GREMLIN Database
HPRT - Hypoxanthine phosphoribosyltransferase
UniProt: P0A9M2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20098
Length: 178 (167)
Sequences: 2985 (1831)
Seq/√Len: 141.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R143_F3.4121.00
124_A142_E3.3201.00
17_R20_E2.7561.00
40_G49_M2.7471.00
112_R116_S2.6651.00
94_D121_K2.5761.00
10_P13_E2.4511.00
19_A55_E2.4361.00
94_D122_S2.4111.00
91_R119_E2.4031.00
26_T57_Q2.3201.00
38_L53_C2.3011.00
17_R146_F2.2701.00
26_T58_V2.0271.00
34_S94_D2.0171.00
41_L111_V1.9441.00
72_S161_A1.9111.00
22_G26_T1.8941.00
109_S113_E1.8861.00
27_E30_K1.8861.00
120_P123_L1.8611.00
11_E15_K1.8141.00
148_I153_V1.7931.00
51_D54_R1.7361.00
34_S121_K1.7191.00
21_L145_G1.7131.00
130_D135_R1.7071.00
30_K33_G1.7071.00
106_N136_E1.6821.00
51_D156_Y1.6781.00
36_M96_L1.6711.00
112_R125_I1.6301.00
36_M93_K1.6201.00
129_L153_V1.6121.00
102_I141_V1.6121.00
129_L170_I1.5731.00
28_R124_A1.5641.00
61_E93_K1.5591.00
29_Y124_A1.5091.00
29_Y122_S1.4981.00
38_L96_L1.4541.00
85_D118_R1.4491.00
47_M53_C1.4471.00
130_D147_S1.4381.00
84_K87_D1.4361.00
15_K55_E1.4191.00
46_F62_V1.4151.00
114_I118_R1.4121.00
38_L56_V1.3961.00
41_L65_M1.3891.00
17_R24_Q1.3831.00
46_F50_A1.3581.00
6_E151_E1.3561.00
40_G45_S1.3501.00
151_E172_K1.3091.00
25_I52_L1.3031.00
11_E168_P1.2911.00
22_G56_V1.2581.00
25_I56_V1.2541.00
24_Q28_R1.2521.00
50_A54_R1.2371.00
19_A23_R1.2361.00
52_L98_V1.2011.00
134_R150_D1.1741.00
92_G121_K1.1620.99
129_L148_I1.1600.99
20_E146_F1.1550.99
13_E16_A1.1250.99
18_I48_F1.1230.99
47_M50_A1.1180.99
23_R27_E1.1060.99
12_A16_A1.1050.99
133_S150_D1.0910.99
132_P147_S1.0870.99
26_T56_V1.0790.99
63_D84_K1.0750.99
133_S149_P1.0720.99
47_M54_R1.0700.99
24_Q27_E1.0690.99
6_E172_K1.0690.99
90_I120_P1.0450.99
11_E55_E1.0370.99
141_V144_I1.0200.99
15_K51_D1.0050.99
35_D93_K1.0040.99
29_Y96_L1.0010.98
23_R26_T1.0000.98
113_E116_S0.9950.98
48_F126_C0.9930.98
46_F64_F0.9920.98
21_L126_C0.9920.98
67_A107_T0.9890.98
37_V88_E0.9880.98
86_L90_I0.9810.98
99_E127_T0.9730.98
29_Y94_D0.9680.98
110_K113_E0.9540.98
35_D61_E0.9540.98
37_V61_E0.9380.98
20_E24_Q0.9360.98
153_V158_I0.9300.98
97_I112_R0.9250.97
25_I126_C0.9200.97
97_I115_L0.9180.97
102_I127_T0.9120.97
37_V93_K0.9090.97
39_V86_L0.9000.97
16_A20_E0.8950.97
43_R162_Q0.8920.97
66_T83_L0.8710.96
7_V171_G0.8690.96
46_F53_C0.8680.96
25_I96_L0.8660.96
65_M82_I0.8570.96
9_I148_I0.8550.96
99_E125_I0.8490.96
130_D134_R0.8370.95
127_T144_I0.8360.95
113_E117_L0.8310.95
109_S137_V0.8210.95
9_I146_F0.8200.95
99_E102_I0.8120.95
41_L110_K0.8050.94
53_C60_H0.8050.94
71_G77_T0.8030.94
53_C62_V0.8000.94
61_E163_R0.8000.94
66_T84_K0.7860.94
60_H166_H0.7850.94
97_I125_I0.7800.93
125_I139_V0.7740.93
95_V123_L0.7680.93
