GREMLIN Database
YDIO - Probable acyl-CoA dehydrogenase YdiO
UniProt: P0A9U8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13974
Length: 383 (364)
Sequences: 33927 (19340)
Seq/√Len: 1013.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_K217_E4.0441.00
150_N215_N3.9291.00
290_K328_E3.4841.00
23_N45_A3.3051.00
194_K214_D2.9671.00
142_R220_E2.9491.00
143_K217_E2.9141.00
102_A106_R2.9001.00
112_T117_D2.8761.00
31_T35_N2.7921.00
182_T223_M2.7571.00
66_D69_T2.7111.00
17_R76_E2.7031.00
283_K332_D2.4161.00
262_R266_Q2.3761.00
112_T118_P2.2691.00
254_E295_R2.2301.00
152_Q212_Y2.2251.00
169_A184_W2.1331.00
303_W307_Q2.1111.00
273_P276_H2.0921.00
18_E22_T2.0661.00
102_A105_L2.0511.00
143_K146_K2.0501.00
226_E229_M2.0451.00
101_S104_Q2.0291.00
344_D349_S1.9791.00
264_A336_I1.9511.00
349_S353_R1.9001.00
229_M232_L1.8891.00
57_P97_R1.8841.00
75_M295_R1.8561.00
165_M188_S1.8551.00
324_R365_D1.8081.00
147_V184_W1.7881.00
45_A48_D1.7791.00
257_F291_I1.7661.00
9_Q69_T1.7571.00
152_Q210_E1.7491.00
142_R227_E1.7461.00
143_K148_Y1.7401.00
44_R48_D1.7251.00
79_K258_E1.7191.00
76_E79_K1.6891.00
148_Y217_E1.6851.00
254_E258_E1.6821.00
159_A209_C1.6811.00
268_I273_P1.6771.00
223_M227_E1.6621.00
121_A165_M1.6541.00
279_M282_E1.6361.00
141_T150_N1.6291.00
219_E222_D1.6221.00
107_K221_S1.6191.00
125_T155_F1.6151.00
147_V220_E1.6071.00
264_A280_I1.6031.00
304_Q314_S1.5991.00
190_K216_V1.5931.00
287_M329_V1.5861.00
148_Y215_N1.5491.00
187_D222_D1.5351.00
10_E13_L1.5281.00
145_G220_E1.5271.00
106_R110_E1.5211.00
150_N214_D1.5211.00
293_N321_Y1.5181.00
194_K212_Y1.5071.00
58_E64_P1.4971.00
269_A277_N1.4951.00
300_K304_Q1.4871.00
126_E153_K1.4871.00
14_A18_E1.4851.00
107_K112_T1.4841.00
11_L14_A1.4811.00
340_L346_A1.4751.00
220_E223_M1.4701.00
9_Q66_D1.4691.00
256_A330_I1.4671.00
259_D347_R1.4661.00
196_N210_E1.4631.00
60_F105_L1.4561.00
20_I80_C1.4521.00
280_I336_I1.4451.00
160_K209_C1.4331.00
140_Y184_W1.4251.00
272_K276_H1.4241.00
28_Y32_C1.4201.00
149_I184_W1.4151.00
142_R146_K1.4061.00
292_D300_K1.4021.00
294_M322_C1.3991.00
261_A265_N1.3971.00
9_Q72_L1.3951.00
11_L15_S1.3951.00
259_D262_R1.3881.00
103_E107_K1.3851.00
199_H344_D1.3781.00
32_C205_M1.3571.00
255_C259_D1.3491.00
320_L365_D1.3471.00
327_M359_R1.3441.00
79_K254_E1.3441.00
81_G84_A1.3391.00
331_D356_R1.3371.00
75_M299_L1.3351.00
328_E332_D1.3341.00
287_M332_D1.3311.00
13_L76_E1.3311.00
187_D190_K1.3241.00
99_F236_Y1.3241.00
218_V222_D1.3081.00
103_E221_S1.2961.00
16_I51_I1.2931.00
104_Q108_T1.2861.00
40_R44_R1.2861.00
34_Q199_H1.2831.00
68_V303_W1.2791.00
146_K220_E1.2751.00
67_Y306_D1.2711.00
286_L369_I1.2681.00
75_M254_E1.2681.00
123_A156_I1.2591.00
54_L73_A1.2521.00
253_A291_I1.2431.00
113_L120_Y1.2381.00
193_I216_V1.2301.00
145_G217_E1.2231.00
188_S193_I1.2211.00
247_A298_V1.2201.00
253_A329_V1.2151.00
291_I329_V1.2141.00
260_A333_A1.2121.00
44_R47_A1.2081.00
