GREMLIN Database
SERA - D-3-phosphoglycerate dehydrogenase
UniProt: P0A9T0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10944
Length: 410 (312)
Sequences: 7710 (4970)
Seq/√Len: 281.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_G225_E4.4501.00
245_D248_A3.7371.00
223_A251_D3.4321.00
231_P257_H2.7701.00
198_S228_L2.7131.00
154_L170_A2.6531.00
196_H199_D2.5951.00
153_K176_Y2.5741.00
67_E96_K2.4951.00
219_N267_P2.3471.00
67_E71_N2.2531.00
117_I170_A2.2491.00
254_A284_F2.2231.00
124_L206_V2.2011.00
202_N228_L2.1721.00
201_L225_E2.1531.00
126_G129_E2.1191.00
153_K178_Y2.1101.00
221_M226_I2.0991.00
227_S257_H2.0311.00
155_G200_L2.0261.00
233_S258_L2.0241.00
152_K299_E2.0051.00
314_K319_G1.9981.00
117_I173_L1.9361.00
213_E242_T1.9261.00
55_H77_V1.9141.00
155_G204_S1.8971.00
44_D68_D1.8951.00
235_L244_V1.8621.00
178_Y203_M1.8541.00
251_D255_S1.8421.00
118_G127_V1.8321.00
53_D75_K1.8051.00
14_L54_A1.7991.00
250_C284_F1.7951.00
154_L175_M1.7941.00
123_L260_G1.7611.00
201_L221_M1.7571.00
94_A101_V1.7431.00
254_A280_P1.7421.00
21_Q25_E1.7371.00
93_A96_K1.7321.00
234_L260_G1.7251.00
234_L259_A1.7241.00
199_D203_M1.7191.00
131_N135_H1.6921.00
44_D66_T1.6791.00
43_D46_Q1.6671.00
115_L294_G1.6521.00
116_V166_L1.6491.00
71_N97_R1.6461.00
219_N245_D1.6431.00
223_A227_S1.6241.00
209_L243_V1.6111.00
215_P218_K1.5861.00
224_K228_L1.5771.00
226_I235_L1.5761.00
25_E29_A1.5661.00
70_I97_R1.5581.00
156_I163_G1.5441.00
213_E218_K1.5211.00
170_A175_M1.5171.00
100_P324_A1.5151.00
229_M233_S1.5151.00
55_H75_K1.5021.00
44_D48_K1.4991.00
70_I79_I1.4941.00
205_D230_K1.4721.00
226_I252_A1.4591.00
25_E28_R1.4591.00
56_F78_A1.4571.00
200_L204_S1.4511.00
250_C254_A1.4421.00
195_Q199_D1.4311.00
166_L208_S1.4301.00
211_V243_V1.4281.00
198_S225_E1.4261.00
314_K322_L1.4201.00
78_A102_F1.4201.00
95_A326_N1.4141.00
166_L210_H1.3891.00
284_F287_V1.3871.00
223_A248_A1.3831.00
306_L310_G1.3771.00
114_E169_L1.3751.00
120_L206_V1.3681.00
307_E323_S1.3611.00
221_M225_E1.3541.00
123_L234_L1.3301.00
48_K72_A1.3291.00
159_Y179_F1.3221.00
176_Y193_Q1.3191.00
165_Q168_I1.3161.00
93_A97_R1.3081.00
36_E54_A1.3001.00
208_S238_A1.2961.00
89_V94_A1.2911.00
67_E93_A1.2811.00
247_P280_P1.2801.00
315_Y321_T1.2791.00
210_H238_A1.2761.00
253_L287_V1.2671.00
157_I207_V1.2591.00
30_A313_I1.2511.00
66_T69_V1.2451.00
192_T195_Q1.2451.00
132_A136_R1.2441.00
226_I229_M1.2421.00
156_I208_S1.2411.00
78_A312_L1.2361.00
78_A315_Y1.2311.00
108_N295_G1.2291.00
122_L128_P1.2261.00
