GREMLIN Database
LON - Lon protease
UniProt: P0A9M0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10542
Length: 784 (764)
Sequences: 3202 (1844)
Seq/√Len: 66.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
716_I719_L5.5921.00
738_F741_K4.8451.00
317_Q321_D4.7631.00
503_K525_D4.6541.00
307_S415_V4.6041.00
738_F761_K4.4111.00
322_T371_K4.1411.00
343_R556_V3.7231.00
51_M98_A3.7161.00
733_T758_H3.5591.00
409_K420_F3.5091.00
500_N504_R3.4911.00
507_L523_V3.3251.00
101_S115_E3.1301.00
615_T687_A3.1061.00
551_L570_I3.0811.00
558_Q577_D3.0751.00
256_R260_A3.0741.00
102_A113_K3.0501.00
749_D752_I3.0301.00
407_I461_Y3.0281.00
323_D371_K3.0111.00
736_I759_P2.9961.00
632_E635_Q2.9691.00
723_L757_I2.9361.00
186_M191_E2.9271.00
758_H769_L2.8981.00
702_A731_I2.8401.00
760_V765_E2.8241.00
271_A298_M2.7801.00
524_D527_A2.7551.00
428_M440_L2.7371.00
507_L548_I2.7371.00
733_T756_D2.7021.00
99_R115_E2.6561.00
530_G534_Y2.6501.00
255_K279_K2.6371.00
700_D732_K2.6341.00
306_R465_D2.6261.00
167_D192_R2.6231.00
571_N574_N2.5931.00
727_H754_D2.5771.00
258_I271_A2.5761.00
657_D661_K2.5741.00
306_R416_K2.5311.00
258_I275_L2.5291.00
719_L736_I2.5131.00
265_K269_E2.5041.00
416_K461_Y2.4721.00
514_N549_S2.4121.00
264_P267_A2.3831.00
317_Q561_L2.3801.00
682_I766_V2.3791.00
626_Y638_I2.3711.00
531_I551_L2.3701.00
11_I74_V2.3421.00
523_V551_L2.3341.00
74_V98_A2.2701.00
765_E768_T2.2701.00
744_L759_P2.2561.00
268_K272_E2.2481.00
182_S195_Y2.2431.00
735_L769_L2.2301.00
648_R651_K2.2181.00
521_L552_C2.2161.00
410_M461_Y2.2091.00
307_S376_K2.1961.00
53_V100_I2.1931.00
301_V461_Y2.1841.00
557_K561_L2.1801.00
496_D750_N2.1691.00
298_M459_V2.1471.00
621_K660_E2.1281.00
733_T769_L2.1261.00
648_R764_E2.1221.00
315_Q318_E2.1161.00
482_L487_V2.0841.00
33_R55_Q2.0831.00
735_L760_V2.0671.00
261_A305_A2.0551.00
685_C707_I2.0211.00
499_L529_I2.0041.00
53_V68_L1.9871.00
534_Y582_Q1.9831.00
475_M487_V1.9591.00
510_Q549_S1.9581.00
593_N772_Q1.9531.00
495_E533_R1.9421.00
73_T94_G1.9291.00
181_Q185_E1.9271.00
354_L369_I1.9171.00
531_I579_L1.9171.00
741_K759_P1.9171.00
318_E322_T1.9151.00
230_L237_I1.9121.00
760_V766_V1.9041.00
126_E190_N1.9001.00
695_N771_L1.8861.00
13_V112_A1.8861.00
686_T770_A1.8821.00
314_R561_L1.8661.00
258_I272_E1.8581.00
635_Q639_Q1.8551.00
378_V413_V1.8501.00
386_R455_H1.8411.00
263_M299_V1.8411.00
507_L528_I1.8231.00
749_D753_A1.8191.00
622_G663_D1.8191.00
416_K465_D1.8121.00
315_Q319_I1.8121.00
