LON - ECOLI - GREMLIN Contacts

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LON - Lon protease

UniProt:	P0A9M0	Sequences: MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLESPTIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRGLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADNENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10542
Length:	784 (764)
Sequences:	3202 (1844)
Seq/√Len:	66.7

ECOLI - LON
BACSU - LON1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
716_I	719_L	5.592	1.00
738_F	741_K	4.845	1.00
317_Q	321_D	4.763	1.00
503_K	525_D	4.654	1.00
307_S	415_V	4.604	1.00
738_F	761_K	4.411	1.00
322_T	371_K	4.141	1.00
343_R	556_V	3.723	1.00
51_M	98_A	3.716	1.00
733_T	758_H	3.559	1.00
409_K	420_F	3.509	1.00
500_N	504_R	3.491	1.00
507_L	523_V	3.325	1.00
101_S	115_E	3.130	1.00
615_T	687_A	3.106	1.00
551_L	570_I	3.081	1.00
558_Q	577_D	3.075	1.00
256_R	260_A	3.074	1.00
102_A	113_K	3.050	1.00
749_D	752_I	3.030	1.00
407_I	461_Y	3.028	1.00
323_D	371_K	3.011	1.00
736_I	759_P	2.996	1.00
632_E	635_Q	2.969	1.00
723_L	757_I	2.936	1.00
186_M	191_E	2.927	1.00
758_H	769_L	2.898	1.00
702_A	731_I	2.840	1.00
760_V	765_E	2.824	1.00
271_A	298_M	2.780	1.00
524_D	527_A	2.755	1.00
428_M	440_L	2.737	1.00
507_L	548_I	2.737	1.00
733_T	756_D	2.702	1.00
99_R	115_E	2.656	1.00
530_G	534_Y	2.650	1.00
255_K	279_K	2.637	1.00
700_D	732_K	2.634	1.00
306_R	465_D	2.626	1.00
167_D	192_R	2.623	1.00
571_N	574_N	2.593	1.00
727_H	754_D	2.577	1.00
258_I	271_A	2.576	1.00
657_D	661_K	2.574	1.00
306_R	416_K	2.531	1.00
258_I	275_L	2.529	1.00
719_L	736_I	2.513	1.00
265_K	269_E	2.504	1.00
416_K	461_Y	2.472	1.00
514_N	549_S	2.412	1.00
264_P	267_A	2.383	1.00
317_Q	561_L	2.380	1.00
682_I	766_V	2.379	1.00
626_Y	638_I	2.371	1.00
531_I	551_L	2.370	1.00
11_I	74_V	2.342	1.00
523_V	551_L	2.334	1.00
74_V	98_A	2.270	1.00
765_E	768_T	2.270	1.00
744_L	759_P	2.256	1.00
268_K	272_E	2.248	1.00
182_S	195_Y	2.243	1.00
735_L	769_L	2.230	1.00
648_R	651_K	2.218	1.00
521_L	552_C	2.216	1.00
410_M	461_Y	2.209	1.00
307_S	376_K	2.196	1.00
53_V	100_I	2.193	1.00
301_V	461_Y	2.184	1.00
557_K	561_L	2.180	1.00
496_D	750_N	2.169	1.00
298_M	459_V	2.147	1.00
621_K	660_E	2.128	1.00
733_T	769_L	2.126	1.00
648_R	764_E	2.122	1.00
315_Q	318_E	2.116	1.00
482_L	487_V	2.084	1.00
33_R	55_Q	2.083	1.00
735_L	760_V	2.067	1.00
261_A	305_A	2.055	1.00
685_C	707_I	2.021	1.00
499_L	529_I	2.004	1.00
53_V	68_L	1.987	1.00
534_Y	582_Q	1.983	1.00
475_M	487_V	1.959	1.00
510_Q	549_S	1.958	1.00
593_N	772_Q	1.953	1.00
495_E	533_R	1.942	1.00
73_T	94_G	1.929	1.00
181_Q	185_E	1.927	1.00
354_L	369_I	1.917	1.00
531_I	579_L	1.917	1.00
741_K	759_P	1.917	1.00
318_E	322_T	1.915	1.00
230_L	237_I	1.912	1.00
760_V	766_V	1.904	1.00
126_E	190_N	1.900	1.00
695_N	771_L	1.886	1.00
13_V	112_A	1.886	1.00
686_T	770_A	1.882	1.00
314_R	561_L	1.866	1.00
258_I	272_E	1.858	1.00
635_Q	639_Q	1.855	1.00
378_V	413_V	1.850	1.00
386_R	455_H	1.841	1.00
263_M	299_V	1.841	1.00
507_L	528_I	1.823	1.00
749_D	753_A	1.819	1.00
622_G	663_D	1.819	1.00
416_K	465_D	1.812	1.00
315_Q	319_I	1.812	1.00
310_K	315_Q	1.809	1.00
615_T	691_C	1.800	1.00
707_I	763_I	1.799	1.00
530_G	582_Q	1.785	1.00
716_I	736_I	1.784	1.00
378_V	420_F	1.784	1.00
335_L	557_K	1.777	1.00
574_N	578_Y	1.774	1.00
259_D	268_K	1.768	1.00
188_D	191_E	1.766	1.00
255_K	272_E	1.757	1.00
179_D	182_S	1.756	1.00
701_V	733_T	1.748	1.00
530_G	572_G	1.745	1.00
530_G	575_L	1.738	1.00