100_G104_Q1.2081.00
147_V227_E1.2041.00
110_E115_T1.1991.00
331_D359_R1.1991.00
257_F261_A1.1981.00
10_E14_A1.1971.00
107_K222_D1.1961.00
128_G137_T1.1901.00
241_E362_G1.1851.00
66_D306_D1.1811.00
30_R34_Q1.1751.00
56_V114_E1.1741.00
326_A355_V1.1731.00
105_L109_A1.1711.00
300_K303_W1.1701.00
142_R147_V1.1691.00
171_D182_T1.1671.00
190_K222_D1.1631.00
255_C351_F1.1521.00
71_M302_A1.1511.00
108_T164_Y1.1511.00
283_K366_E1.1501.00
231_F235_M1.1471.00
65_A69_T1.1471.00
239_E312_R1.1391.00
316_A368_M1.1391.00
259_D337_M1.1381.00
141_T148_Y1.1351.00
272_K277_N1.1331.00
333_A348_V1.1311.00
13_L72_L1.1231.00
45_A49_N1.1231.00
139_T150_N1.1221.00
288_A292_D1.1211.00
78_S85_F1.1171.00
15_S49_N1.1161.00
118_P163_P1.1081.00
168_L183_L1.1051.00
138_T149_I1.1051.00
28_Y31_T1.0981.00
71_M247_A1.0961.00
356_R359_R1.0951.00
294_M325_T1.0851.00
327_M331_D1.0841.00
167_V186_V1.0811.00
304_Q309_Q1.0791.00
104_Q185_W1.0781.00
149_I167_V1.0771.00
188_S195_I1.0711.00
289_I317_L1.0681.00
47_A52_S1.0661.00
290_K332_D1.0651.00
250_T291_I1.0641.00
192_G216_V1.0631.00
147_V171_D1.0571.00
193_I211_V1.0511.00
217_E220_E1.0451.00
120_Y164_Y1.0411.00
44_R117_D1.0411.00
59_E106_R1.0411.00
168_L181_F1.0341.00
140_Y169_A1.0331.00
359_R365_D1.0171.00
16_I20_I1.0161.00
144_N217_E1.0161.00
141_T215_N1.0151.00
123_A165_M1.0141.00
41_E44_R1.0081.00
290_K325_T1.0051.00
167_V213_L1.0031.00
15_S51_I0.9991.00
324_R328_E0.9901.00
330_I355_V0.9821.00
103_E106_R0.9821.00
182_T227_E0.9821.00
132_D135_S0.9791.00
123_A213_L0.9781.00
324_R359_R0.9711.00
327_M352_W0.9671.00
92_C120_Y0.9671.00
98_R236_Y0.9661.00
149_I169_A0.9651.00
249_S358_E0.9651.00
250_T298_V0.9631.00
202_G354_D0.9631.00
320_L369_I0.9621.00
107_K187_D0.9591.00
265_N275_G0.9591.00
19_L45_A0.9591.00
112_T115_T0.9571.00
264_A274_I0.9551.00
104_Q222_D0.9511.00
172_P180_A0.9481.00
165_M193_I0.9461.00
296_N300_K0.9411.00
184_W223_M0.9381.00
141_T172_P0.9341.00
165_M211_V0.9321.00
256_A351_F0.9301.00
261_A284_L0.9291.00
172_P176_D0.9221.00
201_I352_W0.9111.00
155_F340_L0.9071.00
59_E102_A0.9011.00
365_D369_I0.9001.00
17_R21_T0.8981.00
325_T328_E0.8971.00
33_D353_R0.8961.00
99_F233_N0.8931.00
121_A188_S0.8891.00
323_A365_D0.8891.00
34_Q344_D0.8891.00
149_I218_V0.8861.00
159_A195_I0.8851.00
324_R369_I0.8821.00
16_I73_A0.8821.00
264_A275_G0.8811.00
288_A317_L0.8791.00
357_C361_G0.8771.00
92_C166_L0.8771.00
40_R163_P0.8731.00
19_L49_N0.8731.00
301_V318_A0.8701.00
154_T210_E0.8681.00
191_P217_E0.8661.00
164_Y187_D0.8621.00
203_W357_C0.8621.00
258_E262_R0.8581.00
286_L290_K0.8531.00
334_I352_W0.8511.00
121_A162_Y0.8481.00
68_V306_D0.8431.00
56_V93_I0.8411.00
131_S367_I0.8401.00
20_I77_V0.8371.00
101_S105_L0.8371.00
262_R265_N0.8301.00
196_N212_Y0.8291.00
358_E361_G0.8261.00
19_L23_N0.8251.00
163_P189_S0.8241.00
327_M356_R0.8231.00
260_A336_I0.8211.00
264_A284_L0.8211.00
325_T329_V0.8191.00
281_Q370_Y0.8191.00
