GREMLIN Database
PPIC - Peptidyl-prolyl cis-trans isomerase C
UniProt: P0A9L5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12352
Length: 93 (88)
Sequences: 6150 (4297)
Seq/√Len: 458.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_L26_K3.3851.00
6_A49_D2.3031.00
15_E19_L2.2801.00
24_Q29_A2.2571.00
56_G63_D2.2371.00
8_L90_L2.1841.00
53_F58_M1.9231.00
69_C75_T1.9151.00
13_K40_I1.7871.00
6_A90_L1.7661.00
60_P64_K1.7101.00
21_L38_H1.7031.00
71_V91_Y1.6871.00
70_P73_E1.6681.00
8_L88_K1.6421.00
22_L76_G1.6251.00
20_D24_Q1.6001.00
23_E27_N1.5931.00
52_E91_Y1.5891.00
14_E17_L1.5661.00
6_A52_E1.4671.00
30_D33_K1.4621.00
5_A67_F1.4441.00
22_L86_I1.4211.00
69_C89_V1.4021.00
21_L34_L1.3871.00
25_I34_L1.3191.00
54_R57_Q1.2521.00
24_Q38_H1.2421.00
59_V82_F1.2141.00
6_A91_Y1.1941.00
4_T52_E1.1921.00
7_A66_V1.1851.00
55_Q67_F1.1831.00
15_E84_Y1.1701.00
78_L87_I1.1601.00
34_L38_H1.1501.00
17_L20_D1.1481.00
29_A34_L1.1281.00
80_T83_G1.1191.00
69_C73_E1.1111.00
5_A66_V1.1101.00
22_L77_P1.0981.00
79_H84_Y1.0771.00
18_A22_L1.0591.00
17_L38_H1.0481.00
33_K37_K1.0381.00
20_D23_E1.0361.00
33_K36_K1.0351.00
53_F66_V1.0071.00
23_E26_K0.9901.00
32_G47_G0.9711.00
64_K68_S0.9701.00
9_H85_H0.9561.00
12_V21_L0.9531.00
7_A53_F0.9481.00
22_L74_P0.9461.00
65_V78_L0.9391.00
77_P84_Y0.9261.00
8_L32_G0.9221.00
12_V18_A0.9081.00
16_K19_L0.9041.00
19_L23_E0.8941.00
49_D90_L0.8911.00
71_V89_V0.8791.00
17_L40_I0.8721.00
4_T54_R0.8681.00
74_P88_K0.8641.00
63_D67_F0.8491.00
25_I74_P0.8461.00
59_V81_Q0.8211.00
14_E40_I0.8091.00
10_I31_F0.8001.00
20_D38_H0.7981.00
80_T85_H0.7971.00
19_L76_G0.7901.00
55_Q63_D0.7841.00
17_L21_L0.7831.00
39_S43_S0.7751.00
26_K74_P0.7561.00
66_V87_I0.7451.00
5_A89_V0.7431.00
21_L24_Q0.7361.00
14_E18_A0.7331.00
16_K20_D0.7051.00
39_S42_P0.7031.00
65_V69_C0.6931.00
46_R49_D0.6861.00
39_S48_G0.6841.00
49_D52_E0.6781.00
19_L77_P0.6621.00
62_F85_H0.6591.00
41_C44_G0.6541.00
61_A81_Q0.6521.00
28_G88_K0.6491.00
53_F57_Q0.6421.00
65_V68_S0.6401.00
24_Q37_K0.6391.00
61_A80_T0.6360.99
32_G88_K0.6290.99
26_K76_G0.6240.99
30_D34_L0.6150.99
61_A64_K0.6150.99
18_A84_Y0.6100.99
36_K45_K0.6070.99
22_L25_I0.5960.99
70_P89_V0.5960.99
36_K47_G0.5930.99
72_L90_L0.5830.99
64_K67_F0.5830.99
18_A86_I0.5810.99
35_A44_G0.5730.99
18_A21_L0.5650.99
75_T89_V0.5640.99
59_V80_T0.5610.99
30_D88_K0.5590.99
82_F85_H0.5560.99
18_A40_I0.5540.99
44_G47_G0.5530.99
78_L86_I0.5530.99
58_M63_D0.5520.99
65_V75_T0.5520.99
54_R63_D0.5380.98
5_A63_D0.5340.98
32_G36_K0.5280.98
42_P45_K0.5260.98
22_L75_T0.5230.98
41_C45_K0.5200.98
31_F35_A0.5190.98
4_T57_Q0.5090.98
66_V89_V0.5070.97
65_V76_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jnsA 1 0.9892 99.9 0.094 Contact Map
2lj4A 1 0.9785 99.9 0.109 Contact Map
2pv1A 1 0.9785 99.9 0.109 Contact Map
3gpkA 1 1 99.9 0.113 Contact Map
2mntA 1 0.9677 99.9 0.129 Contact Map
2m08A 1 0.9785 99.9 0.129 Contact Map
4tnsA 1 0.9785 99.9 0.133 Contact Map
1j6yA 1 0.9785 99.9 0.137 Contact Map
3i6cA 1 0.9785 99.9 0.14 Contact Map
3tc5A 1 0.9785 99.9 0.141 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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