376_K	415_V	1.735	1.00
610_L	729_G	1.729	1.00
105_D	108_E	1.726	1.00
263_M	271_A	1.724	1.00
689_V	767_L	1.721	1.00
391_I	443_V	1.718	1.00
558_Q	578_Y	1.712	1.00
510_Q	545_E	1.688	0.99
166_A	193_L	1.686	0.99
76_S	95_L	1.680	0.99
13_V	51_M	1.680	0.99
668_V	684_M	1.677	0.99
382_L	422_L	1.670	0.99
179_D	202_S	1.668	0.99
479_A	482_L	1.668	0.99
736_I	744_L	1.663	0.99
761_K	765_E	1.658	0.99
555_A	568_I	1.653	0.99
735_L	766_V	1.648	0.99
500_N	503_K	1.647	0.99
32_G	36_S	1.637	0.99
234_M	237_I	1.628	0.99
723_L	734_V	1.625	0.99
686_T	766_V	1.620	0.99
499_L	525_D	1.611	0.99
682_I	760_V	1.606	0.99
527_A	575_L	1.605	0.99
140_G	208_Q	1.605	0.99
509_K	545_E	1.592	0.99
517_K	520_E	1.592	0.99
595_V	694_G	1.590	0.99
617_C	691_C	1.585	0.99
262_K	304_N	1.584	0.99
716_I	723_L	1.578	0.99
33_R	36_S	1.564	0.99
719_L	759_P	1.559	0.99
269_E	414_G	1.558	0.99
376_K	414_G	1.551	0.99
258_I	263_M	1.544	0.99
685_C	763_I	1.544	0.99
695_N	773_N	1.534	0.99
17_R	33_R	1.532	0.99
453_S	460_D	1.527	0.99
369_I	469_V	1.526	0.99
618_V	643_T	1.525	0.99
522_T	567_H	1.515	0.99
33_R	63_P	1.512	0.99
521_L	551_L	1.509	0.99
167_D	187_S	1.508	0.99
329_R	550_K	1.507	0.99
60_T	67_D	1.505	0.99
503_K	528_I	1.498	0.99
723_L	736_I	1.495	0.99
555_A	559_L	1.494	0.99
277_K	293_G	1.492	0.99
719_L	723_L	1.484	0.99
644_V	763_I	1.475	0.99
752_I	757_I	1.471	0.98
263_M	298_M	1.469	0.98
613_I	683_A	1.469	0.98
524_D	569_E	1.467	0.98
97_R	192_R	1.466	0.98
386_R	389_A	1.463	0.98
330_V	354_L	1.462	0.98
396_R	458_E	1.453	0.98
163_A	166_A	1.444	0.98
70_T	99_R	1.439	0.98
558_Q	563_K	1.437	0.98
510_Q	548_I	1.430	0.98
163_A	167_D	1.430	0.98
297_W	408_Q	1.426	0.98
71_V	187_S	1.421	0.98
522_T	569_E	1.404	0.98
686_T	697_V	1.402	0.98
265_K	268_K	1.390	0.98
626_Y	635_Q	1.386	0.98
271_A	295_I	1.384	0.98
35_K	62_E	1.381	0.98
74_V	96_Q	1.380	0.98
625_T	639_Q	1.380	0.98
183_V	196_L	1.379	0.98
218_K	222_E	1.377	0.98
134_A	193_L	1.377	0.98
17_R	55_Q	1.376	0.98
50_I	75_A	1.374	0.98
216_R	239_K	1.374	0.98
547_E	583_R	1.373	0.98
698_R	733_T	1.373	0.98
332_D	554_K	1.371	0.98
10_E	113_K	1.367	0.98
523_V	548_I	1.360	0.97
97_R	167_D	1.353	0.97
120_P	188_D	1.352	0.97
304_N	416_K	1.350	0.97
96_Q	116_Y	1.349	0.97
586_Y	609_D	1.348	0.97
531_I	548_I	1.346	0.97
119_S	163_A	1.340	0.97
100_I	112_A	1.336	0.97
254_L	296_D	1.331	0.97
642_L	664_I	1.330	0.97
68_L	100_I	1.322	0.97
319_I	371_K	1.319	0.97
736_I	757_I	1.316	0.97
645_V	689_V	1.309	0.97
682_I	713_V	1.308	0.97
527_A	572_G	1.306	0.97
651_K	764_E	1.305	0.97
132_R	203_E	1.305	0.97
601_L	734_V	1.304	0.97
377_Y	421_L	1.302	0.97
629_S	632_E	1.301	0.97
51_M	114_A	1.297	0.97
576_H	745_E	1.295	0.97
525_D	529_I	1.295	0.97
17_R	32_G	1.291	0.97
620_G	663_D	1.285	0.96
523_V	575_L	1.279	0.96
271_A	275_L	1.278	0.96
223_K	227_E	1.274	0.96
521_L	555_A	1.271	0.96
767_L	771_L	1.271	0.96
617_C	662_R	1.268	0.96
554_K	578_Y	1.264	0.96
581_V	745_E	1.263	0.96
65_V	103_L	1.259	0.96
425_I	440_L	1.259	0.96
664_I	692_L	1.258	0.96
186_M	195_Y	1.258	0.96
723_L	755_L	1.256	0.96
57_E	60_T	1.252	0.96
380_M	409_K	1.249	0.96
585_D	739_E	1.246	0.96
261_A	264_P	1.245	0.96
499_L	532_I	1.244	0.96
664_I	688_L	1.244	0.96
366_G	421_L	1.241	0.96
260_A	265_K	1.236	0.96
593_N	699_A	1.235	0.96
475_M	482_L	1.234	0.95
317_Q	557_K	1.234	0.95
134_A	200_M	1.233	0.95
258_I	299_V	1.231	0.95
262_K	265_K	1.231	0.95
144_L	207_L	1.227	0.95
659_Y	692_L	1.219	0.95
638_I	666_V	1.216	0.95
347_I	350_P	1.212	0.95
526_S	572_G	1.210	0.95
