GREMLIN Database
ACCD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
UniProt: P0A9Q5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10217
Length: 304 (250)
Sequences: 7883 (3568)
Seq/√Len: 225.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_L113_G4.4681.00
234_E240_K4.1451.00
65_L122_A3.2801.00
197_V270_L3.2191.00
121_V145_A3.1941.00
121_V154_C2.7021.00
110_V145_A2.6131.00
147_E183_A2.6041.00
220_E262_R2.4871.00
69_S114_T2.4101.00
148_Q152_D2.3871.00
43_L47_P2.3721.00
252_I257_I2.3691.00
70_L111_M2.3531.00
54_R200_D2.3431.00
159_F197_V2.2491.00
150_L187_M2.1951.00
248_S260_I2.1721.00
114_T119_P2.1561.00
116_Y271_A2.1451.00
196_S214_G2.1451.00
262_R265_E2.1171.00
120_V157_I2.1081.00
261_V269_K2.0621.00
230_P244_G2.0621.00
123_A158_C2.0581.00
47_P51_H2.0501.00
127_F131_G2.0421.00
55_M63_S1.9721.00
153_N190_R1.9331.00
243_P246_Q1.9291.00
157_I197_V1.8851.00
160_S196_S1.8441.00
107_A138_V1.8351.00
112_K152_D1.7941.00
218_I259_M1.7811.00
269_K272_S1.7711.00
259_M269_K1.7191.00
108_L142_F1.7071.00
150_L190_R1.6991.00
143_V183_A1.6911.00
64_L159_F1.6611.00
116_Y275_A1.6531.00
29_S33_V1.6511.00
72_E75_S1.6251.00
64_L115_L1.5991.00
187_M192_L1.5971.00
58_R72_E1.5911.00
118_M278_M1.5791.00
166_R169_E1.5721.00
252_I260_I1.5631.00
61_L65_L1.5561.00
61_L122_A1.5521.00
56_T59_N1.5501.00
265_E269_K1.5471.00
46_C50_D1.5261.00
249_E253_E1.5091.00
146_V156_L1.5051.00
71_V112_K1.4951.00
73_L148_Q1.4891.00
74_G144_R1.4781.00
148_Q151_E1.4371.00
74_G110_V1.4321.00
220_E249_E1.4121.00
57_A109_V1.4111.00
72_E141_R1.4101.00
57_A124_A1.4101.00
142_F180_T1.4041.00
115_L120_V1.4021.00
28_D32_Q1.4001.00
50_D262_R1.3841.00
150_L192_L1.3811.00
112_K154_C1.3791.00
119_P154_C1.3761.00
136_S172_M1.3711.00
265_E268_L1.3551.00
46_C49_C1.3491.00
242_P245_F1.3261.00
133_S163_G1.3201.00
112_K121_V1.2941.00
112_K119_P1.2911.00
116_Y268_L1.2901.00
220_E260_I1.2851.00
145_A156_L1.2651.00
33_V36_R1.2651.00
35_Y38_E1.2471.00
50_D59_N1.2341.00
34_L75_S1.2341.00
134_M138_V1.2251.00
23_V26_K1.2111.00
59_N62_H1.1871.00
266_M270_L1.1851.00
215_D219_A1.1661.00
218_I261_V1.1661.00
196_S213_L1.1621.00
139_G176_Q1.1541.00
263_R266_M1.1391.00
48_K51_H1.1271.00
27_C30_C1.1221.00
26_K33_V1.1131.00
217_N270_L1.1121.00
63_S268_L1.1101.00
160_S211_A1.1091.00
267_R271_A1.1061.00
203_M224_L1.1001.00
118_M275_A1.0921.00
65_L69_S1.0721.00
123_A156_L1.0721.00
37_A40_E1.0711.00
150_L186_K1.0531.00
24_W28_D1.0381.00
79_P137_V1.0341.00
242_P246_Q1.0341.00
69_S111_M1.0301.00
118_M279_N1.0291.00
81_D84_K1.0261.00
228_A232_V1.0231.00
81_D136_S1.0141.00
217_N269_K1.0121.00
123_A145_A1.0111.00
218_I223_A1.0081.00
217_N266_M1.0081.00
110_V121_V1.0071.00
44_E59_N1.0041.00
