ACCD - ECOLI - GREMLIN Contacts

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ACCD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

UniProt:	P0A9Q5	Sequences: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10217
Length:	304 (250)
Sequences:	7883 (3568)
Seq/√Len:	225.7

ECOLI - ACCD ACCA
BACSU - ACCD PCCB YNGE ACCA
HALSA - Q9HRN1 Q9HPQ0
SULSO - Q97VY8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_L	113_G	4.468	1.00
234_E	240_K	4.145	1.00
65_L	122_A	3.280	1.00
197_V	270_L	3.219	1.00
121_V	145_A	3.194	1.00
121_V	154_C	2.702	1.00
110_V	145_A	2.613	1.00
147_E	183_A	2.604	1.00
220_E	262_R	2.487	1.00
69_S	114_T	2.410	1.00
148_Q	152_D	2.387	1.00
43_L	47_P	2.372	1.00
252_I	257_I	2.369	1.00
70_L	111_M	2.353	1.00
54_R	200_D	2.343	1.00
159_F	197_V	2.249	1.00
150_L	187_M	2.195	1.00
248_S	260_I	2.172	1.00
114_T	119_P	2.156	1.00
116_Y	271_A	2.145	1.00
196_S	214_G	2.145	1.00
262_R	265_E	2.117	1.00
120_V	157_I	2.108	1.00
261_V	269_K	2.062	1.00
230_P	244_G	2.062	1.00
123_A	158_C	2.058	1.00
47_P	51_H	2.050	1.00
127_F	131_G	2.042	1.00
55_M	63_S	1.972	1.00
153_N	190_R	1.933	1.00
243_P	246_Q	1.929	1.00
157_I	197_V	1.885	1.00
160_S	196_S	1.844	1.00
107_A	138_V	1.835	1.00
112_K	152_D	1.794	1.00
218_I	259_M	1.781	1.00
269_K	272_S	1.771	1.00
259_M	269_K	1.719	1.00
108_L	142_F	1.707	1.00
150_L	190_R	1.699	1.00
143_V	183_A	1.691	1.00
64_L	159_F	1.661	1.00
116_Y	275_A	1.653	1.00
29_S	33_V	1.651	1.00
72_E	75_S	1.625	1.00
64_L	115_L	1.599	1.00
187_M	192_L	1.597	1.00
58_R	72_E	1.591	1.00
118_M	278_M	1.579	1.00
166_R	169_E	1.572	1.00
252_I	260_I	1.563	1.00
61_L	65_L	1.556	1.00
61_L	122_A	1.552	1.00
56_T	59_N	1.550	1.00
265_E	269_K	1.547	1.00
46_C	50_D	1.526	1.00
249_E	253_E	1.509	1.00
146_V	156_L	1.505	1.00
71_V	112_K	1.495	1.00
73_L	148_Q	1.489	1.00
74_G	144_R	1.478	1.00
148_Q	151_E	1.437	1.00
74_G	110_V	1.432	1.00
220_E	249_E	1.412	1.00
57_A	109_V	1.411	1.00
72_E	141_R	1.410	1.00
57_A	124_A	1.410	1.00
142_F	180_T	1.404	1.00
115_L	120_V	1.402	1.00
28_D	32_Q	1.400	1.00
50_D	262_R	1.384	1.00
150_L	192_L	1.381	1.00
112_K	154_C	1.379	1.00
119_P	154_C	1.376	1.00
136_S	172_M	1.371	1.00
265_E	268_L	1.355	1.00
46_C	49_C	1.349	1.00
242_P	245_F	1.326	1.00
133_S	163_G	1.320	1.00
112_K	121_V	1.294	1.00
112_K	119_P	1.291	1.00
116_Y	268_L	1.290	1.00
220_E	260_I	1.285	1.00
145_A	156_L	1.265	1.00
33_V	36_R	1.265	1.00