574_N	577_D	1.210	0.95
261_A	271_A	1.209	0.95
286_A	399_I	1.206	0.95
547_E	550_K	1.204	0.95
100_I	103_L	1.204	0.95
14_L	50_I	1.201	0.95
494_T	720_K	1.200	0.95
162_P	166_A	1.200	0.95
658_F	692_L	1.200	0.95
766_V	770_A	1.199	0.95
162_P	193_L	1.193	0.95
330_V	490_L	1.188	0.94
343_R	559_L	1.188	0.94
21_V	75_A	1.187	0.94
598_V	683_A	1.185	0.94
365_L	490_L	1.181	0.94
36_S	55_Q	1.179	0.94
760_V	769_L	1.179	0.94
10_E	111_S	1.172	0.94
317_Q	335_L	1.161	0.94
70_T	185_E	1.154	0.94
649_A	654_I	1.151	0.93
410_M	466_V	1.150	0.93
301_V	407_I	1.150	0.93
630_L	668_V	1.150	0.93
379_R	485_M	1.149	0.93
52_L	75_A	1.147	0.93
212_R	216_R	1.141	0.93
176_K	179_D	1.138	0.93
262_K	308_K	1.138	0.93
355_V	474_S	1.126	0.93
137_Q	197_M	1.125	0.93
377_Y	419_L	1.125	0.93
293_G	456_Y	1.125	0.93
55_Q	63_P	1.122	0.93
260_A	308_K	1.120	0.93
297_W	411_A	1.119	0.92
741_K	745_E	1.107	0.92
281_M	289_T	1.107	0.92
762_R	765_E	1.106	0.92
348_K	513_R	1.106	0.92
689_V	771_L	1.105	0.92
309_V	373_T	1.103	0.92
343_R	560_L	1.103	0.92
32_G	55_Q	1.101	0.92
17_R	36_S	1.100	0.92
373_T	467_M	1.095	0.92
51_M	100_I	1.095	0.92
543_G	546_R	1.093	0.92
377_Y	381_A	1.092	0.92
570_I	575_L	1.086	0.91
510_Q	552_C	1.081	0.91
511_I	521_L	1.076	0.91
71_V	117_L	1.075	0.91
134_A	197_M	1.072	0.91
305_A	308_K	1.070	0.91
257_K	300_Q	1.069	0.91
378_V	409_K	1.067	0.91
410_M	416_K	1.066	0.91
39_C	43_A	1.066	0.91
545_E	549_S	1.060	0.90
524_D	571_N	1.058	0.90
744_L	757_I	1.055	0.90
355_V	475_M	1.054	0.90
301_V	457_L	1.054	0.90
523_V	527_A	1.053	0.90
342_S	560_L	1.050	0.90
744_L	747_I	1.049	0.90
555_A	578_Y	1.048	0.90
281_M	291_V	1.047	0.90
53_V	112_A	1.046	0.90
355_V	482_L	1.044	0.90
648_R	652_L	1.041	0.89
54_A	177_L	1.040	0.89
205_D	208_Q	1.038	0.89
474_S	482_L	1.037	0.89
265_K	308_K	1.036	0.89
325_Y	500_N	1.031	0.89
52_L	92_V	1.031	0.89
30_F	89_K	1.030	0.89
670_E	708_T	1.026	0.89
314_R	563_K	1.025	0.89
618_V	646_R	1.024	0.89
175_L	199_M	1.023	0.89
252_E	255_K	1.023	0.89
682_I	685_C	1.021	0.89
313_L	339_A	1.020	0.88
511_I	518_K	1.020	0.88
13_V	53_V	1.018	0.88
336_E	557_K	1.017	0.88
385_V	455_H	1.016	0.88
323_D	368_S	1.014	0.88
598_V	697_V	1.014	0.88
42_A	46_H	1.014	0.88
447_E	509_K	1.011	0.88
597_Q	612_T	1.009	0.88
343_R	520_E	1.008	0.88
42_A	109_H	1.005	0.88
272_E	275_L	1.005	0.88
723_L	752_I	1.005	0.88
425_I	428_M	1.002	0.88
316_A	338_L	0.999	0.87
652_L	689_V	0.998	0.87
13_V	110_F	0.995	0.87
275_L	299_V	0.993	0.87
602_A	611_L	0.990	0.87
708_T	714_L	0.989	0.87
407_I	410_M	0.988	0.87
654_I	693_T	0.988	0.87
577_D	749_D	0.987	0.87
316_A	319_I	0.986	0.87
13_V	98_A	0.986	0.87
524_D	573_D	0.985	0.87
332_D	557_K	0.982	0.87
701_V	769_L	0.976	0.86
225_Q	228_Y	0.975	0.86
543_G	547_E	0.974	0.86
195_Y	198_A	0.970	0.86
732_K	754_D	0.964	0.86
624_L	642_L	0.962	0.85
297_W	457_L	0.961	0.85
227_E	241_L	0.960	0.85
646_R	658_F	0.959	0.85
343_R	515_A	0.959	0.85
609_D	613_I	0.958	0.85
257_K	299_V	0.957	0.85
685_C	689_V	0.956	0.85
309_V	417_N	0.956	0.85
763_I	767_L	0.955	0.85
654_I	689_V	0.955	0.85
252_E	256_R	0.953	0.85
649_A	653_G	0.951	0.85
217_V	236_A	0.951	0.85
508_P	512_E	0.950	0.85
18_D	30_F	0.949	0.85
437_A	478_P	0.947	0.84
281_M	288_A	0.946	0.84
695_N	772_Q	0.945	0.84
98_A	114_A	0.944	0.84
41_E	82_K	0.942	0.84
367_Q	447_E	0.942	0.84
255_K	259_D	0.942	0.84
263_M	267_A	0.942	0.84
60_T	63_P	0.942	0.84
258_I	261_A	0.941	0.84
453_S	458_E	0.939	0.84
216_R	236_A	0.937	0.84
385_V	428_M	0.937	0.84
251_N	275_L	0.934	0.84
