GREMLIN Database
TRXB - Thioredoxin reductase
UniProt: P0A9P4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11032
Length: 321 (286)
Sequences: 60364 (42211)
Seq/√Len: 2496.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_A237_V4.0461.00
37_G84_H3.7001.00
148_K171_E3.4341.00
173_H203_H3.2921.00
210_E222_R3.0471.00
171_E201_I3.0231.00
8_K107_D2.9051.00
212_T222_R2.7831.00
267_Q276_Q2.7521.00
8_K31_Q2.5141.00
225_D233_E2.5061.00
148_K238_A2.4481.00
150_A175_I2.3971.00
123_P210_E2.3671.00
203_H233_E2.3461.00
21_A110_I2.3311.00
222_R234_S2.2641.00
10_L35_I2.2601.00
33_V81_I2.2571.00
9_L25_A2.2551.00
258_E265_K2.2531.00
118_R247_S2.2411.00
212_T220_G2.2361.00
10_L97_L2.2211.00
35_I104_Y2.1561.00
209_E224_R2.1501.00
150_A221_V2.1461.00
93_R281_G2.1441.00
6_H105_T2.1291.00
7_S33_V2.1121.00
207_T224_R2.1061.00
110_I310_A2.0911.00
10_L104_Y2.0471.00
96_R103_E2.0461.00
148_K173_H2.0421.00
192_M196_E1.9521.00
209_E222_R1.9101.00
220_G234_S1.8711.00
6_H107_D1.8531.00
177_R207_T1.8111.00
90_L279_I1.8071.00
8_K33_V1.7971.00
17_A285_A1.7611.00
212_T234_S1.7481.00
127_A213_G1.7141.00
99_G102_G1.7091.00
148_K236_D1.7071.00
106_C109_L1.6931.00
108_A281_G1.6581.00
31_Q79_E1.6521.00
116_S249_N1.6511.00
206_R225_D1.6351.00
175_I235_L1.6081.00
98_N103_E1.6071.00
135_A138_T1.5891.00
213_G219_T1.5751.00
147_Q238_A1.5551.00
148_K170_S1.5521.00
116_S247_S1.5461.00
220_G236_D1.5441.00
260_E263_Y1.5421.00
99_G104_Y1.5351.00
173_H201_I1.5321.00
223_L235_L1.4971.00
87_K98_N1.4951.00
116_S251_A1.4911.00
223_L226_T1.4901.00
211_V240_L1.4831.00
307_A311_E1.4831.00
110_I285_A1.4791.00
10_L106_C1.4771.00
61_T64_L1.4771.00
96_R105_T1.4731.00
10_L33_V1.4731.00
89_D92_N1.4511.00
258_E278_S1.4391.00
306_A310_A1.4261.00
303_G307_A1.4151.00
203_H206_R1.3901.00
11_I18_G1.3791.00
90_L282_V1.3631.00
11_I22_A1.3551.00
149_V165_L1.3521.00
89_D96_R1.3511.00
113_T288_V1.3251.00
84_H100_D1.3151.00
22_A34_L1.2981.00
206_R223_L1.2931.00
67_E71_E1.2841.00
108_A310_A1.2831.00
14_S36_T1.2791.00
206_R233_E1.2681.00
283_F309_D1.2641.00
173_H237_V1.2501.00
108_A283_F1.2481.00
9_L110_I1.2401.00
24_Y308_L1.2251.00
279_I282_V1.2181.00
72_H76_F1.2161.00
260_E265_K1.2111.00
33_V104_Y1.2081.00
179_D205_N1.1971.00
121_G125_E1.1871.00
88_V109_L1.1841.00
159_V174_L1.1601.00
70_H74_T1.1581.00
146_N170_S1.1541.00
252_I255_G1.1511.00
112_A285_A1.1501.00
24_Y27_R1.1501.00
223_L233_E1.1481.00
154_G176_H1.1471.00
134_S138_T1.1451.00
180_G188_I1.1451.00
260_E290_D1.1241.00
9_L30_L1.1211.00
264_I284_A1.1111.00
35_I81_I1.1091.00
86_N98_N1.1061.00
25_A307_A1.0991.00
176_H204_T1.0951.00
267_Q274_A1.0891.00
152_I240_L1.0871.00
51_E55_G1.0871.00
305_M309_D1.0771.00
185_K189_K1.0701.00
194_K197_N1.0701.00
166_S200_I1.0671.00
145_R170_S1.0631.00
276_Q280_P1.0611.00
266_V289_M1.0591.00
264_I288_V1.0481.00
17_A299_S1.0451.00
158_A176_H1.0451.00
12_L111_I1.0411.00
175_I223_L1.0381.00
7_S10_L1.0351.00
86_N100_D1.0331.00
149_V239_G1.0111.00
162_A174_L1.0021.00
89_D98_N1.0011.00
71_E74_T0.9971.00
214_D236_D0.9961.00
166_S171_E0.9901.00
