GREMLIN Database
ADHE - Aldehyde-alcohol dehydrogenase
UniProt: P0A9Q7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10031
Length: 891 (846)
Sequences: 658 (304)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_K151_D5.5831.00
688_A696_N5.3221.00
654_A682_L4.7881.00
256_D345_R4.6801.00
692_E696_N4.6711.00
750_R796_E4.5031.00
275_Q279_L4.4181.00
369_S391_T4.1940.99
721_V854_L4.1480.99
276_G279_L3.9940.99
655_V679_L3.8220.99
51_K834_E3.8090.99
679_L778_I3.8080.99
647_C689_S3.7970.98
523_S614_D3.6850.98
482_A539_V3.6590.98
190_I205_S3.6460.98
73_S121_I3.5630.98
351_D355_K3.5540.98
42_A121_I3.5530.98
659_M798_L3.5200.97
33_K37_A3.5150.97
649_F739_L3.4980.97
688_A698_V3.4870.97
90_S99_T3.4800.97
661_A675_A3.4740.97
107_I127_S3.3340.96
822_E863_Y3.2780.96
682_L703_V3.2640.96
357_E388_K3.2530.96
856_Q860_D3.2330.96
725_M854_L3.2130.96
251_S359_L3.1980.95
252_V266_F3.1350.95
235_L271_G3.0480.94
256_D347_K3.0270.94
826_L863_Y2.9350.93
306_E311_S2.8970.92
373_T381_R2.8890.92
229_R767_D2.8880.92
27_T30_Q2.8440.92
733_F828_N2.8400.91
303_K306_E2.8370.91
658_A678_A2.8320.91
672_D675_A2.8160.91
467_L638_L2.8150.91
45_A48_P2.8050.91
42_A73_S2.7700.90
346_A351_D2.7490.90
371_L396_I2.7350.90
275_Q278_E2.7340.90
661_A672_D2.7270.90
282_V287_L2.7220.90
830_D855_K2.7130.89
266_F320_I2.7020.89
680_K684_E2.6690.89
833_S851_I2.6160.88
687_P808_E2.6050.87
680_K777_E2.5580.86
109_G134_I2.5500.86
154_L158_I2.5500.86
149_A153_V2.5120.85
155_Q159_A2.5100.85
822_E826_L2.4860.85
254_V343_M2.4850.85
293_N298_G2.4780.84
785_S797_K2.4740.84
691_H808_E2.4360.83
749_I795_I2.4280.83
431_E437_H2.4210.83
124_S136_F2.4180.83
17_K186_D2.4100.83
15_R165_D2.4000.82
235_L318_I2.3870.82
293_N296_I2.3860.82
492_N536_K2.3770.82
688_A692_E2.3640.81
585_K626_A2.3550.81
38_A153_V2.3190.80
276_G280_K2.3050.80
299_Q303_K2.2860.79
137_S143_K2.2590.78
22_E164_K2.2410.78
690_Y810_G2.2400.78
826_L859_L2.2360.78
183_H205_S2.1840.76
327_D333_A2.1740.75
52_M148_K2.1730.75
801_W804_T2.1620.75
780_D794_K2.1510.75
107_I189_L2.1500.75
689_S696_N2.1440.74
259_Y345_R2.1410.74
325_V330_E2.1360.74
281_A288_K2.0540.71
277_K280_K2.0440.71
281_A287_L2.0390.71
652_L811_I2.0260.70
772_R792_A2.0250.70
196_P214_A2.0180.70
685_Y702_R2.0090.69
281_A284_D1.9940.69
282_V288_K1.9870.68
677_Q680_K1.9860.68
221_I225_A1.9630.67
404_G680_K1.9450.67
38_A128_L1.9390.66
220_V255_V1.9310.66
283_Q288_K1.9000.65
834_E851_I1.8950.65
