GREMLIN Database
GLDA - Glycerol dehydrogenase
UniProt: P0A9S5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11904
Length: 367 (323)
Sequences: 13909 (9679)
Seq/√Len: 538.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_E345_P3.4551.00
323_R349_Y3.3091.00
284_V297_A3.0411.00
215_E302_A3.0061.00
78_G82_T2.8691.00
76_L103_L2.6121.00
71_N133_D2.5771.00
15_A155_K2.5551.00
88_I100_A2.4721.00
216_K227_T2.4541.00
46_S50_K2.4501.00
344_T347_Q2.4091.00
32_W87_A2.3731.00
220_A227_T2.3631.00
20_R23_E2.3301.00
316_E353_L2.3001.00
163_R273_E2.2801.00
349_Y353_L2.2181.00
31_R58_V2.1931.00
162_A166_A2.1881.00
16_D155_K2.1451.00
110_P148_N2.1221.00
158_A228_P2.0961.00
256_V352_L2.0561.00
322_M349_Y2.0471.00
213_E233_V2.0341.00
90_G100_A1.9921.00
77_R106_F1.9821.00
49_E53_K1.9631.00
79_I83_A1.9481.00
315_K321_K1.9371.00
315_K320_A1.8881.00
39_F43_F1.8861.00
63_P75_R1.8761.00
19_N47_T1.8731.00
345_P349_Y1.8711.00
17_V20_R1.8661.00
46_S49_E1.8431.00
215_E219_L1.8361.00
298_A302_A1.8341.00
60_E83_A1.8241.00
97_L113_I1.8151.00
205_L208_N1.7891.00
72_E75_R1.7811.00
167_A273_E1.7801.00
257_H274_K1.7751.00
152_V235_E1.7741.00
79_I82_T1.7521.00
176_W206_C1.7181.00
53_K59_V1.7091.00
80_A107_M1.6851.00
326_A349_Y1.6761.00
30_E86_G1.6731.00
286_E339_M1.6491.00
301_H307_I1.6491.00
80_A109_V1.6361.00
65_G72_E1.6251.00
321_K324_I1.6131.00
325_V352_L1.5851.00
308_T311_Q1.5781.00
24_Y27_P1.5601.00
33_L80_A1.5511.00
188_T295_T1.5391.00
80_A85_C1.5331.00
323_R345_P1.5291.00
22_G51_S1.5121.00
263_I324_I1.5121.00
326_A345_P1.4861.00
33_L79_I1.4851.00
283_L296_V1.4781.00
324_I328_A1.4781.00
294_E298_A1.4751.00
41_L62_A1.4621.00
213_E216_K1.4501.00
70_Q74_D1.4431.00
290_V294_E1.4401.00
216_K220_A1.4351.00
35_V100_A1.4331.00
246_E249_G1.4261.00
227_T230_L1.4221.00
60_E79_I1.4201.00
350_A353_L1.4181.00
173_L207_Y1.4151.00
73_I99_T1.4131.00
37_D40_V1.4111.00
75_R78_G1.3981.00
32_W89_L1.3791.00
132_T135_G1.3751.00
165_L231_E1.3721.00
155_K158_A1.3581.00
50_K54_D1.3371.00
112_A149_M1.3311.00
73_I130_I1.3231.00
33_L85_C1.3211.00
277_F312_L1.3201.00
47_T155_K1.3191.00
172_A210_L1.3021.00
49_E59_V1.2891.00
71_N74_D1.2851.00
24_Y149_M1.2771.00
14_G20_R1.2671.00
15_A158_A1.2571.00
297_A301_H1.2541.00
347_Q350_A1.2481.00
88_I104_A1.2471.00
269_Y274_K1.2461.00
97_L122_A1.2451.00
215_E218_M1.2391.00
295_T298_A1.2391.00
170_G300_S1.2381.00
229_A233_V1.2371.00
50_K53_K1.2271.00
157_V235_E1.2181.00
26_K55_A1.2161.00
157_V231_E1.2161.00
38_K63_P1.2151.00
31_R60_E1.2051.00
346_D349_Y1.2051.00
90_G111_V1.1901.00