290_K321_Y0.8141.00
124_L238_F0.8141.00
201_I349_S0.8121.00
28_Y41_E0.8121.00
170_R181_F0.8101.00
57_P60_F0.8091.00
147_V223_M0.8071.00
155_F343_T0.8061.00
282_E370_Y0.8051.00
260_A337_M0.8041.00
19_L46_L0.8031.00
334_I348_V0.8021.00
252_F326_A0.8001.00
146_K219_E0.7991.00
21_T79_K0.7971.00
252_F351_F0.7951.00
46_L51_I0.7931.00
253_A325_T0.7911.00
68_V72_L0.7891.00
195_I211_V0.7891.00
72_L76_E0.7891.00
282_E286_L0.7891.00
68_V299_L0.7881.00
60_F102_A0.7861.00
13_L17_R0.7841.00
190_K193_I0.7831.00
118_P164_Y0.7821.00
213_L216_V0.7811.00
140_Y171_D0.7811.00
164_Y185_W0.7811.00
184_W218_V0.7811.00
123_A167_V0.7761.00
245_N362_G0.7761.00
9_Q68_V0.7741.00
252_F355_V0.7731.00
55_G70_Q0.7731.00
140_Y147_V0.7731.00
108_T185_W0.7711.00
292_D295_R0.7701.00
330_I351_F0.7661.00
283_K336_I0.7631.00
30_R350_R0.7621.00
42_F84_A0.7621.00
289_I321_Y0.7601.00
260_A264_A0.7591.00
331_D352_W0.7591.00
292_D296_N0.7581.00
149_I186_V0.7581.00
15_S18_E0.7571.00
287_M333_A0.7571.00
182_T228_G0.7521.00
136_A168_L0.7521.00
330_I352_W0.7501.00
166_L183_L0.7441.00
250_T294_M0.7421.00
146_K221_S0.7421.00
123_A211_V0.7411.00
138_T153_K0.7411.00
31_T34_Q0.7401.00
41_E45_A0.7401.00
170_R173_Q0.7401.00
246_A318_A0.7341.00
352_W356_R0.7321.00
126_E138_T0.7291.00
311_L314_S0.7291.00
182_T225_G0.7271.00
21_T80_C0.7261.00
136_A181_F0.7251.00
263_Y340_L0.7241.00
259_D351_F0.7221.00
286_L332_D0.7221.00
278_Q282_E0.7181.00
172_P228_G0.7161.00
286_L328_E0.7151.00
20_I24_F0.7151.00
274_I277_N0.7131.00
257_F288_A0.7081.00
256_A333_A0.7081.00
171_D180_A0.7071.00
59_E62_G0.7071.00
40_R161_E0.7071.00
122_L234_V0.7061.00
21_T25_P0.7051.00
59_E105_L0.7041.00
289_I320_L0.7041.00
163_P188_S0.7021.00
297_M317_L0.7011.00
335_Q356_R0.6991.00
166_L224_V0.6991.00
246_A322_C0.6971.00
199_H204_H0.6971.00
257_F376_I0.6951.00
321_Y325_T0.6941.00
277_N281_Q0.6911.00
297_M318_A0.6911.00
93_I113_L0.6891.00
246_A298_V0.6881.00
249_S323_A0.6861.00
160_K207_S0.6861.00
79_K255_C0.6851.00
328_E331_D0.6821.00
281_Q373_G0.6821.00
370_Y374_R0.6791.00
368_M371_V0.6791.00
108_T222_D0.6781.00
189_S193_I0.6771.00
254_E288_A0.6761.00
72_L299_L0.6761.00
293_N297_M0.6741.00
171_D227_E0.6731.00
229_M233_N0.6731.00
113_L164_Y0.6721.00
302_A306_D0.6671.00
59_E64_P0.6651.00
93_I109_A0.6621.00
350_R354_D0.6611.00
18_E21_T0.6601.00
170_R180_A0.6591.00
330_I348_V0.6591.00
326_A330_I0.6581.00
54_L65_A0.6581.00
298_V322_C0.6571.00
124_L133_N0.6551.00
203_W361_G0.6541.00
334_I341_G0.6531.00
200_K208_T0.6521.00
24_F42_F0.6521.00
29_F350_R0.6511.00
177_P180_A0.6421.00
156_I211_V0.6411.00
136_A170_R0.6401.00
223_M226_E0.6401.00
202_G342_Y0.6391.00
12_L73_A0.6371.00
42_F45_A0.6361.00
13_L75_M0.6351.00
290_K293_N0.6341.00
36_G199_H0.6331.00
108_T118_P0.6301.00
96_M100_G0.6281.00
143_K220_E0.6261.00
317_L372_A0.6261.00
100_G105_L0.6251.00
168_L234_V0.6221.00
204_H344_D0.6221.00
220_E227_E0.6201.00