35_Y	38_E	1.247	1.00
50_D	59_N	1.234	1.00
34_L	75_S	1.234	1.00
134_M	138_V	1.225	1.00
23_V	26_K	1.211	1.00
59_N	62_H	1.187	1.00
266_M	270_L	1.185	1.00
215_D	219_A	1.166	1.00
218_I	261_V	1.166	1.00
196_S	213_L	1.162	1.00
139_G	176_Q	1.154	1.00
263_R	266_M	1.139	1.00
48_K	51_H	1.127	1.00
27_C	30_C	1.122	1.00
26_K	33_V	1.113	1.00
217_N	270_L	1.112	1.00
63_S	268_L	1.110	1.00
160_S	211_A	1.109	1.00
267_R	271_A	1.106	1.00
203_M	224_L	1.100	1.00
118_M	275_A	1.092	1.00
65_L	69_S	1.072	1.00
123_A	156_L	1.072	1.00
37_A	40_E	1.071	1.00
150_L	186_K	1.053	1.00
24_W	28_D	1.038	1.00
79_P	137_V	1.034	1.00
242_P	246_Q	1.034	1.00
69_S	111_M	1.030	1.00
118_M	279_N	1.029	1.00
81_D	84_K	1.026	1.00
228_A	232_V	1.023	1.00
81_D	136_S	1.014	1.00
217_N	269_K	1.012	1.00
123_A	145_A	1.011	1.00
218_I	223_A	1.008	1.00
217_N	266_M	1.008	1.00
110_V	121_V	1.007	1.00
44_E	59_N	1.004	1.00
146_V	184_L	1.004	1.00
241_L	245_F	1.002	1.00
65_L	120_V	0.999	1.00
39_L	43_L	0.997	1.00
140_A	179_K	0.995	1.00
230_P	247_R	0.992	1.00
29_S	32_Q	0.991	1.00
154_C	192_L	0.989	1.00
25_T	36_R	0.988	1.00
214_G	219_A	0.985	1.00
113_G	122_A	0.973	1.00
185_A	189_E	0.972	1.00
268_L	272_S	0.971	1.00
182_A	186_K	0.962	1.00
108_L	123_A	0.945	1.00
34_L	38_E	0.944	1.00
63_S	267_R	0.940	1.00
39_L	42_N	0.939	1.00
249_E	260_I	0.931	1.00
121_V	148_Q	0.931	1.00
62_H	67_E	0.930	1.00
193_P	277_L	0.929	1.00
116_Y	267_R	0.921	1.00
147_E	186_K	0.918	1.00
143_V	179_K	0.917	1.00
146_V	187_M	0.914	0.99
33_V	37_A	0.912	0.99
184_L	194_Y	0.910	0.99
106_D	137_V	0.906	0.99
112_K	148_Q	0.905	0.99
32_Q	35_Y	0.902	0.99
127_F	201_P	0.902	0.99
24_W	35_Y	0.901	0.99
159_F	199_T	0.899	0.99
79_P	106_D	0.898	0.99
73_L	121_V	0.891	0.99
261_V	266_M	0.884	0.99
143_V	147_E	0.880	0.99
31_G	34_L	0.878	0.99
58_R	109_V	0.873	0.99
159_F	267_R	0.869	0.99
146_V	183_A	0.868	0.99
65_L	70_L	0.868	0.99
78_E	105_K	0.867	0.99
199_T	267_R	0.863	0.99
38_E	75_S	0.862	0.99
157_I	274_L	0.853	0.99
50_D	56_T	0.851	0.99
37_A	41_R	0.847	0.99
141_R	144_R	0.846	0.99
140_A	144_R	0.844	0.99
147_E	151_E	0.844	0.99
78_E	137_V	0.842	0.99
32_Q	36_R	0.839	0.99
48_K	52_H	0.831	0.99
26_K	29_S	0.830	0.99
58_R	62_H	0.830	0.99
178_A	182_A	0.828	0.99
110_V	123_A	0.827	0.99
40_E	44_E	0.824	0.99
37_A	77_L	0.818	0.99
138_V	142_F	0.818	0.99
135_G	166_R	0.816	0.99
185_A	188_Q	0.816	0.99
217_N	261_V	0.808	0.99
