GREMLIN Database
ARCA - Aerobic respiration control protein ArcA
UniProt: P0A9Q1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10061
Length: 238 (209)
Sequences: 77258 (55545)
Seq/√Len: 3842.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_R32_E3.7751.00
16_R34_T3.3171.00
20_K32_E3.2861.00
9_V39_M2.8151.00
40_H68_E2.7691.00
37_A59_G2.5791.00
31_F48_I2.4701.00
44_S72_Q2.3981.00
36_G60_K2.3891.00
60_K68_E2.3881.00
35_D59_G2.3301.00
5_H31_F2.2161.00
5_H29_D2.0871.00
33_A42_I2.0791.00
20_K24_E2.0601.00
26_E111_T2.0451.00
22_I107_P2.0431.00
56_N83_R1.9261.00
89_K109_E1.9131.00
34_T38_E1.8941.00
53_M65_L1.8821.00
199_R202_D1.8451.00
66_A77_L1.8271.00
31_F42_I1.8001.00
35_D38_E1.7761.00
79_F92_G1.7761.00
7_L33_A1.7521.00
164_S167_R1.7361.00
68_E72_Q1.7231.00
70_R98_D1.6841.00
79_F97_A1.6611.00
42_I46_Y1.6561.00
86_E106_N1.6391.00
31_F46_Y1.6221.00
4_P118_L1.5801.00
67_R95_I1.5801.00
36_G65_L1.5711.00
99_D113_R1.5701.00
60_K64_L1.5661.00
61_N64_L1.5591.00
43_L69_L1.5251.00
42_I45_E1.5221.00
170_L174_E1.5191.00
182_R202_D1.5021.00
68_E71_E1.4891.00
83_R88_D1.4801.00
171_H188_K1.4721.00
204_T207_R1.4711.00
23_F114_A1.4611.00
51_V75_V1.4191.00
37_A60_K1.4171.00
66_A79_F1.4141.00
64_L67_R1.3801.00
40_H65_L1.3641.00
98_D120_R1.3411.00
50_L114_A1.3401.00
138_K143_E1.3301.00
78_M117_L1.3251.00
98_D117_L1.3171.00
13_L34_T1.3131.00
141_G155_D1.2991.00
42_I48_I1.2951.00
55_I63_L1.2761.00
41_Q45_E1.2571.00
10_E16_R1.2431.00
53_M66_A1.2341.00
11_D54_D1.2281.00
171_H175_N1.2271.00
9_V57_L1.2211.00
40_H60_K1.2091.00
5_H46_Y1.1971.00
38_E41_Q1.1961.00
55_I79_F1.1961.00
28_Y115_R1.1851.00
33_A39_M1.1831.00
7_L48_I1.1821.00
63_L92_G1.1761.00
38_E42_I1.1661.00
111_T115_R1.1611.00
184_E188_K1.1601.00
37_A41_Q1.1581.00
145_D148_S1.1571.00
181_S184_E1.1561.00
63_L91_L1.1551.00
85_N88_D1.1411.00
150_S158_Q1.1391.00
7_L39_M1.1361.00
91_L95_I1.1331.00
205_I209_R1.1191.00
200_T204_T1.1171.00
176_P188_K1.1151.00
86_E90_I1.1091.00
150_S153_G1.1091.00
26_E115_R1.0951.00
143_E153_G1.0921.00
6_I28_Y1.0831.00
199_R203_V1.0731.00
39_M65_L1.0711.00
27_G115_R1.0711.00
7_L42_I1.0701.00
94_E115_R1.0621.00
67_R91_L1.0571.00
112_I116_N1.0551.00
40_H44_S1.0441.00
166_F170_L1.0391.00
109_E112_I1.0361.00
176_P180_Q1.0301.00
165_E211_H1.0271.00
17_N32_E1.0271.00
203_V206_R1.0191.00
33_A38_E1.0161.00
90_I94_E1.0071.00
87_V91_L0.9981.00
50_L118_L0.9861.00
39_M43_L0.9851.00
89_K102_T0.9821.00
20_K30_V0.9811.00
167_R170_L0.9761.00
8_I19_L0.9691.00
164_S190_T0.9631.00
51_V69_L0.9601.00
14_V18_T0.9601.00
146_I170_L0.9601.00
7_L43_L0.9591.00
13_L17_N0.9581.00
4_P28_Y0.9551.00
63_L95_I0.9551.00
144_L173_C0.9541.00
86_E89_K0.9531.00
183_A198_D0.9531.00
53_M77_L0.9451.00
55_I61_N0.9411.00
9_V33_A0.9231.00
41_Q44_S0.9161.00
66_A95_I0.9151.00
19_L80_L0.9151.00
9_V51_V0.9131.00
53_M79_F0.9121.00
64_L68_E0.9121.00
153_G158_Q0.8871.00
51_V77_L0.8841.00
4_P122_M0.8841.00
215_T218_T0.8781.00
91_L94_E0.8711.00
66_A97_A0.8701.00
8_I30_V0.8681.00
144_L166_F0.8681.00
207_R210_K0.8681.00
76_A98_D0.8631.00
17_N20_K0.8591.00
13_L16_R0.8571.00
117_L120_R0.8551.00
163_R167_R0.8511.00
216_P219_P0.8511.00
55_I88_D0.8491.00
171_H180_Q0.8471.00
28_Y111_T0.8471.00
84_D102_T0.8451.00
21_S25_A0.8441.00
5_H49_N0.8441.00
52_I110_L0.8431.00
109_E113_R0.8391.00
65_L69_L0.8381.00
67_R71_E0.8381.00
171_H185_L0.8321.00