35_V103_L1.1891.00
219_L302_A1.1891.00
38_K62_A1.1891.00
10_K24_Y1.1871.00
167_A270_Y1.1841.00
11_Y239_Y1.1841.00
48_V91_I1.1841.00
74_D78_G1.1811.00
324_I327_E1.1711.00
87_A112_A1.1651.00
169_I214_G1.1621.00
161_P164_L1.1571.00
73_I103_L1.1521.00
256_V278_G1.1501.00
214_G218_M1.1481.00
25_L87_A1.1381.00
105_H143_L1.1371.00
18_I47_T1.1361.00
38_K42_G1.1291.00
170_G305_L1.1291.00
322_M353_L1.1231.00
31_R83_A1.1201.00
21_L48_V1.1161.00
12_I24_Y1.1101.00
211_L214_G1.1081.00
15_A228_P1.1061.00
127_L142_L1.1051.00
73_I77_R1.1021.00
80_A88_I1.1001.00
77_R81_E1.1001.00
169_I234_I1.0991.00
327_E331_A1.0921.00
252_A343_A1.0921.00
14_G17_V1.0881.00
346_D350_A1.0811.00
18_I156_I1.0801.00
65_G69_S1.0721.00
16_D19_N1.0681.00
39_F42_G1.0671.00
15_A232_R1.0641.00
280_L297_A1.0601.00
216_K229_A1.0501.00
18_I114_A1.0431.00
284_V290_V1.0341.00
40_V43_F1.0241.00
19_N51_S1.0241.00
213_E217_A1.0191.00
17_V151_I1.0181.00
160_A164_L1.0131.00
34_V49_E1.0131.00
269_Y277_F1.0091.00
205_L209_T1.0071.00
47_T50_K1.0021.00
35_V64_F1.0021.00
20_R24_Y1.0011.00
252_A279_T0.9981.00
263_I328_A0.9971.00
216_K219_L0.9941.00
201_A205_L0.9911.00
285_L347_Q0.9901.00
217_A220_A0.9901.00
214_G217_A0.9811.00
75_R79_I0.9801.00
298_A301_H0.9801.00
330_C345_P0.9751.00
90_G113_I0.9751.00
40_V44_A0.9681.00
78_G81_E0.9681.00
16_D153_D0.9631.00
264_P321_K0.9611.00
102_A106_F0.9551.00
60_E85_C0.9541.00
23_E55_A0.9511.00
291_E294_E0.9501.00
12_I149_M0.9471.00
212_E233_V0.9391.00
200_L203_A0.9391.00
12_I20_R0.9381.00
100_A111_V0.9371.00
165_L217_A0.9361.00
165_L221_A0.9331.00
210_L234_I0.9321.00
10_K27_P0.9141.00
124_C239_Y0.9141.00
162_A218_M0.9131.00
118_A165_L0.9111.00
217_A221_A0.9111.00
204_E208_N0.9111.00
328_A331_A0.9091.00
256_V348_V0.9081.00
285_L341_G0.9071.00
323_R327_E0.9061.00
40_V45_Q0.8981.00
47_T51_S0.8961.00
316_E320_A0.8961.00
284_V293_I0.8951.00
53_K58_V0.8921.00
162_A304_G0.8861.00
209_T212_E0.8851.00
31_R86_G0.8831.00
124_C150_V0.8831.00
41_L45_Q0.8821.00
208_N212_E0.8811.00
25_L112_A0.8791.00
253_A279_T0.8791.00
71_N75_R0.8781.00
34_V59_V0.8761.00
70_Q130_I0.8741.00
211_L295_T0.8731.00
253_A275_V0.8711.00
69_S72_E0.8661.00
170_G276_A0.8651.00
257_H261_T0.8651.00
87_A110_P0.8621.00
80_A103_L0.8611.00
56_G59_V0.8471.00
99_T103_L0.8411.00
22_G26_K0.8371.00
64_F99_T0.8341.00
179_A244_G0.8331.00
90_G97_L0.8321.00
176_W241_S0.8301.00
254_H271_H0.8291.00
18_I155_K0.8281.00
155_K228_P0.8261.00
36_G41_L0.8241.00
53_K56_G0.8241.00
77_R107_M0.8231.00
181_A185_S0.8221.00
23_E27_P0.8221.00
283_L293_I0.8191.00
