GREMLIN Database
DLDH - Dihydrolipoyl dehydrogenase
UniProt: P0A9P0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10543
Length: 474 (447)
Sequences: 14371 (9611)
Seq/√Len: 454.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_R116_L4.4111.00
179_L264_Y4.1321.00
298_D302_R3.8671.00
177_R200_Q3.0551.00
288_E296_R2.9141.00
411_G425_I2.8851.00
121_G124_T2.8641.00
200_Q231_N2.6941.00
202_D233_M2.6231.00
373_S404_E2.5661.00
7_T111_K2.5411.00
6_K139_D2.5051.00
281_D284_K2.4831.00
148_R278_K2.4721.00
7_T33_V2.4471.00
373_S403_K2.4451.00
249_Y261_P2.4281.00
223_T227_S2.4211.00
240_A251_T2.4081.00
402_D405_S2.3851.00
6_K137_N2.3691.00
242_E251_T2.3171.00
424_E443_H2.3151.00
21_A142_I2.2981.00
174_V199_S2.2861.00
150_I274_V2.2731.00
299_K341_Y2.2571.00
148_R276_N2.2441.00
216_K365_K2.2291.00
375_E403_K2.2251.00
138_F141_A2.2041.00
33_V113_V2.1911.00
126_E135_V2.1881.00
177_R265_D2.1751.00
124_T135_V2.1181.00
290_D294_F2.1131.00
406_H436_E2.1121.00
10_V136_I2.0931.00
362_L370_K2.0881.00
254_G260_E2.0681.00
233_M260_E2.0631.00
179_L204_V2.0571.00
407_R432_G2.0501.00
9_V25_C2.0401.00
237_K253_E2.0281.00
362_L367_A2.0271.00
155_I240_A2.0201.00
331_A335_I1.9971.00
239_T253_E1.9961.00
249_Y263_R1.9661.00
17_A311_I1.9511.00
242_E249_Y1.9461.00
179_L250_V1.9331.00
208_D235_E1.9251.00
428_A433_C1.9081.00
188_L203_V1.9061.00
120_T126_E1.8881.00
413_I418_G1.8741.00
10_V35_V1.8551.00
118_K126_E1.8291.00
140_N307_H1.8201.00
148_R274_V1.8141.00
364_E368_K1.7971.00
75_V82_D1.7781.00
164_D167_D1.7711.00
120_T135_V1.7571.00
10_V125_L1.7551.00
8_Q31_E1.7541.00
374_Y400_I1.7421.00
195_H200_Q1.7361.00
75_V80_K1.7011.00
35_V136_I1.6951.00
244_K249_Y1.6881.00
251_T261_P1.6691.00
365_K369_E1.6681.00
10_V138_F1.6451.00
119_F141_A1.6391.00
236_T254_G1.6311.00
302_R306_P1.6251.00
178_L194_Y1.5841.00
143_I314_I1.5841.00
206_M237_K1.5841.00
399_L411_G1.5831.00
178_L199_S1.5731.00
8_Q139_D1.5661.00
12_L117_G1.5651.00
142_I335_I1.5641.00
82_D85_K1.5581.00
209_Q219_V1.5411.00
364_E398_K1.5301.00
356_E419_G1.5291.00
188_L353_T1.5281.00
367_A374_Y1.5211.00
10_V33_V1.5141.00
124_T137_N1.5071.00
9_V30_L1.5011.00
113_V136_I1.4991.00
309_F334_V1.4971.00
163_W266_A1.4951.00
196_A229_K1.4731.00
217_D378_T1.4561.00
125_L129_G1.4511.00
202_D231_N1.4451.00
102_A114_N1.4421.00
434_D437_D1.4351.00
372_I409_I1.4331.00
239_T251_T1.4271.00
162_I241_V1.4181.00
85_K88_T1.4171.00
252_M262_Q1.4141.00
145_A314_I1.4131.00
221_V414_V1.3931.00
176_E200_Q1.3831.00
140_N335_I1.3821.00
233_M236_T1.3801.00
366_E369_E1.3721.00
122_A305_V1.3721.00
195_H230_F1.3711.00
176_E265_D1.3541.00
367_A400_I1.3511.00
301_L315_V1.3421.00
126_E133_K1.3411.00
31_E111_K1.3371.00
163_W171_L1.3361.00
91_E95_N1.3321.00
24_R333_E1.3181.00
300_Q334_V1.3171.00
247_G263_R1.3171.00
288_E304_N1.3121.00
