GREMLIN Database
SLYD - FKBP-type peptidyl-prolyl cis-trans isomerase SlyD
UniProt: P0A9K9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11663
Length: 196 (160)
Sequences: 1414 (956)
Seq/√Len: 75.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A129_N4.8541.00
57_K135_E4.4081.00
7_L141_E3.6971.00
59_D133_N3.6891.00
2_K53_E2.9341.00
65_N70_Q2.8601.00
149_H153_H2.6451.00
14_Q25_E2.5521.00
47_T66_D2.5211.00
63_G66_D2.5081.00
52_H58_F2.3011.00
154_G157_D2.2761.00
54_V138_A2.2331.00
53_E56_D2.1731.00
17_T128_Q2.0561.00
92_V112_V1.9671.00
63_G129_N1.9461.00
61_A129_N1.8701.00
12_A135_E1.8121.00
62_V67_A1.8071.00
42_I62_V1.8011.00
8_V152_V1.7371.00
78_R116_H1.7271.00
113_E118_V1.6941.00
78_R118_V1.6761.00
6_D38_H1.6731.00
100_T104_P1.6521.00
41_L45_L1.6251.00
157_D160_H1.6191.00
25_E28_V1.6101.00
10_S138_A1.6000.99
144_E148_A1.5990.99
54_V139_I1.5790.99
5_K50_E1.5760.99
15_V23_V1.5600.99
12_A26_S1.4970.99
17_T21_V1.4950.99
3_V9_V1.4550.99
10_S33_D1.4320.99
45_L60_V1.4240.99
58_F134_V1.4230.99
95_R108_E1.4150.99
36_H50_E1.4150.99
81_K117_V1.4010.99
8_V150_G1.4010.99
84_F117_V1.3380.98
52_H56_D1.3310.98
97_L106_P1.3180.98
11_L136_V1.3170.98
48_A60_V1.2810.98
61_A131_K1.2780.97
42_I67_A1.2730.97
45_L134_V1.2400.97
90_L109_I1.2270.97
95_R106_P1.2150.97
80_P116_H1.2140.97
154_G160_H1.2130.97
111_A118_V1.2050.96
107_V121_G1.1870.96
111_A114_D1.1760.96
156_H159_H1.1690.96
12_A25_E1.1580.96
90_L112_V1.1370.95
16_R22_L1.1280.95
3_V139_I1.1160.95
81_K115_D1.1150.94
17_T23_V1.1070.94
35_L38_H1.1040.94
77_Q80_P1.0910.94
100_T105_V1.0820.94
8_V35_L1.0810.94
154_G158_H1.0720.93
44_G47_T1.0650.93
9_V139_I1.0370.92
16_R131_K1.0260.92
85_M107_V1.0230.92
42_I68_Y1.0120.91
140_R146_E1.0070.91
41_L60_V1.0040.91
98_A107_V0.9800.90
149_H152_V0.9690.89
75_L96_F0.9610.89
14_Q133_N0.9530.88
14_Q22_L0.9400.88
98_A121_G0.9350.87
18_E131_K0.9320.87
92_V111_A0.9270.87
107_V119_V0.9230.87
71_Y76_V0.9200.86
154_G159_H0.9190.86
34_Y50_E0.9170.86
87_V90_L0.9150.86
4_A7_L0.9150.86
12_A27_P0.9130.86
49_L58_F0.9000.85
45_L68_Y0.8990.85
90_L96_F0.8990.85
18_E129_N0.8940.85
11_L49_L0.8940.85
75_L121_G0.8910.85
44_G66_D0.8900.85
33_D138_A0.8850.84
12_A137_V0.8800.84
35_L151_H0.8650.83
3_V36_H0.8610.83
142_A146_E0.8580.82
47_T50_E0.8560.82
4_A50_E0.8550.82
9_V36_H0.8520.82
105_V121_G0.8400.81
35_L147_L0.8360.81
6_D147_L0.8140.79
57_K133_N0.8120.79
24_D32_L0.8040.78
109_I112_V0.8030.78
84_F96_F0.7920.77
59_D131_K0.7760.76
145_E158_H0.7750.76
17_T121_G0.7700.75
11_L45_L0.7690.75
32_L68_Y0.7670.75
44_G62_V0.7640.74
68_Y130_L0.7610.74
155_A158_H0.7520.73
73_E128_Q0.7490.73
96_F106_P0.7480.73
16_R20_G0.7460.73