254_V262_V1.8860.64
386_G444_V1.8720.64
659_M778_I1.8710.64
283_Q287_L1.8570.63
690_Y696_N1.8270.62
228_K261_A1.8260.62
373_T382_V1.8150.61
392_A404_G1.8020.61
259_Y322_E1.7920.60
303_K307_L1.7890.60
348_D351_D1.7860.60
227_I265_R1.7820.60
320_I343_M1.7580.59
312_V316_T1.7540.58
812_P817_E1.7500.58
676_L778_I1.7330.57
62_V851_I1.7210.57
347_K350_E1.7150.57
814_S864_G1.7140.57
729_L815_I1.7090.56
670_F705_S1.6870.55
821_Q824_D1.6860.55
26_F30_Q1.6850.55
454_H674_Q1.6770.55
784_L801_W1.6730.55
610_V621_P1.6620.54
854_L857_I1.6610.54
151_D155_Q1.6600.54
92_D95_F1.6560.54
654_A722_C1.6540.54
295_A298_G1.6500.54
344_Y359_L1.6480.53
517_E521_T1.6370.53
205_S426_G1.6360.53
804_T808_E1.6360.53
489_F493_N1.6360.53
257_S348_D1.6320.53
724_S842_T1.6290.53
137_S147_N1.6280.53
31_V128_L1.6170.52
148_K152_I1.6080.52
231_V262_V1.6010.51
301_A312_V1.5940.51
639_V704_H1.5760.50
733_F824_D1.5730.50
528_G555_M1.5730.50
323_V342_A1.5670.50
816_R862_Y1.5640.50
384_Y388_K1.5630.49
725_M858_L1.5500.49
263_R343_M1.5400.48
521_T524_I1.5320.48
746_C803_E1.5290.48
676_L680_K1.5270.48
825_F829_V1.5200.47
223_E257_S1.5200.47
104_I189_L1.5160.47
617_G734_H1.5130.47
758_T853_E1.5120.47
644_K691_H1.5050.47
778_I782_L1.4930.46
656_T741_N1.4880.46
298_G301_A1.4870.46
782_L797_K1.4840.46
22_E26_F1.4800.46
151_D154_L1.4770.45
654_A708_T1.4760.45
323_V333_A1.4760.45
529_A533_N1.4740.45
226_D767_D1.4680.45
254_V481_R1.4600.45
721_V725_M1.4600.45
184_H704_H1.4560.44
532_A555_M1.4510.44
652_L806_K1.4370.44
287_L290_G1.4350.44
485_V532_A1.4330.43
814_S817_E1.4330.43
488_R492_N1.4280.43
687_P691_H1.4270.43
395_L398_T1.4230.43
517_E527_K1.4140.43
655_V802_L1.4140.43
672_D774_R1.4120.42
599_S704_H1.4110.42
26_F154_L1.4040.42
663_V771_A1.4000.42
334_H362_M1.3950.42
253_V359_L1.3940.42
694_S697_P1.3930.42
350_E384_Y1.3870.41
645_S649_F1.3830.41
729_L858_L1.3760.41
125_L128_L1.3710.41
45_A152_I1.3670.40
275_Q280_K1.3670.40
284_D288_K1.3640.40
18_K52_M1.3640.40
333_A863_Y1.3630.40
611_V650_G1.3630.40
16_V133_A1.3530.40
226_D680_K1.3490.40
786_A797_K1.3430.39
292_L296_I1.3430.39
655_V682_L1.3370.39
223_E255_V1.3340.39
38_A149_A1.3330.39
111_V137_S1.3330.39
292_L298_G1.3320.39
483_L532_A1.3280.39
251_S342_A1.3200.38
284_D287_L1.3170.38
458_K626_A1.3170.38
346_A352_A1.3160.38
234_V266_F1.3130.38
70_H574_M1.3100.38
36_R77_Y1.3060.38
304_I308_A1.3010.37
661_A774_R1.2970.37
685_Y688_A1.2960.37
107_I145_A1.2940.37
312_V319_L1.2940.37