168_I174_G1.2141.00
157_I220_M1.2111.00
232_G257_H1.2081.00
70_I94_A1.2071.00
198_S224_K1.2051.00
92_D96_K1.2051.00
178_Y195_Q1.2041.00
201_L207_V1.1921.00
195_Q200_L1.1861.00
147_F152_K1.1841.00
24_L28_R1.1801.00
71_N93_A1.1801.00
123_L288_L1.1731.00
157_I221_M1.1711.00
313_I317_D1.1691.00
176_Y203_M1.1681.00
148_E303_N1.1641.00
22_K302_E1.1591.00
118_G121_L1.1521.00
157_I211_V1.1481.00
123_L262_A1.1351.00
207_V233_S1.1311.00
209_L235_L1.1251.00
249_L261_A1.1251.00
100_P321_T1.1221.00
220_M243_V1.1201.00
51_I73_A1.1201.00
239_S243_V1.1201.00
226_I257_H1.1151.00
225_E228_L1.1141.00
26_S313_I1.1071.00
246_I267_P1.0911.00
56_F312_L1.0881.00
80_G308_V1.0841.00
159_Y164_T1.0771.00
254_A283_E1.0751.00
165_Q169_L1.0741.00
12_K53_D1.0721.00
91_L95_A1.0671.00
30_A317_D1.0661.00
83_C88_Q1.0631.00
132_A135_H1.0611.00
81_C89_V1.0581.00
116_V238_A1.0581.00
221_M235_L1.0561.00
132_A285_D1.0511.00
222_G248_A1.0511.00
115_L290_T1.0511.00
157_I209_L1.0491.00
110_R150_R1.0461.00
222_G245_D1.0451.00
271_A279_S1.0431.00
128_P131_N1.0401.00
193_Q203_M1.0401.00
224_K227_S1.0331.00
121_L173_L1.0311.00
207_V229_M1.0311.00
175_M206_V1.0281.00
31_G313_I1.0281.00
230_K233_S1.0261.00
46_Q49_E1.0231.00
232_G258_L1.0211.00
310_G314_K1.0201.00
253_L286_N1.0171.00
266_F289_L1.0151.00
150_R174_G1.0121.00
48_K68_D1.0101.00
218_K242_T1.0081.00
212_P217_T1.0071.00
247_P267_P1.0021.00
109_T165_Q0.9981.00
124_L234_L0.9981.00
157_I197_L0.9921.00
254_A286_N0.9831.00
206_V234_L0.9801.00
302_E306_L0.9791.00
52_R72_A0.9761.00
211_V220_M0.9621.00
90_D93_A0.9591.00
122_L288_L0.9571.00
12_K32_Y0.9561.00
119_E262_A0.9481.00
89_V101_V0.9461.00
26_S309_A0.9441.00
153_K204_S0.9371.00
133_K138_V0.9341.00
181_D185_K0.9301.00
249_L258_L0.9261.00
197_L201_L0.9261.00
26_S306_L0.9251.00
164_T185_K0.9181.00
250_C280_P0.9181.00
79_I94_A0.9181.00
57_I65_L0.9111.00
81_C88_Q0.9101.00
26_S310_G0.9101.00
178_Y204_S0.9041.00
110_R165_Q0.9021.00
134_A282_C0.9011.00
156_I167_G0.8981.00
56_F316_S0.8941.00
164_T188_L0.8891.00
111_S148_E0.8891.00
49_E52_R0.8871.00
233_S257_H0.8861.00
22_K25_E0.8821.00
195_Q203_M0.8791.00
140_N143_A0.8791.00
268_T271_A0.8771.00
23_A305_G0.8731.00
153_K203_M0.8671.00
48_K69_V0.8651.00
268_T272_T0.8631.00
191_A195_Q0.8601.00
68_D71_N0.8591.00
227_S255_S0.8571.00
186_L189_G0.8541.00
156_I166_L0.8511.00
310_G322_L0.8481.00
219_N222_G0.8481.00
246_I268_T0.8441.00
251_D254_A0.8431.00
128_P132_A0.8381.00
252_A258_L0.8381.00
198_S202_N0.8371.00
197_L220_M0.8371.00
92_D95_A0.8351.00