104_A109_V0.8171.00
97_L115_P0.8151.00
113_I147_P0.8121.00
287_N293_I0.8111.00
202_L240_L0.8111.00
203_A206_C0.8101.00
39_F63_P0.8101.00
51_S54_D0.8071.00
280_L300_S0.8051.00
22_G55_A0.8041.00
259_G328_A0.8041.00
61_I76_L0.7991.00
169_I172_A0.7941.00
71_N134_E0.7841.00
182_C185_S0.7841.00
236_A240_L0.7841.00
126_A144_P0.7841.00
211_L215_E0.7801.00
61_I67_E0.7761.00
104_A111_V0.7751.00
259_G352_L0.7741.00
174_A279_T0.7731.00
70_Q133_D0.7711.00
19_N155_K0.7691.00
212_E216_K0.7681.00
31_R84_Q0.7671.00
18_I153_D0.7651.00
22_G54_D0.7641.00
293_I297_A0.7621.00
69_S133_D0.7591.00
35_V76_L0.7591.00
281_T284_V0.7541.00
37_D63_P0.7531.00
160_A168_G0.7531.00
37_D43_F0.7531.00
270_Y273_E0.7511.00
58_V83_A0.7511.00
41_L46_S0.7501.00
74_D77_R0.7501.00
287_N290_V0.7481.00
24_Y151_I0.7481.00
154_T232_R0.7441.00
207_Y211_L0.7441.00
326_A330_C0.7431.00
210_L237_N0.7381.00
163_R167_A0.7371.00
277_F280_L0.7301.00
294_E297_A0.7271.00
158_A222_E0.7261.00
15_A154_T0.7241.00
67_E95_K0.7231.00
32_W86_G0.7201.00
21_L114_A0.7171.00
73_I102_A0.7141.00
252_A282_Q0.7131.00
36_G96_T0.7131.00
320_A323_R0.7121.00
330_C348_V0.7111.00
209_T213_E0.7111.00
166_A218_M0.7101.00
78_G134_E0.7071.00
73_I106_F0.7061.00
76_L99_T0.7061.00
307_I311_Q0.7031.00
177_F292_E0.7031.00
23_E26_K0.7031.00
67_E268_H0.7011.00
12_I17_V0.7001.00
232_R243_V0.6981.00
276_A300_S0.6971.00
36_G62_A0.6941.00
183_S342_G0.6931.00
257_H275_V0.6931.00
278_G351_A0.6931.00
21_L151_I0.6921.00
228_P246_E0.6891.00
260_L274_K0.6881.00
202_L206_C0.6881.00
32_W57_L0.6881.00
297_A307_I0.6881.00
341_G347_Q0.6861.00
18_I48_V0.6841.00
213_E230_L0.6801.00
185_S189_T0.6771.00
41_L44_A0.6771.00
258_N332_E0.6761.00
296_V300_S0.6741.00
19_N54_D0.6731.00
325_V329_A0.6721.00
285_L343_A0.6701.00
206_C209_T0.6681.00
88_I109_V0.6661.00
24_Y28_L0.6651.00
200_L204_E0.6641.00
74_D106_F0.6641.00
206_C241_S0.6621.00
162_A219_L0.6621.00
229_A232_R0.6621.00
211_L218_M0.6601.00
113_I150_V0.6581.00
323_R326_A0.6571.00
283_L292_E0.6561.00
166_A304_G0.6561.00
306_P311_Q0.6551.00
218_M304_G0.6551.00
216_K230_L0.6551.00
73_I129_V0.6491.00
343_A347_Q0.6491.00
41_L49_E0.6481.00
61_I96_T0.6451.00
209_T233_V0.6431.00
291_E295_T0.6421.00
218_M303_V0.6371.00
252_A348_V0.6371.00
282_Q286_E0.6361.00
207_Y210_L0.6321.00
173_L177_F0.6291.00
186_G189_T0.6281.00
10_K149_M0.6271.00
256_V281_T0.6261.00
12_I151_I0.6261.00
33_L83_A0.6261.00
102_A130_I0.6251.00
287_N291_E0.6251.00
61_I75_R0.6241.00
273_E306_P0.6221.00
228_P232_R0.6201.00
61_I72_E0.6191.00
132_T141_L0.6191.00
177_F296_V0.6161.00