310_K315_Q1.8091.00
615_T691_C1.8001.00
707_I763_I1.7991.00
530_G582_Q1.7851.00
716_I736_I1.7841.00
378_V420_F1.7841.00
335_L557_K1.7771.00
574_N578_Y1.7741.00
259_D268_K1.7681.00
188_D191_E1.7661.00
255_K272_E1.7571.00
179_D182_S1.7561.00
701_V733_T1.7481.00
530_G572_G1.7451.00
530_G575_L1.7381.00
376_K415_V1.7351.00
610_L729_G1.7291.00
105_D108_E1.7261.00
263_M271_A1.7241.00
689_V767_L1.7211.00
391_I443_V1.7181.00
558_Q578_Y1.7121.00
510_Q545_E1.6880.99
166_A193_L1.6860.99
76_S95_L1.6800.99
13_V51_M1.6800.99
668_V684_M1.6770.99
382_L422_L1.6700.99
179_D202_S1.6680.99
479_A482_L1.6680.99
736_I744_L1.6630.99
761_K765_E1.6580.99
555_A568_I1.6530.99
735_L766_V1.6480.99
500_N503_K1.6470.99
32_G36_S1.6370.99
234_M237_I1.6280.99
723_L734_V1.6250.99
686_T766_V1.6200.99
499_L525_D1.6110.99
682_I760_V1.6060.99
527_A575_L1.6050.99
140_G208_Q1.6050.99
509_K545_E1.5920.99
517_K520_E1.5920.99
595_V694_G1.5900.99
617_C691_C1.5850.99
262_K304_N1.5840.99
716_I723_L1.5780.99
33_R36_S1.5640.99
719_L759_P1.5590.99
269_E414_G1.5580.99
376_K414_G1.5510.99
258_I263_M1.5440.99
685_C763_I1.5440.99
695_N773_N1.5340.99
17_R33_R1.5320.99
453_S460_D1.5270.99
369_I469_V1.5260.99
618_V643_T1.5250.99
522_T567_H1.5150.99
33_R63_P1.5120.99
521_L551_L1.5090.99
167_D187_S1.5080.99
329_R550_K1.5070.99
60_T67_D1.5050.99
503_K528_I1.4980.99
723_L736_I1.4950.99
555_A559_L1.4940.99
277_K293_G1.4920.99
719_L723_L1.4840.99
644_V763_I1.4750.99
752_I757_I1.4710.98
263_M298_M1.4690.98
613_I683_A1.4690.98
524_D569_E1.4670.98
97_R192_R1.4660.98
386_R389_A1.4630.98
330_V354_L1.4620.98
396_R458_E1.4530.98
163_A166_A1.4440.98
70_T99_R1.4390.98
558_Q563_K1.4370.98
510_Q548_I1.4300.98
163_A167_D1.4300.98
297_W408_Q1.4260.98
71_V187_S1.4210.98
522_T569_E1.4040.98
686_T697_V1.4020.98
265_K268_K1.3900.98
626_Y635_Q1.3860.98
271_A295_I1.3840.98
35_K62_E1.3810.98
74_V96_Q1.3800.98
625_T639_Q1.3800.98
183_V196_L1.3790.98
218_K222_E1.3770.98
134_A193_L1.3770.98
17_R55_Q1.3760.98
50_I75_A1.3740.98
216_R239_K1.3740.98
547_E583_R1.3730.98
698_R733_T1.3730.98
332_D554_K1.3710.98
10_E113_K1.3670.98
523_V548_I1.3600.97
97_R167_D1.3530.97
120_P188_D1.3520.97
304_N416_K1.3500.97
96_Q116_Y1.3490.97
586_Y609_D1.3480.97
531_I548_I1.3460.97
119_S163_A1.3400.97
100_I112_A1.3360.97
254_L296_D1.3310.97
642_L664_I1.3300.97
68_L100_I1.3220.97
319_I371_K1.3190.97
736_I757_I1.3160.97
645_V689_V1.3090.97
682_I713_V1.3080.97
527_A572_G1.3060.97
651_K764_E1.3050.97
