GREMLIN Database
FUCO - Lactaldehyde reductase
UniProt: P0A9S1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10351
Length: 382 (364)
Sequences: 10577 (7305)
Seq/√Len: 382.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
354_Q371_L3.9171.00
350_P375_V3.8331.00
229_R332_D3.6481.00
81_G85_N3.1661.00
346_K379_H3.1471.00
289_R327_F3.1001.00
74_T156_E2.8601.00
230_G235_D2.8351.00
79_G106_I2.7451.00
370_T373_D2.6181.00
227_A241_E2.6111.00
48_A52_D2.5531.00
15_R179_D2.5401.00
182_D236_K2.5331.00
32_K60_A2.5021.00
349_I375_V2.4101.00
345_R348_D2.3691.00
20_A23_D2.3401.00
66_G78_E2.3251.00
264_M378_Y2.3221.00
219_K222_E2.2541.00
338_H341_D2.2431.00
375_V379_H2.2421.00
33_A90_Y2.2111.00
200_A220_A2.1741.00
17_A20_A2.1561.00
328_A332_D2.1441.00
16_G179_D2.0551.00
176_I243_A2.0251.00
214_D298_K2.0121.00
83_F132_V1.9891.00
40_T44_C1.9551.00
100_Q136_A1.9481.00
189_K239_G1.9461.00
371_L375_V1.9411.00
51_T55_D1.9311.00
91_L103_C1.9181.00
62_A86_S1.8851.00
196_A224_I1.8641.00
197_L221_I1.8591.00
353_A375_V1.8551.00
225_A306_M1.8441.00
376_E380_T1.8311.00
191_A278_V1.8151.00
83_F110_S1.7801.00
48_A51_T1.7751.00
325_A328_A1.7591.00
291_N365_N1.7531.00
265_A279_A1.7451.00
352_L378_Y1.7391.00
353_A371_L1.7311.00
289_R380_T1.7241.00
68_V75_V1.7091.00
42_V65_D1.7031.00
229_R233_A1.6831.00
75_V78_E1.6731.00
350_P371_L1.6731.00
303_A322_A1.6331.00
282_I342_V1.6281.00
15_R236_K1.6241.00
19_G49_K1.6171.00
233_A332_D1.6171.00
116_A121_L1.6101.00
55_D61_W1.6011.00
186_P190_A1.6011.00
78_E81_G1.5981.00
331_R337_P1.5951.00
62_A82_V1.5951.00
237_D241_E1.5751.00
187_A278_V1.5731.00
31_Q89_D1.5631.00
22_T53_K1.5581.00
82_V86_S1.5551.00
93_A134_I1.5421.00
235_D238_A1.5351.00
221_I302_I1.5221.00
271_F351_A1.5091.00
181_M239_G1.5041.00
52_D56_A1.4941.00
77_K117_D1.4921.00
230_G234_G1.4921.00
62_A88_A1.4911.00
193_G228_L1.4911.00
93_A103_C1.4791.00
116_A120_S1.4791.00
324_E328_A1.4691.00
376_E379_H1.4631.00
288_M326_V1.4551.00
10_T24_E1.4531.00
32_K62_A1.4531.00
25_V90_Y1.4511.00
15_R240_E1.4321.00
351_A355_A1.4321.00
292_A320_N1.4171.00
348_D351_A1.4161.00
24_E27_R1.4101.00
33_A92_I1.4071.00
51_T61_W1.3971.00
76_V153_I1.3841.00
82_V85_N1.3811.00
218_I301_D1.3801.00
111_N130_P1.3801.00
179_D236_K1.3741.00
80_L109_I1.3731.00
73_I77_K1.3631.00
264_M283_L1.3631.00
36_V106_I1.3471.00
274_T279_A1.3401.00
227_A230_G1.3281.00
289_R320_N1.3211.00
354_Q358_D1.3141.00
181_M243_A1.3081.00
12_W24_E1.3061.00
193_G242_M1.3001.00
24_E173_V1.2971.00
186_P232_V1.2961.00
194_V330_N1.2921.00
112_N116_A1.2911.00
83_F88_A1.2841.00
107_G131_S1.2811.00
76_V102_T1.2721.00
135_L173_V1.2671.00
218_I222_E1.2621.00
91_L107_G1.2611.00
49_K179_D1.2611.00
373_D376_E1.2411.00
36_V103_C1.2361.00
179_D182_D1.2321.00
77_K81_G1.2261.00
90_Y135_L1.2231.00
320_N324_E1.2221.00
226_G241_E1.2211.00
36_V67_V1.2161.00
68_V72_T1.2131.00
11_A247_Y1.2051.00
