HPRT - ECOLI - GREMLIN Contacts

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HPRT - Hypoxanthine phosphoribosyltransferase

UniProt:	P0A9M2	Sequences: MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDYAQRYRHLPYIGKVILLDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG20098
Length:	178 (167)
Sequences:	2985 (1831)
Seq/√Len:	141.6

ECOLI - HPRT
BACSU - HPRT
HALSA - Q9HS98
SULSO - Q97W95 Q97W22

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_R	143_F	3.412	1.00
124_A	142_E	3.320	1.00
17_R	20_E	2.756	1.00
40_G	49_M	2.747	1.00
112_R	116_S	2.665	1.00
94_D	121_K	2.576	1.00
10_P	13_E	2.451	1.00
19_A	55_E	2.436	1.00
94_D	122_S	2.411	1.00
91_R	119_E	2.403	1.00
26_T	57_Q	2.320	1.00
38_L	53_C	2.301	1.00
17_R	146_F	2.270	1.00
26_T	58_V	2.027	1.00
34_S	94_D	2.017	1.00
41_L	111_V	1.944	1.00
72_S	161_A	1.911	1.00
22_G	26_T	1.894	1.00
109_S	113_E	1.886	1.00
27_E	30_K	1.886	1.00
120_P	123_L	1.861	1.00
11_E	15_K	1.814	1.00
148_I	153_V	1.793	1.00
51_D	54_R	1.736	1.00
34_S	121_K	1.719	1.00
21_L	145_G	1.713	1.00
130_D	135_R	1.707	1.00
30_K	33_G	1.707	1.00
106_N	136_E	1.682	1.00
51_D	156_Y	1.678	1.00
36_M	96_L	1.671	1.00
112_R	125_I	1.630	1.00
36_M	93_K	1.620	1.00
129_L	153_V	1.612	1.00
102_I	141_V	1.612	1.00
129_L	170_I	1.573	1.00
28_R	124_A	1.564	1.00
61_E	93_K	1.559	1.00
29_Y	124_A	1.509	1.00
29_Y	122_S	1.498	1.00
38_L	96_L	1.454	1.00
85_D	118_R	1.449	1.00
47_M	53_C	1.447	1.00
130_D	147_S	1.438	1.00
84_K	87_D	1.436	1.00
15_K	55_E	1.419	1.00
46_F	62_V	1.415	1.00
114_I	118_R	1.412	1.00
38_L	56_V	1.396	1.00
41_L	65_M	1.389	1.00
17_R	24_Q	1.383	1.00
46_F	50_A	1.358	1.00
6_E	151_E	1.356	1.00
40_G	45_S	1.350	1.00
151_E	172_K	1.309	1.00
25_I	52_L	1.303	1.00
11_E	168_P	1.291	1.00
22_G	56_V	1.258	1.00
25_I	56_V	1.254	1.00
24_Q	28_R	1.252	1.00
50_A	54_R	1.237	1.00
19_A	23_R	1.236	1.00
52_L	98_V	1.201	1.00
134_R	150_D	1.174	1.00
92_G	121_K	1.162	0.99
129_L	148_I	1.160	0.99
20_E	146_F	1.155	0.99
13_E	16_A	1.125	0.99
18_I	48_F	1.123	0.99
47_M	50_A	1.118	0.99
23_R	27_E	1.106	0.99
12_A	16_A	1.105	0.99
133_S	150_D	1.091	0.99
132_P	147_S	1.087	0.99
26_T	56_V	1.079	0.99
63_D	84_K	1.075	0.99
133_S	149_P	1.072	0.99
47_M	54_R	1.070	0.99
24_Q	27_E	1.069	0.99
6_E	172_K	1.069	0.99
90_I	120_P	1.045	0.99
11_E	55_E	1.037	0.99
141_V	144_I	1.020	0.99
15_K	51_D	1.005	0.99
35_D	93_K	1.004	0.99
29_Y	96_L	1.001	0.98
23_R	26_T	1.000	0.98
113_E	116_S	0.995	0.98
48_F	126_C	0.993	0.98
46_F	64_F	0.992	0.98
21_L	126_C	0.992	0.98
67_A	107_T	0.989	0.98
37_V	88_E	0.988	0.98
86_L	90_I	0.981	0.98
99_E	127_T	0.973	0.98
29_Y	94_D	0.968	0.98
110_K	113_E	0.954	0.98
35_D	61_E	0.954	0.98
37_V	61_E	0.938	0.98
20_E	24_Q	0.936	0.98
153_V	158_I	0.930	0.98
97_I	112_R	0.925	0.97
25_I	126_C	0.920	0.97
97_I	115_L	0.918	0.97
102_I	127_T	0.912	0.97
37_V	93_K	0.909	0.97
39_V	86_L	0.900	0.97
16_A	20_E	0.895	0.97
43_R	162_Q	0.892	0.97
66_T	83_L	0.871	0.96
7_V	171_G	0.869	0.96
46_F	53_C	0.868	0.96
25_I	96_L	0.866	0.96
65_M	82_I	0.857	0.96
9_I	148_I	0.855	0.96
99_E	125_I	0.849	0.96
130_D	134_R	0.837	0.95
127_T	144_I	0.836	0.95
113_E	117_L	0.831	0.95
109_S	137_V	0.821	0.95
9_I	146_F	0.820	0.95
99_E	102_I	0.812	0.95
41_L	110_K	0.805	0.94
53_C	60_H	0.805	0.94
71_G	77_T	0.803	0.94
53_C	62_V	0.800	0.94