350_E354_E1.2900.37
293_N297_V1.2870.37
227_I258_V1.2800.37
187_I704_H1.2800.37
539_V593_I1.2800.37
636_A705_S1.2770.36
18_K22_E1.2740.36
164_K347_K1.2740.36
370_C400_A1.2710.36
572_R838_D1.2640.36
533_N536_K1.2630.36
593_I631_M1.2630.36
264_E268_T1.2620.36
778_I798_L1.2600.36
645_S736_P1.2570.36
227_I262_V1.2550.35
258_V340_T1.2450.35
360_V391_T1.2400.35
321_G332_F1.2340.35
675_A774_R1.2310.34
323_V344_Y1.2300.34
855_K859_L1.2280.34
351_D354_E1.2270.34
89_L101_A1.2260.34
354_E358_K1.2170.34
175_V178_S1.2150.34
744_L857_I1.2150.34
610_V620_Y1.2140.34
120_A707_A1.2120.34
223_E381_R1.2110.34
263_R273_L1.2090.34
782_L785_S1.2080.33
556_W590_A1.2070.33
252_V343_M1.2050.33
824_D828_N1.2040.33
110_I548_P1.2030.33
680_K857_I1.1950.33
815_I858_L1.1950.33
807_A813_K1.1920.33
239_T317_K1.1920.33
724_S728_K1.1900.33
327_D362_M1.1880.33
831_K835_D1.1880.33
110_I201_A1.1870.33
248_S339_P1.1840.32
751_Y860_D1.1830.32
735_I740_A1.1830.32
220_V352_A1.1820.32
644_K690_Y1.1810.32
38_A42_A1.1800.32
642_M646_L1.1800.32
497_D500_T1.1790.32
258_V381_R1.1790.32
682_L708_T1.1790.32
497_D512_V1.1780.32
37_A40_L1.1770.32
784_L797_K1.1760.32
517_E524_I1.1740.32
430_S774_R1.1730.32
685_Y860_D1.1710.32
265_R429_I1.1700.32
773_R791_T1.1680.32
361_A365_I1.1670.32
59_M141_R1.1660.32
239_T344_Y1.1640.32
790_R793_A1.1640.32
99_T441_K1.1630.32
529_A532_A1.1610.32
529_A622_L1.1610.32
42_A153_V1.1610.32
776_A791_T1.1560.31
272_Y275_Q1.1530.31
473_E593_I1.1520.31
262_V266_F1.1510.31
110_I197_G1.1500.31
647_C700_R1.1470.31
54_V145_A1.1460.31
732_Q831_K1.1420.31
92_D266_F1.1390.31
228_K768_R1.1390.31
504_K510_T1.1350.31
786_A794_K1.1310.30
641_D689_S1.1260.30
302_Y314_E1.1240.30
689_S693_G1.1240.30
17_K188_N1.1230.30
605_V708_T1.1200.30
622_L662_Y1.1130.30
110_I392_A1.1130.30
184_H639_V1.1110.30
822_E862_Y1.1050.29
222_D255_V1.1030.29
750_R803_E1.1030.29
43_A70_H1.1000.29
152_I531_L1.0970.29
171_D177_L1.0960.29
829_V833_S1.0920.29
672_D677_Q1.0920.29
239_T753_A1.0910.29
484_I496_A1.0860.29
88_V187_I1.0830.28
322_E345_R1.0820.28
135_I338_S1.0780.28
462_F668_S1.0770.28
782_L798_L1.0760.28
13_V186_D1.0750.28
679_L784_L1.0700.28
608_F623_A1.0690.28
561_H735_I1.0690.28
226_D684_E1.0680.28
282_V286_I1.0680.28
353_V389_M1.0630.28
473_E506_A1.0600.28
22_E25_S1.0580.28
500_T504_K1.0540.27
221_I262_V1.0510.27
735_I815_I1.0470.27
676_L781_H1.0460.27
248_S402_Q1.0450.27
521_T612_T1.0450.27
272_Y313_P1.0440.27
