GREMLIN Database
TAS - Protein tas
UniProt: P0A9T4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13093
Length: 346 (287)
Sequences: 26863 (16658)
Seq/√Len: 983.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_Y316_K3.5851.00
29_E71_N3.1541.00
115_H172_K3.0411.00
74_A122_Q3.0411.00
284_H330_V2.9221.00
327_S330_V2.5521.00
111_R170_A2.5101.00
38_Y42_Q2.5051.00
114_L167_Y2.5001.00
283_R333_E2.4741.00
111_R166_E2.3601.00
5_R12_E2.2971.00
165_A169_R2.2961.00
278_V282_R2.1621.00
125_Y174_R2.1311.00
64_L67_T2.0831.00
328_E332_A2.0351.00
298_R331_L2.0321.00
78_S81_K2.0011.00
17_G46_L1.9401.00
4_H15_T1.9321.00
283_R330_V1.9131.00
42_Q316_K1.8981.00
276_A279_D1.8611.00
107_R166_E1.8581.00
130_Q203_T1.8551.00
86_S126_L1.8551.00
279_D333_E1.8481.00
286_L324_L1.8471.00
166_E169_R1.8321.00
166_E170_A1.8201.00
312_M316_K1.8031.00
28_S31_D1.8021.00
38_Y312_M1.7811.00
332_A336_A1.7671.00
222_V226_E1.7521.00
33_H71_N1.7381.00
88_V110_I1.7191.00
163_A166_E1.7111.00
39_A44_I1.7071.00
187_M191_H1.7071.00
320_E323_H1.7021.00
42_Q319_I1.6881.00
116_D120_R1.6721.00
107_R111_R1.6701.00
67_T120_R1.6651.00
33_H72_W1.6621.00
287_D317_T1.6561.00
223_S230_L1.6521.00
88_V129_Y1.6471.00
114_L129_Y1.6401.00
20_T47_I1.6371.00
84_I123_T1.6241.00
111_R115_H1.6151.00
130_Q231_L1.6051.00
165_A199_P1.6041.00
112_E116_D1.5931.00
294_A324_L1.5901.00
86_S117_S1.5871.00
85_A130_Q1.5751.00
29_E33_H1.5731.00
31_D34_A1.5551.00
286_L290_Q1.5101.00
51_E113_A1.5081.00
33_H37_D1.4991.00
299_Q335_E1.4971.00
38_Y41_A1.4961.00
218_G221_E1.4931.00
36_L72_W1.4781.00
224_Q300_P1.4721.00
182_T185_G1.4701.00
229_E304_S1.4611.00
11_L175_Y1.4551.00
114_L126_L1.4451.00
187_M222_V1.4441.00
40_V82_L1.4211.00
276_A333_E1.3781.00
173_I176_I1.3761.00
11_L83_I1.3661.00
111_R163_A1.3651.00
190_L226_E1.3651.00
286_L291_M1.3491.00
126_L173_I1.3481.00
183_A222_V1.3471.00
333_E336_A1.3431.00
116_D119_K1.3381.00
70_G122_Q1.3291.00
37_D41_A1.3131.00
167_Y173_I1.2991.00
221_E225_Y1.2971.00
187_M225_Y1.2911.00
71_N122_Q1.2901.00
107_R162_D1.2851.00
279_D283_R1.2821.00
67_T71_N1.2691.00
316_K320_E1.2661.00
175_Y202_V1.2611.00
287_D290_Q1.2601.00
47_I69_V1.2601.00
134_P185_G1.2601.00
115_H119_K1.2601.00
206_N230_L1.2591.00
190_L222_V1.2571.00
313_D316_K1.2451.00
224_Q301_F1.2311.00
207_P212_N1.2301.00
131_V164_L1.2231.00
168_Q199_P1.2161.00
45_N83_I1.2101.00
34_A312_M1.2071.00
280_I291_M1.2051.00
5_R10_S1.2051.00
294_A298_R1.2011.00
35_Q315_L1.1991.00
128_L203_T1.1981.00
278_V288_P1.1941.00
30_A34_A1.1921.00
210_L334_I1.1871.00
275_A278_V1.1841.00
34_A38_Y1.1801.00
46_L85_A1.1771.00
79_R123_T1.1761.00
309_A315_L1.1741.00
66_E117_S1.1701.00
158_L192_L1.1631.00
83_I128_L1.1621.00
121_L126_L1.1471.00
164_L176_I1.1271.00
275_A279_D1.1091.00
296_V305_T1.1041.00
290_Q320_E1.1031.00
20_T69_V1.0991.00
79_R125_Y1.0951.00
15_T297_R1.0951.00
279_D282_R1.0941.00
159_D162_D1.0841.00
194_D200_R1.0811.00
37_D72_W1.0771.00
107_R159_D1.0771.00
73_L82_L1.0761.00
115_H170_A1.0741.00
109_N112_E1.0721.00
46_L231_L1.0721.00
162_D166_E1.0691.00
