GATD - ECOLI - GREMLIN Contacts

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GATD - Galactitol-1-phosphate 5-dehydrogenase

UniProt:	P0A9S3	Sequences: MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12417
Length:	346 (302)
Sequences:	52810 (36317)
Seq/√Len:	2089.8

ECOLI - GATD YBDR YDJL RSPB FRMA YGGP YDJJ ADHP YPHC YJJN TDH AHR YAHK IDND QOR1 YCJQ ACUI CURA
BACSU - ADHB YJMD TDH DHSO BDHA YYCR ADHA YOGA YFMJ YHFP
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HR85 Q9HQS8
SULSO - ADH Q7LXK1 Q97YT7 Q97XR4 Q97ZV3 Q97VV5 Q97V32 Q97YM2 Q97TZ4 Q97WA1 Q97VW0 GLCD2 GLCD1 Q97W06 GLCD3 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
325_S	328_Q	2.995	1.00
33_A	137_I	2.896	1.00
31_K	66_D	2.823	1.00
33_A	64_Y	2.742	1.00
29_R	66_D	2.672	1.00
28_V	128_V	2.596	1.00
136_P	139_D	2.589	1.00
7_D	15_A	2.521	1.00
181_V	207_M	2.498	1.00
79_D	130_A	2.389	1.00
76_H	79_D	2.371	1.00
80_A	131_L	2.367	1.00
220_M	223_V	2.344	1.00
321_G	332_D	2.304	1.00
31_K	64_Y	2.258	1.00
61_F	116_G	2.256	1.00
19_I	120_Y	2.202	1.00
31_K	120_Y	2.169	1.00
138_E	320_R	2.165	1.00
163_N	186_K	2.158	1.00
304_R	308_E	2.103	1.00
74_D	125_R	2.090	1.00
164_V	180_A	2.078	1.00
7_D	13_R	2.070	1.00
319_H	332_D	2.060	1.00
169_A	190_A	2.039	1.00
322_S	325_S	2.037	1.00
159_C	162_K	2.036	1.00
199_A	203_S	2.034	1.00
23_K	27_E	2.021	1.00
198_L	202_K	2.013	1.00
25_Q	70_S	2.007	1.00
199_A	202_K	1.998	1.00
5_V	15_A	1.960	1.00
134_D	307_T	1.958	1.00
26_D	71_G	1.953	1.00
25_Q	71_G	1.930	1.00
177_I	206_A	1.926	1.00
61_F	83_C	1.905	1.00
80_A	137_I	1.890	1.00
331_R	335_R	1.880	1.00
21_E	67_A	1.872	1.00
62_S	137_I	1.868	1.00
146_I	175_L	1.791	1.00
215_M	220_M	1.790	1.00
195_S	199_A	1.784	1.00
29_R	122_V	1.770	1.00
328_Q	331_R	1.769	1.00
66_D	120_Y	1.769	1.00
162_K	255_Q	1.757	1.00
46_F	334_A	1.752	1.00
165_I	230_N	1.748	1.00
165_I	191_I	1.714	1.00
182_A	310_K	1.711	1.00
231_Q	251_G	1.705	1.00
321_G	329_A	1.668	1.00
255_Q	282_T	1.659	1.00
332_D	337_A	1.651	1.00
131_L	137_I	1.650	1.00
192_D	198_L	1.640	1.00
328_Q	332_D	1.625	1.00
211_N	214_E	1.621	1.00
189_T	230_N	1.615	1.00
200_L	203_S	1.600	1.00
198_L	209_T	1.580	1.00
131_L	140_G	1.578	1.00
250_A	256_L	1.564	1.00
139_D	314_E	1.561	1.00
69_G	72_V	1.560	1.00
75_L	130_A	1.555	1.00
156_A	232_L	1.550	1.00
167_I	246_A	1.547	1.00