86_G94_M0.7430.72
86_G107_V0.7420.72
97_L121_G0.7390.72
64_A67_A0.7290.71
15_V130_L0.7200.70
15_V67_A0.7030.68
120_D139_I0.6960.67
153_H160_H0.6960.67
96_F121_G0.6960.67
155_A160_H0.6890.67
114_D118_V0.6820.66
35_L152_V0.6810.66
46_E67_A0.6810.66
3_V49_L0.6780.65
143_T146_E0.6780.65
49_L134_V0.6760.65
8_V140_R0.6720.65
8_V142_A0.6660.64
43_S66_D0.6570.63
150_G153_H0.6550.63
110_T118_V0.6510.62
67_A129_N0.6490.62
35_L150_G0.6480.62
78_R115_D0.6460.62
16_R133_N0.6430.61
65_N129_N0.6420.61
55_G109_I0.6400.61
98_A119_V0.6380.61
15_V126_A0.6380.61
96_F107_V0.6370.61
58_F130_L0.6340.60
7_L139_I0.6330.60
3_V56_D0.6320.60
8_V151_H0.6280.60
3_V51_G0.6260.59
155_A159_H0.6220.59
2_K139_I0.6180.58
16_R59_D0.6180.58
103_G119_V0.6180.58
36_H46_E0.6130.58
156_H160_H0.6080.57
32_L130_L0.6070.57
44_G48_A0.6040.57
38_H119_V0.6040.57
43_S47_T0.6040.57
87_V94_M0.6020.56
15_V24_D0.6020.56
67_A123_H0.6010.56
41_L108_E0.6000.56
13_Y68_Y0.5990.56
35_L149_H0.5980.56
63_G144_E0.5970.56
67_A131_K0.5950.55
89_E111_A0.5940.55
64_A70_Q0.5940.55
39_G42_I0.5930.55
68_Y79_V0.5930.55
83_V119_V0.5910.55
153_H156_H0.5890.55
141_E144_E0.5890.55
18_E61_A0.5860.54
35_L40_S0.5840.54
140_R143_T0.5830.54
122_N127_G0.5820.54
13_Y41_L0.5810.54
146_E150_G0.5810.54
19_D128_Q0.5780.53
21_V111_A0.5780.53
147_L151_H0.5770.53
99_E103_G0.5720.53
8_V153_H0.5690.52
2_K7_L0.5670.52
77_Q107_V0.5610.51
84_F119_V0.5600.51
35_L140_R0.5590.51
91_Q94_M0.5540.50
31_P136_V0.5510.50
94_M107_V0.5510.50
90_L94_M0.5500.50
25_E30_A0.5490.50
148_A151_H0.5430.49
2_K50_E0.5410.49
86_G90_L0.5410.49
4_A155_A0.5400.49
11_L41_L0.5380.48
27_P57_K0.5380.48
81_K90_L0.5370.48
14_Q71_Y0.5370.48
120_D127_G0.5350.48
82_D85_M0.5330.48
49_L147_L0.5300.47
42_I134_V0.5300.47
83_V105_V0.5290.47
113_E116_H0.5290.47
8_V149_H0.5280.47
83_V92_V0.5270.47
127_G130_L0.5250.47
79_V107_V0.5230.46
7_L73_E0.5210.46
46_E120_D0.5210.46
111_A115_D0.5200.46
54_V76_V0.5160.46
79_V83_V0.5140.45
29_S59_D0.5140.45
16_R21_V0.5140.45
87_V107_V0.5140.45
11_L97_L0.5130.45
35_L156_H0.5130.45
52_H136_V0.5130.45
26_S29_S0.5100.45
58_F136_V0.5060.44
35_L142_A0.5030.44
93_G122_N0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kfwA 1 1 100 0.109 Contact Map
2k8iA 1 0.8724 100 0.235 Contact Map
4odkA 1 0.7755 100 0.28 Contact Map
2kr7A 1 0.7347 100 0.313 Contact Map
4dt4A 1 0.7398 100 0.326 Contact Map
1ix5A 1 0.6939 100 0.35 Contact Map
3pr9A 1 0.6888 100 0.365 Contact Map
3prbA 2 0.8929 100 0.377 Contact Map
2lknA 1 0.699 99.9 0.571 Contact Map
4odpA 1 0.5153 99.9 0.597 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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