GREMLIN Database
P5CR - Pyrroline-5-carboxylate reductase
UniProt: P0A9L8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10769
Length: 269 (261)
Sequences: 5216 (3883)
Seq/√Len: 240.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_K143_D3.1481.00
76_M97_A2.7471.00
128_A213_K2.7251.00
220_E228_M2.6791.00
118_A131_T2.5481.00
179_V208_V2.4791.00
213_K217_E2.4381.00
182_F252_V2.4341.00
183_I215_V2.3871.00
242_V246_K2.2861.00
6_G60_V2.2261.00
35_Y57_A2.1991.00
156_E202_K2.1301.00
196_P199_Q2.0441.00
180_F211_S2.0421.00
148_L159_V2.0331.00
106_A136_N1.9821.00
187_A201_Y1.9781.00
130_M156_E1.9771.00
88_N91_S1.9641.00
246_K251_A1.9341.00
209_M213_K1.9171.00
148_L152_R1.9111.00
144_T159_V1.9111.00
10_C34_V1.8651.00
158_E202_K1.8451.00
213_K216_L1.8411.00
175_S207_A1.8291.00
123_P129_G1.7921.00
39_P43_A1.7911.00
186_M256_M1.7551.00
178_Y239_A1.7441.00
224_A228_M1.7431.00
244_E249_R1.7401.00
220_E224_A1.7401.00
135_P144_T1.7111.00
152_R157_A1.7111.00
191_V197_R1.7091.00
246_K254_E1.6841.00
182_F248_F1.6781.00
132_S168_V1.6611.00
140_T143_D1.6551.00
17_I154_F1.6551.00
36_T41_K1.6281.00
262_K265_K1.6091.00
6_G64_A1.5941.00
94_V147_V1.5941.00
237_I241_R1.5901.00
4_K31_Q1.5701.00
166_H263_S1.5351.00
205_A216_L1.5211.00
161_A164_M1.5091.00
128_A209_M1.5081.00
33_W52_N1.5021.00
224_A227_D1.4891.00
133_V159_V1.4891.00
33_W54_A1.4781.00
93_V109_L1.4761.00
66_I92_L1.4741.00
13_M96_I1.4721.00
230_C237_I1.4621.00
56_S59_E1.4591.00
245_E254_E1.4521.00
77_I104_Q1.4401.00
77_I108_A1.4401.00
141_P145_A1.4371.00
248_F251_A1.4291.00
34_V51_I1.4121.00
37_P75_I1.4081.00
80_L109_L1.4031.00
15_K41_K1.3961.00
193_G257_T1.3881.00
183_I208_V1.3771.00
95_S105_L1.3751.00
41_K44_A1.3751.00
206_Q209_M1.3731.00
43_A47_D1.3611.00
188_D197_R1.3441.00
130_M206_Q1.3361.00
192_L257_T1.3311.00
242_V245_E1.3281.00
160_I165_I1.3251.00
101_T104_Q1.3131.00
179_V182_F1.3031.00
7_F14_G1.2891.00
184_E226_K1.2741.00
174_S235_T1.2681.00
260_M264_E1.2651.00
116_I147_V1.2641.00
221_H224_A1.2581.00
257_T261_E1.2531.00
188_D249_R1.2461.00
250_A254_E1.2421.00
44_A48_Q1.2371.00
248_F252_V1.2371.00
70_A96_I1.2191.00
192_L253_I1.2111.00
76_M100_V1.2041.00
7_F18_L1.2011.00
184_E223_G1.1891.00
148_L157_A1.1831.00
170_G256_M1.1781.00
239_A255_A1.1741.00
104_Q108_A1.1731.00
190_A195_M1.1721.00
28_L31_Q1.1711.00
43_A46_H1.1651.00
19_G48_Q1.1621.00
133_V157_A1.1581.00
97_A100_V1.1531.00
124_A129_G1.1481.00
128_A206_Q1.1321.00
60_V64_A1.1311.00
145_A149_N1.1291.00
243_L255_A1.1241.00
106_A137_A1.1201.00
66_I146_D1.1191.00
17_I21_L1.1131.00
238_E241_R1.1081.00
33_W63_I1.1001.00
7_F68_F1.0991.00
38_S41_K1.0951.00
230_C240_V1.0941.00
14_G18_L1.0871.00
160_I168_V1.0871.00
133_V151_F1.0691.00
133_V148_L1.0671.00
102_L134_T1.0631.00
106_A138_L1.0521.00
241_R245_E1.0511.00