195_S	211_N	1.540	1.00
208_Q	224_L	1.534	1.00
68_V	77_P	1.519	1.00
250_A	281_L	1.511	1.00
22_I	122_V	1.509	1.00
4_V	326_F	1.508	1.00
255_Q	284_I	1.506	1.00
27_E	124_K	1.483	1.00
67_A	77_P	1.477	1.00
29_R	120_Y	1.460	1.00
186_K	208_Q	1.459	1.00
32_I	61_F	1.443	1.00
75_L	79_D	1.442	1.00
22_I	29_R	1.434	1.00
117_F	330_V	1.431	1.00
195_S	214_E	1.427	1.00
216_S	219_Q	1.424	1.00
250_A	254_A	1.417	1.00
80_A	133_T	1.405	1.00
26_D	124_K	1.403	1.00
64_Y	80_A	1.386	1.00
27_E	122_V	1.367	1.00
34_S	138_E	1.353	1.00
233_I	246_A	1.353	1.00
327_A	331_R	1.349	1.00
233_I	250_A	1.342	1.00
65_I	75_L	1.337	1.00
219_Q	223_V	1.333	1.00
28_V	75_L	1.302	1.00
186_K	207_M	1.297	1.00
177_I	190_A	1.295	1.00
29_R	67_A	1.289	1.00
318_A	332_D	1.286	1.00
45_I	330_V	1.279	1.00
163_N	189_T	1.265	1.00
304_R	307_T	1.260	1.00
64_Y	137_I	1.259	1.00
154_H	301_T	1.252	1.00
176_A	234_L	1.241	1.00
193_I	198_L	1.234	1.00
182_A	305_L	1.227	1.00
143_I	306_L	1.218	1.00
167_I	191_I	1.199	1.00
154_H	298_E	1.194	1.00
4_V	14_V	1.181	1.00
33_A	80_A	1.172	1.00
193_I	212_S	1.169	1.00
75_L	128_V	1.169	1.00
158_G	185_A	1.155	1.00
19_I	29_R	1.141	1.00
22_I	27_E	1.140	1.00
195_S	198_L	1.137	1.00
163_N	231_Q	1.120	1.00
26_D	125_R	1.111	1.00
220_M	224_L	1.107	1.00
198_L	211_N	1.097	1.00
301_T	304_R	1.089	1.00
123_V	128_V	1.083	1.00
66_D	77_P	1.081	1.00
202_K	209_T	1.080	1.00
32_I	121_I	1.075	1.00
296_G	300_E	1.075	1.00
8_T	11_I	1.074	1.00
30_V	63_G	1.072	1.00
162_K	231_Q	1.060	1.00
203_S	315_P	1.053	1.00
155_L	282_T	1.048	1.00
37_L	329_A	1.046	1.00
248_E	275_K	1.043	1.00
156_A	257_A	1.041	1.00
14_V	324_E	1.040	1.00
214_E	220_M	1.036	1.00
151_H	298_E	1.034	1.00
200_L	339_P	1.020	1.00
45_I	334_A	1.016	1.00
190_A	206_A	1.015	1.00
135_M	140_G	1.014	1.00
237_A	242_T	1.009	1.00
305_L	310_K	1.009	1.00
34_S	137_I	1.005	1.00
4_V	323_F	1.005	1.00
30_V	81_V	1.005	1.00
300_E	304_R	1.001	1.00
216_S	220_M	0.994	1.00
149_G	179_C	0.989	1.00
38_C	60_E	0.983	1.00
149_G	176_A	0.975	1.00
158_G	162_K	0.974	1.00
33_A	62_S	0.972	1.00
218_P	248_E	0.967	1.00
35_S	117_F	0.966	1.00
189_T	208_Q	0.965	1.00
5_V	17_S	0.963	1.00
38_C	59_H	0.961	1.00
193_I	213_S	0.957	1.00
326_F	344_L	0.949	1.00
117_F	326_F	0.943	1.00
19_I	67_A	0.937	1.00
166_I	176_A	0.935	1.00
35_S	116_G	0.935	1.00
177_I	188_V	0.930	1.00
