GREMLIN Database
NRDG - Anaerobic ribonucleoside-triphosphate reductase-activating protein
UniProt: P0A9N8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12523
Length: 154 (141)
Sequences: 3734 (2585)
Seq/√Len: 217.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_I92_I3.5541.00
71_L85_I3.0861.00
4_H38_T2.9061.00
91_R95_E2.7181.00
90_Q122_L2.6181.00
134_D148_Q2.5071.00
134_D146_S2.4591.00
71_L89_V2.2231.00
107_Y127_V2.2011.00
135_L146_S2.2011.00
103_V123_I2.1971.00
91_R94_A2.1391.00
86_L118_Q2.0921.00
90_Q118_Q2.0781.00
89_V101_I2.0601.00
131_F136_K2.0091.00
41_V78_H1.9851.00
32_G133_Q1.9061.00
27_V78_H1.8011.00
59_L63_R1.8011.00
140_L146_S1.7681.00
67_Q100_D1.7671.00
93_R124_N1.7601.00
71_L88_L1.6501.00
77_L103_V1.6441.00
83_P115_A1.5931.00
60_N95_E1.5771.00
29_E39_W1.5731.00
52_E91_R1.5671.00
93_R122_L1.5451.00
58_D61_D1.5441.00
19_C58_D1.5431.00
3_Y23_V1.5271.00
110_D149_V1.4511.00
118_Q121_D1.4411.00
10_D20_T1.4341.00
136_K141_I1.3971.00
86_L122_L1.3751.00
132_V135_L1.3701.00
6_Y19_C1.3521.00
23_V85_I1.3431.00
27_V106_G1.3401.00
49_K53_D1.3391.00
20_T72_S1.3251.00
86_L90_Q1.3151.00
24_S43_S1.3131.00
70_S104_W1.3111.00
8_P58_D1.3101.00
7_Y10_D1.3091.00
28_H130_K1.3051.00
56_I95_E1.2861.00
53_D56_I1.2441.00
117_M121_D1.2391.00
57_N60_N1.2001.00
53_D91_R1.1981.00
92_I99_K1.1621.00
44_G48_T1.1501.00
49_K91_R1.1401.00
103_V125_V1.1351.00
93_R101_I1.1231.00
108_K145_S1.1101.00
31_P133_Q1.0811.00
13_N34_Y1.0771.00
111_E117_M1.0741.00
34_Y104_W1.0691.00
75_D78_H1.0681.00
53_D57_N1.0651.00
82_V115_A1.0601.00
58_D62_T1.0481.00
76_P85_I1.0451.00
102_W125_V1.0431.00
31_P141_I1.0351.00
3_Y21_L1.0191.00
133_Q136_K1.0141.00
34_Y72_S1.0121.00
31_P142_W1.0101.00
77_L119_V1.0081.00
76_P103_V0.9991.00
89_V123_I0.9951.00
23_V71_L0.9941.00
143_R150_V0.9861.00
50_A53_D0.9841.00
59_L92_I0.9671.00
131_F142_W0.9611.00
139_S147_N0.9411.00
4_H37_S0.9190.99
48_T51_M0.9120.99
92_I101_I0.9070.99
40_R43_S0.8830.99
90_Q94_A0.8810.99
139_S150_V0.8800.99
84_D87_K0.8690.99
56_I59_L0.8630.99
9_V17_T0.8610.99
101_I123_I0.8550.99
89_V119_V0.8390.99
18_R68_G0.8320.99
148_Q152_H0.8290.99
82_V86_L0.8170.99
52_E88_L0.8170.99
10_D22_F0.8070.99
86_L119_V0.8060.99
52_E87_K0.8040.99
71_L103_V0.8030.98
77_L109_L0.8020.98
104_W126_L0.8010.98
120_V123_I0.7960.98
44_G47_F0.7950.98
28_H150_V0.7910.98
89_V122_L0.7820.98
3_Y47_F0.7800.98
10_D13_N0.7800.98