83_P205_M0.6181.00
295_R299_L0.6181.00
145_G221_S0.6171.00
337_M348_V0.6171.00
364_T367_I0.6131.00
173_Q176_D0.6131.00
142_R148_Y0.6131.00
313_T375_Q0.6121.00
87_I91_Q0.6121.00
297_M321_Y0.6111.00
82_A252_F0.6111.00
138_T213_L0.6081.00
56_V60_F0.6061.00
159_A211_V0.6051.00
204_H354_D0.6021.00
95_S237_N0.6001.00
310_S314_S0.5981.00
280_I284_L0.5951.00
243_L302_A0.5881.00
320_L372_A0.5871.00
144_N148_Y0.5871.00
260_A287_M0.5851.00
253_A294_M0.5841.00
270_F277_N0.5831.00
57_P62_G0.5821.00
139_T173_Q0.5791.00
305_A311_L0.5771.00
280_I283_K0.5771.00
267_R270_F0.5771.00
95_S99_F0.5741.00
255_C258_E0.5731.00
167_V216_V0.5721.00
127_P152_Q0.5711.00
40_R119_A0.5701.00
253_A256_A0.5701.00
60_F106_R0.5681.00
186_V213_L0.5671.00
189_S192_G0.5661.00
30_R347_R0.5661.00
250_T254_E0.5641.00
247_A251_G0.5641.00
184_W220_E0.5631.00
292_D297_M0.5621.00
184_W222_D0.5581.00
283_K335_Q0.5561.00
138_T151_G0.5551.00
12_L69_T0.5541.00
300_K314_S0.5521.00
29_F33_D0.5521.00
124_L168_L0.5521.00
289_I293_N0.5511.00
255_C347_R0.5511.00
227_E230_G0.5511.00
157_T208_T0.5481.00
339_G342_Y0.5481.00
294_M321_Y0.5471.00
269_A274_I0.5461.00
283_K286_L0.5451.00
17_R79_K0.5451.00
226_E233_N0.5441.00
12_L16_I0.5441.00
97_R105_L0.5421.00
239_E315_A0.5421.00
58_E61_G0.5401.00
92_C113_L0.5381.00
286_L289_I0.5371.00
24_F84_A0.5371.00
297_M301_V0.5361.00
89_N93_I0.5341.00
29_F32_C0.5341.00
238_F241_E0.5331.00
327_M355_V0.5331.00
104_Q107_K0.5331.00
72_L75_M0.5331.00
267_R339_G0.5331.00
17_R80_C0.5321.00
286_L324_R0.5311.00
294_M318_A0.5291.00
186_V216_V0.5281.00
70_Q244_I0.5281.00
139_T172_P0.5271.00
36_G344_D0.5261.00
308_H311_L0.5261.00
53_M63_I0.5251.00
323_A358_E0.5241.00
290_K324_R0.5231.00
24_F27_E0.5211.00
164_Y222_D0.5211.00
33_D204_H0.5201.00
356_R360_I0.5191.00
320_L324_R0.5191.00
185_W224_V0.5191.00
288_A376_I0.5181.00
161_E207_S0.5161.00
37_T40_R0.5161.00
197_P210_E0.5131.00
243_L298_V0.5131.00
71_M299_L0.5121.00
294_M329_V0.5121.00
138_T167_V0.5111.00
171_D184_W0.5101.00
142_R184_W0.5101.00
287_M336_I0.5091.00
146_K222_D0.5091.00
225_G228_G0.5081.00
176_D179_K0.5081.00
268_I276_H0.5081.00
53_M114_E0.5081.00
193_I213_L0.5061.00
129_A137_T0.5061.00
88_T113_L0.5041.00
67_Y305_A0.5031.00
263_Y266_Q0.5031.00
60_F110_E0.5021.00
70_Q90_G0.5021.00
195_I209_C0.5021.00
274_I280_I0.5011.00
367_I370_Y0.5011.00
238_F242_R0.5011.00
47_A116_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rm7A 4 0.9687 100 0.078 Contact Map
4l1fA 4 0.9817 100 0.083 Contact Map
2d29A 4 0.9869 100 0.089 Contact Map
4p13A 4 0.9922 100 0.092 Contact Map
3pfdA 4 0.9556 100 0.093 Contact Map
4irnA 4 0.9713 100 0.095 Contact Map
1ivhA 4 0.9843 100 0.095 Contact Map
2jifA 4 0.9817 100 0.095 Contact Map
1bucA 4 0.9791 100 0.096 Contact Map
4m9aA 4 0.9713 100 0.097 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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