310_K	374_G	0.933	0.84
603_W	725_A	0.932	0.84
261_A	268_K	0.931	0.83
28_P	78_L	0.930	0.83
623_K	663_D	0.928	0.83
723_L	759_P	0.928	0.83
646_R	659_Y	0.925	0.83
616_A	643_T	0.919	0.83
644_V	648_R	0.916	0.82
734_V	755_L	0.915	0.82
736_I	741_K	0.913	0.82
63_P	67_D	0.912	0.82
716_I	759_P	0.911	0.82
101_S	113_K	0.910	0.82
734_V	757_I	0.908	0.82
221_M	228_Y	0.907	0.82
40_L	88_V	0.903	0.82
170_A	183_V	0.899	0.81
17_R	63_P	0.898	0.81
65_V	70_T	0.897	0.81
314_R	318_E	0.896	0.81
16_L	52_L	0.895	0.81
124_E	190_N	0.894	0.81
601_L	702_A	0.894	0.81
381_A	411_A	0.894	0.81
365_L	408_Q	0.893	0.81
689_V	763_I	0.892	0.81
629_S	670_E	0.890	0.81
159_I	168_T	0.888	0.80
220_Q	239_K	0.888	0.80
511_I	516_L	0.886	0.80
253_A	273_A	0.882	0.80
132_R	206_L	0.881	0.80
163_A	192_R	0.880	0.80
619_P	662_R	0.878	0.80
142_I	148_I	0.877	0.80
273_A	411_A	0.868	0.79
298_M	457_L	0.868	0.79
81_L	84_P	0.868	0.79
698_R	770_A	0.866	0.79
277_K	297_W	0.865	0.79
602_A	725_A	0.864	0.79
328_E	332_D	0.862	0.78
317_Q	332_D	0.860	0.78
598_V	687_A	0.859	0.78
619_P	656_P	0.859	0.78
638_I	683_A	0.854	0.78
502_A	528_I	0.853	0.78
133_T	197_M	0.853	0.78
117_L	187_S	0.848	0.77
261_A	304_N	0.847	0.77
682_I	763_I	0.846	0.77
727_H	751_V	0.846	0.77
373_T	419_L	0.846	0.77
53_V	98_A	0.845	0.77
312_D	315_Q	0.845	0.77
165_L	169_I	0.845	0.77
499_L	503_K	0.844	0.77
523_V	555_A	0.843	0.77
410_M	457_L	0.842	0.77
429_S	433_R	0.840	0.77
295_I	299_V	0.839	0.77
526_S	573_D	0.839	0.77
738_F	765_E	0.837	0.76
21_V	52_L	0.836	0.76
311_K	342_S	0.836	0.76
645_V	707_I	0.834	0.76
131_V	135_I	0.834	0.76
428_M	478_P	0.834	0.76
267_A	459_V	0.833	0.76
511_I	552_C	0.832	0.76
230_L	241_L	0.832	0.76
129_V	206_L	0.831	0.76
713_V	766_V	0.830	0.76
304_N	461_Y	0.829	0.76
261_A	275_L	0.828	0.76
74_V	114_A	0.827	0.76
346_K	465_D	0.826	0.75
510_Q	513_R	0.825	0.75
319_I	322_T	0.824	0.75
520_E	559_L	0.822	0.75
49_K	76_S	0.820	0.75
371_K	374_G	0.818	0.75
259_D	272_E	0.818	0.75
286_A	290_V	0.817	0.75
245_D	248_P	0.814	0.74
723_L	727_H	0.813	0.74
527_A	570_I	0.813	0.74
599_T	612_T	0.812	0.74
763_I	766_V	0.810	0.74
258_I	295_I	0.806	0.74
697_V	770_A	0.803	0.73
598_V	645_V	0.802	0.73
592_E	595_V	0.802	0.73
129_V	132_R	0.801	0.73
741_K	744_L	0.795	0.73
701_V	770_A	0.794	0.72
354_L	469_V	0.794	0.72
599_T	610_L	0.793	0.72
232_E	235_K	0.792	0.72
662_R	692_L	0.792	0.72
325_Y	504_R	0.792	0.72
36_S	63_P	0.791	0.72
529_I	533_R	0.791	0.72
487_V	543_G	0.790	0.72
64_G	67_D	0.790	0.72
740_N	743_D	0.790	0.72
558_Q	562_D	0.789	0.72
33_R	67_D	0.789	0.72
371_K	505_H	0.788	0.72
299_V	459_V	0.788	0.72
683_A	725_A	0.787	0.72
556_V	560_L	0.785	0.72
54_A	181_Q	0.785	0.72
410_M	413_V	0.784	0.72
18_D	89_K	0.783	0.71
270_K	458_E	0.783	0.71
763_I	771_L	0.783	0.71
723_L	744_L	0.783	0.71
623_K	639_Q	0.781	0.71
108_E	111_S	0.779	0.71
96_Q	118_E	0.778	0.71
166_A	196_L	0.778	0.71
73_T	684_M	0.774	0.71
78_L	93_E	0.774	0.71
744_L	752_I	0.772	0.70
759_P	765_E	0.772	0.70
20_V	226_R	0.771	0.70
321_D	335_L	0.771	0.70
309_V	376_K	0.768	0.70
716_I	740_N	0.767	0.70
28_P	89_K	0.767	0.70
237_I	241_L	0.767	0.70
698_R	772_Q	0.766	0.70
234_M	238_Q	0.766	0.70
666_V	684_M	0.765	0.70
195_Y	199_M	0.764	0.70
533_R	586_Y	0.763	0.69
715_P	739_E	0.760	0.69
577_D	753_A	0.758	0.69
297_W	407_I	0.757	0.69
163_A	188_D	0.757	0.69
182_S	186_M	0.757	0.69
309_V	341_Q	0.756	0.69
380_M	420_F	0.756	0.69
382_L	392_R	0.756	0.69
507_L	551_L	0.755	0.69
270_K	274_E	0.755	0.69
233_Q	239_K	0.755	0.69
