P5CR - ECOLI - GREMLIN Contacts

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P5CR - Pyrroline-5-carboxylate reductase

UniProt:	P0A9L8	Sequences: MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQFGINAAESAQEVAQIADIIFAAVKPGIMIKVLSEITSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAVRVLEEKGFRAAVIEAMTKCMEKSEKLSKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10769
Length:	269 (261)
Sequences:	5216 (3883)
Seq/√Len:	240.4

ECOLI - P5CR
BACSU - P5CR1 P5CR2 COMER P5CR3
SULSO - Q97ZT3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_K	143_D	3.148	1.00
76_M	97_A	2.747	1.00
128_A	213_K	2.725	1.00
220_E	228_M	2.679	1.00
118_A	131_T	2.548	1.00
179_V	208_V	2.479	1.00
213_K	217_E	2.438	1.00
182_F	252_V	2.434	1.00
183_I	215_V	2.387	1.00
242_V	246_K	2.286	1.00
6_G	60_V	2.226	1.00
35_Y	57_A	2.199	1.00
156_E	202_K	2.130	1.00
196_P	199_Q	2.044	1.00
180_F	211_S	2.042	1.00
148_L	159_V	2.033	1.00
106_A	136_N	1.982	1.00
187_A	201_Y	1.978	1.00
130_M	156_E	1.977	1.00
88_N	91_S	1.964	1.00
246_K	251_A	1.934	1.00
209_M	213_K	1.917	1.00
148_L	152_R	1.911	1.00
144_T	159_V	1.911	1.00
10_C	34_V	1.865	1.00
158_E	202_K	1.845	1.00
213_K	216_L	1.841	1.00
175_S	207_A	1.829	1.00
123_P	129_G	1.792	1.00
39_P	43_A	1.791	1.00
186_M	256_M	1.755	1.00
178_Y	239_A	1.744	1.00
224_A	228_M	1.743	1.00
244_E	249_R	1.740	1.00
220_E	224_A	1.740	1.00
135_P	144_T	1.711	1.00
152_R	157_A	1.711	1.00
191_V	197_R	1.709	1.00
246_K	254_E	1.684	1.00
182_F	248_F	1.678	1.00
132_S	168_V	1.661	1.00
140_T	143_D	1.655	1.00
17_I	154_F	1.655	1.00
36_T	41_K	1.628	1.00
262_K	265_K	1.609	1.00
6_G	64_A	1.594	1.00
94_V	147_V	1.594	1.00
237_I	241_R	1.590	1.00
4_K	31_Q	1.570	1.00
166_H	263_S	1.535	1.00
205_A	216_L	1.521	1.00
161_A	164_M	1.509	1.00
128_A	209_M	1.508	1.00
33_W	52_N	1.502	1.00
224_A	227_D	1.489	1.00
133_V	159_V	1.489	1.00
33_W	54_A	1.478	1.00
93_V	109_L	1.476	1.00
66_I	92_L	1.474	1.00
13_M	96_I	1.472	1.00
230_C	237_I	1.462	1.00
56_S	59_E	1.459	1.00
245_E	254_E	1.452	1.00
77_I	104_Q	1.440	1.00
77_I	108_A	1.440	1.00
141_P	145_A	1.437	1.00
248_F	251_A	1.429	1.00
34_V	51_I	1.412	1.00
37_P	75_I	1.408	1.00
80_L	109_L	1.403	1.00
15_K	41_K	1.396	1.00
193_G	257_T	1.388	1.00
183_I	208_V	1.377	1.00
95_S	105_L	1.375	1.00
41_K	44_A	1.375	1.00
206_Q	209_M	1.373	1.00
43_A	47_D	1.361	1.00
188_D	197_R	1.344	1.00
130_M	206_Q	1.336	1.00
192_L	257_T	1.331	1.00
242_V	245_E	1.328	1.00
160_I	165_I	1.325	1.00
101_T	104_Q	1.313	1.00
179_V	182_F	1.303	1.00