301_D304_R1.2031.00
372_E375_V1.2031.00
81_G84_Q1.2011.00
34_L82_V1.2011.00
290_Y373_D1.2001.00
194_V335_I1.1931.00
349_I379_H1.1931.00
227_A238_A1.1861.00
189_K231_S1.1821.00
218_I305_V1.1731.00
103_C134_I1.1721.00
12_W20_A1.1551.00
224_I242_M1.1551.00
40_T43_Q1.1501.00
18_V137_I1.1451.00
351_A354_Q1.1451.00
286_H380_T1.1451.00
83_F106_I1.1451.00
260_L369_A1.1421.00
155_D158_K1.1371.00
141_A189_K1.1251.00
300_R318_A1.1251.00
52_D55_D1.1241.00
357_L371_L1.1191.00
80_L84_Q1.1121.00
34_L83_F1.1111.00
17_A175_F1.1051.00
215_A219_K1.1031.00
21_L50_V1.1001.00
321_A324_E1.0991.00
184_M188_L1.0981.00
15_R182_D1.0971.00
32_K86_S1.0891.00
50_V94_I1.0891.00
302_I322_A1.0831.00
18_V49_K1.0821.00
35_I61_W1.0811.00
219_K223_I1.0791.00
34_L88_A1.0791.00
203_G252_G1.0791.00
372_E376_E1.0731.00
178_A240_E1.0691.00
26_K57_A1.0691.00
147_V247_Y1.0621.00
14_G17_A1.0581.00
42_V47_V1.0571.00
39_K66_G1.0531.00
72_T75_V1.0501.00
150_N165_V1.0411.00
32_K87_G1.0411.00
261_V284_L1.0401.00
39_K65_D1.0371.00
74_T157_E1.0341.00
264_M374_I1.0301.00
293_D367_R1.0291.00
230_G237_D1.0261.00
292_A319_R1.0251.00
16_G19_G1.0211.00
261_V280_N1.0191.00
25_V135_L1.0171.00
133_P172_Q1.0051.00
271_F355_A1.0001.00
38_D41_L0.9911.00
190_A232_V0.9881.00
35_I47_V0.9851.00
263_G362_T0.9841.00
200_A249_A0.9831.00
300_R319_R0.9791.00
186_P233_A0.9771.00
37_T65_D0.9681.00
23_D57_A0.9631.00
42_V48_A0.9631.00
225_A325_A0.9611.00
55_D60_A0.9571.00
73_I156_E0.9521.00
350_P354_Q0.9511.00
194_V281_A0.9491.00
204_Y301_D0.9491.00
304_R318_A0.9421.00
191_A275_P0.9351.00
294_F367_R0.9321.00
117_D120_S0.9311.00
147_V174_A0.9311.00
80_L110_S0.9291.00
14_G20_A0.9291.00
47_V51_T0.9281.00
67_V102_T0.9261.00
136_A171_P0.9251.00
290_Y367_R0.9251.00
230_G238_A0.9181.00
16_G177_D0.9141.00
41_L44_C0.9081.00
260_L287_V0.9051.00
187_A191_A0.9051.00
337_P341_D0.9041.00
39_K43_Q0.9041.00
42_V51_T0.8991.00
100_Q138_P0.8991.00
49_K53_K0.8991.00
10_T27_R0.8961.00
33_A89_D0.8931.00
265_A269_G0.8911.00
22_T56_A0.8881.00
93_A136_A0.8871.00
20_A24_E0.8861.00
18_V180_M0.8831.00
222_E226_G0.8831.00
223_I245_G0.8811.00
70_N273_N0.8811.00
355_A358_D0.8771.00
232_V334_G0.8741.00
64_Y78_E0.8721.00
19_G53_K0.8721.00
49_K52_D0.8691.00
197_L224_I0.8681.00
72_T156_E0.8671.00
216_L248_V0.8641.00
18_V179_D0.8591.00
33_A59_L0.8591.00
229_R232_V0.8581.00
317_E321_A0.8561.00
203_G214_D0.8561.00
336_P341_D0.8511.00
107_G132_V0.8491.00
214_D217_H0.8481.00
222_E304_R0.8481.00
80_L106_I0.8471.00
286_H289_R0.8421.00
198_T284_L0.8411.00
327_F331_R0.8351.00
232_V333_V0.8341.00
267_P378_Y0.8311.00
76_V105_A0.8301.00
41_L46_V0.8261.00
215_A222_E0.8261.00
223_I241_E0.8241.00
201_I302_I0.8201.00
35_I51_T0.8201.00
118_V121_L0.8171.00
353_A357_L0.8131.00
308_V321_A0.8131.00
68_V78_E0.8101.00
93_A100_Q0.8101.00
41_L47_V0.8101.00
224_I245_G0.8091.00
112_N129_K0.8091.00
272_Y348_D0.8071.00