495_E	529_I	0.755	0.69
624_L	638_I	0.755	0.69
723_L	747_I	0.754	0.69
727_H	748_P	0.753	0.68
645_V	688_L	0.751	0.68
227_E	231_N	0.750	0.68
654_I	659_Y	0.750	0.68
650_E	656_P	0.749	0.68
589_A	729_G	0.749	0.68
54_A	69_F	0.749	0.68
732_K	756_D	0.748	0.68
683_A	766_V	0.748	0.68
524_D	572_G	0.748	0.68
552_C	556_V	0.747	0.68
213_I	230_L	0.747	0.68
128_E	132_R	0.746	0.68
372_A	532_I	0.745	0.68
494_T	750_N	0.744	0.68
597_Q	712_Q	0.744	0.68
251_N	278_L	0.743	0.67
720_K	724_L	0.742	0.67
405_K	609_D	0.740	0.67
163_A	189_V	0.740	0.67
712_Q	761_K	0.739	0.67
26_V	78_L	0.737	0.67
44_M	80_M	0.737	0.67
254_L	299_V	0.737	0.67
594_R	712_Q	0.736	0.67
379_R	451_A	0.736	0.67
367_Q	371_K	0.735	0.67
36_S	39_C	0.735	0.67
217_V	229_Y	0.735	0.67
130_L	194_E	0.734	0.66
396_R	748_P	0.734	0.66
228_Y	235_K	0.733	0.66
683_A	703_M	0.732	0.66
124_E	127_Q	0.732	0.66
215_N	267_A	0.732	0.66
79_Q	93_E	0.731	0.66
533_R	587_G	0.731	0.66
595_V	696_P	0.731	0.66
233_Q	379_R	0.729	0.66
274_E	284_M	0.729	0.66
527_A	571_N	0.725	0.66
163_A	183_V	0.725	0.66
735_L	757_I	0.725	0.66
51_M	74_V	0.724	0.65
21_V	27_I	0.724	0.65
80_M	88_V	0.723	0.65
159_I	165_L	0.722	0.65
65_V	110_F	0.722	0.65
765_E	769_L	0.722	0.65
526_S	753_A	0.721	0.65
330_V	488_I	0.718	0.65
77_I	90_V	0.717	0.65
598_V	731_I	0.716	0.65
160_D	176_K	0.715	0.64
144_L	204_I	0.714	0.64
191_E	194_E	0.714	0.64
386_R	431_D	0.714	0.64
21_V	92_V	0.712	0.64
341_Q	347_I	0.712	0.64
747_I	752_I	0.711	0.64
261_A	299_V	0.711	0.64
685_C	767_L	0.710	0.64
296_D	300_Q	0.710	0.64
650_E	655_N	0.709	0.64
208_Q	212_R	0.708	0.64
230_L	234_M	0.707	0.64
169_I	173_M	0.707	0.64
134_A	169_I	0.706	0.63
13_V	104_S	0.705	0.63
378_V	385_V	0.705	0.63
212_R	236_A	0.705	0.63
662_R	694_G	0.704	0.63
119_S	189_V	0.703	0.63
613_I	668_V	0.703	0.63
237_I	242_G	0.702	0.63
166_A	192_R	0.701	0.63
210_E	233_Q	0.700	0.63
558_Q	565_L	0.700	0.63
258_I	268_K	0.700	0.63
233_Q	240_E	0.700	0.63
217_V	228_Y	0.699	0.63
654_I	692_L	0.699	0.63
590_D	710_R	0.697	0.62
559_L	562_D	0.697	0.62
227_E	237_I	0.696	0.62
585_D	742_R	0.694	0.62
316_A	335_L	0.694	0.62
419_L	469_V	0.693	0.62
551_L	575_L	0.692	0.62
569_E	573_D	0.692	0.62
29_L	365_L	0.691	0.62
318_E	321_D	0.690	0.62
74_V	95_L	0.689	0.62
480_P	485_M	0.689	0.62
408_Q	412_K	0.687	0.61
355_V	489_R	0.686	0.61
297_W	349_G	0.686	0.61
97_R	180_K	0.684	0.61
576_H	582_Q	0.683	0.61
255_K	275_L	0.682	0.61
166_A	189_V	0.682	0.61
38_R	300_Q	0.680	0.61
296_D	299_V	0.680	0.61
686_T	771_L	0.679	0.60
193_L	377_Y	0.678	0.60
100_I	110_F	0.677	0.60
64_G	110_F	0.676	0.60
220_Q	236_A	0.674	0.60
18_D	25_M	0.674	0.60
225_Q	229_Y	0.674	0.60
103_L	112_A	0.674	0.60
266_E	376_K	0.673	0.60
322_T	374_G	0.672	0.60
11_I	98_A	0.670	0.59
203_E	242_G	0.669	0.59
18_D	28_P	0.667	0.59
558_Q	575_L	0.667	0.59
288_A	291_V	0.665	0.59
531_I	581_V	0.665	0.59
366_G	377_Y	0.664	0.59
405_K	453_S	0.662	0.59
127_Q	193_L	0.662	0.59
253_A	256_R	0.661	0.58
308_K	345_N	0.659	0.58
141_Y	468_F	0.658	0.58
337_Y	341_Q	0.658	0.58
141_Y	207_L	0.656	0.58
274_E	421_L	0.656	0.58
330_V	419_L	0.655	0.58
589_A	731_I	0.653	0.57
531_I	578_Y	0.653	0.57
496_D	727_H	0.652	0.57
167_D	189_V	0.652	0.57
263_M	272_E	0.649	0.57
313_L	335_L	0.648	0.57
30_F	85_D	0.648	0.57
29_L	372_A	0.648	0.57
131_V	162_P	0.647	0.57
350_P	720_K	0.647	0.57
366_G	496_D	0.647	0.57
317_Q	328_E	0.646	0.57
329_R	746_E	0.645	0.57
69_F	181_Q	0.644	0.56
264_P	304_N	0.643	0.56
197_M	201_E	0.642	0.56