148_Q	154_C	0.807	0.99
279_N	283_P	0.803	0.99
135_G	170_A	0.801	0.99
121_V	149_A	0.800	0.99
30_C	49_C	0.797	0.99
58_R	104_E	0.795	0.99
86_R	99_Q	0.790	0.99
264_P	267_R	0.783	0.98
45_V	52_H	0.780	0.98
137_V	140_A	0.779	0.98
273_I	277_L	0.764	0.98
219_A	257_I	0.764	0.98
166_R	170_A	0.760	0.98
207_S	212_M	0.756	0.98
81_D	85_F	0.754	0.98
39_L	46_C	0.753	0.98
146_V	150_L	0.751	0.98
28_D	31_G	0.750	0.98
66_D	69_S	0.746	0.98
38_E	41_R	0.745	0.98
184_L	209_S	0.741	0.98
99_Q	105_K	0.738	0.98
266_M	269_K	0.737	0.98
116_Y	279_N	0.734	0.98
52_H	55_M	0.734	0.98
179_K	183_A	0.734	0.98
46_C	56_T	0.733	0.98
43_L	46_C	0.730	0.98
44_E	47_P	0.728	0.97
272_S	276_K	0.722	0.97
73_L	112_K	0.721	0.97
25_T	28_D	0.720	0.97
162_S	206_V	0.716	0.97
41_R	45_V	0.715	0.97
118_M	271_A	0.714	0.97
149_A	156_L	0.714	0.97
30_C	46_C	0.713	0.97
61_L	124_A	0.713	0.97
142_F	158_C	0.710	0.97
216_L	219_A	0.709	0.97
59_N	63_S	0.705	0.97
224_L	230_P	0.698	0.97
240_K	245_F	0.696	0.97
143_V	146_V	0.694	0.97
121_V	152_D	0.693	0.97
104_E	126_E	0.692	0.97
120_V	274_L	0.691	0.97
215_D	220_E	0.689	0.96
146_V	158_C	0.689	0.96
39_L	53_M	0.687	0.96
28_D	51_H	0.683	0.96
119_P	152_D	0.683	0.96
72_E	109_V	0.682	0.96
37_A	105_K	0.682	0.96
34_L	37_A	0.678	0.96
61_L	111_M	0.676	0.96
203_M	226_G	0.672	0.96
32_Q	48_K	0.671	0.96
106_D	166_R	0.666	0.96
215_D	218_I	0.665	0.96
77_L	144_R	0.663	0.96
215_D	259_M	0.661	0.96
103_G	130_M	0.659	0.95
74_G	77_L	0.659	0.95
217_N	273_I	0.658	0.95
194_Y	214_G	0.657	0.95
153_N	192_L	0.655	0.95
217_N	257_I	0.654	0.95
131_G	159_F	0.652	0.95
278_M	281_P	0.646	0.95
42_N	45_V	0.646	0.95
74_G	141_R	0.642	0.95
110_V	141_R	0.642	0.95
134_M	142_F	0.640	0.95
56_T	128_A	0.640	0.95
113_G	120_V	0.639	0.95
162_S	201_P	0.637	0.95
221_P	262_R	0.635	0.94
186_K	189_E	0.634	0.94
195_I	273_I	0.634	0.94
199_T	264_P	0.631	0.94
161_A	199_T	0.631	0.94
23_V	33_V	0.628	0.94
156_L	192_L	0.628	0.94
64_L	122_A	0.626	0.94
158_C	194_Y	0.620	0.94
42_N	46_C	0.617	0.94
23_V	38_E	0.615	0.94
35_Y	39_L	0.614	0.93
257_I	260_I	0.614	0.93
49_C	52_H	0.613	0.93
181_S	213_L	0.613	0.93
187_M	193_P	0.612	0.93
229_G	232_V	0.611	0.93
130_M	168_Q	0.611	0.93
30_C	34_L	0.611	0.93
26_K	38_E	0.609	0.93
196_S	210_F	0.605	0.93
165_A	174_L	0.600	0.93
70_L	109_V	0.600	0.93
199_T	222_K	0.598	0.93
200_D	247_R	0.597	0.92
184_L	213_L	0.597	0.92
40_E	43_L	0.595	0.92