132_R203_E1.3050.97
601_L734_V1.3040.97
377_Y421_L1.3020.97
629_S632_E1.3010.97
51_M114_A1.2970.97
576_H745_E1.2950.97
525_D529_I1.2950.97
17_R32_G1.2910.97
620_G663_D1.2850.96
523_V575_L1.2790.96
271_A275_L1.2780.96
223_K227_E1.2740.96
521_L555_A1.2710.96
767_L771_L1.2710.96
617_C662_R1.2680.96
554_K578_Y1.2640.96
581_V745_E1.2630.96
65_V103_L1.2590.96
425_I440_L1.2590.96
664_I692_L1.2580.96
186_M195_Y1.2580.96
723_L755_L1.2560.96
57_E60_T1.2520.96
380_M409_K1.2490.96
585_D739_E1.2460.96
261_A264_P1.2450.96
499_L532_I1.2440.96
664_I688_L1.2440.96
366_G421_L1.2410.96
260_A265_K1.2360.96
593_N699_A1.2350.96
475_M482_L1.2340.95
317_Q557_K1.2340.95
134_A200_M1.2330.95
258_I299_V1.2310.95
262_K265_K1.2310.95
144_L207_L1.2270.95
659_Y692_L1.2190.95
638_I666_V1.2160.95
347_I350_P1.2120.95
526_S572_G1.2100.95
574_N577_D1.2100.95
261_A271_A1.2090.95
286_A399_I1.2060.95
547_E550_K1.2040.95
100_I103_L1.2040.95
14_L50_I1.2010.95
494_T720_K1.2000.95
162_P166_A1.2000.95
658_F692_L1.2000.95
766_V770_A1.1990.95
162_P193_L1.1930.95
330_V490_L1.1880.94
343_R559_L1.1880.94
21_V75_A1.1870.94
598_V683_A1.1850.94
365_L490_L1.1810.94
36_S55_Q1.1790.94
760_V769_L1.1790.94
10_E111_S1.1720.94
317_Q335_L1.1610.94
70_T185_E1.1540.94
649_A654_I1.1510.93
410_M466_V1.1500.93
301_V407_I1.1500.93
630_L668_V1.1500.93
379_R485_M1.1490.93
52_L75_A1.1470.93
212_R216_R1.1410.93
176_K179_D1.1380.93
262_K308_K1.1380.93
355_V474_S1.1260.93
137_Q197_M1.1250.93
377_Y419_L1.1250.93
293_G456_Y1.1250.93
55_Q63_P1.1220.93
260_A308_K1.1200.93
297_W411_A1.1190.92
741_K745_E1.1070.92
281_M289_T1.1070.92
762_R765_E1.1060.92
348_K513_R1.1060.92
689_V771_L1.1050.92
309_V373_T1.1030.92
343_R560_L1.1030.92
32_G55_Q1.1010.92
17_R36_S1.1000.92
373_T467_M1.0950.92
51_M100_I1.0950.92
543_G546_R1.0930.92
377_Y381_A1.0920.92
570_I575_L1.0860.91
510_Q552_C1.0810.91
511_I521_L1.0760.91
71_V117_L1.0750.91
134_A197_M1.0720.91
305_A308_K1.0700.91
257_K300_Q1.0690.91
378_V409_K1.0670.91
410_M416_K1.0660.91
39_C43_A1.0660.91
545_E549_S1.0600.90
524_D571_N1.0580.90
744_L757_I1.0550.90
355_V475_M1.0540.90
301_V457_L1.0540.90
523_V527_A1.0530.90
342_S560_L1.0500.90
744_L747_I1.0490.90
555_A578_Y1.0480.90
281_M291_V1.0470.90
53_V112_A1.0460.90
355_V482_L1.0440.90
648_R652_L1.0410.89
54_A177_L1.0400.89
205_D208_Q1.0380.89
474_S482_L1.0370.89
265_K308_K1.0360.89
325_Y500_N1.0310.89
52_L92_V1.0310.89
30_F89_K1.0300.89
670_E708_T1.0260.89
314_R563_K1.0250.89