131_R135_A0.9881.00
194_K198_G0.9791.00
39_E70_H0.9771.00
284_A288_V0.9681.00
28_A311_E0.9651.00
51_E54_P0.9571.00
26_A78_T0.9571.00
138_T141_G0.9561.00
149_V170_S0.9501.00
73_A76_F0.9451.00
7_S79_E0.9431.00
81_I104_Y0.9431.00
285_A306_A0.9411.00
7_S31_Q0.9381.00
28_A308_L0.9331.00
131_R134_S0.9331.00
21_A285_A0.9331.00
268_S274_A0.9301.00
193_D196_E0.9301.00
66_M70_H0.9301.00
150_A235_L0.9261.00
214_D219_T0.9211.00
167_N198_G0.9201.00
53_W56_D0.9181.00
71_E75_K0.9171.00
12_L85_I0.9161.00
201_I233_E0.9051.00
35_I85_I0.9041.00
266_V284_A0.9001.00
169_A172_V0.8951.00
139_C142_F0.8911.00
151_V162_A0.8891.00
287_D299_S0.8881.00
24_Y28_A0.8861.00
136_C139_C0.8821.00
25_A30_L0.8771.00
189_K192_M0.8771.00
259_L265_K0.8761.00
52_N56_D0.8761.00
21_A303_G0.8721.00
299_S303_G0.8681.00
8_K30_L0.8681.00
208_L221_V0.8661.00
267_Q275_T0.8641.00
6_H31_Q0.8631.00
276_Q281_G0.8611.00
134_S142_F0.8611.00
68_R71_E0.8611.00
154_G181_F0.8571.00
33_V106_C0.8561.00
150_A240_L0.8561.00
35_I99_G0.8551.00
124_S127_A0.8521.00
12_L113_T0.8501.00
25_A310_A0.8481.00
132_G135_A0.8431.00
193_D197_N0.8421.00
18_G22_A0.8401.00
109_L282_V0.8391.00
87_K255_G0.8381.00
111_I288_V0.8381.00
9_L108_A0.8381.00
33_V79_E0.8371.00
8_K105_T0.8341.00
21_A306_A0.8291.00
206_R224_R0.8291.00
192_M204_T0.8261.00
85_I97_L0.8261.00
83_D101_N0.8201.00
7_S108_A0.8141.00
289_M302_T0.8141.00
173_H235_L0.8141.00
175_I206_R0.8071.00
52_N55_G0.8051.00
283_F310_A0.8031.00
137_A141_G0.7951.00
276_Q279_I0.7921.00
62_G69_M0.7861.00
124_S210_E0.7851.00
23_V27_R0.7841.00
211_V221_V0.7791.00
175_I203_H0.7781.00
67_E70_H0.7781.00
152_I242_V0.7741.00
275_T306_A0.7741.00
91_Q96_R0.7741.00
203_H235_L0.7731.00
189_K193_D0.7731.00
237_V240_L0.7721.00
9_L310_A0.7701.00
11_I21_A0.7671.00
251_A254_E0.7651.00
152_I244_I0.7621.00
24_Y304_C0.7611.00
22_A78_T0.7601.00
275_T305_M0.7591.00
22_A32_P0.7581.00
147_Q170_S0.7531.00
275_T289_M0.7531.00
26_A32_P0.7371.00
7_S107_D0.7351.00
285_A310_A0.7331.00
152_I208_L0.7321.00
148_K237_V0.7281.00
18_G112_A0.7271.00
306_A309_D0.7271.00
83_D100_D0.7241.00
192_M202_L0.7151.00
8_K104_Y0.7141.00
284_A289_M0.7111.00
140_D144_Y0.7101.00
98_N101_N0.7101.00
110_I306_A0.7071.00
136_C140_D0.7071.00
180_G185_K0.7061.00
155_G245_G0.7051.00
69_M72_H0.7011.00
64_L67_E0.7011.00
8_K106_C0.7001.00
196_E201_I0.6981.00
73_A78_T0.6941.00
188_I192_M0.6921.00
139_C143_F0.6911.00
59_D62_G0.6881.00
181_F204_T0.6871.00
298_T302_T0.6861.00
20_T303_G0.6841.00
30_L311_E0.6781.00
14_S34_L0.6751.00
134_S143_F0.6751.00
285_A303_G0.6741.00
212_T215_Q0.6731.00
14_S40_K0.6721.00
62_G66_M0.6711.00
190_R194_K0.6691.00
135_A143_F0.6671.00
122_L125_E0.6661.00
136_C143_F0.6591.00
304_C308_L0.6591.00
115_A246_H0.6591.00
184_E187_L0.6551.00
166_S198_G0.6531.00
135_A140_D0.6531.00
187_L190_R0.6521.00
25_A32_P0.6511.00
256_Q259_L0.6511.00
162_A200_I0.6501.00
176_H179_D0.6471.00
40_K82_F0.6461.00
134_S239_G0.6441.00
63_P67_E0.6421.00
120_L242_V0.6401.00
30_L107_D0.6381.00
147_Q239_G0.6371.00
205_N226_T0.6371.00
274_A277_T0.6371.00