67_T119_K1.0671.00
246_L278_V1.0631.00
107_R163_A1.0481.00
309_A314_Q1.0471.00
290_Q317_T1.0451.00
15_T322_L1.0451.00
178_V201_I1.0431.00
14_S45_N1.0401.00
187_M226_E1.0401.00
91_P104_A1.0391.00
14_S44_I1.0301.00
108_K112_E1.0251.00
36_L47_I1.0241.00
220_A224_Q1.0151.00
186_V228_V1.0141.00
168_Q202_V1.0111.00
158_L188_R1.0081.00
167_Y172_K1.0071.00
277_Y288_P1.0051.00
208_Y299_Q1.0051.00
176_I201_I1.0021.00
74_A77_G0.9991.00
315_L319_I0.9991.00
111_R114_L0.9991.00
165_A168_Q0.9951.00
169_R194_D0.9861.00
163_A167_Y0.9721.00
297_R321_S0.9641.00
9_S202_V0.9601.00
42_Q320_E0.9601.00
40_V78_S0.9561.00
51_E109_N0.9541.00
329_D332_A0.9541.00
215_F230_L0.9541.00
188_R191_H0.9471.00
111_R167_Y0.9461.00
210_L292_A0.9411.00
332_A335_E0.9361.00
224_Q302_V0.9311.00
299_Q331_L0.9261.00
127_D174_R0.9251.00
317_T320_E0.9231.00
268_E272_K0.9221.00
167_Y170_A0.9191.00
203_T231_L0.9151.00
188_R192_L0.9151.00
162_D165_A0.9151.00
34_A37_D0.9131.00
9_S175_Y0.9131.00
178_V186_V0.9081.00
183_A187_M0.9041.00
85_A128_L0.8981.00
217_V221_E0.8941.00
313_D317_T0.8881.00
280_I284_H0.8861.00
246_L275_A0.8811.00
231_L304_S0.8781.00
180_N233_Y0.8761.00
31_D312_M0.8711.00
106_D109_N0.8681.00
329_D333_E0.8671.00
220_A230_L0.8621.00
44_I319_I0.8601.00
18_L39_A0.8551.00
298_R328_E0.8541.00
221_E224_Q0.8541.00
298_R325_E0.8511.00
20_T65_T0.8481.00
247_N275_A0.8471.00
51_E120_R0.8461.00
29_E68_Y0.8461.00
229_E303_A0.8431.00
276_A337_V0.8421.00
29_E64_L0.8391.00
113_A116_D0.8351.00
110_I167_Y0.8341.00
311_T314_Q0.8331.00
161_L189_Y0.8331.00
66_E120_R0.8261.00
112_E115_H0.8261.00
204_I223_S0.8221.00
18_L23_F0.8181.00
310_T314_Q0.8141.00
232_A305_T0.8121.00
133_W180_N0.8101.00
282_R285_G0.7911.00
272_K275_A0.7881.00
16_L297_R0.7851.00
178_V181_E0.7811.00
326_L331_L0.7811.00
37_D78_S0.7771.00
271_Q275_A0.7761.00
78_S82_L0.7761.00
161_L201_I0.7761.00
284_H327_S0.7761.00
213_R216_E0.7741.00
30_A33_H0.7711.00
23_F35_Q0.7711.00
36_L69_V0.7691.00
222_V225_Y0.7681.00
36_L40_V0.7671.00
17_G307_L0.7611.00
17_G304_S0.7591.00
49_V69_V0.7561.00
35_Q312_M0.7561.00
37_D77_G0.7521.00
161_L176_I0.7511.00
213_R335_E0.7511.00
157_L192_L0.7501.00
235_C307_L0.7471.00
265_Y268_E0.7451.00
110_I160_T0.7381.00
80_E125_Y0.7381.00
280_I330_V0.7361.00
85_A231_L0.7361.00
32_A68_Y0.7321.00
8_H227_G0.7291.00
118_L172_K0.7261.00
164_L168_Q0.7251.00
289_A317_T0.7251.00
105_L131_V0.7201.00
232_A235_C0.7171.00
223_S228_V0.7141.00
40_V47_I0.7141.00
272_K276_A0.7111.00
160_T163_A0.7101.00
294_A321_S0.7091.00
208_Y296_V0.7081.00
183_A218_G0.7071.00
51_E116_D0.7041.00
64_L68_Y0.7031.00
213_R338_H0.7021.00
291_M326_L0.7001.00
211_L274_V0.6951.00
277_Y334_I0.6921.00
118_L123_T0.6891.00
40_V81_K0.6881.00
295_F335_E0.6841.00
283_R327_S0.6821.00
215_F220_A0.6801.00
8_H202_V0.6801.00
157_L160_T0.6761.00
117_S129_Y0.6761.00
274_V278_V0.6731.00
6_I229_E0.6701.00
280_I337_V0.6691.00
178_V204_I0.6691.00
293_L321_S0.6691.00
211_L240_T0.6641.00
156_S159_D0.6631.00
326_L330_V0.6621.00
23_F32_A0.6611.00
45_N81_K0.6611.00
13_V46_L0.6591.00