110_S132_V0.8061.00
290_Y369_A0.8041.00
244_L248_V0.8031.00
32_K89_D0.7991.00
72_T273_N0.7971.00
222_E301_D0.7971.00
36_V99_P0.7921.00
231_S238_A0.7891.00
136_A174_A0.7871.00
141_A243_A0.7871.00
77_K80_L0.7821.00
102_T106_I0.7821.00
100_Q145_A0.7821.00
64_Y79_G0.7821.00
209_A214_D0.7811.00
49_K180_M0.7791.00
357_L374_I0.7791.00
107_G134_I0.7771.00
230_G233_A0.7761.00
197_L201_I0.7751.00
328_A331_R0.7741.00
201_I221_I0.7721.00
267_P355_A0.7711.00
203_G217_H0.7711.00
205_I288_M0.7681.00
134_I172_Q0.7661.00
190_A335_I0.7651.00
74_T78_E0.7611.00
108_I169_D0.7601.00
220_A249_A0.7561.00
149_I167_P0.7551.00
207_R368_E0.7541.00
12_W17_A0.7541.00
159_R273_N0.7531.00
260_L374_I0.7521.00
51_T63_I0.7521.00
18_V177_D0.7511.00
262_H276_H0.7491.00
200_A217_H0.7461.00
33_A61_W0.7461.00
302_I326_V0.7401.00
227_A242_M0.7391.00
227_A237_D0.7381.00
21_L137_I0.7371.00
38_D44_C0.7351.00
288_M299_Y0.7341.00
184_M192_T0.7341.00
18_V50_V0.7321.00
350_P353_A0.7311.00
186_P334_G0.7301.00
181_M189_K0.7251.00
78_E82_V0.7251.00
283_L377_L0.7231.00
53_K56_A0.7211.00
225_A229_R0.7201.00
26_K31_Q0.7151.00
13_F240_E0.7151.00
37_T63_I0.7121.00
289_R323_V0.7121.00
25_V92_I0.7071.00
227_A231_S0.7021.00
105_A153_I0.7011.00
226_G230_G0.7001.00
46_V94_I0.7001.00
31_Q60_A0.6980.99
268_L279_A0.6980.99
141_A181_M0.6950.99
24_E28_R0.6920.99
111_N132_V0.6920.99
308_V325_A0.6910.99
45_G48_A0.6910.99
288_M323_V0.6890.99
22_T57_A0.6880.99
204_Y298_K0.6870.99
336_P342_V0.6870.99
289_R292_A0.6860.99
19_G56_A0.6860.99
204_Y218_I0.6860.99
237_D240_E0.6840.99
300_R304_R0.6830.99
327_F337_P0.6830.99
349_I378_Y0.6800.99
208_G257_G0.6780.99
18_V53_K0.6780.99
195_D276_H0.6780.99
265_A280_N0.6780.99
209_A298_K0.6770.99
329_L333_V0.6770.99
331_R341_D0.6760.99
219_K248_V0.6740.99
285_P330_N0.6660.99
292_A296_G0.6660.99
309_K318_A0.6650.99
221_I225_A0.6600.99
193_G333_V0.6570.99
303_A308_V0.6570.99
38_D43_Q0.6550.99
19_G179_D0.6530.99
296_G319_R0.6530.99
77_K109_I0.6520.99
25_V54_M0.6510.99
288_M322_A0.6500.99
93_A99_P0.6500.99
22_T26_K0.6420.99
34_L86_S0.6410.99
32_K88_A0.6390.99
278_V336_P0.6390.99
76_V106_I0.6350.99
198_T280_N0.6350.99
235_D239_G0.6330.99
105_A151_Y0.6320.99
324_E327_F0.6320.99
318_A321_A0.6320.99
109_I113_P0.6300.99
321_A325_A0.6300.99
55_D58_G0.6290.99
367_R373_D0.6250.99
209_A213_T0.6240.99
48_A55_D0.6230.99
23_D26_K0.6190.99
290_Y370_T0.6180.99
369_A374_I0.6160.99
305_V308_V0.6150.99
12_W173_V0.6130.99
240_E244_L0.6120.99
295_T299_Y0.6120.99
135_L175_F0.6110.99
195_D262_H0.6110.99
231_S242_M0.6100.99
257_G364_G0.6100.99
369_A377_L0.6090.99
108_I127_T0.6090.99
236_K240_E0.6090.99
281_A330_N0.6080.99
266_H359_D0.6060.99
198_T261_V0.6060.99
117_D121_L0.6050.99
176_I247_Y0.6050.99
274_T342_V0.6040.99
34_L62_A0.6030.99
301_D305_V0.6030.99
296_G300_R0.6020.98
222_E305_V0.6020.98
205_I299_Y0.6000.98
218_I304_R0.6000.98