618_V646_R1.0240.89
175_L199_M1.0230.89
252_E255_K1.0230.89
682_I685_C1.0210.89
313_L339_A1.0200.88
511_I518_K1.0200.88
13_V53_V1.0180.88
336_E557_K1.0170.88
385_V455_H1.0160.88
323_D368_S1.0140.88
598_V697_V1.0140.88
42_A46_H1.0140.88
447_E509_K1.0110.88
597_Q612_T1.0090.88
343_R520_E1.0080.88
42_A109_H1.0050.88
272_E275_L1.0050.88
723_L752_I1.0050.88
425_I428_M1.0020.88
316_A338_L0.9990.87
652_L689_V0.9980.87
13_V110_F0.9950.87
275_L299_V0.9930.87
602_A611_L0.9900.87
708_T714_L0.9890.87
407_I410_M0.9880.87
654_I693_T0.9880.87
577_D749_D0.9870.87
316_A319_I0.9860.87
13_V98_A0.9860.87
524_D573_D0.9850.87
332_D557_K0.9820.87
701_V769_L0.9760.86
225_Q228_Y0.9750.86
543_G547_E0.9740.86
195_Y198_A0.9700.86
732_K754_D0.9640.86
624_L642_L0.9620.85
297_W457_L0.9610.85
227_E241_L0.9600.85
646_R658_F0.9590.85
343_R515_A0.9590.85
609_D613_I0.9580.85
257_K299_V0.9570.85
685_C689_V0.9560.85
309_V417_N0.9560.85
763_I767_L0.9550.85
654_I689_V0.9550.85
252_E256_R0.9530.85
649_A653_G0.9510.85
217_V236_A0.9510.85
508_P512_E0.9500.85
18_D30_F0.9490.85
437_A478_P0.9470.84
281_M288_A0.9460.84
695_N772_Q0.9450.84
98_A114_A0.9440.84
41_E82_K0.9420.84
367_Q447_E0.9420.84
255_K259_D0.9420.84
263_M267_A0.9420.84
60_T63_P0.9420.84
258_I261_A0.9410.84
453_S458_E0.9390.84
216_R236_A0.9370.84
385_V428_M0.9370.84
251_N275_L0.9340.84
310_K374_G0.9330.84
603_W725_A0.9320.84
261_A268_K0.9310.83
28_P78_L0.9300.83
623_K663_D0.9280.83
723_L759_P0.9280.83
646_R659_Y0.9250.83
616_A643_T0.9190.83
644_V648_R0.9160.82
734_V755_L0.9150.82
736_I741_K0.9130.82
63_P67_D0.9120.82
716_I759_P0.9110.82
101_S113_K0.9100.82
734_V757_I0.9080.82
221_M228_Y0.9070.82
40_L88_V0.9030.82
170_A183_V0.8990.81
17_R63_P0.8980.81
65_V70_T0.8970.81
314_R318_E0.8960.81
16_L52_L0.8950.81
124_E190_N0.8940.81
601_L702_A0.8940.81
381_A411_A0.8940.81
365_L408_Q0.8930.81
689_V763_I0.8920.81
629_S670_E0.8900.81
159_I168_T0.8880.80
220_Q239_K0.8880.80
511_I516_L0.8860.80
253_A273_A0.8820.80
132_R206_L0.8810.80
163_A192_R0.8800.80
619_P662_R0.8780.80
142_I148_I0.8770.80
273_A411_A0.8680.79
298_M457_L0.8680.79
81_L84_P0.8680.79
698_R770_A0.8660.79
277_K297_W0.8650.79
602_A725_A0.8640.79
328_E332_D0.8620.78
317_Q332_D0.8600.78
598_V687_A0.8590.78
619_P656_P0.8590.78
638_I683_A0.8540.78
502_A528_I0.8530.78
133_T197_M0.8530.78
117_L187_S0.8480.77
261_A304_N0.8470.77
682_I763_I0.8460.77
727_H751_V0.8460.77
373_T419_L0.8460.77
53_V98_A0.8450.77
312_D315_Q0.8450.77