36_M58_V0.7540.92
8_M172_K0.7540.92
167_L171_G0.7480.92
152_F160_Y0.7470.92
36_M94_D0.7450.92
11_E169_Y0.7390.91
76_T106_N0.7390.91
6_E174_I0.7370.91
22_G55_E0.7360.91
35_D163_R0.7360.91
128_L170_I0.7340.91
112_R139_V0.7320.91
133_S147_S0.7310.91
130_D144_I0.7260.91
114_I117_L0.7220.91
126_C143_F0.7200.90
116_S123_L0.7160.90
164_Y171_G0.7150.90
14_I128_L0.7140.90
71_G161_A0.7130.90
39_V115_L0.7100.90
15_K54_R0.7090.90
23_R57_Q0.7080.90
55_E168_P0.7060.90
30_K34_S0.7030.89
49_M62_V0.6960.89
42_L64_F0.6800.88
56_V60_H0.6770.87
18_I156_Y0.6750.87
39_V63_D0.6690.87
18_I55_E0.6680.87
49_M98_V0.6650.87
38_L98_V0.6640.86
41_L45_S0.6640.86
79_D89_D0.6630.86
128_L146_F0.6570.86
90_I115_L0.6540.86
15_K19_A0.6520.85
67_A111_V0.6450.85
115_L120_P0.6430.85
24_Q143_F0.6400.84
130_D141_V0.6390.84
51_D55_E0.6370.84
71_G152_F0.6370.84
63_D88_E0.6360.84
7_V10_P0.6280.83
106_N137_V0.6250.83
67_A83_L0.6220.83
37_V90_I0.6210.83
96_L143_F0.6210.83
90_I95_V0.6200.82
35_D59_S0.6150.82
81_K87_D0.6100.81
127_T130_D0.6090.81
69_S103_D0.6090.81
110_K114_I0.6070.81
61_E88_E0.6070.81
18_I128_L0.6060.81
75_S79_D0.6000.80
124_A143_F0.5930.80
82_I85_D0.5930.80
52_L56_V0.5930.80
69_S76_T0.5920.80
69_S104_S0.5910.79
34_S122_S0.5880.79
163_R166_H0.5860.79
8_M153_V0.5860.79
38_L49_M0.5850.79
109_S116_S0.5830.78
18_I51_D0.5820.78
107_T110_K0.5810.78
22_G107_T0.5800.78
158_I173_V0.5760.78
79_D110_K0.5750.78
72_S77_T0.5740.77
67_A80_V0.5700.77
72_S162_Q0.5670.77
159_D162_Q0.5670.77
82_I114_I0.5650.76
81_K114_I0.5620.76
102_I137_V0.5600.76
101_I148_I0.5590.76
43_R66_T0.5580.75
90_I123_L0.5520.75
74_M161_A0.5510.75
67_A82_I0.5510.75
108_L125_I0.5500.74
73_G161_A0.5460.74
28_R122_S0.5440.74
25_I143_F0.5430.73
168_P171_G0.5420.73
48_F156_Y0.5420.73
119_E123_L0.5410.73
9_I17_R0.5400.73
49_M108_L0.5380.73
20_E145_G0.5380.73
82_I110_K0.5370.73
160_Y163_R0.5350.72
52_L126_C0.5300.72
59_S62_V0.5300.72
25_I28_R0.5300.72
76_T80_V0.5280.71
77_T80_V0.5270.71
128_L158_I0.5250.71
65_M111_V0.5240.71
154_V164_Y0.5220.71
46_F166_H0.5220.71
38_L60_H0.5220.71
160_Y164_Y0.5210.70
59_S163_R0.5200.70
13_E17_R0.5160.70
112_R140_P0.5160.70
109_S138_N0.5160.70
85_D114_I0.5150.70
88_E92_G0.5120.69
33_G94_D0.5090.69
106_N109_S0.5080.69
21_L128_L0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jbhA 4 0.9719 100 0.368 Contact Map
3ozfA 4 0.9831 100 0.368 Contact Map
4raoA 4 0.9438 100 0.37 Contact Map
4qyiA 3 0.9663 100 0.375 Contact Map
1fsgA 4 0.9831 100 0.376 Contact Map
4qriA 2 0.8876 100 0.38 Contact Map
4lyyA 3 0.9326 100 0.382 Contact Map
1pzmA 2 0.9157 100 0.384 Contact Map
2gebA 3 0.9888 100 0.39 Contact Map
4rhxA 3 0.9663 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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