GREMLIN Database
PUUR - HTH-type transcriptional regulator PuuR
UniProt: P0A9U6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12431
Length: 185 (172)
Sequences: 6011 (4046)
Seq/√Len: 308.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_E151_V3.9811.00
136_E175_R3.7241.00
140_V147_D3.1151.00
140_V167_S3.0641.00
139_I174_C2.9991.00
140_V149_H2.9541.00
140_V169_T2.9161.00
111_F175_R2.8401.00
138_E149_H2.6871.00
113_T173_I2.5891.00
113_T175_R2.3151.00
115_Q173_I2.2951.00
136_E152_A2.2291.00
25_R29_L2.1811.00
23_Q37_I2.0331.00
24_R28_E2.0211.00
85_L96_K1.9641.00
144_N162_I1.9621.00
142_T147_D1.9351.00
14_E18_Q1.9071.00
141_L156_Y1.8691.00
15_I61_L1.8561.00
26_A59_Y1.7931.00
119_T167_S1.7601.00
25_R28_E1.7301.00
24_R34_H1.6941.00
81_N154_Q1.6861.00
135_L177_I1.6561.00
142_T167_S1.6531.00
109_M131_I1.6281.00
21_L29_L1.5921.00
142_T165_S1.5841.00
138_E170_S1.5351.00
150_L154_Q1.5201.00
136_E172_G1.5011.00
139_I176_I1.4971.00
132_G178_S1.4951.00
96_K111_F1.4921.00
126_H130_E1.4481.00
132_G156_Y1.4471.00
109_M179_A1.4351.00
7_A43_D1.4241.00
130_E164_H1.4141.00
133_T177_I1.3991.00
138_E169_T1.3781.00
149_H169_T1.3681.00
36_A40_I1.3661.00
33_T36_A1.3601.00
82_Q154_Q1.3521.00
136_E173_I1.3431.00
32_L51_T1.3321.00
96_K113_T1.3281.00
15_I19_Q1.3261.00
94_S115_Q1.3131.00
19_Q60_G1.2971.00
40_I47_P1.2771.00
11_R14_E1.2731.00
79_V156_Y1.2651.00
134_V174_C1.2551.00
142_T145_G1.2521.00
62_S65_E1.2461.00
151_V154_Q1.2421.00
81_N84_D1.2321.00
38_S42_Q1.2091.00
87_E96_K1.2031.00
129_E157_A1.2031.00
21_L26_A1.1761.00
170_S174_C1.1511.00
94_S113_T1.1501.00
13_S17_Q1.1451.00
131_I155_S1.1451.00
126_H164_H1.1431.00
119_T165_S1.1321.00
127_Q161_G1.1151.00
26_A58_V1.1101.00
30_S58_V1.0961.00
116_P172_G1.0921.00
36_A45_V1.0821.00
143_I162_I1.0781.00
15_I59_Y1.0751.00
114_Y176_I1.0751.00
111_F133_T1.0691.00
168_N173_I1.0591.00
134_V139_I1.0531.00
135_L175_R1.0321.00
16_R41_E1.0321.00
89_G94_S1.0281.00
143_I158_I1.0141.00
32_L36_A1.0081.00
77_Q148_Y1.0011.00
144_N163_P0.9951.00
9_G43_D0.9871.00
116_P173_I0.9811.00
79_V148_Y0.9801.00
21_L25_R0.9791.00
87_E94_S0.9721.00
111_F135_L0.9701.00
56_L61_L0.9691.00
56_L66_F0.9681.00
111_F177_I0.9671.00
112_E176_I0.9531.00
15_I18_Q0.9471.00
23_Q38_S0.9451.00
36_A51_T0.9371.00
107_L157_A0.9281.00
133_T155_S0.9081.00
116_P168_N0.8971.00
134_V176_I0.8871.00
27_A34_H0.8821.00
36_A39_T0.8821.00
105_R129_E0.8781.00
39_T44_K0.8711.00
8_P52_L0.8641.00
32_L37_I0.8591.00
105_R157_A0.8431.00
35_S38_S0.8331.00
52_L63_L0.8241.00
29_L58_V0.8211.00
124_I164_H0.8141.00
39_T45_V0.8121.00
10_K14_E0.8121.00
40_I55_L0.8101.00
82_Q152_A0.7951.00
53_Q57_K0.7951.00
81_N151_V0.7871.00
131_I179_A0.7871.00
93_V112_E0.7851.00
23_Q34_H0.7800.99
12_L59_Y0.7780.99
130_E160_T0.7660.99
107_L179_A0.7560.99
80_I84_D0.7560.99
158_I164_H0.7550.99
11_R69_E0.7540.99
30_S34_H0.7530.99
