GREMLIN Database
FKBB - FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase
UniProt: P0A9L3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12503
Length: 206 (194)
Sequences: 2137 (1610)
Seq/√Len: 115.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_R172_E3.9141.00
136_V142_A3.2061.00
116_I166_P3.1141.00
128_T136_V3.1041.00
170_K201_E2.9631.00
191_P194_S2.8811.00
161_A173_L2.8801.00
172_E199_E2.8201.00
177_Q193_F2.6901.00
167_V204_E2.6631.00
150_P153_G2.5351.00
128_T141_V2.4471.00
166_P169_S2.4161.00
91_N105_Q2.3761.00
124_R204_E2.3371.00
183_E193_F2.3131.00
131_L135_T2.2911.00
167_V205_I2.1531.00
129_G137_F2.0981.00
161_A171_W2.0491.00
85_V89_E2.0281.00
124_R148_E2.0061.00
82_A86_K2.0041.00
186_A189_S2.0021.00
107_R174_T1.9921.00
109_I172_E1.9741.00
185_G192_P1.9171.00
120_T152_N1.9051.00
81_A85_V1.8941.00
170_K199_E1.8721.00
173_L200_V1.8561.00
54_P57_V1.8261.00
104_L179_L1.8191.00
102_S160_E1.8021.00
165_M171_W1.7921.00
151_V161_A1.7361.00
117_P202_L1.7111.00
86_K90_E1.7041.00
128_T199_E1.6941.00
185_G194_S1.6681.00
78_Q82_A1.6151.00
125_V158_W1.5941.00
99_S105_Q1.5811.00
19_L51_P1.5551.00
146_P203_L1.5441.00
87_Y174_T1.5251.00
11_A34_L1.5221.00
84_G195_T1.5191.00
79_A83_E1.4641.00
111_Q169_S1.4411.00
90_E94_K1.4211.00
124_R146_P1.3711.00
132_I197_V1.3301.00
20_Q24_Q1.3141.00
108_V171_W1.3121.00
80_M191_P1.2931.00
104_L160_E1.2870.99
126_H140_S1.2820.99
77_F193_F1.2680.99
119_R163_T1.2670.99
82_A85_V1.2660.99
164_L171_W1.2370.99
140_S143_R1.2280.99
115_A167_V1.2270.99
122_R150_P1.2230.99
154_V158_W1.2220.99
126_H201_E1.2130.99
131_L191_P1.2120.99
116_I169_S1.1960.99
94_K107_R1.1880.99
35_P39_V1.1820.99
156_P159_I1.1710.99
100_T171_W1.1650.99
15_Y18_G1.1630.99
80_M84_G1.1600.99
132_I195_T1.1590.99
41_G45_A1.1560.99
135_T189_S1.1510.99
126_H203_L1.1510.99
23_Q55_V1.1500.99
139_S143_R1.1480.99
108_V165_M1.1420.99
126_H141_V1.1310.99
174_T197_V1.1250.99
136_V139_S1.0940.98
165_M202_L1.0770.98
57_V60_R1.0740.98
161_A200_V1.0450.98
118_A152_N1.0420.98
63_R67_E1.0390.98
91_N94_K1.0210.97
160_E179_L1.0180.97
74_R78_Q1.0140.97
114_G166_P1.0110.97
104_L173_L1.0020.97
36_E43_A0.9940.97
151_V162_L0.9930.97
111_Q166_P0.9840.97
122_R148_E0.9710.96
136_V141_V0.9710.96
100_T160_E0.9520.96
92_A99_S0.9480.96
81_A193_F0.9380.96
53_V61_A0.9290.95
83_E86_K0.9270.95
67_E71_A0.9230.95
128_T142_A0.9110.95
186_A192_P0.9090.95
43_A47_E0.9080.95
157_G175_I0.8950.94
88_L91_N0.8900.94
126_H143_R0.8820.94
126_H146_P0.8750.94
16_G58_V0.8750.94
178_E183_E0.8690.94
130_K136_V0.8680.93
151_V163_T0.8610.93
100_T164_L0.8610.93
155_I158_W0.8550.93
108_V169_S0.8540.93
109_I170_K0.8510.93
166_P171_W0.8450.93
91_N99_S0.8390.92
102_S179_L0.8370.92
174_T195_T0.8350.92
119_R152_N0.8270.92
109_I199_E0.8270.92
71_A75_Q0.8210.91
86_K89_E0.8130.91
90_E93_K0.8120.91
154_V159_I0.8120.91
117_P151_V0.8110.91
159_I163_T0.8080.91
70_D74_R0.8060.91
165_M169_S0.8060.91
16_G20_Q0.8000.90
40_A52_A0.8000.90
80_M83_E0.7980.90
75_Q78_Q0.7970.90
177_Q195_T0.7950.90
110_N170_K0.7920.90
108_V111_Q0.7910.90
71_A74_R0.7860.90
141_V199_E0.7860.90
138_D200_V0.7840.89
103_G176_P0.7800.89
12_Q57_V0.7790.89
113_E167_V0.7720.89
64_E68_R0.7680.89
53_V57_V0.7640.88