30_F	366_G	0.642	0.56
385_V	438_S	0.642	0.56
104_S	113_K	0.642	0.56
273_A	300_Q	0.642	0.56
166_A	183_V	0.641	0.56
295_I	576_H	0.641	0.56
272_E	276_Q	0.641	0.56
129_V	203_E	0.640	0.56
389_A	474_S	0.640	0.56
266_E	459_V	0.639	0.56
28_P	85_D	0.637	0.56
446_P	453_S	0.637	0.56
145_N	148_I	0.637	0.56
55_Q	67_D	0.637	0.56
453_S	710_R	0.637	0.56
654_I	657_D	0.636	0.56
179_D	195_Y	0.635	0.55
301_V	416_K	0.634	0.55
337_Y	350_P	0.634	0.55
231_N	460_D	0.633	0.55
649_A	689_V	0.633	0.55
559_L	645_V	0.633	0.55
522_T	573_D	0.632	0.55
37_I	88_V	0.632	0.55
71_V	181_Q	0.632	0.55
619_P	661_K	0.632	0.55
311_K	373_T	0.631	0.55
221_M	229_Y	0.631	0.55
430_S	433_R	0.630	0.55
523_V	583_R	0.630	0.55
389_A	402_M	0.629	0.55
104_S	111_S	0.629	0.55
32_G	63_P	0.628	0.55
492_G	724_L	0.627	0.54
545_E	548_I	0.627	0.54
271_A	299_V	0.626	0.54
523_V	574_N	0.626	0.54
230_L	240_E	0.626	0.54
253_A	257_K	0.626	0.54
13_V	100_I	0.626	0.54
612_T	668_V	0.626	0.54
659_Y	662_R	0.625	0.54
603_W	634_M	0.624	0.54
39_C	691_C	0.624	0.54
349_G	513_R	0.623	0.54
409_K	412_K	0.622	0.54
41_E	139_E	0.621	0.54
56_K	69_F	0.621	0.54
507_L	527_A	0.621	0.54
325_Y	505_H	0.621	0.54
559_L	568_I	0.621	0.54
686_T	703_M	0.620	0.54
388_E	443_V	0.620	0.54
323_D	505_H	0.620	0.54
262_K	305_A	0.619	0.54
244_M	247_A	0.619	0.54
10_E	104_S	0.618	0.53
402_M	415_V	0.618	0.53
161_D	164_R	0.617	0.53
505_H	509_K	0.617	0.53
44_M	48_K	0.617	0.53
355_V	476_N	0.617	0.53
719_L	758_H	0.616	0.53
270_K	670_E	0.616	0.53
34_E	38_R	0.615	0.53
328_E	748_P	0.615	0.53
323_D	510_Q	0.615	0.53
419_L	467_M	0.612	0.53
654_I	662_R	0.612	0.53
263_M	304_N	0.610	0.52
581_V	742_R	0.609	0.52
319_I	380_M	0.608	0.52
511_I	514_N	0.608	0.52
645_V	654_I	0.608	0.52
402_M	605_E	0.608	0.52
526_S	577_D	0.607	0.52
587_G	670_E	0.606	0.52
33_R	57_E	0.606	0.52
634_M	668_V	0.606	0.52
238_Q	635_Q	0.606	0.52
343_R	552_C	0.605	0.52
683_A	713_V	0.605	0.52
591_N	696_P	0.605	0.52
591_N	699_A	0.605	0.52
570_I	578_Y	0.604	0.52
590_D	599_T	0.604	0.52
391_I	439_A	0.604	0.52
89_K	288_A	0.603	0.52
443_V	463_L	0.603	0.52
354_L	371_K	0.603	0.52
593_N	771_L	0.603	0.52
635_Q	659_Y	0.602	0.51
53_V	56_K	0.602	0.51
247_A	251_N	0.601	0.51
594_R	710_R	0.600	0.51
343_R	460_D	0.600	0.51
766_V	771_L	0.600	0.51
566_K	573_D	0.600	0.51
525_D	528_I	0.599	0.51
236_A	239_K	0.599	0.51
93_E	274_E	0.599	0.51
350_P	724_L	0.597	0.51
658_F	662_R	0.597	0.51
507_L	511_I	0.597	0.51
562_D	565_L	0.597	0.51
226_R	234_M	0.596	0.51
492_G	539_A	0.596	0.51
425_I	470_A	0.596	0.51
24_H	164_R	0.596	0.51
194_E	216_R	0.595	0.51
226_R	651_K	0.595	0.51
65_V	100_I	0.595	0.51
221_M	225_Q	0.594	0.51
213_I	237_I	0.594	0.51
178_A	399_I	0.593	0.50
335_L	338_L	0.592	0.50
274_E	294_Y	0.591	0.50
524_D	577_D	0.591	0.50
640_A	643_T	0.591	0.50
482_L	489_R	0.590	0.50
428_M	437_A	0.590	0.50
99_R	117_L	0.590	0.50
365_L	390_E	0.589	0.50
134_A	166_A	0.588	0.50
127_Q	162_P	0.588	0.50
125_R	128_E	0.587	0.50
390_E	611_L	0.587	0.50
308_K	512_E	0.587	0.50
9_I	113_K	0.586	0.50
234_M	686_T	0.586	0.50
17_R	353_C	0.585	0.49
264_P	410_M	0.585	0.49
440_L	470_A	0.585	0.49
292_R	296_D	0.585	0.49
519_G	522_T	0.585	0.49
568_I	574_N	0.584	0.49
476_N	673_T	0.584	0.49
391_I	455_H	0.584	0.49
278_L	288_A	0.583	0.49
32_G	360_V	0.583	0.49
748_P	752_I	0.583	0.49
289_T	399_I	0.583	0.49
646_R	663_D	0.583	0.49
124_E	162_P	0.583	0.49
416_K	505_H	0.582	0.49
719_L	727_H	0.582	0.49
360_V	365_L	0.582	0.49
286_A	433_R	0.582	0.49
308_K	417_N	0.582	0.49