169_A	192_D	0.928	1.00
146_I	302_A	0.928	1.00
225_R	229_F	0.927	1.00
180_A	185_A	0.927	1.00
152_A	259_V	0.926	1.00
26_D	69_G	0.914	1.00
68_V	72_V	0.914	1.00
331_R	334_A	0.912	1.00
332_D	342_V	0.909	1.00
244_E	248_E	0.905	1.00
235_E	238_G	0.904	1.00
218_P	245_L	0.903	1.00
276_I	283_V	0.899	1.00
179_C	302_A	0.896	1.00
31_K	119_E	0.891	1.00
76_H	130_A	0.888	1.00
5_V	56_T	0.887	1.00
245_L	248_E	0.885	1.00
189_T	210_F	0.883	1.00
72_V	125_R	0.882	1.00
169_A	201_A	0.880	1.00
166_I	180_A	0.879	1.00
73_D	125_R	0.878	1.00
194_S	197_K	0.877	1.00
150_L	301_T	0.876	1.00
42_L	333_I	0.875	1.00
55_I	114_D	0.874	1.00
275_K	279_K	0.872	1.00
167_I	233_I	0.870	1.00
7_D	11_I	0.868	1.00
221_Q	230_N	0.867	1.00
165_I	249_I	0.866	1.00
21_E	29_R	0.861	1.00
17_S	114_D	0.861	1.00
36_G	60_E	0.861	1.00
155_L	284_I	0.861	1.00
194_S	211_N	0.858	1.00
174_L	200_L	0.857	1.00
169_A	177_I	0.857	1.00
61_F	121_I	0.854	1.00
19_I	66_D	0.853	1.00
272_T	275_K	0.853	1.00
152_A	234_L	0.853	1.00
163_N	230_N	0.848	1.00
196_E	199_A	0.841	1.00
218_P	222_S	0.840	1.00
253_H	280_E	0.838	1.00
133_T	307_T	0.837	1.00
333_I	342_V	0.836	1.00
117_F	344_L	0.833	1.00
202_K	208_Q	0.826	1.00
23_K	122_V	0.818	1.00
301_T	305_L	0.817	1.00
82_A	303_S	0.816	1.00
191_I	212_S	0.815	1.00
321_G	325_S	0.814	1.00
162_K	232_L	0.812	1.00
192_D	209_T	0.810	1.00
197_K	339_P	0.808	1.00
190_A	201_A	0.808	1.00
297_Q	301_T	0.803	1.00
4_V	12_V	0.802	1.00
179_C	305_L	0.800	1.00
26_D	70_S	0.797	1.00
201_A	206_A	0.795	1.00
153_F	180_A	0.795	1.00
37_L	333_I	0.785	1.00
225_R	228_R	0.782	1.00
147_T	298_E	0.780	1.00
81_V	128_V	0.779	1.00
38_C	41_D	0.779	1.00
217_A	245_L	0.774	1.00
34_S	343_L	0.766	1.00
152_A	176_A	0.764	1.00
14_V	323_F	0.760	1.00
149_G	175_L	0.758	1.00
218_P	249_I	0.757	1.00
189_T	224_L	0.753	1.00
158_G	232_L	0.752	1.00
167_I	242_T	0.751	1.00
149_G	172_I	0.749	1.00
233_I	256_L	0.748	1.00
216_S	245_L	0.746	1.00
83_C	123_V	0.746	1.00
40_S	59_H	0.742	1.00
246_A	256_L	0.740	1.00
193_I	201_A	0.738	1.00
297_Q	300_E	0.737	1.00
37_L	117_F	0.733	1.00
22_I	67_A	0.731	1.00
321_G	344_L	0.730	1.00
258_L	283_V	0.729	1.00
241_Q	245_L	0.728	1.00
22_I	69_G	0.728	1.00
135_M	306_L	0.727	1.00
276_I	285_G	0.727	1.00
68_V	76_H	0.727	1.00
183_L	301_T	0.727	1.00
219_Q	222_S	0.726	1.00
305_L	308_E	0.723	1.00
332_D	335_R	0.721	1.00