201_I284_L0.5990.98
182_D239_G0.5980.98
369_A373_D0.5970.98
23_D27_R0.5960.98
275_P278_V0.5950.98
11_A174_A0.5950.98
302_I306_M0.5940.98
268_L378_Y0.5930.98
285_P327_F0.5930.98
130_P168_H0.5920.98
74_T77_K0.5910.98
83_F91_L0.5910.98
113_P121_L0.5890.98
70_N98_S0.5880.98
263_G361_C0.5840.98
199_H249_A0.5840.98
201_I322_A0.5830.98
21_L53_K0.5830.98
19_G52_D0.5820.98
13_F244_L0.5810.98
224_I228_L0.5790.98
151_Y164_C0.5770.98
207_R364_G0.5720.98
226_G229_R0.5720.98
280_N283_L0.5700.98
161_K276_H0.5670.98
268_L339_L0.5660.98
299_Y303_A0.5660.98
344_V349_I0.5640.98
326_V330_N0.5630.98
304_R307_G0.5610.98
178_A236_K0.5600.98
193_G224_I0.5580.98
138_P246_Q0.5570.98
111_N131_S0.5570.98
37_T99_P0.5560.97
216_L220_A0.5560.97
50_V53_K0.5550.97
147_V251_M0.5550.97
289_R324_E0.5540.97
68_V273_N0.5530.97
204_Y214_D0.5530.97
285_P323_V0.5520.97
278_V335_I0.5510.97
259_G266_H0.5510.97
117_D122_E0.5490.97
201_I288_M0.5460.97
206_T209_A0.5460.97
92_I135_L0.5460.97
225_A228_L0.5460.97
206_T364_G0.5450.97
21_L175_F0.5450.97
43_Q48_A0.5450.97
137_I175_F0.5440.97
194_V333_V0.5430.97
131_S172_Q0.5430.97
46_V180_M0.5410.97
346_K349_I0.5410.97
199_H276_H0.5410.97
253_F258_L0.5400.97
119_R122_E0.5390.97
118_V122_E0.5380.97
113_P116_A0.5380.97
25_V59_L0.5370.97
138_P176_I0.5370.97
148_T250_G0.5360.97
15_R237_D0.5350.97
260_L365_N0.5350.97
44_C47_V0.5350.97
47_V94_I0.5340.97
67_V70_N0.5330.97
28_R135_L0.5320.97
112_N131_S0.5310.97
330_N335_I0.5300.97
34_L64_Y0.5300.97
283_L287_V0.5300.97
292_A299_Y0.5290.97
35_I94_I0.5280.97
349_I353_A0.5280.97
91_L106_I0.5280.97
26_K59_L0.5270.97
36_V79_G0.5260.97
353_A374_I0.5260.97
12_W175_F0.5250.96
340_R346_K0.5240.96
54_M61_W0.5240.96
62_A85_N0.5240.96
241_E244_L0.5230.96
198_T259_G0.5210.96
239_G243_A0.5200.96
223_I227_A0.5180.96
120_S125_S0.5160.96
356_A378_Y0.5160.96
113_P117_D0.5150.96
193_G232_V0.5120.96
166_D169_D0.5120.96
286_H377_L0.5120.96
156_E159_R0.5120.96
260_L263_G0.5110.96
40_T99_P0.5110.96
298_K301_D0.5090.96
112_N128_N0.5080.96
60_A86_S0.5080.96
22_T25_V0.5060.96
223_I248_V0.5060.96
259_G364_G0.5060.96
278_V342_V0.5060.96
266_H269_G0.5050.96
339_L344_V0.5050.96
186_P189_K0.5050.96
90_Y133_P0.5050.96
149_I254_S0.5040.96
330_N333_V0.5030.96
70_N269_G0.5030.96
264_M267_P0.5010.95
75_V102_T0.5010.95
210_W213_T0.5010.95
282_I285_P0.5010.95
46_V49_K0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rrmA 2 0.9974 100 0.078 Contact Map
3bfjA 5 0.9921 100 0.086 Contact Map
3ox4A 2 0.9948 100 0.088 Contact Map
4fr2A 2 0.9921 100 0.105 Contact Map
1vljA 2 0.9869 100 0.116 Contact Map
3zdrA 2 0.9764 100 0.137 Contact Map
4qgsA 2 0.9686 100 0.144 Contact Map
1o2dA 1 0.9346 100 0.152 Contact Map
3w5sA 2 0.8874 100 0.188 Contact Map
3jzdA 3 0.8979 100 0.189 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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