GREMLIN Database
DHAS - Aspartate-semialdehyde dehydrogenase
UniProt: P0A9Q9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10088
Length: 367 (327)
Sequences: 2912 (1343)
Seq/√Len: 74.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_G149_A4.6531.00
167_G218_F3.8501.00
44_A51_T3.7791.00
118_V254_N3.7301.00
164_A222_L3.1991.00
291_V342_L3.0871.00
159_A277_A3.0621.00
25_R364_R3.0101.00
57_A81_I3.0011.00
307_N312_T2.9341.00
226_L268_V2.9301.00
3_N31_R2.8751.00
5_G66_L2.8641.00
154_D283_K2.8531.00
147_L282_L2.8311.00
303_K326_T2.7851.00
38_S56_D2.7521.00
150_N290_T2.5401.00
117_D254_N2.4701.00
150_N294_L2.4671.00
44_A53_T2.4501.00
236_N243_W2.4131.00
33_V55_Q2.3771.00
231_D240_R2.3671.00
63_L85_L2.2661.00
278_F346_T2.2461.00
79_N100_S2.2401.00
46_S51_T2.1761.00
111_L141_L2.0931.00
140_M278_F1.9841.00
325_L352_L1.9481.00
304_V332_L1.9391.00
151_D286_V1.9201.00
220_V317_T1.9041.00
285_D334_K1.8991.00
23_E48_G1.8981.00
7_I57_A1.8891.00
118_V121_D1.8791.00
288_I332_L1.8321.00
116_Q365_Q1.7891.00
154_D281_K1.7851.00
181_H186_V1.7791.00
155_W281_K1.7671.00
3_N30_I1.7591.00
169_A173_R1.7581.00
84_K88_S1.7551.00
353_W361_R1.7311.00
338_G341_F1.7211.00
256_S259_I1.6981.00
173_R176_L1.6921.00
106_D125_N1.6911.00
34_F45_P1.6851.00
80_E84_K1.6521.00
232_K240_R1.6521.00
229_W313_M1.6381.00
26_D48_G1.6100.99
290_T293_E1.6080.99
292_E332_L1.6060.99
152_L283_K1.5960.99
226_L318_P1.5880.99
147_L291_V1.5870.99
39_Q42_Q1.5830.99
16_V19_Q1.5810.99
84_K87_E1.5810.99
260_P339_P1.5670.99
29_A32_P1.5280.99
17_L70_V1.5230.99
179_M224_G1.5170.99
31_R55_Q1.4940.99
81_I84_K1.4920.99
316_L330_G1.4740.99
293_E297_A1.4560.99
324_T328_P1.4440.99
299_N302_A1.4390.99
142_M299_N1.4320.99
176_L271_L1.4150.99
167_G171_H1.4140.99
157_S279_T1.4130.99
24_E352_L1.4100.99
10_R54_L1.4010.99
255_T259_I1.4010.99
82_Y94_W1.3760.98
148_F255_T1.3710.98
29_A47_F1.3630.98
158_V276_Q1.3580.98
37_T40_L1.3570.98
292_E304_V1.3550.98
85_L94_W1.3540.98
21_M357_E1.3490.98
69_I92_G1.3490.98
295_L302_A1.3270.98
32_P52_G1.3220.98
41_G53_T1.3160.98
3_N66_L1.3070.98
288_I334_K1.2930.98
262_D337_M1.2830.97
33_V66_L1.2770.97
174_E178_Q1.2760.97
83_P87_E1.2710.97
19_Q23_E1.2710.97
4_V27_F1.2700.97
3_N33_V1.2700.97
21_M360_R1.2540.97
71_T82_Y1.2390.97
172_M271_L1.2340.97
270_A275_S1.2330.97
183_Y224_G1.2300.97
173_R177_T1.2240.97
145_G253_L1.2230.97
305_V320_A1.1950.96
139_L348_G1.1910.96
293_E296_A1.1910.96
280_I344_A1.1880.96
114_V142_M1.1860.96
176_L180_G1.1840.96
295_L304_V1.1790.96
60_L88_S1.1790.96
124_N127_I1.1740.96
71_T85_L1.1720.96
307_N314_R1.1670.95