146_V184_L1.0041.00
241_L245_F1.0021.00
65_L120_V0.9991.00
39_L43_L0.9971.00
140_A179_K0.9951.00
230_P247_R0.9921.00
29_S32_Q0.9911.00
154_C192_L0.9891.00
25_T36_R0.9881.00
214_G219_A0.9851.00
113_G122_A0.9731.00
185_A189_E0.9721.00
268_L272_S0.9711.00
182_A186_K0.9621.00
108_L123_A0.9451.00
34_L38_E0.9441.00
63_S267_R0.9401.00
39_L42_N0.9391.00
249_E260_I0.9311.00
121_V148_Q0.9311.00
62_H67_E0.9301.00
193_P277_L0.9291.00
116_Y267_R0.9211.00
147_E186_K0.9181.00
143_V179_K0.9171.00
146_V187_M0.9140.99
33_V37_A0.9120.99
184_L194_Y0.9100.99
106_D137_V0.9060.99
112_K148_Q0.9050.99
32_Q35_Y0.9020.99
127_F201_P0.9020.99
24_W35_Y0.9010.99
159_F199_T0.8990.99
79_P106_D0.8980.99
73_L121_V0.8910.99
261_V266_M0.8840.99
143_V147_E0.8800.99
31_G34_L0.8780.99
58_R109_V0.8730.99
159_F267_R0.8690.99
146_V183_A0.8680.99
65_L70_L0.8680.99
78_E105_K0.8670.99
199_T267_R0.8630.99
38_E75_S0.8620.99
157_I274_L0.8530.99
50_D56_T0.8510.99
37_A41_R0.8470.99
141_R144_R0.8460.99
140_A144_R0.8440.99
147_E151_E0.8440.99
78_E137_V0.8420.99
32_Q36_R0.8390.99
48_K52_H0.8310.99
26_K29_S0.8300.99
58_R62_H0.8300.99
178_A182_A0.8280.99
110_V123_A0.8270.99
40_E44_E0.8240.99
37_A77_L0.8180.99
138_V142_F0.8180.99
135_G166_R0.8160.99
185_A188_Q0.8160.99
217_N261_V0.8080.99
148_Q154_C0.8070.99
279_N283_P0.8030.99
135_G170_A0.8010.99
121_V149_A0.8000.99
30_C49_C0.7970.99
58_R104_E0.7950.99
86_R99_Q0.7900.99
264_P267_R0.7830.98
45_V52_H0.7800.98
137_V140_A0.7790.98
273_I277_L0.7640.98
219_A257_I0.7640.98
166_R170_A0.7600.98
207_S212_M0.7560.98
81_D85_F0.7540.98
39_L46_C0.7530.98
146_V150_L0.7510.98
28_D31_G0.7500.98
66_D69_S0.7460.98
38_E41_R0.7450.98
184_L209_S0.7410.98
99_Q105_K0.7380.98
266_M269_K0.7370.98
116_Y279_N0.7340.98
52_H55_M0.7340.98
179_K183_A0.7340.98
46_C56_T0.7330.98
43_L46_C0.7300.98
44_E47_P0.7280.97
272_S276_K0.7220.97
73_L112_K0.7210.97
25_T28_D0.7200.97
162_S206_V0.7160.97
41_R45_V0.7150.97
118_M271_A0.7140.97
149_A156_L0.7140.97
30_C46_C0.7130.97
61_L124_A0.7130.97
142_F158_C0.7100.97
216_L219_A0.7090.97
59_N63_S0.7050.97
224_L230_P0.6980.97
240_K245_F0.6960.97
143_V146_V0.6940.97
121_V152_D0.6930.97
104_E126_E0.6920.97
120_V274_L0.6910.97
215_D220_E0.6890.96
146_V158_C0.6890.96
39_L53_M0.6870.96
28_D51_H0.6830.96
119_P152_D0.6830.96
72_E109_V0.6820.96
37_A105_K0.6820.96
34_L37_A0.6780.96
61_L111_M0.6760.96
203_M226_G0.6720.96
32_Q48_K0.6710.96
106_D166_R0.6660.96
215_D218_I0.6650.96
77_L144_R0.6630.96
215_D259_M0.6610.96
103_G130_M0.6590.95
74_G77_L0.6590.95
217_N273_I0.6580.95
194_Y214_G0.6570.95
153_N192_L0.6550.95
217_N257_I0.6540.95
131_G159_F0.6520.95
278_M281_P0.6460.95
42_N45_V0.6460.95
74_G141_R0.6420.95
110_V141_R0.6420.95
134_M142_F0.6400.95