7_F	14_G	1.289	1.00
184_E	226_K	1.274	1.00
174_S	235_T	1.268	1.00
260_M	264_E	1.265	1.00
116_I	147_V	1.264	1.00
221_H	224_A	1.258	1.00
257_T	261_E	1.253	1.00
188_D	249_R	1.246	1.00
250_A	254_E	1.242	1.00
44_A	48_Q	1.237	1.00
248_F	252_V	1.237	1.00
70_A	96_I	1.219	1.00
192_L	253_I	1.211	1.00
76_M	100_V	1.204	1.00
7_F	18_L	1.201	1.00
184_E	223_G	1.189	1.00
148_L	157_A	1.183	1.00
170_G	256_M	1.178	1.00
239_A	255_A	1.174	1.00
104_Q	108_A	1.173	1.00
190_A	195_M	1.172	1.00
28_L	31_Q	1.171	1.00
43_A	46_H	1.165	1.00
19_G	48_Q	1.162	1.00
133_V	157_A	1.158	1.00
97_A	100_V	1.153	1.00
124_A	129_G	1.148	1.00
128_A	206_Q	1.132	1.00
60_V	64_A	1.131	1.00
145_A	149_N	1.129	1.00
243_L	255_A	1.124	1.00
106_A	137_A	1.120	1.00
66_I	146_D	1.119	1.00
17_I	21_L	1.113	1.00
238_E	241_R	1.108	1.00
33_W	63_I	1.100	1.00
7_F	68_F	1.099	1.00
38_S	41_K	1.095	1.00
230_C	240_V	1.094	1.00
14_G	18_L	1.087	1.00
160_I	168_V	1.087	1.00
133_V	151_F	1.069	1.00
133_V	148_L	1.067	1.00
102_L	134_T	1.063	1.00
106_A	138_L	1.052	1.00
241_R	245_E	1.051	1.00
193_G	260_M	1.051	1.00
130_M	158_E	1.049	1.00
103_D	107_R	1.048	1.00
139_V	143_D	1.045	1.00
226_K	230_C	1.039	1.00
42_V	53_A	1.039	1.00
102_L	115_I	1.037	1.00
71_V	97_A	1.035	1.00
209_M	216_L	1.033	1.00
166_H	264_E	1.033	1.00
69_A	76_M	1.032	1.00
102_L	105_L	1.030	1.00
183_I	204_A	1.029	1.00
243_L	252_V	1.023	1.00
4_K	33_W	1.020	1.00
171_V	256_M	1.018	1.00
19_G	49_F	1.018	1.00
92_L	143_D	1.011	1.00
23_A	127_N	1.000	1.00
66_I	94_V	0.997	1.00
118_A	151_F	0.995	1.00
180_F	214_M	0.986	1.00
12_N	228_M	0.985	1.00
158_E	199_Q	0.984	1.00
17_I	96_I	0.983	1.00
58_Q	82_E	0.972	1.00
172_S	203_F	0.972	1.00
21_L	150_I	0.967	1.00
156_E	206_Q	0.965	1.00
18_L	34_V	0.964	1.00
36_T	42_V	0.963	1.00
181_M	240_V	0.951	1.00
87_L	93_V	0.950	1.00
135_P	159_V	0.950	1.00
15_K	49_F	0.949	1.00
67_I	91_S	0.949	1.00
77_I	81_S	0.940	1.00
75_I	79_V	0.939	1.00
42_V	55_E	0.937	1.00
247_G	250_A	0.933	1.00
168_V	203_F	0.931	1.00
134_T	165_I	0.928	1.00
68_F	94_V	0.928	1.00
242_V	258_K	0.927	1.00
215_V	222_P	0.926	1.00
59_E	63_I	0.921	1.00
238_E	262_K	0.916	1.00
75_I	78_K	0.914	1.00
242_V	254_E	0.912	1.00
168_V	172_S	0.904	1.00
100_V	104_Q	0.903	1.00
20_G	154_F	0.903	1.00
198_A	202_K	0.902	1.00
188_D	191_V	0.902	1.00
10_C	45_L	0.898	1.00
61_A	67_I	0.887	0.99
105_L	115_I	0.883	0.99
58_Q	62_Q	0.880	0.99
205_A	212_A	0.880	0.99
104_Q	107_R	0.878	0.99
181_M	244_E	0.876	0.99
247_G	251_A	0.875	0.99
4_K	65_D	0.873	0.99
199_Q	202_K	0.872	0.99