77_F81_A0.7540.88
14_S33_L0.7530.88
131_L190_I0.7390.87
60_R63_R0.7380.86
141_V170_K0.7350.86
44_D49_K0.7340.86
56_D59_H0.7320.86
154_V200_V0.7310.86
141_V201_E0.7300.86
181_Y198_F0.7280.86
155_I180_A0.7250.86
124_R203_L0.7210.85
36_E39_V0.7160.85
127_Y138_D0.7160.85
99_S104_L0.7150.85
162_L173_L0.7130.85
110_N113_E0.7130.85
72_V75_Q0.7110.84
65_I68_R0.7100.84
35_P43_A0.7080.84
19_L58_V0.7030.84
130_K172_E0.6990.83
94_K105_Q0.6990.83
75_Q79_A0.6960.83
77_F177_Q0.6940.83
24_Q28_S0.6920.83
130_K142_A0.6900.83
100_T104_L0.6870.82
161_A169_S0.6870.82
19_L45_A0.6830.82
60_R64_E0.6810.82
190_I198_F0.6810.82
121_D205_I0.6760.81
118_A121_D0.6750.81
152_N159_I0.6690.81
109_I165_M0.6680.81
10_E14_S0.6660.80
166_P205_I0.6640.80
97_V105_Q0.6630.80
158_W173_L0.6630.80
149_F159_I0.6610.80
176_P179_L0.6590.80
11_A37_A0.6560.79
20_Q23_Q0.6470.78
132_I174_T0.6450.78
22_G26_S0.6450.78
139_S144_G0.6410.78
185_G190_I0.6400.78
95_E101_E0.6370.77
13_A17_I0.6330.77
11_A16_G0.6300.77
129_G198_F0.6290.76
14_S31_E0.6280.76
113_E166_P0.6240.76
44_D52_A0.6230.76
34_L37_A0.6180.75
125_V153_G0.6120.74
129_G138_D0.6080.74
96_G107_R0.6070.74
149_F158_W0.6060.74
126_H139_S0.6060.74
103_G106_F0.6050.74
16_G19_L0.6030.73
106_F179_L0.6000.73
12_Q23_Q0.5990.73
138_D198_F0.5990.73
14_S18_G0.5970.73
112_G169_S0.5970.73
39_V42_I0.5950.72
25_L30_L0.5930.72
156_P178_E0.5930.72
129_G158_W0.5890.72
35_P46_L0.5850.71
123_V162_L0.5820.71
40_A44_D0.5800.70
137_F198_F0.5800.70
28_S31_E0.5770.70
149_F196_L0.5740.70
190_I194_S0.5740.70
53_V58_V0.5710.69
47_E50_H0.5700.69
138_D190_I0.5680.69
24_Q32_G0.5680.69
10_E13_A0.5670.69
83_E133_D0.5660.69
128_T139_S0.5660.69
54_P60_R0.5660.69
55_V59_H0.5620.68
149_F154_V0.5620.68
59_H62_L0.5600.68
25_L28_S0.5600.68
31_E34_L0.5590.68
39_V43_A0.5580.68
102_S164_L0.5580.68
36_E40_A0.5580.68
56_D62_L0.5500.66
69_A73_R0.5490.66
21_V42_I0.5490.66
88_L105_Q0.5490.66
104_L164_L0.5470.66
110_N169_S0.5470.66
20_Q32_G0.5460.66
89_E92_A0.5440.66
158_W202_L0.5430.65
59_H66_H0.5420.65
100_T103_G0.5420.65
131_L194_S0.5410.65
185_G189_S0.5410.65
42_I45_A0.5410.65
14_S19_L0.5400.65
151_V159_I0.5380.65
81_A178_E0.5360.64
58_V62_L0.5340.64
175_I180_A0.5330.64
13_A16_G0.5290.63
45_A58_V0.5280.63
14_S24_Q0.5280.63
137_F155_I0.5270.63
115_A166_P0.5240.63
155_I198_F0.5240.63
177_Q183_E0.5220.62
147_A150_P0.5210.62
95_E113_E0.5210.62
111_Q171_W0.5190.62
158_W196_L0.5180.62
97_V174_T0.5140.61
109_I201_E0.5140.61
117_P121_D0.5130.61
124_R145_E0.5130.61
98_N111_Q0.5130.61
127_Y157_G0.5130.61
16_G28_S0.5100.61
25_L42_I0.5090.61
89_E93_K0.5060.60
91_N97_V0.5050.60
88_L174_T0.5040.60
190_I196_L0.5030.60
162_L171_W0.5020.59
10_E32_G0.5010.59
158_W198_F0.5010.59
65_I69_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fd9A 2 0.9612 100 0.186 Contact Map
3oe2A 1 0.6359 100 0.198 Contact Map
1q6hA 2 0.966 100 0.212 Contact Map
1jvwA 1 0.6699 100 0.371 Contact Map
2mf9A 1 0.6505 100 0.413 Contact Map
2mphA 1 0.9272 100 0.425 Contact Map
2f4eA 1 0.5825 100 0.426 Contact Map
3uf8A 1 0.9029 100 0.431 Contact Map
3jxvA 1 0.0049 100 0.444 Contact Map
2lgoA 1 0.6165 100 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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