721_V857_I1.0420.27
159_A264_E1.0400.27
183_H190_I1.0360.27
270_G315_N1.0350.27
812_P818_A1.0350.27
561_H588_V1.0340.27
143_K147_N1.0310.27
690_Y740_A1.0290.26
357_E390_K1.0280.26
282_V310_F1.0250.26
832_L858_L1.0240.26
106_I854_L1.0220.26
99_T229_R1.0210.26
665_V761_T1.0180.26
392_A609_A1.0150.26
301_A304_I1.0150.26
722_C745_I1.0140.26
282_V289_N1.0130.26
481_R536_K1.0120.26
681_L820_V1.0090.26
448_A668_S1.0090.26
224_T373_T1.0080.26
146_T149_A1.0070.26
769_P847_R1.0030.26
179_N201_A1.0000.25
404_G677_Q0.9980.25
497_D501_S0.9950.25
654_A707_A0.9950.25
184_H187_I0.9920.25
346_A609_A0.9920.25
585_K588_V0.9900.25
8_E110_I0.9900.25
135_I159_A0.9890.25
301_A305_A0.9880.25
154_L166_L0.9840.25
610_V730_G0.9830.25
741_N744_L0.9830.25
286_I290_G0.9820.25
518_A524_I0.9820.25
239_T301_A0.9820.25
221_I231_V0.9800.25
48_P481_R0.9780.25
683_K801_W0.9780.25
124_S153_V0.9770.25
859_L863_Y0.9750.25
325_V333_A0.9750.25
825_F858_L0.9740.25
564_T569_L0.9710.24
17_K106_I0.9690.24
282_V290_G0.9680.24
124_S167_I0.9670.24
253_V356_A0.9640.24
485_V529_A0.9630.24
481_R631_M0.9630.24
302_Y315_N0.9620.24
724_S841_C0.9610.24
714_F737_H0.9600.24
66_V837_F0.9590.24
370_C404_G0.9570.24
38_A125_L0.9550.24
217_T368_T0.9530.24
222_D373_T0.9520.24
271_G677_Q0.9470.24
821_Q827_A0.9470.24
454_H712_I0.9460.24
52_M55_A0.9440.23
253_V342_A0.9440.23
823_A827_A0.9420.23
499_I543_L0.9420.23
488_R548_P0.9420.23
209_A301_A0.9420.23
197_G405_I0.9410.23
465_G637_N0.9410.23
106_I186_D0.9380.23
482_A593_I0.9380.23
495_Y543_L0.9360.23
373_T386_G0.9360.23
822_E864_G0.9350.23
54_V62_V0.9310.23
395_L443_T0.9290.23
328_E362_M0.9280.23
501_S505_A0.9280.23
190_I214_A0.9270.23
391_T465_G0.9260.23
184_H525_V0.9240.23
502_V505_A0.9240.23
62_V834_E0.9230.23
11_A165_D0.9220.23
18_K823_A0.9220.23
753_A799_L0.9220.23
548_P638_L0.9200.23
345_R350_E0.9180.23
88_V98_I0.9170.23
659_M745_I0.9170.23
214_A292_L0.9160.23
496_A512_V0.9150.23
481_R593_I0.9140.22
159_A185_P0.9130.22
401_S404_G0.9120.22
806_K813_K0.9120.22
37_A175_V0.9120.22
40_L834_E0.9110.22
689_S731_S0.9080.22
292_L310_F0.9080.22
120_A146_T0.9060.22
617_G731_S0.9050.22
455_K458_K0.9020.22
334_H352_A0.9010.22
184_H599_S0.9010.22
519_D626_A0.9000.22
121_I153_V0.8990.22
372_Y424_W0.8980.22
653_D730_G0.8970.22
302_Y306_E0.8960.22
689_S692_E0.8950.22
121_I125_L0.8930.22
252_V342_A0.8930.22
652_L809_L0.8930.22
548_P844_A0.8910.22
323_V330_E0.8910.22
219_V402_Q0.8900.22
