GREMLIN Database
GATD - Galactitol-1-phosphate 5-dehydrogenase
UniProt: P0A9S3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12417
Length: 346 (302)
Sequences: 52810 (36317)
Seq/√Len: 2089.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_S328_Q2.9951.00
33_A137_I2.8961.00
31_K66_D2.8231.00
33_A64_Y2.7421.00
29_R66_D2.6721.00
28_V128_V2.5961.00
136_P139_D2.5891.00
7_D15_A2.5211.00
181_V207_M2.4981.00
79_D130_A2.3891.00
76_H79_D2.3711.00
80_A131_L2.3671.00
220_M223_V2.3441.00
321_G332_D2.3041.00
31_K64_Y2.2581.00
61_F116_G2.2561.00
19_I120_Y2.2021.00
31_K120_Y2.1691.00
138_E320_R2.1651.00
163_N186_K2.1581.00
304_R308_E2.1031.00
74_D125_R2.0901.00
164_V180_A2.0781.00
7_D13_R2.0701.00
319_H332_D2.0601.00
169_A190_A2.0391.00
322_S325_S2.0371.00
159_C162_K2.0361.00
199_A203_S2.0341.00
23_K27_E2.0211.00
198_L202_K2.0131.00
25_Q70_S2.0071.00
199_A202_K1.9981.00
5_V15_A1.9601.00
134_D307_T1.9581.00
26_D71_G1.9531.00
25_Q71_G1.9301.00
177_I206_A1.9261.00
61_F83_C1.9051.00
80_A137_I1.8901.00
331_R335_R1.8801.00
21_E67_A1.8721.00
62_S137_I1.8681.00
146_I175_L1.7911.00
215_M220_M1.7901.00
195_S199_A1.7841.00
29_R122_V1.7701.00
328_Q331_R1.7691.00
66_D120_Y1.7691.00
162_K255_Q1.7571.00
46_F334_A1.7521.00
165_I230_N1.7481.00
165_I191_I1.7141.00
182_A310_K1.7111.00
231_Q251_G1.7051.00
321_G329_A1.6681.00
255_Q282_T1.6591.00
332_D337_A1.6511.00
131_L137_I1.6501.00
192_D198_L1.6401.00
328_Q332_D1.6251.00
211_N214_E1.6211.00
189_T230_N1.6151.00
200_L203_S1.6001.00
198_L209_T1.5801.00
131_L140_G1.5781.00
250_A256_L1.5641.00
139_D314_E1.5611.00
69_G72_V1.5601.00
75_L130_A1.5551.00
156_A232_L1.5501.00
167_I246_A1.5471.00
195_S211_N1.5401.00
208_Q224_L1.5341.00
68_V77_P1.5191.00
250_A281_L1.5111.00
22_I122_V1.5091.00
4_V326_F1.5081.00
255_Q284_I1.5061.00
27_E124_K1.4831.00
67_A77_P1.4771.00
29_R120_Y1.4601.00
186_K208_Q1.4591.00
32_I61_F1.4431.00
75_L79_D1.4421.00
22_I29_R1.4341.00
117_F330_V1.4311.00
195_S214_E1.4271.00
216_S219_Q1.4241.00
250_A254_A1.4171.00
80_A133_T1.4051.00
26_D124_K1.4031.00
64_Y80_A1.3861.00
27_E122_V1.3671.00
34_S138_E1.3531.00
233_I246_A1.3531.00
327_A331_R1.3491.00
233_I250_A1.3421.00
65_I75_L1.3371.00
219_Q223_V1.3331.00
28_V75_L1.3021.00
186_K207_M1.2971.00
177_I190_A1.2951.00
29_R67_A1.2891.00
318_A332_D1.2861.00
45_I330_V1.2791.00
163_N189_T1.2651.00
304_R307_T1.2601.00
64_Y137_I1.2591.00
154_H301_T1.2521.00