153_G245_G0.6361.00
166_S199_N0.6341.00
214_D220_G0.6331.00
174_L202_L0.6311.00
68_R72_H0.6311.00
120_L125_E0.6231.00
125_E242_V0.6201.00
275_T309_D0.6201.00
35_I106_C0.6201.00
139_C165_L0.6171.00
190_R193_D0.6161.00
137_A140_D0.6151.00
186_I190_R0.6141.00
302_T306_A0.6121.00
132_G242_V0.6111.00
11_I112_A0.6111.00
119_Y126_E0.6111.00
119_Y242_V0.6101.00
134_S137_A0.6101.00
180_G192_M0.6081.00
140_D143_F0.6081.00
181_F188_I0.6071.00
136_C142_F0.6011.00
30_L310_A0.5981.00
17_A112_A0.5941.00
120_L244_I0.5931.00
21_A307_A0.5921.00
147_Q171_E0.5921.00
127_A131_R0.5911.00
162_A172_V0.5911.00
87_K90_L0.5911.00
257_L279_I0.5901.00
9_L307_A0.5901.00
64_L68_R0.5891.00
149_V241_F0.5881.00
265_K278_S0.5881.00
211_V219_T0.5871.00
131_R137_A0.5871.00
85_I99_G0.5861.00
163_L167_N0.5861.00
40_K80_I0.5861.00
61_T68_R0.5841.00
135_A139_C0.5831.00
215_Q234_S0.5821.00
60_L64_L0.5811.00
203_H223_L0.5801.00
205_N225_D0.5781.00
134_S139_C0.5771.00
72_H75_K0.5771.00
274_A278_S0.5761.00
26_A77_E0.5761.00
119_Y135_A0.5731.00
219_T222_R0.5701.00
257_L264_I0.5701.00
118_R244_I0.5691.00
61_T65_L0.5681.00
259_L264_I0.5671.00
11_I32_P0.5671.00
277_T284_A0.5661.00
65_L68_R0.5661.00
183_A186_I0.5661.00
158_A177_R0.5651.00
26_A31_Q0.5651.00
45_T48_T0.5641.00
183_A190_R0.5631.00
134_S140_D0.5621.00
26_A79_E0.5611.00
131_R138_T0.5611.00
72_H77_E0.5611.00
132_G138_T0.5601.00
20_T24_Y0.5601.00
254_E259_L0.5581.00
11_I34_L0.5571.00
161_E241_F0.5561.00
131_R136_C0.5551.00
136_C141_G0.5531.00
308_L312_R0.5531.00
133_V211_V0.5511.00
85_I90_L0.5501.00
134_S141_G0.5491.00
89_D93_R0.5491.00
159_V202_L0.5481.00
184_E188_I0.5441.00
131_R143_F0.5431.00
301_G304_C0.5421.00
175_I237_V0.5421.00
184_E190_R0.5391.00
51_E56_D0.5381.00
207_T226_T0.5371.00
151_V158_A0.5371.00
109_L281_G0.5371.00
69_M73_A0.5361.00
36_T80_I0.5361.00
61_T69_M0.5351.00
122_L211_V0.5341.00
38_M47_T0.5341.00
290_D302_T0.5331.00
161_E243_A0.5321.00
119_Y125_E0.5311.00
196_E199_N0.5311.00
283_F306_A0.5301.00
62_G65_L0.5291.00
20_T300_A0.5281.00
36_T82_F0.5211.00
63_P66_M0.5211.00
150_A173_H0.5201.00
131_R142_F0.5201.00
93_R96_R0.5191.00
20_T23_V0.5191.00
276_Q309_D0.5191.00
24_Y307_A0.5171.00
21_A310_A0.5161.00
184_E191_L0.5151.00
121_G126_E0.5141.00
295_Q298_T0.5131.00
50_V54_P0.5131.00
186_I189_K0.5121.00
275_T278_S0.5111.00
183_A187_L0.5111.00
92_N96_R0.5111.00
301_G305_M0.5111.00
142_F239_G0.5091.00
132_G136_C0.5081.00
127_A210_E0.5051.00
195_V202_L0.5051.00
261_N290_D0.5041.00
34_L78_T0.5021.00
138_T142_F0.5011.00
66_M69_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1trbA 2 0.9844 100 0.226 Contact Map
2q0lA 2 0.9439 100 0.254 Contact Map
2a87A 2 0.9688 100 0.254 Contact Map
2q7vA 2 0.9533 100 0.254 Contact Map
3r9uA 2 0.9439 100 0.264 Contact Map
4jnqA 2 0.9626 100 0.266 Contact Map
1vdcA 2 0.9502 100 0.27 Contact Map
4up3A 2 0.9439 100 0.274 Contact Map
3ctyA 2 0.9439 100 0.274 Contact Map
1fl2A 2 0.9439 100 0.282 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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