187_M190_L0.6581.00
247_N268_E0.6571.00
40_V45_N0.6571.00
286_L320_E0.6551.00
284_H291_M0.6551.00
130_Q177_G0.6531.00
190_L200_R0.6501.00
291_M324_L0.6471.00
49_V65_T0.6461.00
208_Y220_A0.6461.00
88_V105_L0.6441.00
280_I333_E0.6421.00
134_P181_E0.6411.00
135_Q154_A0.6391.00
235_C296_V0.6381.00
114_L163_A0.6361.00
219_L223_S0.6351.00
111_R172_K0.6341.00
240_T274_V0.6301.00
190_L228_V0.6281.00
291_M330_V0.6271.00
210_L338_H0.6261.00
73_L78_S0.6261.00
178_V189_Y0.6261.00
330_V333_E0.6241.00
291_M334_I0.6221.00
277_Y292_A0.6211.00
208_Y213_R0.6191.00
296_V303_A0.6191.00
168_Q173_I0.6171.00
104_A109_N0.6161.00
185_G188_R0.6161.00
292_A296_V0.6151.00
17_G306_L0.6141.00
281_A291_M0.6121.00
314_Q317_T0.6111.00
110_I163_A0.6101.00
69_V72_W0.6091.00
165_A176_I0.6091.00
286_L294_A0.6081.00
42_Q315_L0.6071.00
290_Q324_L0.6071.00
271_Q274_V0.6061.00
232_A302_V0.6051.00
156_S188_R0.6041.00
86_S129_Y0.6041.00
297_R305_T0.6031.00
131_V160_T0.6021.00
11_L174_R0.6021.00
21_M234_S0.6021.00
168_Q176_I0.6021.00
47_I73_L0.6011.00
126_L129_Y0.5961.00
135_Q155_V0.5961.00
35_Q309_A0.5951.00
40_V72_W0.5941.00
87_K132_H0.5901.00
294_A325_E0.5891.00
51_E92_S0.5881.00
88_V113_A0.5881.00
63_G120_R0.5871.00
183_A219_L0.5861.00
177_G203_T0.5841.00
48_D205_Q0.5821.00
33_H68_Y0.5801.00
176_I199_P0.5801.00
293_L318_N0.5771.00
13_V304_S0.5761.00
129_Y173_I0.5751.00
168_Q200_R0.5741.00
168_Q175_Y0.5731.00
208_Y216_E0.5721.00
184_F187_M0.5721.00
216_E221_E0.5701.00
93_R102_D0.5701.00
39_A47_I0.5691.00
128_L177_G0.5661.00
165_A194_D0.5651.00
264_R267_G0.5651.00
165_A193_A0.5651.00
66_E86_S0.5641.00
54_P64_L0.5631.00
206_N219_L0.5631.00
6_I9_S0.5601.00
158_L162_D0.5601.00
155_V159_D0.5601.00
46_L83_I0.5581.00
235_C293_L0.5581.00
281_A284_H0.5561.00
312_M315_L0.5551.00
193_A201_I0.5541.00
18_L35_Q0.5521.00
161_L193_A0.5521.00
214_S217_V0.5441.00
24_G65_T0.5441.00
114_L118_L0.5431.00
17_G231_L0.5431.00
284_H324_L0.5421.00
118_L124_D0.5391.00
181_E186_V0.5391.00
99_I102_D0.5371.00
67_T122_Q0.5331.00
16_L322_L0.5321.00
157_L185_G0.5291.00
31_D313_D0.5291.00
36_L73_L0.5291.00
114_L172_K0.5281.00
109_N113_A0.5261.00
309_A318_N0.5241.00
91_P103_Q0.5241.00
184_F188_R0.5191.00
267_G270_T0.5191.00
79_R127_D0.5181.00
189_Y201_I0.5171.00
240_T270_T0.5111.00
201_I228_V0.5091.00
72_W77_G0.5081.00
191_H226_E0.5081.00
14_S46_L0.5071.00
9_S168_Q0.5071.00
70_G74_A0.5061.00
247_N271_Q0.5061.00
105_L160_T0.5051.00
118_L126_L0.5051.00
170_A173_I0.5051.00
269_Q273_A0.5031.00
269_Q272_K0.5031.00
281_A288_P0.5021.00
91_P102_D0.5021.00
115_H167_Y0.5011.00
181_E204_I0.5001.00
280_I283_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lqaA 2 1 100 0.12 Contact Map
1pz1A 1 0.9017 100 0.167 Contact Map
4xk2A 5 0.8584 100 0.171 Contact Map
1pyfA 1 0.8815 100 0.172 Contact Map
3v0sA 1 0.7832 100 0.174 Contact Map
3n2tA 1 0.9017 100 0.175 Contact Map
3eauA 3 0.9075 100 0.179 Contact Map
3lutA 3 0.9046 100 0.18 Contact Map
3erpA 6 0.8497 100 0.186 Contact Map
2bp1A 2 0.8699 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.