270_L	273_I	0.595	0.92
55_M	264_P	0.594	0.92
269_K	273_I	0.588	0.92
199_T	219_A	0.586	0.92
77_L	80_K	0.586	0.92
105_K	141_R	0.586	0.92
125_F	210_F	0.584	0.92
106_D	135_G	0.582	0.92
196_S	217_N	0.582	0.92
251_L	257_I	0.580	0.91
64_L	270_L	0.579	0.91
228_A	233_I	0.577	0.91
22_G	35_Y	0.575	0.91
131_G	193_P	0.575	0.91
115_L	118_M	0.574	0.91
155_P	192_L	0.571	0.91
122_A	159_F	0.570	0.91
26_K	31_G	0.570	0.91
23_V	37_A	0.568	0.91
61_L	109_V	0.567	0.90
78_E	99_Q	0.567	0.90
81_D	86_R	0.566	0.90
58_R	61_L	0.565	0.90
85_F	98_A	0.565	0.90
125_F	138_V	0.565	0.90
131_G	163_G	0.565	0.90
82_V	172_M	0.562	0.90
158_C	184_L	0.562	0.90
25_T	29_S	0.562	0.90
221_P	249_E	0.560	0.90
115_L	157_I	0.559	0.90
184_L	187_M	0.556	0.90
25_T	34_L	0.554	0.89
83_L	86_R	0.554	0.89
170_A	173_S	0.553	0.89
261_V	265_E	0.548	0.89
62_H	70_L	0.545	0.89
107_A	134_M	0.542	0.88
214_G	217_N	0.542	0.88
49_C	56_T	0.538	0.88
175_M	179_K	0.538	0.88
73_L	110_V	0.536	0.88
47_P	50_D	0.534	0.88
71_V	74_G	0.533	0.88
24_W	27_C	0.529	0.87
124_A	159_F	0.528	0.87
61_L	70_L	0.527	0.87
201_P	224_L	0.526	0.87
251_L	254_K	0.524	0.87
137_V	178_A	0.524	0.87
191_G	281_P	0.523	0.87
58_R	65_L	0.522	0.86
250_F	253_E	0.521	0.86
73_L	152_D	0.521	0.86
214_G	220_E	0.519	0.86
153_N	191_G	0.517	0.86
98_A	102_T	0.517	0.86
111_M	141_R	0.516	0.86
272_S	275_A	0.513	0.86
125_F	146_V	0.512	0.85
184_L	196_S	0.512	0.85
173_S	177_M	0.510	0.85
198_L	217_N	0.508	0.85
22_G	26_K	0.508	0.85
273_I	278_M	0.507	0.85
213_L	216_L	0.507	0.85
40_E	45_V	0.507	0.85
157_I	195_I	0.506	0.85
244_G	247_R	0.506	0.85
57_A	126_E	0.505	0.85
57_A	61_L	0.505	0.85
184_L	188_Q	0.505	0.85
128_A	132_G	0.505	0.85
156_L	187_M	0.505	0.85
280_L	283_P	0.505	0.85
122_A	157_I	0.504	0.85
55_M	59_N	0.503	0.84
82_V	85_F	0.502	0.84
30_C	33_V	0.501	0.84
207_S	256_A	0.500	0.84
248_S	257_I	0.500	0.84
176_Q	179_K	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vrgA	4	0.8882	100	0.224	Contact Map
3u9rB	5	0.9375	100	0.228	Contact Map
1pixA	4	0.9243	100	0.251	Contact Map
3gf3A	4	0.9178	100	0.261	Contact Map
3n6rB	4	0.8684	100	0.269	Contact Map
4rcnA	6	0.8914	100	0.278	Contact Map
2bzrA	4	0.898	100	0.292	Contact Map
2f9yB	1	0.8454	100	0.297	Contact Map
3iavA	4	0.8947	100	0.319	Contact Map
1x0uA	5	0.8914	100	0.321	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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