193_G260_M1.0511.00
130_M158_E1.0491.00
103_D107_R1.0481.00
139_V143_D1.0451.00
226_K230_C1.0391.00
42_V53_A1.0391.00
102_L115_I1.0371.00
71_V97_A1.0351.00
209_M216_L1.0331.00
166_H264_E1.0331.00
69_A76_M1.0321.00
102_L105_L1.0301.00
183_I204_A1.0291.00
243_L252_V1.0231.00
4_K33_W1.0201.00
171_V256_M1.0181.00
19_G49_F1.0181.00
92_L143_D1.0111.00
23_A127_N1.0001.00
66_I94_V0.9971.00
118_A151_F0.9951.00
180_F214_M0.9861.00
12_N228_M0.9851.00
158_E199_Q0.9841.00
17_I96_I0.9831.00
58_Q82_E0.9721.00
172_S203_F0.9721.00
21_L150_I0.9671.00
156_E206_Q0.9651.00
18_L34_V0.9641.00
36_T42_V0.9631.00
181_M240_V0.9511.00
87_L93_V0.9501.00
135_P159_V0.9501.00
15_K49_F0.9491.00
67_I91_S0.9491.00
77_I81_S0.9401.00
75_I79_V0.9391.00
42_V55_E0.9371.00
247_G250_A0.9331.00
168_V203_F0.9311.00
134_T165_I0.9281.00
68_F94_V0.9281.00
242_V258_K0.9271.00
215_V222_P0.9261.00
59_E63_I0.9211.00
238_E262_K0.9161.00
75_I78_K0.9141.00
242_V254_E0.9121.00
168_V172_S0.9041.00
100_V104_Q0.9031.00
20_G154_F0.9031.00
198_A202_K0.9021.00
188_D191_V0.9021.00
10_C45_L0.8981.00
61_A67_I0.8870.99
105_L115_I0.8830.99
58_Q62_Q0.8800.99
205_A212_A0.8800.99
104_Q107_R0.8780.99
181_M244_E0.8760.99
247_G251_A0.8750.99
4_K65_D0.8730.99
199_Q202_K0.8720.99
62_Q86_S0.8690.99
261_E265_K0.8600.99
235_T263_S0.8590.99
258_K261_E0.8560.99
167_P195_M0.8550.99
221_H227_D0.8470.99
124_A154_F0.8440.99
5_I21_L0.8430.99
76_M80_L0.8420.99
187_A191_V0.8410.99
227_D237_I0.8400.99
15_K48_Q0.8340.99
44_A47_D0.8330.99
171_V190_A0.8310.99
19_G125_L0.8280.99
6_G35_Y0.8270.99
142_E145_A0.8170.99
22_I29_P0.8160.99
35_Y54_A0.8140.99
81_S108_A0.8140.99
41_K45_L0.8130.99
65_D91_S0.8090.99
40_D43_A0.8030.99
193_G256_M0.8010.99
201_Y205_A0.7990.99
8_I79_V0.7930.99
135_P139_V0.7900.99
92_L147_V0.7890.99
130_M203_F0.7890.99
15_K44_A0.7890.99
116_I135_P0.7820.99
223_G227_D0.7800.99
170_G260_M0.7760.99
12_N231_S0.7760.99
209_M212_A0.7700.99
134_T161_A0.7690.99
21_L26_Q0.7590.98
18_L32_I0.7560.98
33_W64_A0.7540.98
185_A249_R0.7540.98
76_M95_S0.7520.98
181_M249_R0.7520.98
238_E242_V0.7470.98
42_V46_H0.7470.98
4_K63_I0.7420.98
39_P42_V0.7370.98
109_L113_R0.7370.98
195_M203_F0.7370.98
117_R162_E0.7360.98
246_K250_A0.7350.98
240_V244_E0.7330.98
46_H53_A0.7330.98
52_N63_I0.7320.98
145_A148_L0.7310.98
192_L241_R0.7300.98
261_E264_E0.7290.98
77_I100_V0.7290.98
96_I118_A0.7270.98
136_N139_V0.7250.98
239_A242_V0.7250.98
190_A204_A0.7200.98
126_V213_K0.7180.98
165_I263_S0.7170.98
81_S84_T0.7160.98
184_E188_D0.7130.98
110_G113_R0.7120.98
169_V263_S0.7050.97
57_A82_E0.7050.97
169_V175_S0.7030.97
78_K81_S0.7020.97
119_M173_G0.7010.97
14_G70_A0.6990.97
80_L97_A0.6990.97
149_N152_R0.6970.97
98_A235_T0.6960.97
239_A259_C0.6940.97
205_A215_V0.6940.97
188_D192_L0.6930.97
106_A115_I0.6910.97
59_E62_Q0.6890.97