56_T128_A0.6400.95
113_G120_V0.6390.95
162_S201_P0.6370.95
221_P262_R0.6350.94
186_K189_E0.6340.94
195_I273_I0.6340.94
199_T264_P0.6310.94
161_A199_T0.6310.94
23_V33_V0.6280.94
156_L192_L0.6280.94
64_L122_A0.6260.94
158_C194_Y0.6200.94
42_N46_C0.6170.94
23_V38_E0.6150.94
35_Y39_L0.6140.93
257_I260_I0.6140.93
49_C52_H0.6130.93
181_S213_L0.6130.93
187_M193_P0.6120.93
229_G232_V0.6110.93
130_M168_Q0.6110.93
30_C34_L0.6110.93
26_K38_E0.6090.93
196_S210_F0.6050.93
165_A174_L0.6000.93
70_L109_V0.6000.93
199_T222_K0.5980.93
200_D247_R0.5970.92
184_L213_L0.5970.92
40_E43_L0.5950.92
270_L273_I0.5950.92
55_M264_P0.5940.92
269_K273_I0.5880.92
199_T219_A0.5860.92
77_L80_K0.5860.92
105_K141_R0.5860.92
125_F210_F0.5840.92
106_D135_G0.5820.92
196_S217_N0.5820.92
251_L257_I0.5800.91
64_L270_L0.5790.91
228_A233_I0.5770.91
22_G35_Y0.5750.91
131_G193_P0.5750.91
115_L118_M0.5740.91
155_P192_L0.5710.91
122_A159_F0.5700.91
26_K31_G0.5700.91
23_V37_A0.5680.91
61_L109_V0.5670.90
78_E99_Q0.5670.90
81_D86_R0.5660.90
58_R61_L0.5650.90
85_F98_A0.5650.90
125_F138_V0.5650.90
131_G163_G0.5650.90
82_V172_M0.5620.90
158_C184_L0.5620.90
25_T29_S0.5620.90
221_P249_E0.5600.90
115_L157_I0.5590.90
184_L187_M0.5560.90
25_T34_L0.5540.89
83_L86_R0.5540.89
170_A173_S0.5530.89
261_V265_E0.5480.89
62_H70_L0.5450.89
107_A134_M0.5420.88
214_G217_N0.5420.88
49_C56_T0.5380.88
175_M179_K0.5380.88
73_L110_V0.5360.88
47_P50_D0.5340.88
71_V74_G0.5330.88
24_W27_C0.5290.87
124_A159_F0.5280.87
61_L70_L0.5270.87
201_P224_L0.5260.87
251_L254_K0.5240.87
137_V178_A0.5240.87
191_G281_P0.5230.87
58_R65_L0.5220.86
250_F253_E0.5210.86
73_L152_D0.5210.86
214_G220_E0.5190.86
153_N191_G0.5170.86
98_A102_T0.5170.86
111_M141_R0.5160.86
272_S275_A0.5130.86
125_F146_V0.5120.85
184_L196_S0.5120.85
173_S177_M0.5100.85
198_L217_N0.5080.85
22_G26_K0.5080.85
273_I278_M0.5070.85
213_L216_L0.5070.85
40_E45_V0.5070.85
157_I195_I0.5060.85
244_G247_R0.5060.85
57_A126_E0.5050.85
57_A61_L0.5050.85
184_L188_Q0.5050.85
128_A132_G0.5050.85
156_L187_M0.5050.85
280_L283_P0.5050.85
122_A157_I0.5040.85
55_M59_N0.5030.84
82_V85_F0.5020.84
30_C33_V0.5010.84
207_S256_A0.5000.84
248_S257_I0.5000.84
176_Q179_K0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vrgA 4 0.8882 100 0.224 Contact Map
3u9rB 5 0.9375 100 0.228 Contact Map
1pixA 4 0.9243 100 0.251 Contact Map
3gf3A 4 0.9178 100 0.261 Contact Map
3n6rB 4 0.8684 100 0.269 Contact Map
4rcnA 6 0.8914 100 0.278 Contact Map
2bzrA 4 0.898 100 0.292 Contact Map
2f9yB 1 0.8454 100 0.297 Contact Map
3iavA 4 0.8947 100 0.319 Contact Map
1x0uA 5 0.8914 100 0.321 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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