140_L143_R0.7790.98
108_K111_E0.7650.98
85_I89_V0.7600.98
47_F51_M0.7540.98
114_A117_M0.7530.98
56_I60_N0.7520.98
56_I91_R0.7520.98
55_I58_D0.7460.98
51_M54_Q0.7450.98
50_A91_R0.7450.98
4_H24_S0.7310.97
82_V119_V0.7280.97
54_Q57_N0.7270.97
21_L55_I0.7260.97
134_D140_L0.7250.97
71_L101_I0.7200.97
147_N150_V0.7170.97
118_Q122_L0.7060.97
83_P118_Q0.7020.96
58_D63_R0.7010.96
21_L88_L0.6990.96
132_V147_N0.6970.96
77_L116_Q0.6960.96
119_V123_I0.6850.96
135_L140_L0.6710.95
23_V76_P0.6690.95
95_E98_G0.6600.95
28_H108_K0.6500.95
77_L106_G0.6490.95
28_H106_G0.6490.95
18_R70_S0.6470.94
108_K149_V0.6460.94
8_P54_Q0.6430.94
6_Y47_F0.6430.94
27_V41_V0.6390.94
15_P102_W0.6390.94
86_L115_A0.6390.94
29_E36_K0.6390.94
71_L76_P0.6350.94
87_K91_R0.6310.94
57_N95_E0.6300.94
14_G18_R0.6300.94
55_I69_I0.6280.94
100_D124_N0.6280.94
13_N35_N0.6260.93
102_W127_V0.6200.93
27_V75_D0.6150.93
20_T70_S0.6120.93
55_I61_D0.6120.93
8_P19_C0.6050.92
105_T127_V0.6010.92
49_K52_E0.5970.92
7_Y17_T0.5910.91
4_H7_Y0.5910.91
63_R66_R0.5910.91
27_V108_K0.5890.91
57_N61_D0.5850.91
60_N63_R0.5830.91
47_F52_E0.5810.91
13_N22_F0.5760.90
116_Q121_D0.5710.90
62_T66_R0.5680.90
102_W126_L0.5670.90
51_M58_D0.5630.89
12_V34_Y0.5620.89
35_N38_T0.5620.89
109_L116_Q0.5610.89
7_Y20_T0.5610.89
61_D64_I0.5550.89
115_A121_D0.5480.88
50_A55_I0.5470.88
28_H107_Y0.5470.88
86_L121_D0.5460.88
129_G145_S0.5440.88
34_Y39_W0.5430.88
5_Q8_P0.5430.88
15_P100_D0.5420.87
114_A118_Q0.5400.87
3_Y45_Q0.5360.87
11_I22_F0.5300.86
5_Q37_S0.5280.86
131_F143_R0.5280.86
105_T123_I0.5270.86
7_Y19_C0.5270.86
120_V125_V0.5260.86
134_D147_N0.5250.86
55_I63_R0.5220.85
63_R99_K0.5220.85
60_N64_I0.5220.85
140_L145_S0.5220.85
50_A54_Q0.5200.85
149_V152_H0.5190.85
140_L144_G0.5180.85
90_Q93_R0.5140.85
55_I92_I0.5080.84
111_E130_K0.5030.83
56_I64_I0.5020.83
92_I95_E0.5000.83
83_P114_A0.5000.83
45_Q50_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8fA 1 0.961 99.9 0.547 Contact Map
4njhA 2 0.8831 99.7 0.675 Contact Map
2yx0A 1 0.9416 99.5 0.711 Contact Map
3rfaA 1 0.9156 99.3 0.74 Contact Map
1tv8A 2 0.8831 99.3 0.747 Contact Map
3canA 2 0.526 99.3 0.747 Contact Map
2z2uA 1 0.8377 99.2 0.751 Contact Map
4k36A 1 0.8377 99.2 0.755 Contact Map
2qgqA 1 0.7727 99.2 0.758 Contact Map
1oltA 1 0.9481 99.2 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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