26_S29_A0.8281.00
58_G308_V0.8231.00
74_E97_R0.8180.99
197_L225_E0.8100.99
67_E90_D0.8100.99
46_Q50_S0.8080.99
106_F161_H0.8070.99
65_L69_V0.8060.99
45_E49_E0.8000.99
180_Y197_L0.7930.99
117_I166_L0.7840.99
120_L236_I0.7840.99
201_L229_M0.7780.99
51_I57_I0.7780.99
12_K34_N0.7750.99
119_E288_L0.7750.99
12_K36_E0.7700.99
232_G255_S0.7680.99
209_L221_M0.7670.99
117_I154_L0.7640.99
262_A288_L0.7610.99
110_R114_E0.7590.99
184_N189_G0.7580.99
201_L228_L0.7560.99
70_I99_I0.7560.99
106_F109_T0.7550.99
78_A316_S0.7510.99
103_N325_V0.7510.99
199_D202_N0.7500.99
111_S297_T0.7490.99
130_A293_I0.7430.99
147_F232_G0.7400.99
146_S297_T0.7400.99
207_V235_L0.7400.99
211_V239_S0.7380.99
65_L70_I0.7370.99
178_Y200_L0.7370.99
184_N194_V0.7370.99
213_E217_T0.7360.99
166_L170_A0.7360.99
246_I279_S0.7330.99
235_L258_L0.7310.99
185_K188_L0.7300.99
36_E50_S0.7300.99
115_L119_E0.7280.99
128_P288_L0.7240.99
117_I120_L0.7230.99
303_N306_L0.7230.99
120_L149_A0.7220.99
296_S301_Q0.7210.99
116_V210_H0.7170.99
80_G102_F0.7130.99
113_A169_L0.7130.99
249_L263_I0.7120.99
274_S280_P0.7100.99
120_L154_L0.7090.99
117_I169_L0.7090.99
148_E297_T0.7080.99
11_I55_H0.7080.99
247_P251_D0.7070.99
201_L233_S0.6930.98
167_G177_V0.6910.98
111_S300_A0.6900.98
204_S207_V0.6900.98
171_E191_A0.6880.98
182_I216_S0.6880.98
86_T91_L0.6870.98
110_R169_L0.6860.98
45_E68_D0.6860.98
73_A76_L0.6850.98
234_L262_A0.6850.98
120_L170_A0.6840.98
139_W142_L0.6840.98
26_S30_A0.6840.98
147_F298_Q0.6840.98
110_R148_E0.6840.98
59_L65_L0.6820.98
115_L118_G0.6820.98
115_L262_A0.6810.98
185_K189_G0.6800.98
261_A287_V0.6760.98
131_N289_L0.6760.98
23_A306_L0.6750.98
219_N242_T0.6740.98
178_Y194_V0.6740.98
109_T161_H0.6710.98
21_Q28_R0.6680.98
223_A257_H0.6570.98
112_V294_G0.6550.98
246_I281_L0.6530.98
52_R74_E0.6500.97
102_F321_T0.6480.97
58_G312_L0.6460.97
176_Y192_T0.6440.97
253_L284_F0.6440.97
12_K54_A0.6430.97
53_D74_E0.6430.97
168_I171_E0.6430.97
250_C281_L0.6420.97
147_F259_A0.6420.97
235_L249_L0.6410.97
110_R174_G0.6410.97
122_L127_V0.6400.97
149_A206_V0.6390.97
67_E97_R0.6390.97
115_L127_V0.6390.97
252_A257_H0.6330.97
201_L220_M0.6330.97
12_K55_H0.6300.97
70_I93_A0.6300.97
247_P279_S0.6290.97
282_C289_L0.6270.97
272_T279_S0.6260.97
171_E190_N0.6260.97
273_N280_P0.6260.97
250_C283_E0.6250.97
107_S295_G0.6200.97
50_S54_A0.6180.97
250_C287_V0.6160.97
138_V142_L0.6150.96
80_G312_L0.6120.96
244_V249_L0.6070.96
154_L208_S0.6070.96
123_L236_I0.6070.96
250_C263_I0.6070.96
214_N217_T0.6050.96
