GREMLIN Database
PTSO - Phosphocarrier protein NPr
UniProt: P0A9N0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12147
Length: 90 (82)
Sequences: 2937 (1918)
Seq/√Len: 211.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_T62_Q2.9931.00
67_A76_L2.9201.00
31_D70_P2.5631.00
7_V80_I2.3581.00
5_Q80_I2.1961.00
32_A71_Q2.1571.00
26_L29_G2.1541.00
30_F78_A2.1241.00
43_E66_E2.0871.00
37_R43_E2.0621.00
37_R66_E2.0471.00
81_A85_S2.0401.00
35_L43_E2.0361.00
37_R64_E1.9181.00
80_I84_N1.8591.00
6_T64_E1.8091.00
31_D71_Q1.7521.00
73_E77_A1.7491.00
8_E62_Q1.6131.00
10_T86_G1.5871.00
39_D61_R1.4851.00
26_L78_A1.4331.00
23_L46_A1.4201.00
10_T84_N1.3721.00
33_E68_T1.3601.00
27_M79_V1.3401.00
77_A81_A1.2941.00
23_L79_V1.2861.00
5_Q77_A1.2471.00
74_E78_A1.2441.00
33_E45_E1.1771.00
57_S63_I1.1431.00
58_A61_R1.1351.00
12_K59_K1.1021.00
23_L83_F1.0961.00
30_F75_A1.0931.00
9_I57_S1.0751.00
32_A67_A1.0641.00
34_V75_A1.0641.00
44_A55_L1.0571.00
23_L36_L0.9971.00
71_Q74_E0.9941.00
37_R41_G0.9901.00
45_E48_S0.9801.00
74_E77_A0.9701.00
15_M23_L0.9651.00
44_A50_I0.9410.99
50_I54_M0.9040.99
82_L87_F0.8970.99
27_M34_V0.8770.99
78_A81_A0.8580.99
35_L66_E0.8480.99
22_K25_E0.8240.99
24_F49_V0.8230.99
48_S51_A0.8200.99
13_L19_P0.8190.99
83_F87_F0.8180.99
7_V65_V0.8120.98
21_M53_L0.8000.98
34_V67_A0.7870.98
63_I83_F0.7860.98
17_A21_M0.7660.98
22_K26_L0.7580.98
27_M75_A0.7390.97
22_K82_L0.7250.97
26_L82_L0.7210.97
34_V46_A0.7180.97
19_P22_K0.7100.96
65_V83_F0.7100.96
35_L45_E0.6940.96
49_V53_L0.6920.96
45_E50_I0.6900.96
76_L80_I0.6870.96
50_I53_L0.6840.96
44_A51_A0.6770.95
65_V76_L0.6740.95
27_M47_N0.6720.95
23_L65_V0.6640.95
11_N82_L0.6630.95
25_E29_G0.6610.95
39_D57_S0.6600.95
20_A52_L0.6540.94
28_Q51_A0.6470.94
30_F71_Q0.6440.94
7_V83_F0.6320.93
11_N53_L0.6250.93
28_Q49_V0.6240.93
16_H82_L0.6200.93
21_M25_E0.6140.92
17_A49_V0.6120.92
28_Q50_I0.6110.92
5_Q84_N0.6100.92
37_R44_A0.6080.92
7_V15_M0.6050.92
9_I83_F0.5970.91
24_F52_L0.5860.90
32_A72_E0.5850.90
36_L52_L0.5840.90
11_N15_M0.5800.90
20_A49_V0.5800.90
65_V79_V0.5780.90
17_A50_I0.5780.90
46_A52_L0.5750.90
9_I63_I0.5740.90
49_V56_D0.5730.89
56_D61_R0.5720.89
21_M48_S0.5680.89
11_N87_F0.5590.88
20_A51_A0.5570.88
17_A51_A0.5450.87
32_A68_T0.5380.86
14_G20_A0.5350.86
17_A56_D0.5330.86
8_E59_K0.5260.85
15_M19_P0.5240.85
11_N16_H0.5210.85
33_E47_N0.5130.84
82_L85_S0.5100.83
44_A54_M0.5070.83
21_M54_M0.5050.83
45_E51_A0.5030.82
19_P57_S0.5020.82
36_L65_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3le1A 1 0.9667 100 0.155 Contact Map
1pchA 1 0.9667 100 0.161 Contact Map
1sphA 2 0.9556 100 0.168 Contact Map
1y51A 1 0.9556 100 0.169 Contact Map
1kklH 1 0.9444 100 0.175 Contact Map
1ptfA 1 0.9556 100 0.185 Contact Map
1ka5A 1 0.9667 100 0.213 Contact Map
3ihsA 1 0.9222 100 0.217 Contact Map
3ccdA 2 0.9444 100 0.217 Contact Map
2jpiA 1 0.8778 38.5 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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