572_G	582_Q	0.581	0.49
130_L	134_A	0.581	0.49
209_V	212_R	0.581	0.49
338_L	373_T	0.581	0.49
327_L	389_A	0.580	0.49
587_G	729_G	0.580	0.49
506_L	531_I	0.579	0.49
599_T	728_R	0.578	0.49
451_A	460_D	0.577	0.49
65_V	102_A	0.577	0.49
710_R	763_I	0.577	0.49
180_K	274_E	0.576	0.48
670_E	714_L	0.576	0.48
254_L	295_I	0.575	0.48
180_K	197_M	0.575	0.48
94_G	97_R	0.575	0.48
472_S	683_A	0.575	0.48
604_T	634_M	0.575	0.48
243_E	406_L	0.575	0.48
264_P	459_V	0.574	0.48
492_G	728_R	0.574	0.48
194_E	355_V	0.574	0.48
154_T	158_S	0.573	0.48
526_S	569_E	0.572	0.48
321_D	504_R	0.572	0.48
183_V	199_M	0.572	0.48
581_V	744_L	0.572	0.48
22_Y	183_V	0.572	0.48
746_E	752_I	0.571	0.48
121_T	161_D	0.571	0.48
723_L	735_L	0.570	0.48
308_K	312_D	0.569	0.48
489_R	673_T	0.569	0.48
347_I	514_N	0.568	0.47
389_A	579_L	0.568	0.47
586_Y	729_G	0.568	0.47
267_A	271_A	0.568	0.47
213_I	233_Q	0.568	0.47
670_E	673_T	0.568	0.47
237_I	240_E	0.568	0.47
640_A	648_R	0.567	0.47
644_V	652_L	0.567	0.47
696_P	772_Q	0.567	0.47
263_M	268_K	0.567	0.47
304_N	410_M	0.567	0.47
453_S	457_L	0.566	0.47
344_V	515_A	0.566	0.47
38_R	41_E	0.566	0.47
295_I	341_Q	0.565	0.47
319_I	372_A	0.565	0.47
402_M	409_K	0.565	0.47
40_L	90_V	0.564	0.47
376_K	413_V	0.564	0.47
19_V	27_I	0.564	0.47
642_L	688_L	0.563	0.47
638_I	668_V	0.562	0.47
735_L	758_H	0.562	0.47
601_L	723_L	0.561	0.47
738_F	759_P	0.561	0.47
79_Q	141_Y	0.560	0.47
409_K	453_S	0.560	0.47
185_E	664_I	0.560	0.47
29_L	90_V	0.559	0.46
165_L	510_Q	0.559	0.46
29_L	52_L	0.558	0.46
49_K	95_L	0.558	0.46
87_T	180_K	0.558	0.46
307_S	417_N	0.558	0.46
29_L	92_V	0.557	0.46
270_K	459_V	0.557	0.46
469_V	519_G	0.557	0.46
68_L	110_F	0.557	0.46
225_Q	241_L	0.556	0.46
74_V	116_Y	0.556	0.46
340_V	515_A	0.555	0.46
197_M	277_K	0.555	0.46
373_T	460_D	0.555	0.46
267_A	298_M	0.554	0.46
507_L	552_C	0.554	0.46
259_D	499_L	0.554	0.46
490_L	626_Y	0.553	0.46
270_K	273_A	0.552	0.46
327_L	490_L	0.552	0.46
263_M	275_L	0.552	0.46
555_A	574_N	0.551	0.45
246_D	643_T	0.551	0.45
15_P	68_L	0.550	0.45
130_L	193_L	0.550	0.45
410_M	414_G	0.550	0.45
381_A	548_I	0.550	0.45
26_V	91_L	0.550	0.45
73_T	283_P	0.550	0.45
482_L	485_M	0.550	0.45
753_A	756_D	0.549	0.45
267_A	528_I	0.548	0.45
602_A	676_D	0.548	0.45
222_E	761_K	0.548	0.45
230_L	242_G	0.547	0.45
26_V	233_Q	0.547	0.45
603_W	676_D	0.547	0.45
194_E	198_A	0.546	0.45
104_S	108_E	0.545	0.45
530_G	576_H	0.545	0.45
532_I	544_L	0.545	0.45
150_P	153_L	0.545	0.45
644_V	647_A	0.543	0.45
651_K	768_T	0.543	0.45
231_N	277_K	0.543	0.45
79_Q	91_L	0.543	0.45
287_E	296_D	0.543	0.45
122_I	188_D	0.543	0.45
217_V	455_H	0.543	0.45
305_A	415_V	0.542	0.44
268_K	299_V	0.542	0.44
52_L	90_V	0.542	0.44
595_V	719_L	0.542	0.44
55_Q	60_T	0.542	0.44
38_R	108_E	0.541	0.44
139_E	157_N	0.541	0.44
90_V	585_D	0.541	0.44
290_V	455_H	0.541	0.44
524_D	574_N	0.540	0.44
735_L	770_A	0.540	0.44
745_E	752_I	0.539	0.44
50_I	53_V	0.539	0.44
95_L	539_A	0.539	0.44
209_V	419_L	0.538	0.44
258_I	366_G	0.538	0.44
323_D	509_K	0.538	0.44
512_E	517_K	0.538	0.44
366_G	603_W	0.537	0.44
14_L	29_L	0.537	0.44
74_V	298_M	0.537	0.44
392_R	536_T	0.536	0.44
274_E	298_M	0.536	0.44
492_G	599_T	0.536	0.44
94_G	207_L	0.535	0.44
21_V	24_H	0.535	0.44
281_M	286_A	0.535	0.44
167_D	188_D	0.535	0.44
191_E	195_Y	0.534	0.43
477_I	579_L	0.534	0.43
293_G	415_V	0.534	0.43
25_M	223_K	0.534	0.43
312_D	321_D	0.533	0.43
496_D	529_I	0.533	0.43
245_D	249_D	0.532	0.43
22_Y	177_L	0.532	0.43
509_K	670_E	0.531	0.43