176_A234_L1.2411.00
193_I198_L1.2341.00
182_A305_L1.2271.00
143_I306_L1.2181.00
167_I191_I1.1991.00
154_H298_E1.1941.00
4_V14_V1.1811.00
33_A80_A1.1721.00
193_I212_S1.1691.00
75_L128_V1.1691.00
158_G185_A1.1551.00
19_I29_R1.1411.00
22_I27_E1.1401.00
195_S198_L1.1371.00
163_N231_Q1.1201.00
26_D125_R1.1111.00
220_M224_L1.1071.00
198_L211_N1.0971.00
301_T304_R1.0891.00
123_V128_V1.0831.00
66_D77_P1.0811.00
202_K209_T1.0801.00
32_I121_I1.0751.00
296_G300_E1.0751.00
8_T11_I1.0741.00
30_V63_G1.0721.00
162_K231_Q1.0601.00
203_S315_P1.0531.00
155_L282_T1.0481.00
37_L329_A1.0461.00
248_E275_K1.0431.00
156_A257_A1.0411.00
14_V324_E1.0401.00
214_E220_M1.0361.00
151_H298_E1.0341.00
200_L339_P1.0201.00
45_I334_A1.0161.00
190_A206_A1.0151.00
135_M140_G1.0141.00
237_A242_T1.0091.00
305_L310_K1.0091.00
34_S137_I1.0051.00
4_V323_F1.0051.00
30_V81_V1.0051.00
300_E304_R1.0011.00
216_S220_M0.9941.00
149_G179_C0.9891.00
38_C60_E0.9831.00
149_G176_A0.9751.00
158_G162_K0.9741.00
33_A62_S0.9721.00
218_P248_E0.9671.00
35_S117_F0.9661.00
189_T208_Q0.9651.00
5_V17_S0.9631.00
38_C59_H0.9611.00
193_I213_S0.9571.00
326_F344_L0.9491.00
117_F326_F0.9431.00
19_I67_A0.9371.00
166_I176_A0.9351.00
35_S116_G0.9351.00
177_I188_V0.9301.00
169_A192_D0.9281.00
146_I302_A0.9281.00
225_R229_F0.9271.00
180_A185_A0.9271.00
152_A259_V0.9261.00
26_D69_G0.9141.00
68_V72_V0.9141.00
331_R334_A0.9121.00
332_D342_V0.9091.00
244_E248_E0.9051.00
235_E238_G0.9041.00
218_P245_L0.9031.00
276_I283_V0.8991.00
179_C302_A0.8961.00
31_K119_E0.8911.00
76_H130_A0.8881.00
5_V56_T0.8871.00
245_L248_E0.8851.00
189_T210_F0.8831.00
72_V125_R0.8821.00
169_A201_A0.8801.00
166_I180_A0.8791.00
73_D125_R0.8781.00
194_S197_K0.8771.00
150_L301_T0.8761.00
42_L333_I0.8751.00
55_I114_D0.8741.00
275_K279_K0.8721.00
167_I233_I0.8701.00
7_D11_I0.8681.00
221_Q230_N0.8671.00
165_I249_I0.8661.00
21_E29_R0.8611.00
17_S114_D0.8611.00
36_G60_E0.8611.00
155_L284_I0.8611.00
194_S211_N0.8581.00
174_L200_L0.8571.00
169_A177_I0.8571.00
61_F121_I0.8541.00
19_I66_D0.8531.00
272_T275_K0.8531.00
152_A234_L0.8531.00
163_N230_N0.8481.00
196_E199_A0.8411.00
218_P222_S0.8401.00
253_H280_E0.8381.00
133_T307_T0.8371.00
333_I342_V0.8361.00
117_F344_L0.8331.00
202_K208_Q0.8261.00
23_K122_V0.8181.00
301_T305_L0.8171.00
82_A303_S0.8161.00
191_I212_S0.8151.00
321_G325_S0.8141.00
162_K232_L0.8121.00
192_D209_T0.8101.00
197_K339_P0.8081.00