244_V261_A0.6040.96
311_K314_K0.6020.96
120_L234_L0.6000.96
119_E238_A0.6000.96
157_I200_L0.5990.96
116_V208_S0.5990.96
44_D69_V0.5970.96
115_L125_R0.5970.96
271_A274_S0.5970.96
147_F206_V0.5960.96
104_A304_I0.5950.96
209_L239_S0.5930.96
104_A107_S0.5930.96
124_L128_P0.5920.96
169_L173_L0.5900.96
271_A282_C0.5900.96
127_V290_T0.5880.95
108_N300_A0.5880.95
218_K267_P0.5880.95
263_I287_V0.5870.95
159_Y163_G0.5860.95
197_L221_M0.5850.95
229_M232_G0.5840.95
114_E149_A0.5830.95
154_L166_L0.5810.95
106_F307_E0.5810.95
110_R168_I0.5800.95
164_T168_I0.5800.95
17_E63_T0.5800.95
191_A194_V0.5770.95
56_F80_G0.5760.95
107_S304_I0.5750.95
27_L309_A0.5740.95
220_M225_E0.5740.95
78_A100_P0.5720.95
79_I99_I0.5670.94
84_I161_H0.5660.94
233_S252_A0.5660.94
226_I249_L0.5660.94
11_I316_S0.5650.94
159_Y181_D0.5650.94
23_A309_A0.5650.94
130_A144_A0.5640.94
102_F323_S0.5620.94
221_M229_M0.5620.94
34_N37_F0.5610.94
57_I76_L0.5590.94
178_Y192_T0.5560.94
56_F308_V0.5560.94
57_I79_I0.5560.94
134_A266_F0.5560.94
42_L46_Q0.5550.94
16_V63_T0.5520.94
147_F234_L0.5510.94
78_A321_T0.5500.94
170_A177_V0.5480.93
295_G301_Q0.5470.93
236_I262_A0.5460.93
147_F299_E0.5450.93
240_R292_H0.5440.93
253_L258_L0.5430.93
311_K323_S0.5430.93
251_D257_H0.5420.93
211_V217_T0.5400.93
131_N134_A0.5340.93
28_R32_Y0.5330.92
120_L166_L0.5320.92
107_S300_A0.5310.92
86_T103_N0.5300.92
102_F311_K0.5300.92
196_H202_N0.5280.92
250_C289_L0.5270.92
124_L147_F0.5270.92
262_A290_T0.5270.92
314_K320_S0.5250.92
135_H283_E0.5250.92
108_N111_S0.5250.92
179_F194_V0.5240.92
290_T293_I0.5230.92
179_F185_K0.5220.92
321_T324_A0.5220.92
312_L315_Y0.5220.92
114_E125_R0.5220.92
14_L50_S0.5220.92
130_A133_K0.5200.92
100_P315_Y0.5190.91
124_L175_M0.5190.91
11_I77_V0.5180.91
261_A284_F0.5170.91
280_P284_F0.5170.91
298_Q302_E0.5160.91
81_C103_N0.5150.91
50_S53_D0.5150.91
179_F189_G0.5130.91
124_L149_A0.5130.91
119_E122_L0.5100.91
207_V221_M0.5070.91
60_R83_C0.5030.90
183_E216_S0.5020.90
274_S283_E0.5020.90
178_Y199_D0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sc6A 4 0.9537 100 0.2 Contact Map
3k5pA 3 0.9732 100 0.202 Contact Map
1ygyA 4 0.961 100 0.309 Contact Map
2g76A 2 0.7317 100 0.383 Contact Map
3ba1A 2 0.7585 100 0.391 Contact Map
4g2nA 3 0.7585 100 0.397 Contact Map
4lswA 2 0.7683 100 0.398 Contact Map
2d0iA 2 0.7902 100 0.399 Contact Map
4xkjA 2 0.7756 100 0.402 Contact Map
2w2kA 2 0.7756 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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