654_I	658_F	0.531	0.43
187_S	192_R	0.531	0.43
140_G	342_S	0.531	0.43
509_K	549_S	0.530	0.43
51_M	112_A	0.530	0.43
68_L	103_L	0.530	0.43
385_V	410_M	0.529	0.43
689_V	695_N	0.529	0.43
232_E	239_K	0.529	0.43
368_S	371_K	0.529	0.43
335_L	588_R	0.529	0.43
390_E	431_D	0.528	0.43
297_W	301_V	0.528	0.43
42_A	111_S	0.528	0.43
616_A	642_L	0.528	0.43
301_V	459_V	0.528	0.43
524_D	753_A	0.528	0.43
183_V	186_M	0.528	0.43
691_C	710_R	0.527	0.43
57_E	162_P	0.527	0.43
28_P	79_Q	0.527	0.43
305_A	512_E	0.527	0.43
135_I	138_F	0.526	0.43
228_Y	240_E	0.526	0.43
50_I	179_D	0.525	0.42
597_Q	610_L	0.525	0.42
429_S	437_A	0.525	0.42
40_L	321_D	0.525	0.42
534_Y	586_Y	0.524	0.42
457_L	461_Y	0.524	0.42
684_M	698_R	0.524	0.42
601_L	610_L	0.524	0.42
11_I	349_G	0.524	0.42
576_H	581_V	0.523	0.42
642_L	646_R	0.523	0.42
155_S	354_L	0.523	0.42
314_R	317_Q	0.523	0.42
130_L	166_A	0.522	0.42
17_R	57_E	0.521	0.42
190_N	194_E	0.521	0.42
158_S	226_R	0.521	0.42
494_T	663_D	0.521	0.42
437_A	618_V	0.521	0.42
30_F	78_L	0.521	0.42
581_V	743_D	0.520	0.42
284_M	288_A	0.520	0.42
138_F	142_I	0.520	0.42
626_Y	642_L	0.519	0.42
141_Y	145_N	0.519	0.42
214_R	233_Q	0.519	0.42
65_V	755_L	0.519	0.42
46_H	312_D	0.519	0.42
197_M	354_L	0.519	0.42
79_Q	82_K	0.519	0.42
428_M	436_P	0.519	0.42
520_E	560_L	0.519	0.42
595_V	693_T	0.519	0.42
616_A	649_A	0.518	0.42
261_A	457_L	0.518	0.42
58_A	90_V	0.518	0.42
701_V	716_I	0.518	0.42
489_R	492_G	0.518	0.42
551_L	555_A	0.518	0.42
560_L	563_K	0.518	0.42
599_T	668_V	0.516	0.41
228_Y	232_E	0.516	0.41
216_R	490_L	0.516	0.41
746_E	754_D	0.516	0.41
668_V	674_P	0.514	0.41
265_K	577_D	0.514	0.41
322_T	354_L	0.514	0.41
622_G	646_R	0.513	0.41
396_R	432_M	0.513	0.41
123_D	503_K	0.513	0.41
517_K	569_E	0.513	0.41
326_G	506_L	0.512	0.41
71_V	124_E	0.512	0.41
360_V	496_D	0.512	0.41
380_M	505_H	0.512	0.41
511_I	559_L	0.512	0.41
186_M	381_A	0.512	0.41
14_L	95_L	0.512	0.41
31_V	35_K	0.512	0.41
259_D	265_K	0.511	0.41
213_I	242_G	0.511	0.41
701_V	758_H	0.510	0.41
135_I	139_E	0.510	0.41
277_K	460_D	0.510	0.41
649_A	652_L	0.509	0.41
516_L	552_C	0.509	0.41
727_H	755_L	0.509	0.41
36_S	67_D	0.509	0.41
408_Q	411_A	0.509	0.41
694_G	767_L	0.509	0.41
28_P	91_L	0.509	0.41
638_I	684_M	0.509	0.41
101_S	105_D	0.509	0.41
105_D	109_H	0.508	0.40
84_P	419_L	0.507	0.40
479_A	605_E	0.507	0.40
491_S	720_K	0.507	0.40
101_S	125_R	0.507	0.40
683_A	697_V	0.507	0.40
599_T	699_A	0.507	0.40
574_N	579_L	0.506	0.40
603_W	606_V	0.506	0.40
666_V	683_A	0.506	0.40
413_V	416_K	0.506	0.40
20_V	85_D	0.506	0.40
429_S	432_M	0.506	0.40
77_I	657_D	0.505	0.40
146_K	150_P	0.505	0.40
562_D	568_I	0.505	0.40
527_A	530_G	0.505	0.40
210_E	270_K	0.504	0.40
360_V	377_Y	0.504	0.40
511_I	731_I	0.503	0.40
629_S	673_T	0.502	0.40
276_Q	516_L	0.502	0.40
30_F	421_L	0.502	0.40
233_Q	480_P	0.501	0.40
256_R	269_E	0.501	0.40
419_L	530_G	0.501	0.40
39_C	55_Q	0.501	0.40
257_K	260_A	0.500	0.40
155_S	196_L	0.500	0.40
46_H	109_H	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m6aA	3	0.6314	100	0.575	Contact Map
3k1jA	4	0.5676	100	0.745	Contact Map
4fwgA	3	0.6441	100	0.797	Contact Map
3wu4A	3	0.2474	100	0.838	Contact Map
3ljcA	1	0.3048	100	0.839	Contact Map
2x36A	3	0.2423	100	0.841	Contact Map
1xhkA	2	0.227	100	0.856	Contact Map
1z0wA	3	0.2462	100	0.857	Contact Map
4gitA	2	0.1173	100	0.861	Contact Map
1qvrA	3	0.6339	100	0.876	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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