68_A71_E1.3071.00
35_V117_G1.3021.00
62_V65_E1.2971.00
399_L456_A1.2951.00
290_D296_R1.2731.00
9_V142_I1.2711.00
33_V136_I1.2671.00
376_T400_I1.2631.00
142_I311_I1.2621.00
161_R243_A1.2601.00
115_G127_V1.2501.00
333_E340_H1.2481.00
215_D398_K1.2451.00
75_V85_K1.2431.00
302_R307_H1.2411.00
41_L112_V1.2351.00
7_T113_V1.2141.00
168_A194_Y1.2101.00
217_D398_K1.2041.00
373_S402_D1.2021.00
218_I414_V1.1961.00
252_M260_E1.1921.00
225_R228_K1.1901.00
285_A305_V1.1841.00
305_V308_I1.1811.00
236_T252_M1.1811.00
183_G210_V1.1751.00
119_F125_L1.1751.00
224_K227_S1.1691.00
244_K247_G1.1681.00
204_V252_M1.1651.00
125_L307_H1.1581.00
381_W415_G1.1551.00
119_F284_K1.1541.00
48_V166_T1.1521.00
216_K220_K1.1491.00
402_D407_R1.1491.00
223_T232_L1.1411.00
118_K281_D1.1411.00
431_M437_D1.1411.00
241_V267_V1.1391.00
252_M255_K1.1391.00
209_Q216_K1.1341.00
218_I396_M1.1341.00
159_D243_A1.1321.00
87_R91_E1.1321.00
349_S359_W1.1261.00
214_A359_W1.1261.00
243_A247_G1.1201.00
92_K96_Q1.1161.00
118_K128_E1.1131.00
119_F143_I1.1121.00
222_F414_V1.1061.00
364_E376_T1.1061.00
181_M267_V1.1051.00
328_G332_A1.1041.00
311_I331_A1.0991.00
399_L425_I1.0981.00
123_N307_H1.0951.00
214_A349_S1.0941.00
350_I444_A1.0941.00
350_I419_G1.0921.00
204_V262_Q1.0901.00
300_Q341_Y1.0901.00
287_V295_I1.0881.00
12_L143_I1.0851.00
295_I314_I1.0831.00
425_I452_V1.0801.00
244_K263_R1.0801.00
397_T451_S1.0721.00
203_V232_L1.0711.00
223_T234_L1.0681.00
161_R248_I1.0671.00
242_E261_P1.0661.00
17_A324_G1.0641.00
102_A106_K1.0591.00
151_Q164_D1.0551.00
209_Q223_T1.0491.00
423_G444_A1.0491.00
23_F108_R1.0461.00
366_E370_K1.0431.00
358_A422_L1.0431.00
88_T92_K1.0421.00
330_V342_F1.0401.00
363_T366_E1.0401.00
205_E234_L1.0331.00
364_E374_Y1.0311.00
378_T396_M1.0191.00
368_K374_Y1.0191.00
367_A372_I1.0161.00
222_F357_V1.0151.00
128_E133_K1.0151.00
58_H62_V1.0101.00
297_V315_V1.0081.00
116_L279_N1.0041.00
83_I87_R1.0031.00
34_I105_A1.0031.00
177_R263_R1.0031.00
362_L366_E1.0031.00
372_I402_D1.0031.00
301_L331_A1.0021.00
279_N282_A1.0011.00
228_K394_D1.0001.00
224_K228_K0.9981.00
357_V414_V0.9971.00
282_A287_V0.9961.00
66_A69_L0.9931.00
24_R28_L0.9901.00
241_V248_I0.9881.00
243_A248_I0.9821.00
243_A246_D0.9781.00
227_S231_N0.9771.00
163_W167_D0.9771.00
346_V429_I0.9751.00
343_D430_E0.9711.00
161_R266_A0.9711.00
433_C437_D0.9691.00
375_E406_H0.9671.00
28_L333_E0.9631.00
178_L266_A0.9631.00
120_T124_T0.9611.00
28_L336_A0.9591.00
277_G289_V0.9571.00
153_P157_H0.9571.00
233_M262_Q0.9531.00
188_L226_I0.9511.00
84_D172_K0.9511.00
177_R247_G0.9511.00
183_G205_E0.9451.00
156_P159_D0.9451.00
423_G449_H0.9401.00
179_L262_Q0.9401.00
66_A76_F0.9321.00
318_P347_I0.9321.00
236_T260_E0.9311.00
87_R90_K0.9301.00
296_R304_N0.9281.00
42_G46_L0.9261.00
30_L140_N0.9251.00
14_A41_L0.9241.00