61_E	163_R	0.800	0.94
66_T	84_K	0.786	0.94
60_H	166_H	0.785	0.94
97_I	125_I	0.780	0.93
125_I	139_V	0.774	0.93
95_V	123_L	0.768	0.93
36_M	58_V	0.754	0.92
8_M	172_K	0.754	0.92
167_L	171_G	0.748	0.92
152_F	160_Y	0.747	0.92
36_M	94_D	0.745	0.92
11_E	169_Y	0.739	0.91
76_T	106_N	0.739	0.91
6_E	174_I	0.737	0.91
22_G	55_E	0.736	0.91
35_D	163_R	0.736	0.91
128_L	170_I	0.734	0.91
112_R	139_V	0.732	0.91
133_S	147_S	0.731	0.91
130_D	144_I	0.726	0.91
114_I	117_L	0.722	0.91
126_C	143_F	0.720	0.90
116_S	123_L	0.716	0.90
164_Y	171_G	0.715	0.90
14_I	128_L	0.714	0.90
71_G	161_A	0.713	0.90
39_V	115_L	0.710	0.90
15_K	54_R	0.709	0.90
23_R	57_Q	0.708	0.90
55_E	168_P	0.706	0.90
30_K	34_S	0.703	0.89
49_M	62_V	0.696	0.89
42_L	64_F	0.680	0.88
56_V	60_H	0.677	0.87
18_I	156_Y	0.675	0.87
39_V	63_D	0.669	0.87
18_I	55_E	0.668	0.87
49_M	98_V	0.665	0.87
38_L	98_V	0.664	0.86
41_L	45_S	0.664	0.86
79_D	89_D	0.663	0.86
128_L	146_F	0.657	0.86
90_I	115_L	0.654	0.86
15_K	19_A	0.652	0.85
67_A	111_V	0.645	0.85
115_L	120_P	0.643	0.85
24_Q	143_F	0.640	0.84
130_D	141_V	0.639	0.84
51_D	55_E	0.637	0.84
71_G	152_F	0.637	0.84
63_D	88_E	0.636	0.84
7_V	10_P	0.628	0.83
106_N	137_V	0.625	0.83
67_A	83_L	0.622	0.83
37_V	90_I	0.621	0.83
96_L	143_F	0.621	0.83
90_I	95_V	0.620	0.82
35_D	59_S	0.615	0.82
81_K	87_D	0.610	0.81
127_T	130_D	0.609	0.81
69_S	103_D	0.609	0.81
110_K	114_I	0.607	0.81
61_E	88_E	0.607	0.81
18_I	128_L	0.606	0.81
75_S	79_D	0.600	0.80
124_A	143_F	0.593	0.80
82_I	85_D	0.593	0.80
52_L	56_V	0.593	0.80
69_S	76_T	0.592	0.80
69_S	104_S	0.591	0.79
34_S	122_S	0.588	0.79
163_R	166_H	0.586	0.79
8_M	153_V	0.586	0.79
38_L	49_M	0.585	0.79
109_S	116_S	0.583	0.78
18_I	51_D	0.582	0.78
107_T	110_K	0.581	0.78
22_G	107_T	0.580	0.78
158_I	173_V	0.576	0.78
79_D	110_K	0.575	0.78
72_S	77_T	0.574	0.77
67_A	80_V	0.570	0.77
72_S	162_Q	0.567	0.77
159_D	162_Q	0.567	0.77
82_I	114_I	0.565	0.76
81_K	114_I	0.562	0.76
102_I	137_V	0.560	0.76
101_I	148_I	0.559	0.76
43_R	66_T	0.558	0.75
90_I	123_L	0.552	0.75
74_M	161_A	0.551	0.75
67_A	82_I	0.551	0.75
108_L	125_I	0.550	0.74
73_G	161_A	0.546	0.74
28_R	122_S	0.544	0.74
25_I	143_F	0.543	0.73
168_P	171_G	0.542	0.73
48_F	156_Y	0.542	0.73
119_E	123_L	0.541	0.73
9_I	17_R	0.540	0.73
49_M	108_L	0.538	0.73
20_E	145_G	0.538	0.73
82_I	110_K	0.537	0.73
160_Y	163_R	0.535	0.72
52_L	126_C	0.530	0.72
59_S	62_V	0.530	0.72
25_I	28_R	0.530	0.72
76_T	80_V	0.528	0.71
77_T	80_V	0.527	0.71
128_L	158_I	0.525	0.71
65_M	111_V	0.524	0.71
154_V	164_Y	0.522	0.71
46_F	166_H	0.522	0.71
38_L	60_H	0.522	0.71
160_Y	164_Y	0.521	0.70
59_S	163_R	0.520	0.70
13_E	17_R	0.516	0.70
112_R	140_P	0.516	0.70
109_S	138_N	0.516	0.70
85_D	114_I	0.515	0.70
88_E	92_G	0.512	0.69
33_G	94_D	0.509	0.69
106_N	109_S	0.508	0.69
21_L	128_L	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jbhA	4	0.9719	100	0.368	Contact Map
3ozfA	4	0.9831	100	0.368	Contact Map
4raoA	4	0.9438	100	0.37	Contact Map
4qyiA	3	0.9663	100	0.375	Contact Map
1fsgA	4	0.9831	100	0.376	Contact Map
4qriA	2	0.8876	100	0.38	Contact Map
4lyyA	3	0.9326	100	0.382	Contact Map
1pzmA	2	0.9157	100	0.384	Contact Map
2gebA	3	0.9888	100	0.39	Contact Map
4rhxA	3	0.9663	100	0.392	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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