119_I365_Q1.1660.95
68_I363_L1.1650.95
295_L344_A1.1610.95
178_Q221_P1.1580.95
64_K88_S1.1530.95
234_L243_W1.1520.95
218_F227_I1.1230.94
145_G148_F1.1180.94
279_T343_S1.1000.94
140_M276_Q1.0910.94
10_R36_S1.0870.93
167_G227_I1.0850.93
60_L80_E1.0830.93
151_D290_T1.0780.93
6_F34_F1.0770.93
273_C350_Q1.0760.93
158_V278_F1.0700.93
303_K328_P1.0680.93
177_T181_H1.0670.93
58_F62_A1.0590.92
116_Q120_T1.0560.92
29_A52_G1.0560.92
314_R317_T1.0550.92
36_S40_L1.0510.92
21_M352_L1.0500.92
174_E217_N1.0500.92
79_N104_K1.0500.92
153_V280_I1.0490.92
113_P361_R1.0470.92
285_D340_E1.0450.92
18_M34_F1.0450.92
97_A132_G1.0420.92
249_T259_I1.0420.92
262_D343_S1.0410.92
181_H214_P1.0400.92
282_L286_V1.0340.92
60_L84_K1.0340.92
307_N311_I1.0320.91
325_L357_E1.0290.91
151_D294_L1.0280.91
16_V272_R1.0280.91
220_V320_A1.0280.91
230_I245_G1.0220.91
233_Q308_D1.0190.91
139_L347_V1.0180.91
229_W233_Q1.0160.91
220_V313_M1.0080.91
180_G184_G1.0070.90
66_L92_G1.0020.90
147_L342_L0.9960.90
21_M24_E0.9860.90
68_I95_I0.9840.89
155_W337_M0.9830.89
148_F152_L0.9820.89
150_N284_K0.9800.89
144_L156_V0.9780.89
272_R350_Q0.9760.89
262_D279_T0.9710.89
140_M156_V0.9700.89
141_L253_L0.9690.89
119_I130_F0.9680.89
134_N244_K0.9640.88
75_G99_S0.9600.88
113_P353_W0.9590.88
285_D339_P0.9580.88
179_M183_Y0.9490.88
289_P292_E0.9450.87
139_L350_Q0.9370.87
238_Q243_W0.9370.87
103_M247_A0.9360.87
243_W247_A0.9330.87
305_V314_R0.9230.86
144_L280_I0.9200.86
236_N336_N0.9190.86
55_Q62_A0.9160.86
144_L153_V0.9150.86
140_M245_G0.9110.85
332_L342_L0.9090.85
272_R322_T0.9030.85
288_I292_E0.9010.85
234_L247_A0.9000.85
287_S334_K0.9000.85
151_D287_S0.8970.85
272_R351_L0.8920.84
19_Q24_E0.8920.84
140_M158_V0.8890.84
114_V141_L0.8870.84
27_F363_L0.8860.84
25_R325_L0.8830.84
56_D62_A0.8790.83
143_S344_A0.8780.83
154_D340_E0.8780.83
12_M172_M0.8770.83
295_L299_N0.8760.83
99_S240_R0.8760.83
250_N256_S0.8760.83
288_I291_V0.8720.83
273_C321_V0.8700.83
18_M52_G0.8600.82
15_S43_A0.8560.82
33_V65_A0.8540.82
260_P337_M0.8520.81
22_V29_A0.8480.81
182_L221_P0.8460.81
25_R28_D0.8450.81
152_L282_L0.8420.81
275_S318_P0.8410.81
112_D138_S0.8370.80
156_V263_G0.8350.80
6_F17_L0.8330.80
58_F84_K0.8320.80
58_F61_E0.8310.80
15_S45_P0.8300.80
153_V259_I0.8300.80
275_S345_F0.8280.80
273_C322_T0.8270.79
337_M343_S0.8210.79
41_G56_D0.8200.79
231_D239_S0.8170.79
57_A77_Y0.8170.79
172_M272_R0.8090.78
23_E47_F0.8080.78
284_K290_T0.8050.78
250_N259_I0.7990.77
317_T320_A0.7970.77
287_S290_T0.7960.77
164_A172_M0.7950.77
246_Q336_N0.7940.77
281_K341_F0.7910.76
181_H213_L0.7910.76
234_L240_R0.7890.76
61_E64_K0.7870.76