319_H	328_Q	0.720	1.00
164_V	185_A	0.720	1.00
28_V	125_R	0.714	1.00
151_H	280_E	0.713	1.00
305_L	309_R	0.713	1.00
180_A	188_V	0.711	1.00
317_I	320_R	0.711	1.00
17_S	56_T	0.710	1.00
82_A	131_L	0.709	1.00
23_K	26_D	0.707	1.00
236_T	259_V	0.707	1.00
157_Q	255_Q	0.706	1.00
189_T	221_Q	0.704	1.00
226_E	229_F	0.704	1.00
80_A	134_D	0.701	1.00
221_Q	249_I	0.701	1.00
34_S	320_R	0.698	1.00
62_S	141_A	0.696	1.00
4_V	327_A	0.695	1.00
252_P	279_K	0.693	1.00
157_Q	284_I	0.684	1.00
228_R	251_G	0.683	1.00
129_F	300_E	0.682	1.00
222_S	225_R	0.682	1.00
230_N	233_I	0.682	1.00
150_L	302_A	0.681	1.00
163_N	228_R	0.680	1.00
186_K	189_T	0.679	1.00
185_A	188_V	0.679	1.00
149_G	153_F	0.677	1.00
232_L	257_A	0.677	1.00
188_V	207_M	0.676	1.00
179_C	183_L	0.666	1.00
319_H	342_V	0.666	1.00
185_A	232_L	0.665	1.00
116_G	121_I	0.662	1.00
148_V	172_I	0.660	1.00
74_D	130_A	0.659	1.00
244_E	275_K	0.655	1.00
276_I	281_L	0.655	1.00
6_N	11_I	0.655	1.00
157_Q	282_T	0.652	1.00
79_D	133_T	0.651	1.00
338_M	342_V	0.651	1.00
26_D	126_K	0.650	1.00
150_L	305_L	0.649	1.00
74_D	296_G	0.647	1.00
10_G	331_R	0.646	1.00
303_S	307_T	0.643	1.00
38_C	145_P	0.643	1.00
161_N	186_K	0.642	1.00
145_P	171_T	0.642	1.00
166_I	190_A	0.641	1.00
62_S	131_L	0.640	1.00
132_P	307_T	0.640	1.00
243_V	256_L	0.638	1.00
28_V	65_I	0.637	1.00
20_P	122_V	0.637	1.00
34_S	62_S	0.634	1.00
129_F	299_W	0.633	1.00
129_F	303_S	0.632	1.00
154_H	183_L	0.632	1.00
200_L	204_F	0.631	1.00
62_S	80_A	0.627	1.00
74_D	77_P	0.627	1.00
39_G	43_P	0.624	1.00
266_L	270_S	0.623	1.00
40_S	44_R	0.623	1.00
265_D	270_S	0.620	1.00
143_I	302_A	0.619	1.00
82_A	144_E	0.618	1.00
178_Q	204_F	0.618	1.00
32_I	35_S	0.615	1.00
30_V	83_C	0.615	1.00
203_S	314_E	0.614	1.00
9_D	331_R	0.612	1.00
177_I	204_F	0.612	1.00
230_N	249_I	0.607	1.00
233_I	249_I	0.607	1.00
144_E	148_V	0.607	1.00
191_I	210_F	0.606	1.00
330_V	334_A	0.605	1.00
22_I	71_G	0.602	1.00
265_D	272_T	0.600	1.00
192_D	212_S	0.599	1.00
198_L	212_S	0.598	1.00
242_T	246_A	0.598	1.00
235_E	256_L	0.593	1.00
156_A	255_Q	0.593	1.00
192_D	211_N	0.592	1.00
20_P	120_Y	0.589	1.00
198_L	201_A	0.589	1.00
54_P	58_G	0.587	1.00
176_A	259_V	0.586	1.00
181_V	188_V	0.586	1.00
202_K	206_A	0.585	1.00
232_L	255_Q	0.584	1.00
321_G	342_V	0.584	1.00
84_V	129_F	0.583	1.00
43_P	48_N	0.582	1.00
