GREMLIN Database
FER - 2Fe-2S ferredoxin
UniProt: P0A9R4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11328
Length: 111 (100)
Sequences: 2075 (1279)
Seq/√Len: 127.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A30_A3.4941.00
16_G97_V2.9181.00
54_I80_E2.7531.00
3_K20_E2.5071.00
56_R99_E2.3911.00
21_A91_V2.3181.00
23_S93_D2.3161.00
27_I98_V2.2751.00
6_I31_A2.2691.00
27_I89_A2.2111.00
8_P17_A2.0361.00
29_D44_K2.0141.00
65_S70_D1.9161.00
3_K18_V1.8811.00
10_Q15_D1.8691.00
22_N25_E1.8541.00
40_H86_S1.7761.00
8_P15_D1.7671.00
7_L97_V1.7031.00
25_E30_A1.6611.00
59_F82_E1.6281.00
6_I30_A1.6271.00
5_V18_V1.6221.00
5_V16_G1.5561.00
2_P91_V1.5541.00
25_E33_R1.5531.00
2_P23_S1.4461.00
54_I82_E1.4141.00
25_E29_D1.3451.00
62_L89_A1.3001.00
3_K94_E1.2981.00
73_L79_L1.2821.00
56_R97_V1.2601.00
7_L16_G1.2441.00
53_C86_S1.2441.00
7_L99_E1.2361.00
58_G61_S1.2361.00
17_A100_I1.1820.99
30_A91_V1.1720.99
6_I19_L1.1590.99
45_S72_M1.1430.99
31_A36_I1.1140.99
47_A75_K1.0790.99
71_D74_D1.0760.99
4_I96_L1.0640.99
17_A37_E1.0560.99
58_G96_L1.0520.98
67_E70_D1.0260.98
55_V58_G1.0010.98
70_D79_L0.9920.98
55_V89_A0.9910.98
2_P95_D0.9840.98
4_I91_V0.9770.98
52_H83_S0.9510.97
80_E99_E0.9410.97
8_P100_I0.9350.97
46_C68_Q0.9050.96
28_L38_I0.8970.96
40_H50_T0.8850.96
28_L44_K0.8820.95
31_A38_I0.8790.95
55_V96_L0.8640.95
56_R80_E0.8640.95
40_H45_S0.8550.95
55_V62_L0.8530.95
6_I98_V0.8490.94
58_G93_D0.8330.94
49_T76_A0.8290.94
76_A79_L0.8240.94
5_V97_V0.8220.93
70_D74_D0.8200.93
27_I91_V0.8160.93
8_P36_I0.8160.93
21_A25_E0.8060.93
6_I28_L0.7940.92
41_A47_A0.7920.92
58_G95_D0.7910.92
26_T90_R0.7810.92
43_E104_T0.7790.91
41_A71_D0.7400.89
37_E41_A0.7390.89
27_I96_L0.7310.89
65_S79_L0.7200.88
39_E47_A0.7150.88
26_T40_H0.7090.87
71_D75_K0.7020.87
37_E100_I0.6980.86
29_D32_L0.6970.86
23_S91_V0.6900.86
32_L38_I0.6890.86
53_C100_I0.6880.86
86_S89_A0.6870.85
47_A72_M0.6750.84
49_T104_T0.6680.84
92_T95_D0.6670.84
28_L31_A0.6570.83
49_T72_M0.6530.82
63_P92_T0.6510.82
54_I59_F0.6500.82
57_E97_V0.6490.82
47_A71_D0.6480.82
23_S92_T0.6470.82
100_I104_T0.6460.82
7_L95_D0.6450.82
54_I78_G0.6420.81
63_P89_A0.6410.81
89_A95_D0.6320.80
9_H102_R0.6310.80
38_I41_A0.6290.80
2_P94_E0.6150.79
19_L30_A0.6120.78
28_L32_L0.6110.78
20_E23_S0.6080.78
40_H44_K0.6070.78
61_S64_E0.6010.77
43_E65_S0.5970.76
49_T75_K0.5960.76
4_I27_I0.5930.76
47_A65_S0.5910.76
31_A104_T0.5870.75
64_E70_D0.5850.75
32_L36_I0.5830.75
60_D64_E0.5800.74
55_V98_V0.5730.74
31_A37_E0.5670.73
54_I101_P0.5650.72
58_G94_E0.5630.72
26_T44_K0.5620.72
38_I86_S0.5600.72
29_D33_R0.5590.72
28_L40_H0.5530.71
49_T86_S0.5520.71
26_T29_D0.5460.70
90_R99_E0.5450.70
77_W86_S0.5400.69
32_L39_E0.5370.69
10_Q17_A0.5370.69
51_C84_R0.5360.69
29_D36_I0.5330.68
42_C48_C0.5290.68
40_H46_C0.5290.68
74_D77_W0.5250.67
45_S70_D0.5240.67
72_M77_W0.5180.66
39_E77_W0.5150.65
50_T101_P0.5130.65
59_F64_E0.5070.64
47_A86_S0.5030.64
38_I104_T0.5020.64
6_I21_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mj3A 1 0.973 99.9 0.462 Contact Map
3n9zC 1 0.2432 99.9 0.469 Contact Map
2mjdA 1 0.973 99.9 0.47 Contact Map
3huiA 1 0.9189 99.9 0.476 Contact Map
4ltuA 1 0.9099 99.9 0.476 Contact Map
1i7hA 1 0.982 99.9 0.48 Contact Map
2y5cA 1 0.9189 99.9 0.481 Contact Map
3lxfA 5 0.9009 99.9 0.485 Contact Map
3ah7A 2 0.982 99.9 0.486 Contact Map
1xlqA 2 0.9099 99.9 0.49 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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