177_R202_D0.9221.00
287_V305_V0.9221.00
77_G80_K0.9211.00
397_T413_I0.9211.00
218_I412_A0.9191.00
221_V225_R0.9181.00
417_N420_E0.9171.00
378_T398_K0.9171.00
297_V310_A0.9161.00
64_E229_K0.9121.00
226_I230_F0.9111.00
177_R199_S0.9101.00
210_V234_L0.9091.00
406_H435_A0.9081.00
331_A334_V0.9061.00
181_M271_I0.9001.00
111_K134_T0.9001.00
30_L336_A0.8971.00
360_V429_I0.8951.00
181_M269_V0.8921.00
302_R334_V0.8911.00
70_A85_K0.8911.00
119_F138_F0.8901.00
25_C332_A0.8871.00
210_V232_L0.8861.00
39_N48_V0.8851.00
302_R309_F0.8851.00
160_P243_A0.8821.00
103_G107_G0.8821.00
94_I97_L0.8781.00
248_I267_V0.8771.00
225_R414_V0.8761.00
358_A418_G0.8751.00
225_R229_K0.8721.00
289_V296_R0.8701.00
105_A110_V0.8691.00
95_N99_G0.8691.00
178_L268_L0.8661.00
140_N309_F0.8641.00
101_L105_A0.8621.00
163_W168_A0.8621.00
364_E400_I0.8601.00
30_L139_D0.8591.00
118_K284_K0.8581.00
221_V224_K0.8551.00
159_D167_D0.8551.00
231_N260_E0.8541.00
92_K95_N0.8531.00
113_V134_T0.8521.00
195_H229_K0.8511.00
209_Q365_K0.8501.00
408_V425_I0.8501.00
91_E94_I0.8491.00
141_A308_I0.8491.00
63_I67_K0.8481.00
7_T31_E0.8481.00
210_V223_T0.8451.00
285_A308_I0.8451.00
177_R264_Y0.8431.00
8_Q30_L0.8431.00
220_K224_K0.8421.00
76_F79_P0.8371.00
59_V86_I0.8361.00
64_E67_K0.8351.00
14_A34_I0.8351.00
122_A307_H0.8341.00
173_E266_A0.8331.00
45_C50_C0.8331.00
372_I400_I0.8301.00
424_E427_L0.8301.00
330_V334_V0.8261.00
295_I310_A0.8251.00
204_V233_M0.8241.00
287_V304_N0.8201.00
150_I271_I0.8191.00
12_L280_L0.8171.00
187_G205_E0.8171.00
20_S325_V0.8161.00
286_G305_V0.8161.00
10_V141_A0.8151.00
233_M252_M0.8151.00
21_A332_A0.8131.00
225_R394_D0.8111.00
220_K223_T0.8101.00
21_A328_G0.8091.00
99_G102_A0.8081.00
129_G132_G0.8081.00
60_A196_A0.8061.00
181_M238_V0.8041.00
142_I331_A0.8001.00
24_R27_D0.7991.00
167_D170_E0.7981.00
332_A336_A0.7971.00
88_T172_K0.7941.00
428_A438_I0.7931.00
119_F281_D0.7921.00
333_E338_K0.7911.00
25_C30_L0.7881.00
222_F353_T0.7881.00
9_V332_A0.7881.00
275_P294_F0.7871.00
375_E401_F0.7861.00
90_K94_I0.7851.00
90_K93_V0.7851.00
61_K65_E0.7831.00
12_L125_L0.7791.00
180_V268_L0.7781.00
119_F285_A0.7771.00
300_Q339_K0.7761.00
281_D285_A0.7761.00
56_L87_R0.7761.00
89_W93_V0.7751.00
285_A304_N0.7731.00
278_K283_G0.7731.00
36_E40_T0.7711.00
310_A314_I0.7711.00
151_Q157_H0.7691.00
70_A75_V0.7681.00
218_I357_V0.7671.00
93_V97_L0.7611.00
121_G125_L0.7611.00
96_Q388_I0.7611.00
204_V236_T0.7601.00
57_L193_V0.7601.00
26_A110_V0.7591.00
84_D88_T0.7591.00
105_A112_V0.7581.00
402_D409_I0.7581.00
430_E440_L0.7571.00
154_F157_H0.7541.00
58_H61_K0.7531.00
118_K279_N0.7511.00
294_F319_M0.7501.00
24_R332_A0.7471.00
53_S57_L0.7421.00
122_A286_G0.7421.00
59_V89_W0.7411.00
226_I232_L0.7411.00
301_L334_V0.7331.00
30_L335_I0.7321.00
282_A285_A0.7281.00
101_L104_M0.7271.00
407_R434_D0.7251.00