190_A201_A0.8081.00
297_Q301_T0.8031.00
4_V12_V0.8021.00
179_C305_L0.8001.00
26_D70_S0.7971.00
201_A206_A0.7951.00
153_F180_A0.7951.00
37_L333_I0.7851.00
225_R228_R0.7821.00
147_T298_E0.7801.00
81_V128_V0.7791.00
38_C41_D0.7791.00
217_A245_L0.7741.00
34_S343_L0.7661.00
152_A176_A0.7641.00
14_V323_F0.7601.00
149_G175_L0.7581.00
218_P249_I0.7571.00
189_T224_L0.7531.00
158_G232_L0.7521.00
167_I242_T0.7511.00
149_G172_I0.7491.00
233_I256_L0.7481.00
216_S245_L0.7461.00
83_C123_V0.7461.00
40_S59_H0.7421.00
246_A256_L0.7401.00
193_I201_A0.7381.00
297_Q300_E0.7371.00
37_L117_F0.7331.00
22_I67_A0.7311.00
321_G344_L0.7301.00
258_L283_V0.7291.00
241_Q245_L0.7281.00
22_I69_G0.7281.00
135_M306_L0.7271.00
276_I285_G0.7271.00
68_V76_H0.7271.00
183_L301_T0.7271.00
219_Q222_S0.7261.00
305_L308_E0.7231.00
332_D335_R0.7211.00
319_H328_Q0.7201.00
164_V185_A0.7201.00
28_V125_R0.7141.00
151_H280_E0.7131.00
305_L309_R0.7131.00
180_A188_V0.7111.00
317_I320_R0.7111.00
17_S56_T0.7101.00
82_A131_L0.7091.00
23_K26_D0.7071.00
236_T259_V0.7071.00
157_Q255_Q0.7061.00
189_T221_Q0.7041.00
226_E229_F0.7041.00
80_A134_D0.7011.00
221_Q249_I0.7011.00
34_S320_R0.6981.00
62_S141_A0.6961.00
4_V327_A0.6951.00
252_P279_K0.6931.00
157_Q284_I0.6841.00
228_R251_G0.6831.00
129_F300_E0.6821.00
222_S225_R0.6821.00
230_N233_I0.6821.00
150_L302_A0.6811.00
163_N228_R0.6801.00
186_K189_T0.6791.00
185_A188_V0.6791.00
149_G153_F0.6771.00
232_L257_A0.6771.00
188_V207_M0.6761.00
179_C183_L0.6661.00
319_H342_V0.6661.00
185_A232_L0.6651.00
116_G121_I0.6621.00
148_V172_I0.6601.00
74_D130_A0.6591.00
244_E275_K0.6551.00
276_I281_L0.6551.00
6_N11_I0.6551.00
157_Q282_T0.6521.00
79_D133_T0.6511.00
338_M342_V0.6511.00
26_D126_K0.6501.00
150_L305_L0.6491.00
74_D296_G0.6471.00
10_G331_R0.6461.00
303_S307_T0.6431.00
38_C145_P0.6431.00
161_N186_K0.6421.00
145_P171_T0.6421.00
166_I190_A0.6411.00
62_S131_L0.6401.00
132_P307_T0.6401.00
243_V256_L0.6381.00
28_V65_I0.6371.00
20_P122_V0.6371.00
34_S62_S0.6341.00
129_F299_W0.6331.00
129_F303_S0.6321.00
154_H183_L0.6321.00
200_L204_F0.6311.00
62_S80_A0.6271.00
74_D77_P0.6271.00
39_G43_P0.6241.00
266_L270_S0.6231.00
40_S44_R0.6231.00
265_D270_S0.6201.00
143_I302_A0.6191.00
82_A144_E0.6181.00
178_Q204_F0.6181.00
32_I35_S0.6151.00
30_V83_C0.6151.00
203_S314_E0.6141.00
9_D331_R0.6121.00
177_I204_F0.6121.00
230_N249_I0.6071.00
233_I249_I0.6071.00
144_E148_V0.6071.00