182_L185_H0.7840.76
7_I35_F0.7840.76
292_E296_A0.7820.76
136_T245_G0.7820.76
143_S156_V0.7810.75
170_R217_N0.7800.75
220_V227_I0.7780.75
135_C244_K0.7740.75
282_L285_D0.7710.74
46_S49_G0.7650.74
82_Y127_I0.7600.73
308_D314_R0.7490.72
17_L360_R0.7470.72
136_T160_T0.7450.72
174_E215_V0.7430.72
112_D362_M0.7420.72
326_T357_E0.7410.72
233_Q239_S0.7340.71
294_L299_N0.7330.71
241_E244_K0.7300.70
158_V245_G0.7300.70
38_S58_F0.7280.70
92_G126_G0.7270.70
148_F282_L0.7270.70
143_S346_T0.7270.70
315_E318_P0.7230.70
227_I317_T0.7190.69
35_F66_L0.7180.69
286_V291_V0.7180.69
352_L357_E0.7180.69
264_L343_S0.7160.69
245_G265_C0.7150.69
177_T216_D0.7130.69
281_K338_G0.7110.68
73_Q98_A0.7100.68
179_M223_A0.7090.68
140_M249_T0.7090.68
29_A34_F0.7070.68
157_S262_D0.7070.68
323_G349_D0.7060.68
142_M361_R0.7050.68
10_R40_L0.7050.68
70_V95_I0.7010.67
86_R126_G0.7010.67
282_L291_V0.6990.67
332_L344_A0.6990.67
58_F81_I0.6940.67
226_L266_V0.6920.66
7_I69_I0.6920.66
243_W336_N0.6910.66
61_E88_S0.6900.66
43_A54_L0.6900.66
301_W353_W0.6890.66
88_S92_G0.6880.66
33_V61_E0.6870.66
270_A345_F0.6860.66
156_V280_I0.6820.65
244_K252_I0.6810.65
5_G57_A0.6800.65
60_L81_I0.6770.65
264_L277_A0.6770.65
58_F80_E0.6770.65
308_D311_I0.6770.65
31_R50_T0.6760.64
134_N166_G0.6760.64
56_D81_I0.6750.64
233_Q315_E0.6750.64
243_W246_Q0.6740.64
8_G11_G0.6700.64
22_V47_F0.6680.64
113_P116_Q0.6670.63
167_G217_N0.6660.63
151_D283_K0.6660.63
4_V29_A0.6650.63
74_G78_T0.6640.63
121_D124_N0.6630.63
322_T350_Q0.6610.63
292_E306_P0.6590.63
75_G79_N0.6580.62
136_T139_L0.6550.62
289_P293_E0.6550.62
166_G244_K0.6540.62
78_T101_L0.6540.62
279_T337_M0.6530.62
142_M353_W0.6500.61
321_V348_G0.6500.61
305_V328_P0.6490.61
174_E216_D0.6490.61
228_P239_S0.6490.61
93_Y366_L0.6470.61
238_Q262_D0.6470.61
150_N291_V0.6470.61
241_E274_H0.6450.61
34_F55_Q0.6440.61
10_R37_T0.6410.60
66_L69_I0.6360.60
218_F222_L0.6350.60
139_L276_Q0.6340.60
70_V359_L0.6340.60
86_R124_N0.6320.59
86_R127_I0.6310.59
275_S347_V0.6300.59
110_I365_Q0.6300.59
62_A65_A0.6270.59
76_D232_K0.6270.59
143_S327_T0.6240.58
44_A54_L0.6220.58
320_A328_P0.6210.58
35_F55_Q0.6200.58
301_W361_R0.6170.57
233_Q240_R0.6170.57
147_L280_I0.6170.57
221_P319_A0.6150.57
171_H218_F0.6150.57
279_T338_G0.6140.57
5_G35_F0.6130.57
34_F52_G0.6120.57
159_A279_T0.6120.57
286_V334_K0.6090.57
285_D338_G0.6070.56
244_K267_R0.6060.56
227_I313_M0.6040.56
7_I71_T0.6040.56
83_P94_W0.6040.56
176_L182_L0.6030.56
280_I295_L0.6020.56
220_V314_R0.6010.56
148_F283_K0.6010.56
16_V357_E0.5990.55
282_L342_L0.5990.55
37_T42_Q0.5990.55
213_L221_P0.5980.55