202_D264_Y0.7251.00
35_V115_G0.7231.00
303_T310_A0.7221.00
75_V79_P0.7211.00
363_T412_A0.7201.00
207_F212_P0.7191.00
241_V250_V0.7191.00
209_Q220_K0.7181.00
151_Q269_V0.7171.00
69_L72_H0.7151.00
360_V426_G0.7151.00
180_V187_G0.7141.00
152_L269_V0.7111.00
323_K347_I0.7081.00
285_A289_V0.7071.00
185_I351_A0.7071.00
150_I153_P0.7061.00
236_T253_E0.7051.00
67_K78_E0.7041.00
154_F238_V0.7031.00
123_N305_V0.7031.00
123_N137_N0.7031.00
208_D216_K0.7021.00
141_A307_H0.7011.00
193_V197_L0.6981.00
129_G133_K0.6981.00
277_G314_I0.6971.00
302_R305_V0.6941.00
85_K89_W0.6921.00
11_V18_G0.6921.00
433_C438_I0.6911.00
69_L76_F0.6911.00
367_A409_I0.6901.00
425_I429_I0.6901.00
301_L330_V0.6901.00
64_E196_A0.6901.00
191_G230_F0.6891.00
28_L338_K0.6851.00
99_G103_G0.6851.00
326_H329_H0.6851.00
21_A331_A0.6851.00
215_D412_A0.6841.00
66_A74_I0.6831.00
7_T10_V0.6821.00
42_G45_C0.6811.00
248_I266_A0.6781.00
427_L433_C0.6781.00
346_V430_E0.6751.00
8_Q33_V0.6751.00
211_I222_F0.6741.00
214_A357_V0.6721.00
401_F435_A0.6721.00
152_L157_H0.6721.00
399_L455_A0.6721.00
411_G429_I0.6711.00
238_V250_V0.6701.00
437_D440_L0.6701.00
95_N98_T0.6701.00
413_I421_L0.6691.00
157_H269_V0.6671.00
408_V429_I0.6671.00
39_N114_N0.6661.00
297_V301_L0.6661.00
221_V396_M0.6661.00
60_A63_I0.6661.00
47_N98_T0.6651.00
83_I86_I0.6651.00
326_H342_F0.6651.00
191_G203_V0.6631.00
380_P383_A0.6611.00
11_V22_A0.6601.00
196_A354_E0.6601.00
53_S190_M0.6591.00
115_G131_N0.6551.00
129_G134_T0.6551.00
282_A289_V0.6541.00
84_D87_R0.6541.00
435_A439_A0.6541.00
427_L441_T0.6541.00
64_E68_A0.6521.00
381_W451_S0.6521.00
187_G206_M0.6511.00
371_G374_Y0.6511.00
356_E448_L0.6491.00
420_E449_H0.6481.00
356_E417_N0.6481.00
171_L266_A0.6461.00
90_K170_E0.6431.00
192_T229_K0.6380.99
327_E344_P0.6370.99
122_A285_A0.6370.99
393_A416_T0.6360.99
377_A455_A0.6360.99
400_I403_K0.6350.99
175_P199_S0.6340.99
188_L210_V0.6320.99
205_E212_P0.6300.99
103_G106_K0.6300.99
206_M212_P0.6290.99
88_T91_E0.6280.99
66_A79_P0.6270.99
427_L438_I0.6250.99
57_L61_K0.6240.99
345_K370_K0.6230.99
25_C335_I0.6220.99
145_A280_L0.6220.99
122_A308_I0.6210.99
91_E170_E0.6200.99
166_T273_R0.6190.99
386_R389_A0.6190.99
427_L431_M0.6190.99
97_L388_I0.6190.99
100_G104_M0.6180.99
377_A401_F0.6160.99
26_A32_T0.6150.99
62_V69_L0.6150.99
438_I456_A0.6140.99
25_C32_T0.6130.99
59_V72_H0.6110.99
287_V308_I0.6110.99
81_T86_I0.6080.99
445_H450_E0.6070.99
346_V426_G0.6070.99
147_S273_R0.6060.99
36_E112_V0.6060.99
68_A391_D0.6050.99
192_T226_I0.6040.99
289_V295_I0.6040.99
385_G389_A0.6040.99
415_G418_G0.6030.99
75_V78_E0.6000.99
65_E68_A0.5980.99
385_G388_I0.5970.99
144_A311_I0.5940.99
192_T196_A0.5930.99
405_S432_G0.5930.99
333_E337_G0.5930.99
374_Y409_I0.5910.99
127_V136_I0.5910.99
19_Y34_I0.5900.99
40_T48_V0.5900.99