62_Q	86_S	0.869	0.99
261_E	265_K	0.860	0.99
235_T	263_S	0.859	0.99
258_K	261_E	0.856	0.99
167_P	195_M	0.855	0.99
221_H	227_D	0.847	0.99
124_A	154_F	0.844	0.99
5_I	21_L	0.843	0.99
76_M	80_L	0.842	0.99
187_A	191_V	0.841	0.99
227_D	237_I	0.840	0.99
15_K	48_Q	0.834	0.99
44_A	47_D	0.833	0.99
171_V	190_A	0.831	0.99
19_G	125_L	0.828	0.99
6_G	35_Y	0.827	0.99
142_E	145_A	0.817	0.99
22_I	29_P	0.816	0.99
35_Y	54_A	0.814	0.99
81_S	108_A	0.814	0.99
41_K	45_L	0.813	0.99
65_D	91_S	0.809	0.99
40_D	43_A	0.803	0.99
193_G	256_M	0.801	0.99
201_Y	205_A	0.799	0.99
8_I	79_V	0.793	0.99
135_P	139_V	0.790	0.99
92_L	147_V	0.789	0.99
130_M	203_F	0.789	0.99
15_K	44_A	0.789	0.99
116_I	135_P	0.782	0.99
223_G	227_D	0.780	0.99
170_G	260_M	0.776	0.99
12_N	231_S	0.776	0.99
209_M	212_A	0.770	0.99
134_T	161_A	0.769	0.99
21_L	26_Q	0.759	0.98
18_L	32_I	0.756	0.98
33_W	64_A	0.754	0.98
185_A	249_R	0.754	0.98
76_M	95_S	0.752	0.98
181_M	249_R	0.752	0.98
238_E	242_V	0.747	0.98
42_V	46_H	0.747	0.98
4_K	63_I	0.742	0.98
39_P	42_V	0.737	0.98
109_L	113_R	0.737	0.98
195_M	203_F	0.737	0.98
117_R	162_E	0.736	0.98
246_K	250_A	0.735	0.98
240_V	244_E	0.733	0.98
46_H	53_A	0.733	0.98
52_N	63_I	0.732	0.98
145_A	148_L	0.731	0.98
192_L	241_R	0.730	0.98
261_E	264_E	0.729	0.98
77_I	100_V	0.729	0.98
96_I	118_A	0.727	0.98
136_N	139_V	0.725	0.98
239_A	242_V	0.725	0.98
190_A	204_A	0.720	0.98
126_V	213_K	0.718	0.98
165_I	263_S	0.717	0.98
81_S	84_T	0.716	0.98
184_E	188_D	0.713	0.98
110_G	113_R	0.712	0.98
169_V	263_S	0.705	0.97
57_A	82_E	0.705	0.97
169_V	175_S	0.703	0.97
78_K	81_S	0.702	0.97
119_M	173_G	0.701	0.97
14_G	70_A	0.699	0.97
80_L	97_A	0.699	0.97
149_N	152_R	0.697	0.97
98_A	235_T	0.696	0.97
239_A	259_C	0.694	0.97
205_A	215_V	0.694	0.97
188_D	192_L	0.693	0.97
106_A	115_I	0.691	0.97
59_E	62_Q	0.689	0.97
68_F	151_F	0.687	0.97
130_M	202_K	0.680	0.97
15_K	19_G	0.678	0.97
18_L	45_L	0.678	0.97
256_M	259_C	0.677	0.97
128_A	156_E	0.677	0.97
58_Q	86_S	0.677	0.97
172_S	207_A	0.675	0.97
67_I	93_V	0.675	0.97
187_A	204_A	0.674	0.97
174_S	259_C	0.674	0.97
102_L	136_N	0.671	0.97
61_A	83_I	0.670	0.97
135_P	141_P	0.664	0.96
164_M	167_P	0.663	0.96
132_S	165_I	0.663	0.96
146_D	149_N	0.657	0.96
78_K	82_E	0.657	0.96
45_L	49_F	0.651	0.96
223_G	226_K	0.651	0.96
190_A	200_A	0.650	0.96
139_V	144_T	0.650	0.96
241_R	244_E	0.649	0.96
189_A	256_M	0.648	0.96
57_A	61_A	0.647	0.96
102_L	106_A	0.647	0.96
114_K	136_N	0.646	0.96
197_R	201_Y	0.646	0.96
241_R	254_E	0.639	0.96
132_S	158_E	0.630	0.95
6_G	67_I	0.629	0.95