77_Q80_I0.7510.99
37_I55_L0.7480.99
23_Q30_S0.7360.99
12_L55_L0.7340.99
40_I46_S0.7290.99
30_S37_I0.7280.99
35_S39_T0.7270.99
11_R15_I0.7260.99
124_I161_G0.7250.99
158_I166_F0.7240.99
124_I166_F0.7240.99
75_E78_V0.7180.99
114_Y174_C0.7170.99
138_E152_A0.7150.99
124_I130_E0.7150.99
46_S50_S0.7090.99
61_L66_F0.7060.99
12_L56_L0.7010.99
143_I148_Y0.7000.99
99_H109_M0.6970.99
80_I85_L0.6970.99
95_M110_I0.6880.99
114_Y118_T0.6870.99
117_G171_A0.6860.99
109_M157_A0.6860.99
116_P170_S0.6850.99
10_K13_S0.6810.99
107_L131_I0.6790.99
97_L110_I0.6790.99
168_N171_A0.6680.98
148_Y156_Y0.6680.98
79_V154_Q0.6670.98
49_I52_L0.6650.98
27_A37_I0.6590.98
38_S67_F0.6530.98
64_S108_A0.6510.98
30_S54_K0.6490.98
53_Q63_L0.6470.98
128_G160_T0.6470.98
11_R66_F0.6420.98
80_I86_I0.6410.98
108_A180_H0.6410.98
160_T164_H0.6400.98
30_S59_Y0.6340.98
79_V150_L0.6320.98
99_H157_A0.6300.98
131_I157_A0.6300.98
29_L60_G0.6280.98
22_S25_R0.6240.98
7_A10_K0.6220.98
134_V151_V0.6200.97
112_E178_S0.6200.97
63_L67_F0.6180.97
114_Y139_I0.6160.97
55_L59_Y0.6150.97
42_Q45_V0.6140.97
51_T54_K0.6140.97
124_I127_Q0.6140.97
95_M99_H0.6130.97
77_Q84_D0.6110.97
129_E159_N0.6070.97
23_Q33_T0.6060.97
115_Q118_T0.6040.97
36_A48_A0.6040.97
12_L38_S0.6040.97
46_S51_T0.6040.97
106_T181_T0.6020.97
22_S34_H0.5910.97
92_G115_Q0.5900.97
21_L59_Y0.5760.96
81_N85_L0.5760.96
123_R163_P0.5740.96
34_H51_T0.5720.96
116_P171_A0.5690.96
150_L156_Y0.5690.96
76_P146_Q0.5690.96
64_S131_I0.5680.96
33_T51_T0.5660.96
147_D169_T0.5640.96
65_E68_S0.5620.96
23_Q42_Q0.5590.95
32_L47_P0.5570.95
83_D151_V0.5570.95
60_G65_E0.5560.95
146_Q162_I0.5550.95
131_I158_I0.5530.95
109_M133_T0.5530.95
147_D167_S0.5500.95
45_V49_I0.5490.95
14_E17_Q0.5470.95
121_G165_S0.5460.95
32_L58_V0.5440.95
117_G168_N0.5410.95
49_I63_L0.5400.94
47_P51_T0.5390.94
152_A175_R0.5330.94
45_V48_A0.5300.94
49_I95_M0.5300.94
134_V150_L0.5300.94
82_Q151_V0.5290.94
27_A31_G0.5290.94
166_F178_S0.5270.94
37_I132_G0.5230.93
149_H171_A0.5230.93
98_V109_M0.5230.93
53_Q166_F0.5210.93
10_K17_Q0.5190.93
54_K58_V0.5160.93
61_L65_E0.5160.93
139_I166_F0.5150.93
132_G139_I0.5150.93
86_I94_S0.5140.93
23_Q27_A0.5130.93
91_Q115_Q0.5120.93
145_G162_I0.5120.93
117_G170_S0.5100.93
67_F114_Y0.5060.92
116_P169_T0.5060.92
98_V155_S0.5050.92
132_G141_L0.5040.92
33_T45_V0.5040.92
107_L181_T0.5040.92
50_S108_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y9qA 1 0.9459 100 0.367 Contact Map
2bnmA 3 0.973 100 0.369 Contact Map
4yarA 2 0.9676 100 0.384 Contact Map
4b29A 1 0.9568 100 0.445 Contact Map
4qm9A 1 0.7351 100 0.465 Contact Map
2p5tA 2 0.5189 99.9 0.501 Contact Map
4lukA 2 0.7784 99.9 0.526 Contact Map
1j58A 5 0.7892 99.9 0.53 Contact Map
4e2qA 6 0.7243 99.9 0.534 Contact Map
3bu7A 3 0.8541 99.8 0.595 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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