153_P158_E0.5880.99
411_G452_V0.5870.99
157_H164_D0.5870.99
309_F335_I0.5860.99
86_I197_L0.5860.99
151_Q156_P0.5850.99
58_H65_E0.5850.99
229_K354_E0.5830.99
311_I328_G0.5830.99
362_L372_I0.5820.99
89_W92_K0.5800.99
218_I221_V0.5800.99
177_R195_H0.5790.99
194_Y199_S0.5770.99
329_H333_E0.5770.99
23_F27_D0.5770.99
17_A144_A0.5730.99
35_V113_V0.5720.99
291_D296_R0.5690.99
50_C56_L0.5670.99
93_V96_Q0.5670.99
188_L232_L0.5670.99
149_P165_S0.5650.99
386_R390_S0.5630.99
333_E339_K0.5630.99
214_A351_A0.5620.99
87_R172_K0.5620.99
401_F406_H0.5600.99
165_S273_R0.5600.99
25_C336_A0.5600.99
37_R276_N0.5590.99
411_G422_L0.5590.99
50_C54_K0.5580.99
350_I358_A0.5570.99
157_H241_V0.5560.99
326_H453_G0.5550.99
131_N134_T0.5550.99
408_V411_G0.5540.99
436_E440_L0.5530.99
202_D262_Q0.5530.99
142_I332_A0.5530.99
381_W448_L0.5530.99
61_K354_E0.5520.99
128_E132_G0.5510.98
235_E255_K0.5510.98
211_I351_A0.5490.98
430_E441_T0.5480.98
71_E391_D0.5480.98
199_S265_D0.5470.98
421_L448_L0.5440.98
241_V269_V0.5440.98
323_K327_E0.5440.98
426_G430_E0.5440.98
122_A125_L0.5430.98
120_T284_K0.5410.98
63_I74_I0.5400.98
205_E238_V0.5390.98
57_L60_A0.5380.98
58_H390_S0.5380.98
181_M204_V0.5380.98
102_A105_A0.5380.98
185_I349_S0.5370.98
42_G47_N0.5340.98
26_A31_E0.5340.98
316_G319_M0.5330.98
171_L194_Y0.5330.98
90_K97_L0.5310.98
84_D173_E0.5300.98
111_K114_N0.5300.98
365_K368_K0.5300.98
33_V111_K0.5290.98
51_I385_G0.5280.98
374_Y403_K0.5270.98
219_V223_T0.5260.98
102_A112_V0.5240.98
294_F316_G0.5230.98
395_G413_I0.5230.98
362_L410_G0.5230.98
326_H330_V0.5230.98
80_K83_I0.5230.98
74_I81_T0.5230.98
359_W412_A0.5220.98
204_V264_Y0.5210.98
155_I158_E0.5210.98
424_E449_H0.5210.98
34_I110_V0.5210.98
9_V335_I0.5200.98
28_L332_A0.5200.98
6_K31_E0.5180.98
399_L408_V0.5170.98
279_N283_G0.5170.98
97_L101_L0.5170.98
315_V327_E0.5160.98
380_P396_M0.5160.98
187_G270_A0.5160.98
453_G457_E0.5150.98
40_T98_T0.5140.98
149_P166_T0.5130.98
295_I303_T0.5130.98
392_C416_T0.5130.98
113_V127_V0.5130.98
427_L443_H0.5120.98
165_S186_I0.5120.98
206_M271_I0.5120.98
247_G265_D0.5100.98
426_G441_T0.5100.98
157_H162_I0.5100.98
190_M268_L0.5080.97
372_I407_R0.5080.97
27_D108_R0.5080.97
387_A448_L0.5070.97
217_D396_M0.5060.97
119_F128_E0.5060.97
231_N234_L0.5040.97
190_M193_V0.5010.97
41_L102_A0.5000.97
354_E416_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9895 100 0.207 Contact Map
3ladA 2 0.9768 100 0.213 Contact Map
4jq9A 3 0.9916 100 0.215 Contact Map
3ic9A 2 0.9831 100 0.229 Contact Map
3urhA 2 0.9641 100 0.231 Contact Map
1zmdA 4 0.981 100 0.231 Contact Map
2qaeA 2 0.9684 100 0.235 Contact Map
1dxlA 2 0.9747 100 0.243 Contact Map
1lvlA 2 0.9578 100 0.243 Contact Map
2eq6A 2 0.9641 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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