_L	0.616	0.99
74_V	80_G	0.616	0.99
127_N	132_T	0.615	0.99
191_L	256_M	0.614	0.99
71_V	93_D	0.614	0.99
119_V	151_L	0.614	0.99
137_A	151_L	0.614	0.99
214_G	217_T	0.613	0.99
137_A	158_L	0.613	0.99
73_N	80_G	0.613	0.99
86_S	114_F	0.611	0.99
180_A	262_S	0.610	0.99
148_T	160_N	0.609	0.99
157_E	204_K	0.609	0.99
177_M	206_M	0.608	0.99
182_N	279_W	0.607	0.99
197_L	202_A	0.606	0.99
151_L	155_G	0.601	0.99
73_N	79_N	0.601	0.99
69_D	72_R	0.600	0.99
71_V	101_Q	0.598	0.99
10_G	66_P	0.597	0.99
243_G	250_N	0.596	0.99
58_A	61_I	0.595	0.99
98_H	244_I	0.592	0.99
60_F	147_A	0.592	0.99
215_H	219_S	0.591	0.99
97_I	102_T	0.590	0.99
181_L	215_H	0.590	0.99
239_H	243_G	0.588	0.99
97_I	168_I	0.583	0.99
246_L	250_N	0.577	0.99
63_T	93_D	0.575	0.99
52_A	79_N	0.574	0.99
269_A	274_R	0.573	0.99
220_W	225_L	0.573	0.99
52_A	83_E	0.573	0.99
31_D	70_L	0.572	0.99
12_M	16_M	0.572	0.99
206_M	211_A	0.570	0.99
264_E	271_A	0.570	0.99
15_P	125_S	0.565	0.99
174_N	209_T	0.563	0.99
203_V	225_L	0.557	0.99
18_S	21_L	0.557	0.99
7_I	54_A	0.557	0.99
141_A	144_V	0.553	0.98
102_T	164_P	0.552	0.98
9_L	17_A	0.552	0.98
189_A	220_W	0.551	0.98
30_F	51_P	0.550	0.98
150_I	153_A	0.549	0.98
61_I	89_A	0.547	0.98
127_N	130_T	0.542	0.98
255_P	268_Q	0.541	0.98
18_S	39_H	0.538	0.98
190_V	254_V	0.537	0.98
156_S	208_G	0.535	0.98
75_L	105_L	0.533	0.98
71_V	105_L	0.531	0.98
92_I	151_L	0.530	0.98
5_A	28_R	0.529	0.98
19_N	23_Q	0.529	0.98
62_I	154_M	0.526	0.98
37_V	40_L	0.525	0.98
99_P	169_R	0.521	0.98
15_P	131_G	0.521	0.98
210_A	215_H	0.520	0.98
141_A	148_T	0.519	0.98
166_M	169_R	0.518	0.98
176_Y	191_L	0.516	0.98
146_R	149_P	0.515	0.98
161_A	201_V	0.512	0.97
56_K	86_S	0.512	0.97
242_L	266_Y	0.511	0.97
3_A	58_A	0.509	0.97
100_L	104_K	0.508	0.97
32_V	73_N	0.508	0.97
149_P	153_A	0.508	0.97
62_I	151_L	0.507	0.97
258_L	261_A	0.506	0.97
159_I	201_V	0.502	0.97
255_P	271_A	0.502	0.97
139_G	143_Q	0.502	0.97
59_E	89_A	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ckyA	4	0.9933	100	0.359	Contact Map
1vpdA	1	0.9866	100	0.36	Contact Map
3pduA	4	0.9631	100	0.36	Contact Map
3dojA	3	0.9698	100	0.363	Contact Map
3pefA	5	0.9631	100	0.364	Contact Map
3obbA	4	0.9698	100	0.365	Contact Map
1yb4A	4	0.9765	100	0.372	Contact Map
3ws7A	2	0.943	100	0.377	Contact Map
3g0oA	3	0.9497	100	0.377	Contact Map
2uyyA	3	0.9631	100	0.377	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.