GREMLIN Database
XGPT - Xanthine phosphoribosyltransferase
UniProt: P0A9M5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10414
Length: 152 (139)
Sequences: 1235 (698)
Seq/√Len: 59.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_H124_D3.3771.00
98_V102_E2.6811.00
113_F137_Q2.6101.00
30_K83_G2.4571.00
83_G106_K2.3671.00
15_H127_V2.3391.00
41_V45_L2.3371.00
63_Y115_K2.3301.00
26_S124_D2.2781.00
101_R105_P2.2371.00
91_V118_G2.1761.00
71_L74_L2.0151.00
91_V97_A2.0111.00
46_L87_I2.0061.00
23_L46_L1.9821.00
64_D69_R1.9731.00
36_S40_L1.9631.00
35_V86_V1.9041.00
35_V100_I1.8941.00
111_T137_Q1.8841.00
92_D115_K1.8631.00
114_A125_Y1.7800.99
31_G84_F1.7400.99
44_A48_R1.7160.99
29_W108_H1.6500.99
8_T11_M1.6480.99
63_Y92_D1.6330.99
90_L115_K1.6160.99
30_K82_E1.6080.99
7_V11_M1.5980.99
16_A112_I1.5920.99
34_A43_G1.5510.98
58_V100_I1.5360.98
11_M15_H1.5200.98
21_S25_P1.4790.98
32_I46_L1.4770.98
19_L126_V1.3950.97
37_R47_A1.3800.97
114_A122_V1.3760.97
15_H126_V1.3730.97
20_A46_L1.3190.96
13_Q45_L1.3120.95
16_A45_L1.2590.94
70_E73_V1.2500.94
18_K22_R1.2390.94
97_A109_F1.2240.93
64_D68_Q1.2240.93
97_A100_I1.2140.93
10_D14_I1.2120.93
9_W138_P1.2090.93
60_I100_I1.2030.93
65_H69_R1.1820.92
101_R107_A1.1660.92
33_I77_A1.1440.91
16_A46_L1.1330.90
7_V135_I1.1320.90
91_V114_A1.1190.90
17_R142_G1.1030.89
82_E106_K1.0980.89
136_E141_M1.0970.89
73_V99_A1.0910.89
99_A102_E1.0740.88
18_K21_S1.0660.88
28_Q108_H1.0580.87
36_S55_V1.0510.87
63_Y132_D1.0430.86
136_E140_D1.0410.86
33_I56_D1.0410.86
37_R94_G1.0360.86
73_V76_R1.0270.86
30_K84_F1.0270.86
34_A137_Q1.0040.84
87_I124_D1.0040.84
32_I87_I0.9890.83
96_T115_K0.9840.83
11_M14_I0.9780.83
14_I18_K0.9690.82
101_R109_F0.9620.82
42_P138_P0.9570.81
71_L78_E0.9560.81
62_S69_R0.9520.81
96_T111_T0.9410.80
86_V104_Y0.9390.80
59_C75_K0.9370.80
66_D69_R0.9360.80
108_H123_D0.9350.80
63_Y134_W0.9290.79
26_S106_K0.9240.79
112_I125_Y0.9230.79
22_R25_P0.9210.79
114_A121_L0.9180.78
6_I32_I0.9130.78
121_L128_D0.8970.77
5_Y133_T0.8970.77
46_L83_G0.8810.76
62_S68_Q0.8660.74
70_E75_K0.8510.73
74_L95_G0.8480.73
65_H68_Q0.8460.73
77_A93_T0.8450.72
95_G98_V0.8410.72
71_L76_R0.8270.71
115_K140_D0.8190.70
35_V58_V0.8170.70
31_G36_S0.8160.70
26_S108_H0.8080.69
72_K76_R0.8060.69
17_R20_A0.8000.68
43_G63_Y0.7990.68
24_M35_V0.7900.67
23_L26_S0.7850.67
44_A59_C0.7840.67
6_I10_D0.7830.67
53_R61_S0.7820.67
109_F123_D0.7780.66
110_V124_D0.7740.66
6_I136_E0.7700.65
89_D94_G0.7680.65
117_A132_D0.7640.65
23_L110_V0.7610.64
47_A118_G0.7540.64
12_L17_R0.7540.64
25_P121_L0.7440.63
42_P139_W0.7420.62
58_V97_A0.7380.62
14_I86_V0.7360.62
32_I43_G0.7320.61
13_Q104_Y0.7300.61
42_P87_I0.7190.60
96_T140_D0.7160.60
36_S58_V0.7140.59
84_F135_I0.7090.59
18_K127_V0.7050.59
28_Q83_G0.7030.58
26_S123_D0.6950.57
35_V133_T0.6890.57
85_I137_Q0.6890.57
121_L125_Y0.6880.57
6_I52_I0.6830.56
71_L86_V0.6710.55
37_R134_W0.6660.54
23_L72_K0.6650.54
58_V103_M0.6640.54
45_L125_Y0.6610.54
119_R128_D0.6610.54
12_L44_A0.6590.53
15_H113_F0.6560.53
17_R49_E0.6560.53
59_C97_A0.6560.53
116_P131_Q0.6520.53
94_G123_D0.6490.52
43_G55_V0.6490.52
58_V99_A0.6460.52
114_A118_G0.6460.52
29_W85_I0.6290.50
71_L99_A0.6190.49
44_A137_Q0.6140.48
23_L108_H0.6090.48
90_L135_I0.6080.48
36_S47_A0.6070.48
61_S71_L0.5990.47
54_H74_L0.5980.47
5_Y112_I0.5970.47
47_A57_T0.5970.47
5_Y135_I0.5900.46
33_I52_I0.5890.46
32_I41_V0.5880.46
20_A49_E0.5840.45
60_I71_L0.5830.45
116_P128_D0.5820.45
9_W13_Q0.5790.45
68_Q77_A0.5790.45
12_L137_Q0.5780.44
61_S64_D0.5750.44
74_L78_E0.5710.44
40_L47_A0.5680.43
105_P109_F0.5670.43
101_R120_P0.5670.43
43_G113_F0.5660.43
18_K108_H0.5640.43
73_V77_A0.5570.42
23_L101_R0.5560.42
48_R90_L0.5560.42
47_A55_V0.5560.42
38_G110_V0.5480.41
94_G108_H0.5460.41
45_L48_R0.5430.41
115_K135_I0.5390.40
48_R143_V0.5350.40
28_Q128_D0.5330.40
5_Y127_V0.5290.39
73_V103_M0.5240.39
16_A19_L0.5210.38
124_D138_P0.5210.38
16_A98_V0.5210.38
15_H18_K0.5190.38
104_Y107_A0.5140.38
11_M127_V0.5120.37
90_L133_T0.5110.37
47_A94_G0.5090.37
72_K75_K0.5080.37
12_L45_L0.5050.37
28_Q105_P0.5040.37
28_Q102_E0.5040.37
41_V50_L0.5030.36
22_R125_Y0.5020.36
10_D28_Q0.5000.36
33_I84_F0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nulA 4 0.9342 100 0.403 Contact Map
2xbuA 2 0.9671 100 0.461 Contact Map
1vdmA 5 0.9474 99.9 0.491 Contact Map
5bqpA 3 0.9408 99.9 0.495 Contact Map
4trbA 2 0.9934 99.9 0.5 Contact Map
4qyiA 3 0.9737 99.9 0.569 Contact Map
3hvuA 3 0.9934 99.9 0.574 Contact Map
2gebA 3 0.9934 99.9 0.575 Contact Map
1dqnA 2 0.9934 99.9 0.575 Contact Map
1tc1A 2 1 99.9 0.576 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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