78_M113_R0.8271.00
180_Q184_E0.8181.00
198_D202_D0.8081.00
214_S224_T0.8071.00
5_H48_I0.8011.00
57_L65_L0.8011.00
43_L75_V0.7971.00
199_R206_R0.7961.00
60_K65_L0.7941.00
107_P111_T0.7921.00
90_I108_R0.7901.00
52_I80_L0.7871.00
43_L48_I0.7801.00
52_I114_A0.7761.00
15_T105_F0.7741.00
214_S220_E0.7741.00
88_D91_L0.7721.00
183_A187_K0.7661.00
55_I83_R0.7621.00
184_E187_K0.7601.00
80_L105_F0.7581.00
168_A172_F0.7571.00
87_V108_R0.7561.00
36_G40_H0.7531.00
9_V65_L0.7481.00
173_C176_P0.7471.00
118_L121_T0.7451.00
19_L110_L0.7391.00
69_L73_A0.7381.00
203_V207_R0.7371.00
105_F110_L0.7351.00
17_N21_S0.7331.00
116_N121_T0.7291.00
121_T125_G0.7271.00
116_N119_S0.7271.00
56_N82_G0.7251.00
106_N109_E0.7211.00
172_F176_P0.7101.00
171_H174_E0.7071.00
93_L113_R0.7071.00
36_G59_G0.7051.00
182_R198_D0.7031.00
76_A124_L0.6981.00
213_E216_P0.6961.00
40_H43_L0.6951.00
44_S68_E0.6951.00
138_K141_G0.6951.00
69_L77_L0.6901.00
74_N124_L0.6901.00
215_T219_P0.6901.00
76_A120_R0.6791.00
162_P211_H0.6781.00
18_T22_I0.6771.00
149_R167_R0.6771.00
196_P201_V0.6751.00
78_M99_D0.6741.00
206_R210_K0.6741.00
99_D116_N0.6711.00
8_I20_K0.6701.00
70_R76_A0.6701.00
22_I111_T0.6701.00
43_L51_V0.6681.00
10_E57_L0.6651.00
94_E112_I0.6611.00
8_I32_E0.6591.00
92_G97_A0.6581.00
108_R112_I0.6581.00
36_G57_L0.6581.00
219_P222_I0.6561.00
213_E220_E0.6561.00
187_K190_T0.6511.00
186_L190_T0.6511.00
142_W154_P0.6501.00
63_L88_D0.6461.00
86_E108_R0.6451.00
89_K106_N0.6441.00
52_I78_M0.6401.00
153_G156_G0.6391.00
40_H72_Q0.6381.00
74_N123_N0.6371.00
16_R20_K0.6361.00
209_R214_S0.6261.00
202_D205_I0.6261.00
215_T220_E0.6251.00
70_R75_V0.6231.00
113_R117_L0.6231.00
149_R166_F0.6231.00
105_F109_E0.6191.00
4_P49_N0.6181.00
24_E30_V0.6171.00
115_R119_S0.6131.00
87_V90_I0.6121.00
6_I50_L0.6091.00
76_A118_L0.6061.00
174_E188_K0.6061.00
167_R171_H0.6041.00
197_H200_T0.6031.00
220_E223_A0.6031.00
141_G154_P0.6011.00
112_I115_R0.5981.00
137_Y141_G0.5971.00
23_F28_Y0.5971.00
171_H176_P0.5961.00
196_P200_T0.5961.00
12_E15_T0.5951.00
6_I23_F0.5931.00
54_D103_K0.5931.00
12_E82_G0.5911.00
15_T18_T0.5891.00
66_A70_R0.5891.00
76_A121_T0.5861.00
162_P165_E0.5771.00
81_T89_K0.5691.00
182_R186_L0.5641.00
55_I92_G0.5621.00
53_M57_L0.5601.00
213_E219_P0.5531.00
172_F205_I0.5491.00
22_I26_E0.5431.00
139_F142_W0.5421.00
202_D206_R0.5381.00
43_L65_L0.5381.00
90_I93_L0.5361.00
69_L75_V0.5331.00
219_P227_G0.5321.00
18_T21_S0.5271.00
11_D81_T0.5261.00
137_Y146_I0.5231.00
43_L72_Q0.5221.00
43_L73_A0.5221.00
84_D104_P0.5221.00
137_Y142_W0.5201.00
145_D150_S0.5201.00
38_E59_G0.5191.00
210_K213_E0.5141.00
146_I174_E0.5111.00
164_S204_T0.5111.00
82_G104_P0.5091.00
114_A118_L0.5091.00
120_R124_L0.5061.00
53_M69_L0.5041.00
116_N120_R0.5041.00
11_D57_L0.5041.00
24_E29_D0.5031.00
8_I16_R0.5021.00
9_V36_G0.5021.00
47_D73_A0.5011.00
216_P220_E0.5001.00
139_F173_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.937 100 0.203 Contact Map
4b09A 2 0.8992 100 0.211 Contact Map
1ys7A 2 0.9454 100 0.212 Contact Map
3r0jA 2 0.9286 100 0.218 Contact Map
2oqrA 2 0.9496 100 0.221 Contact Map
4kfcA 2 0.9412 100 0.223 Contact Map
1kgsA 1 0.916 100 0.235 Contact Map
3q9sA 1 0.8824 100 0.254 Contact Map
2hqrA 2 0.916 100 0.267 Contact Map
1p2fA 1 0.9076 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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