68_F151_F0.6870.97
130_M202_K0.6800.97
15_K19_G0.6780.97
18_L45_L0.6780.97
256_M259_C0.6770.97
128_A156_E0.6770.97
58_Q86_S0.6770.97
172_S207_A0.6750.97
67_I93_V0.6750.97
187_A204_A0.6740.97
174_S259_C0.6740.97
102_L136_N0.6710.97
61_A83_I0.6700.97
135_P141_P0.6640.96
164_M167_P0.6630.96
132_S165_I0.6630.96
146_D149_N0.6570.96
78_K82_E0.6570.96
45_L49_F0.6510.96
223_G226_K0.6510.96
190_A200_A0.6500.96
139_V144_T0.6500.96
241_R244_E0.6490.96
189_A256_M0.6480.96
57_A61_A0.6470.96
102_L106_A0.6470.96
114_K136_N0.6460.96
197_R201_Y0.6460.96
241_R254_E0.6390.96
132_S158_E0.6300.95
6_G67_I0.6290.95
98_A266_L0.6290.95
57_A60_V0.6270.95
167_P193_G0.6270.95
33_W60_V0.6240.95
16_A20_G0.6220.95
39_P55_E0.6190.95
187_A222_P0.6110.94
257_T260_M0.6100.94
143_D146_D0.6090.94
35_Y60_V0.6090.94
35_Y56_S0.6010.94
92_L116_I0.5980.94
55_E59_E0.5980.94
114_K139_V0.5970.94
250_A253_I0.5950.93
116_I139_V0.5940.93
123_P176_P0.5930.93
87_L91_S0.5930.93
177_A236_T0.5920.93
171_V186_M0.5910.93
208_V248_F0.5910.93
180_F225_L0.5830.93
6_G33_W0.5830.93
169_V174_S0.5810.93
175_S259_C0.5810.93
132_S172_S0.5810.93
237_I240_V0.5800.93
231_S235_T0.5780.92
165_I168_V0.5780.92
131_T155_G0.5780.92
131_T154_F0.5770.92
252_V256_M0.5760.92
37_P42_V0.5760.92
72_K231_S0.5740.92
167_P190_A0.5740.92
183_I222_P0.5740.92
164_M199_Q0.5710.92
54_A60_V0.5700.92
180_F215_V0.5680.92
18_L51_I0.5670.92
126_V214_M0.5660.92
175_S256_M0.5650.92
243_L248_F0.5650.92
177_A239_A0.5650.92
22_I25_G0.5640.92
79_V82_E0.5630.91
8_I35_Y0.5620.91
61_A91_S0.5620.91
34_V45_L0.5590.91
36_T96_I0.5570.91
12_N72_K0.5550.91
66_I150_I0.5550.91
156_E216_L0.5540.91
151_F154_F0.5470.90
84_T110_G0.5460.90
115_I136_N0.5450.90
116_I144_T0.5450.90
178_Y259_C0.5430.90
92_L114_K0.5410.90
127_N154_F0.5400.90
141_P144_T0.5370.89
83_I87_L0.5360.89
173_G235_T0.5360.89
86_S91_S0.5330.89
119_M165_I0.5320.89
134_T162_E0.5320.89
189_A253_I0.5300.89
17_I151_F0.5280.89
24_S127_N0.5260.89
164_M196_P0.5230.88
36_T39_P0.5220.88
151_F157_A0.5190.88
10_C18_L0.5180.88
93_V113_R0.5170.88
69_A83_I0.5160.88
26_Q149_N0.5150.87
69_A97_A0.5150.87
178_Y207_A0.5140.87
69_A105_L0.5100.87
61_A64_A0.5100.87
109_L115_I0.5090.87
121_N173_G0.5070.87
185_A188_D0.5040.86
241_R253_I0.5020.86
174_S263_S0.5020.86
64_A91_S0.5020.86
13_M120_P0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.9963 100 0.367 Contact Map
2rcyA 5 0.9665 100 0.377 Contact Map
2ahrA 5 0.9591 100 0.393 Contact Map
1yqgA 2 0.9665 100 0.397 Contact Map
3triA 2 0.9963 100 0.407 Contact Map
3gt0A 3 0.8067 100 0.437 Contact Map
4kqwA 2 0.9628 100 0.456 Contact Map
4wjiA 2 0.9517 100 0.502 Contact Map
3fr7A 2 0.9405 100 0.531 Contact Map
2i76A 2 0.8699 100 0.562 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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