165_L169_I0.8450.77
499_L503_K0.8440.77
523_V555_A0.8430.77
410_M457_L0.8420.77
429_S433_R0.8400.77
295_I299_V0.8390.77
526_S573_D0.8390.77
738_F765_E0.8370.76
21_V52_L0.8360.76
311_K342_S0.8360.76
645_V707_I0.8340.76
131_V135_I0.8340.76
428_M478_P0.8340.76
267_A459_V0.8330.76
511_I552_C0.8320.76
230_L241_L0.8320.76
129_V206_L0.8310.76
713_V766_V0.8300.76
304_N461_Y0.8290.76
261_A275_L0.8280.76
74_V114_A0.8270.76
346_K465_D0.8260.75
510_Q513_R0.8250.75
319_I322_T0.8240.75
520_E559_L0.8220.75
49_K76_S0.8200.75
371_K374_G0.8180.75
259_D272_E0.8180.75
286_A290_V0.8170.75
245_D248_P0.8140.74
723_L727_H0.8130.74
527_A570_I0.8130.74
599_T612_T0.8120.74
763_I766_V0.8100.74
258_I295_I0.8060.74
697_V770_A0.8030.73
598_V645_V0.8020.73
592_E595_V0.8020.73
129_V132_R0.8010.73
741_K744_L0.7950.73
701_V770_A0.7940.72
354_L469_V0.7940.72
599_T610_L0.7930.72
232_E235_K0.7920.72
662_R692_L0.7920.72
325_Y504_R0.7920.72
36_S63_P0.7910.72
529_I533_R0.7910.72
487_V543_G0.7900.72
64_G67_D0.7900.72
740_N743_D0.7900.72
558_Q562_D0.7890.72
33_R67_D0.7890.72
371_K505_H0.7880.72
299_V459_V0.7880.72
683_A725_A0.7870.72
556_V560_L0.7850.72
54_A181_Q0.7850.72
410_M413_V0.7840.72
18_D89_K0.7830.71
270_K458_E0.7830.71
763_I771_L0.7830.71
723_L744_L0.7830.71
623_K639_Q0.7810.71
108_E111_S0.7790.71
96_Q118_E0.7780.71
166_A196_L0.7780.71
73_T684_M0.7740.71
78_L93_E0.7740.71
744_L752_I0.7720.70
759_P765_E0.7720.70
20_V226_R0.7710.70
321_D335_L0.7710.70
309_V376_K0.7680.70
716_I740_N0.7670.70
28_P89_K0.7670.70
237_I241_L0.7670.70
698_R772_Q0.7660.70
234_M238_Q0.7660.70
666_V684_M0.7650.70
195_Y199_M0.7640.70
533_R586_Y0.7630.69
715_P739_E0.7600.69
577_D753_A0.7580.69
297_W407_I0.7570.69
163_A188_D0.7570.69
182_S186_M0.7570.69
309_V341_Q0.7560.69
380_M420_F0.7560.69
382_L392_R0.7560.69
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419_L530_G0.5010.40
39_C55_Q0.5010.40
257_K260_A0.5000.40
155_S196_L0.5000.40
46_H109_H0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m6aA 3 0.6314 100 0.575 Contact Map
3k1jA 4 0.5676 100 0.745 Contact Map
4fwgA 3 0.6441 100 0.797 Contact Map
3wu4A 3 0.2474 100 0.838 Contact Map
3ljcA 1 0.3048 100 0.839 Contact Map
2x36A 3 0.2423 100 0.841 Contact Map
1xhkA 2 0.227 100 0.856 Contact Map
1z0wA 3 0.2462 100 0.857 Contact Map
4gitA 2 0.1173 100 0.861 Contact Map
1qvrA 3 0.6339 100 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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