191_I210_F0.6061.00
330_V334_A0.6051.00
22_I71_G0.6021.00
265_D272_T0.6001.00
192_D212_S0.5991.00
198_L212_S0.5981.00
242_T246_A0.5981.00
235_E256_L0.5931.00
156_A255_Q0.5931.00
192_D211_N0.5921.00
20_P120_Y0.5891.00
198_L201_A0.5891.00
54_P58_G0.5871.00
176_A259_V0.5861.00
181_V188_V0.5861.00
202_K206_A0.5851.00
232_L255_Q0.5841.00
321_G342_V0.5841.00
84_V129_F0.5831.00
43_P48_N0.5821.00
222_S229_F0.5811.00
174_L316_L0.5801.00
39_G170_G0.5781.00
8_T13_R0.5761.00
14_V326_F0.5751.00
164_V232_L0.5751.00
145_P175_L0.5741.00
83_C128_V0.5731.00
73_D76_H0.5691.00
192_D201_A0.5681.00
40_S43_P0.5681.00
42_L334_A0.5671.00
148_V259_V0.5671.00
332_D338_M0.5671.00
244_E270_S0.5661.00
206_A209_T0.5631.00
20_P29_R0.5631.00
257_A286_S0.5621.00
241_Q244_E0.5601.00
160_E184_G0.5601.00
150_L298_E0.5601.00
19_I122_V0.5591.00
68_V79_D0.5581.00
210_F215_M0.5581.00
200_L316_L0.5571.00
19_I22_I0.5561.00
235_E260_G0.5561.00
129_F296_G0.5551.00
165_I233_I0.5541.00
154_H297_Q0.5521.00
20_P27_E0.5511.00
75_L125_R0.5511.00
58_G117_F0.5491.00
153_F179_C0.5481.00
44_R49_G0.5481.00
152_A286_S0.5461.00
280_E290_Y0.5431.00
142_F343_L0.5411.00
163_N225_R0.5391.00
125_R128_V0.5391.00
62_S140_G0.5391.00
177_I201_A0.5381.00
175_L179_C0.5371.00
150_L183_L0.5351.00
208_Q220_M0.5341.00
18_V21_E0.5331.00
217_A221_Q0.5331.00
52_Y55_I0.5321.00
22_I25_Q0.5321.00
210_F224_L0.5301.00
167_I217_A0.5301.00
281_L285_G0.5271.00
30_V128_V0.5241.00
130_A133_T0.5211.00
56_T115_G0.5211.00
160_E183_L0.5201.00
181_V206_A0.5191.00
32_I83_C0.5181.00
136_P320_R0.5181.00
210_F220_M0.5181.00
277_L285_G0.5171.00
223_V226_E0.5171.00
175_L311_L0.5171.00
174_L204_F0.5141.00
210_F217_A0.5141.00
321_G328_Q0.5141.00
38_C341_K0.5131.00
10_G45_I0.5131.00
165_I221_Q0.5111.00
178_Q311_L0.5101.00
11_I45_I0.5101.00
22_I26_D0.5091.00
83_C116_G0.5071.00
132_P140_G0.5051.00
286_S289_N0.5041.00
12_V330_V0.5041.00
319_H325_S0.5031.00
201_A209_T0.5011.00
157_Q162_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uejA 2 0.9971 100 0.125 Contact Map
4ej6A 1 0.9682 100 0.129 Contact Map
2dq4A 4 0.9653 100 0.133 Contact Map
4ilkA 2 0.9624 100 0.135 Contact Map
4cpdA 2 0.9711 100 0.139 Contact Map
1f8fA 4 0.9769 100 0.144 Contact Map
1h2bA 4 0.9595 100 0.145 Contact Map
3m6iA 4 0.9653 100 0.146 Contact Map
1e3iA 2 0.974 100 0.147 Contact Map
3ukoA 4 0.9798 100 0.148 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.