382_V404_G0.8890.22
255_V346_A0.8890.22
263_R322_E0.8890.22
281_A290_G0.8870.22
42_A128_L0.8860.22
12_L15_R0.8860.22
557_V586_M0.8850.22
778_I784_L0.8830.21
747_N861_T0.8830.21
407_D842_T0.8820.21
135_I664_S0.8810.21
269_H755_D0.8810.21
263_R345_R0.8810.21
463_R765_Q0.8770.21
485_V555_M0.8760.21
260_D311_S0.8730.21
264_E350_E0.8720.21
572_R610_V0.8720.21
730_G737_H0.8710.21
327_D358_K0.8700.21
108_C456_L0.8680.21
703_V750_R0.8630.21
222_D381_R0.8630.21
732_Q828_N0.8620.21
304_I340_T0.8610.21
532_A622_L0.8610.21
38_A120_A0.8600.21
188_N704_H0.8580.21
744_L861_T0.8570.21
449_E765_Q0.8560.21
556_W581_Y0.8560.21
149_A668_S0.8560.21
617_G646_L0.8560.21
251_S344_Y0.8510.20
705_S745_I0.8510.20
91_E98_I0.8510.20
100_I673_G0.8500.20
647_C693_G0.8500.20
663_V778_I0.8490.20
338_S427_N0.8490.20
742_A814_S0.8480.20
492_N634_V0.8480.20
601_T730_G0.8450.20
290_G293_N0.8450.20
283_Q290_G0.8450.20
55_A144_D0.8450.20
554_I558_M0.8400.20
183_H426_G0.8390.20
682_L722_C0.8390.20
258_V370_C0.8380.20
495_Y670_F0.8380.20
669_E705_S0.8350.20
473_E631_M0.8340.20
23_Y126_I0.8340.20
301_A853_E0.8330.20
254_V260_D0.8330.20
220_V257_S0.8320.20
148_K345_R0.8320.20
722_C726_A0.8310.20
360_V389_M0.8280.20
520_P730_G0.8270.20
259_Y715_A0.8270.20
663_V749_I0.8270.20
35_F46_R0.8260.20
598_T639_V0.8250.20
30_Q33_K0.8230.20
776_A798_L0.8230.20
353_V371_L0.8220.20
679_L782_L0.8220.20
741_N861_T0.8220.20
284_D290_G0.8200.20
837_F850_L0.8190.20
286_I293_N0.8190.20
7_A11_A0.8190.20
300_P303_K0.8190.20
755_D772_R0.8170.19
491_F514_F0.8170.19
273_L320_I0.8150.19
196_P205_S0.8140.19
346_A355_K0.8120.19
296_I299_Q0.8120.19
816_R863_Y0.8120.19
23_Y30_Q0.8100.19
827_A856_Q0.8090.19
594_A675_A0.8090.19
42_A125_L0.8080.19
315_N758_T0.8070.19
259_Y443_T0.8070.19
181_L771_A0.8060.19
128_L201_A0.8040.19
642_M815_I0.8040.19
10_N184_H0.8030.19
607_P715_A0.8010.19
787_P790_R0.8000.19
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345_R497_D0.5340.12
473_E479_H0.5340.12
260_D306_E0.5340.12
687_P815_I0.5340.12
455_K622_L0.5330.12
672_D863_Y0.5330.12
178_S201_A0.5330.12
339_P372_Y0.5330.12
785_S794_K0.5330.12
22_E314_E0.5320.12
95_F505_A0.5320.12
252_V402_Q0.5320.12
446_K466_S0.5310.12
768_R797_K0.5310.12
227_I852_S0.5300.12
66_V580_I0.5300.12
187_I362_M0.5300.12
187_I598_T0.5300.12
450_N459_S0.5290.12
371_L764_S0.5290.12
666_L763_F0.5290.12
346_A853_E0.5280.12
210_I599_S0.5280.12
145_A802_L0.5270.12
16_V811_I0.5260.12