98_A	266_L	0.629	0.95
57_A	60_V	0.627	0.95
167_P	193_G	0.627	0.95
33_W	60_V	0.624	0.95
16_A	20_G	0.622	0.95
39_P	55_E	0.619	0.95
187_A	222_P	0.611	0.94
257_T	260_M	0.610	0.94
143_D	146_D	0.609	0.94
35_Y	60_V	0.609	0.94
35_Y	56_S	0.601	0.94
92_L	116_I	0.598	0.94
55_E	59_E	0.598	0.94
114_K	139_V	0.597	0.94
250_A	253_I	0.595	0.93
116_I	139_V	0.594	0.93
123_P	176_P	0.593	0.93
87_L	91_S	0.593	0.93
177_A	236_T	0.592	0.93
171_V	186_M	0.591	0.93
208_V	248_F	0.591	0.93
180_F	225_L	0.583	0.93
6_G	33_W	0.583	0.93
169_V	174_S	0.581	0.93
175_S	259_C	0.581	0.93
132_S	172_S	0.581	0.93
237_I	240_V	0.580	0.93
231_S	235_T	0.578	0.92
165_I	168_V	0.578	0.92
131_T	155_G	0.578	0.92
131_T	154_F	0.577	0.92
252_V	256_M	0.576	0.92
37_P	42_V	0.576	0.92
72_K	231_S	0.574	0.92
167_P	190_A	0.574	0.92
183_I	222_P	0.574	0.92
164_M	199_Q	0.571	0.92
54_A	60_V	0.570	0.92
180_F	215_V	0.568	0.92
18_L	51_I	0.567	0.92
126_V	214_M	0.566	0.92
175_S	256_M	0.565	0.92
243_L	248_F	0.565	0.92
177_A	239_A	0.565	0.92
22_I	25_G	0.564	0.92
79_V	82_E	0.563	0.91
8_I	35_Y	0.562	0.91
61_A	91_S	0.562	0.91
34_V	45_L	0.559	0.91
36_T	96_I	0.557	0.91
12_N	72_K	0.555	0.91
66_I	150_I	0.555	0.91
156_E	216_L	0.554	0.91
151_F	154_F	0.547	0.90
84_T	110_G	0.546	0.90
115_I	136_N	0.545	0.90
116_I	144_T	0.545	0.90
178_Y	259_C	0.543	0.90
92_L	114_K	0.541	0.90
127_N	154_F	0.540	0.90
141_P	144_T	0.537	0.89
83_I	87_L	0.536	0.89
173_G	235_T	0.536	0.89
86_S	91_S	0.533	0.89
119_M	165_I	0.532	0.89
134_T	162_E	0.532	0.89
189_A	253_I	0.530	0.89
17_I	151_F	0.528	0.89
24_S	127_N	0.526	0.89
164_M	196_P	0.523	0.88
36_T	39_P	0.522	0.88
151_F	157_A	0.519	0.88
10_C	18_L	0.518	0.88
93_V	113_R	0.517	0.88
69_A	83_I	0.516	0.88
26_Q	149_N	0.515	0.87
69_A	97_A	0.515	0.87
178_Y	207_A	0.514	0.87
69_A	105_L	0.510	0.87
61_A	64_A	0.510	0.87
109_L	115_I	0.509	0.87
121_N	173_G	0.507	0.87
185_A	188_D	0.504	0.86
241_R	253_I	0.502	0.86
174_S	263_S	0.502	0.86
64_A	91_S	0.502	0.86
13_M	120_P	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2izzA	5	0.9963	100	0.367	Contact Map
2rcyA	5	0.9665	100	0.377	Contact Map
2ahrA	5	0.9591	100	0.393	Contact Map
1yqgA	2	0.9665	100	0.397	Contact Map
3triA	2	0.9963	100	0.407	Contact Map
3gt0A	3	0.8067	100	0.437	Contact Map
4kqwA	2	0.9628	100	0.456	Contact Map
4wjiA	2	0.9517	100	0.502	Contact Map
3fr7A	2	0.9405	100	0.531	Contact Map
2i76A	2	0.8699	100	0.562	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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