120_T172_A0.6161.00
174_A253_A0.6161.00
111_V148_N0.6161.00
169_I303_V0.6151.00
35_V96_T0.6151.00
30_E58_V0.6131.00
77_R103_L0.6131.00
164_L167_A0.6131.00
343_A348_V0.6131.00
177_F207_Y0.6121.00
173_L303_V0.6091.00
22_G25_L0.6071.00
90_G96_T0.6071.00
166_A305_L0.6021.00
105_H145_N0.6011.00
162_A221_A0.6001.00
221_A230_L0.5971.00
44_A159_G0.5951.00
177_F184_R0.5941.00
300_S307_I0.5931.00
214_G220_A0.5931.00
47_T156_I0.5911.00
276_A305_L0.5880.99
69_S268_H0.5880.99
48_V51_S0.5880.99
213_E229_A0.5860.99
301_H311_Q0.5850.99
252_A296_V0.5830.99
157_V165_L0.5810.99
279_T300_S0.5800.99
46_S53_K0.5790.99
118_A235_E0.5790.99
31_R85_C0.5790.99
201_A208_N0.5780.99
118_A157_V0.5770.99
34_V91_I0.5770.99
328_A332_E0.5760.99
19_N50_K0.5760.99
275_V278_G0.5730.99
292_E296_V0.5730.99
171_D271_H0.5720.99
67_E72_E0.5710.99
322_M326_A0.5680.99
179_A203_A0.5670.99
173_L299_L0.5660.99
18_I51_S0.5660.99
212_E215_E0.5660.99
174_A275_V0.5650.99
213_E234_I0.5640.99
213_E218_M0.5620.99
273_E305_L0.5610.99
124_C243_V0.5600.99
173_L210_L0.5600.99
210_L214_G0.5580.99
255_A334_E0.5560.99
114_A151_I0.5550.99
206_C214_G0.5530.99
136_E268_H0.5510.99
206_C210_L0.5510.99
261_T274_K0.5510.99
65_G75_R0.5500.99
181_A283_L0.5480.99
252_A255_A0.5470.99
81_E107_M0.5440.99
227_T231_E0.5430.99
42_G46_S0.5420.99
322_M352_L0.5410.99
138_D271_H0.5410.99
218_M222_E0.5400.99
21_L51_S0.5400.99
269_Y273_E0.5400.99
239_Y243_V0.5390.99
260_L352_L0.5360.99
179_A200_L0.5350.99
89_L112_A0.5330.99
297_A308_T0.5320.99
178_E252_A0.5300.99
125_S242_G0.5300.99
11_Y150_V0.5290.99
310_A316_E0.5250.99
163_R270_Y0.5240.99
164_L270_Y0.5240.99
166_A169_I0.5230.99
285_L351_A0.5230.99
39_F67_E0.5210.99
176_W203_A0.5190.99
8_P146_N0.5190.99
102_A128_S0.5190.99
285_L344_T0.5170.99
329_A352_L0.5160.99
102_A141_L0.5120.99
206_C217_A0.5120.99
301_H304_G0.5100.99
258_N334_E0.5100.99
180_R204_E0.5090.99
14_G154_T0.5070.99
105_H141_L0.5070.99
260_L269_Y0.5070.99
284_V294_E0.5050.98
209_T237_N0.5040.98
36_G91_I0.5040.98
171_D254_H0.5030.98
26_K30_E0.5020.98
128_S141_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9128 100 0.142 Contact Map
1rrmA 2 0.9128 100 0.144 Contact Map
3bfjA 5 0.9101 100 0.149 Contact Map
4fr2A 2 0.9101 100 0.159 Contact Map
1vljA 2 0.9155 100 0.167 Contact Map
4mcaA 7 0.9973 100 0.168 Contact Map
3uhjA 5 0.9673 100 0.168 Contact Map
1jq5A 5 0.9891 100 0.177 Contact Map
3zdrA 2 0.921 100 0.179 Contact Map
1ta9A 5 0.9946 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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