47_I568_E0.5260.12
456_L636_A0.5260.12
265_R459_S0.5260.12
195_G212_V0.5260.12
39_A858_L0.5260.12
78_N82_D0.5260.12
170_I766_Y0.5250.12
481_R615_A0.5250.12
137_S424_W0.5250.12
124_S151_D0.5240.12
593_I750_R0.5240.12
591_K857_I0.5230.12
145_A807_A0.5220.12
802_L809_L0.5210.12
230_A805_L0.5210.12
322_E343_M0.5200.12
175_V280_K0.5200.12
138_P470_A0.5200.12
20_Q137_S0.5200.12
271_G316_T0.5200.12
96_G100_I0.5190.12
226_D670_F0.5190.12
33_K370_C0.5190.12
13_V43_A0.5190.12
353_V387_Q0.5190.12
214_A529_A0.5180.12
520_P610_V0.5180.12
20_Q452_L0.5170.12
285_V290_G0.5170.12
747_N833_S0.5170.12
435_P765_Q0.5160.12
88_V280_K0.5160.12
680_K767_D0.5160.12
111_V435_P0.5150.12
168_G765_Q0.5150.12
772_R795_I0.5140.12
357_E543_L0.5140.12
217_T342_A0.5140.12
520_P657_H0.5140.12
128_L594_A0.5140.12
47_I62_V0.5130.12
97_T386_G0.5130.12
754_N847_R0.5130.12
91_E310_F0.5120.12
342_A371_L0.5120.12
786_A834_E0.5120.12
670_F674_Q0.5120.12
587_G590_A0.5120.12
640_M700_R0.5110.12
680_K698_V0.5100.12
12_L707_A0.5100.12
610_V622_L0.5100.12
293_N300_P0.5100.12
696_N810_G0.5100.12
714_F841_C0.5100.12
520_P547_S0.5090.12
610_V782_L0.5090.12
357_E361_A0.5090.12
857_I862_Y0.5090.12
234_V439_I0.5090.12
162_A167_I0.5080.12
75_Y764_S0.5080.12
674_Q679_L0.5080.12
244_V670_F0.5080.12
599_S739_L0.5080.12
100_I790_R0.5080.12
217_T251_S0.5080.12
647_C687_P0.5070.12
675_A713_A0.5070.12
151_D171_D0.5070.12
599_S639_V0.5070.12
120_A623_A0.5060.12
682_L745_I0.5060.12
47_I843_G0.5060.12
404_G812_P0.5050.12
93_D310_F0.5050.12
248_S648_A0.5050.12
284_D289_N0.5040.12
568_E581_Y0.5030.12
280_K348_D0.5030.12
439_I493_N0.5030.12
8_E177_L0.5020.12
200_K263_R0.5020.12
353_V360_V0.5020.12
340_T822_E0.5020.12
229_R772_R0.5020.12
464_R637_N0.5010.12
110_I178_S0.5010.12
310_F331_P0.5010.12
81_K665_V0.5010.12
322_E830_D0.5010.12
356_A385_F0.5010.12
528_G580_I0.5010.12
230_A661_A0.5000.12
59_M452_L0.5000.12
606_T841_C0.5000.12
233_S769_P0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zdrA 2 0.4501 100 0.761 Contact Map
3ox4A 2 0.4287 100 0.799 Contact Map
3bfjA 5 0.4276 100 0.799 Contact Map
4fr2A 2 0.4276 100 0.8 Contact Map
1rrmA 2 0.4299 100 0.801 Contact Map
1vljA 2 0.4332 100 0.806 Contact Map
3my7A 2 0.468 100 0.806 Contact Map
1o2dA 1 0.404 100 0.811 Contact Map
4qgsA 2 0.4175 100 0.812 Contact Map
3iv7A 2 0.3973 100 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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