222_S	229_F	0.581	1.00
174_L	316_L	0.580	1.00
39_G	170_G	0.578	1.00
8_T	13_R	0.576	1.00
14_V	326_F	0.575	1.00
164_V	232_L	0.575	1.00
145_P	175_L	0.574	1.00
83_C	128_V	0.573	1.00
73_D	76_H	0.569	1.00
192_D	201_A	0.568	1.00
40_S	43_P	0.568	1.00
42_L	334_A	0.567	1.00
148_V	259_V	0.567	1.00
332_D	338_M	0.567	1.00
244_E	270_S	0.566	1.00
206_A	209_T	0.563	1.00
20_P	29_R	0.563	1.00
257_A	286_S	0.562	1.00
241_Q	244_E	0.560	1.00
160_E	184_G	0.560	1.00
150_L	298_E	0.560	1.00
19_I	122_V	0.559	1.00
68_V	79_D	0.558	1.00
210_F	215_M	0.558	1.00
200_L	316_L	0.557	1.00
19_I	22_I	0.556	1.00
235_E	260_G	0.556	1.00
129_F	296_G	0.555	1.00
165_I	233_I	0.554	1.00
154_H	297_Q	0.552	1.00
20_P	27_E	0.551	1.00
75_L	125_R	0.551	1.00
58_G	117_F	0.549	1.00
153_F	179_C	0.548	1.00
44_R	49_G	0.548	1.00
152_A	286_S	0.546	1.00
280_E	290_Y	0.543	1.00
142_F	343_L	0.541	1.00
163_N	225_R	0.539	1.00
125_R	128_V	0.539	1.00
62_S	140_G	0.539	1.00
177_I	201_A	0.538	1.00
175_L	179_C	0.537	1.00
150_L	183_L	0.535	1.00
208_Q	220_M	0.534	1.00
18_V	21_E	0.533	1.00
217_A	221_Q	0.533	1.00
52_Y	55_I	0.532	1.00
22_I	25_Q	0.532	1.00
210_F	224_L	0.530	1.00
167_I	217_A	0.530	1.00
281_L	285_G	0.527	1.00
30_V	128_V	0.524	1.00
130_A	133_T	0.521	1.00
56_T	115_G	0.521	1.00
160_E	183_L	0.520	1.00
181_V	206_A	0.519	1.00
32_I	83_C	0.518	1.00
136_P	320_R	0.518	1.00
210_F	220_M	0.518	1.00
277_L	285_G	0.517	1.00
223_V	226_E	0.517	1.00
175_L	311_L	0.517	1.00
174_L	204_F	0.514	1.00
210_F	217_A	0.514	1.00
321_G	328_Q	0.514	1.00
38_C	341_K	0.513	1.00
10_G	45_I	0.513	1.00
165_I	221_Q	0.511	1.00
178_Q	311_L	0.510	1.00
11_I	45_I	0.510	1.00
22_I	26_D	0.509	1.00
83_C	116_G	0.507	1.00
132_P	140_G	0.505	1.00
286_S	289_N	0.504	1.00
12_V	330_V	0.504	1.00
319_H	325_S	0.503	1.00
201_A	209_T	0.501	1.00
157_Q	162_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4uejA	2	0.9971	100	0.125	Contact Map
4ej6A	1	0.9682	100	0.129	Contact Map
2dq4A	4	0.9653	100	0.133	Contact Map
4ilkA	2	0.9624	100	0.135	Contact Map
4cpdA	2	0.9711	100	0.139	Contact Map
1f8fA	4	0.9769	100	0.144	Contact Map
1h2bA	4	0.9595	100	0.145	Contact Map
3m6iA	4	0.9653	100	0.146	Contact Map
1e3iA	2	0.974	100	0.147	Contact Map
3ukoA	4	0.9798	100	0.148	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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