16_V317_T0.5950.55
182_L186_V0.5940.55
47_F50_T0.5910.54
180_G186_V0.5910.54
180_G183_Y0.5910.54
114_V145_G0.5890.54
144_L347_V0.5890.54
79_N240_R0.5880.54
63_L92_G0.5880.54
151_D284_K0.5880.54
80_E83_P0.5870.54
291_V334_K0.5870.54
108_I127_I0.5870.54
177_T180_G0.5860.54
140_M178_Q0.5860.54
140_M263_G0.5840.53
134_N241_E0.5830.53
5_G69_I0.5820.53
103_M251_K0.5810.53
166_G267_R0.5780.53
224_G271_L0.5770.53
262_D336_N0.5750.52
171_H217_N0.5750.52
308_D312_T0.5750.52
156_V253_L0.5730.52
313_M317_T0.5720.52
170_R173_R0.5720.52
7_I81_I0.5710.52
134_N267_R0.5690.52
228_P231_D0.5680.51
288_I304_V0.5660.51
57_A66_L0.5660.51
93_Y130_F0.5630.51
286_V342_L0.5620.51
150_N288_I0.5590.50
321_V328_P0.5580.50
176_L179_M0.5560.50
72_C97_A0.5550.50
12_M272_R0.5530.50
102_R166_G0.5520.49
97_A244_K0.5510.49
23_E46_S0.5500.49
156_V344_A0.5490.49
296_A304_V0.5490.49
137_V276_Q0.5480.49
101_L107_A0.5480.49
36_S54_L0.5460.49
157_S277_A0.5460.49
212_E215_V0.5450.49
152_L255_T0.5450.49
18_M23_E0.5440.48
278_F344_A0.5430.48
86_R125_N0.5430.48
111_L114_V0.5420.48
140_M261_V0.5400.48
75_G231_D0.5400.48
231_D234_L0.5390.48
70_V100_S0.5390.48
143_S146_G0.5380.48
117_D149_A0.5380.48
303_K324_T0.5370.48
311_I314_R0.5370.48
135_C267_R0.5340.47
244_K274_H0.5340.47
150_N286_V0.5340.47
139_L346_T0.5330.47
167_G230_I0.5320.47
102_R241_E0.5310.47
77_Y101_L0.5300.47
35_F62_A0.5280.46
180_G185_H0.5270.46
164_A218_F0.5270.46
237_G311_I0.5270.46
35_F63_L0.5270.46
162_Q244_K0.5260.46
95_I119_I0.5250.46
155_W279_T0.5250.46
33_V62_A0.5250.46
102_R244_K0.5230.46
106_D127_I0.5220.46
73_Q77_Y0.5220.46
171_H219_G0.5200.45
314_R320_A0.5200.45
70_V363_L0.5190.45
212_E304_V0.5190.45
85_L98_A0.5190.45
21_M325_L0.5190.45
155_W341_F0.5180.45
33_V64_K0.5180.45
135_C166_G0.5160.45
17_L359_L0.5160.45
308_D315_E0.5160.45
67_D106_D0.5120.44
336_N343_S0.5110.44
6_F70_V0.5100.44
93_Y127_I0.5070.44
106_D293_E0.5070.44
37_T77_Y0.5070.44
158_V178_Q0.5060.44
288_I342_L0.5050.44
35_F85_L0.5030.43
32_P48_G0.5030.43
121_D125_N0.5030.43
31_R65_A0.5010.43
228_P345_F0.5000.43
69_I82_Y0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uw3A 2 0.9946 100 0.331 Contact Map
1t4bA 2 0.9973 100 0.331 Contact Map
3pzrA 2 0.9918 100 0.337 Contact Map
2yv3A 2 0.8937 100 0.355 Contact Map
2r00A 2 0.8965 100 0.368 Contact Map
3tz6A 2 0.8937 100 0.371 Contact Map
4r3nA 2 0.9101 100 0.379 Contact Map
2hjsA 2 0.8937 100 0.388 Contact Map
1vknA 4 0.8011 100 0.477 Contact Map
2nqtA 4 0.812 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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