PHOU - ECOLI - GREMLIN Contacts

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PHOU - Phosphate-specific transport system accessory protein PhoU

UniProt:	P0A9K7	Sequences: MDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKNVNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQHQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMMEDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAGKDSDK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10735
Length:	241 (211)
Sequences:	4744 (3578)
Seq/√Len:	246.3

ECOLI - PHOU YJBB
HALSA - Q9HS14 Q9HS09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_G	143_L	3.446	1.00
141_D	160_E	3.312	1.00
41_T	45_N	2.899	1.00
33_E	140_H	2.694	1.00
38_D	53_R	2.523	1.00
144_D	148_R	2.511	1.00
100_E	104_D	2.495	1.00
62_N	104_D	2.454	1.00
40_I	132_G	2.347	1.00
61_V	103_G	2.343	1.00
165_D	204_D	2.331	1.00
157_I	210_C	2.259	1.00
98_E	208_N	2.216	1.00
38_D	57_G	2.133	1.00
164_V	203_G	2.125	1.00
58_D	104_D	2.109	1.00
161_D	165_D	2.104	1.00
24_Q	71_A	2.059	1.00
37_S	136_I	2.036	1.00
141_D	156_R	2.025	1.00
32_V	99_L	1.972	1.00
177_T	181_E	1.910	1.00
35_Q	61_V	1.907	1.00
134_H	163_K	1.891	1.00
44_H	129_E	1.848	1.00
98_E	205_R	1.834	1.00
38_D	50_L	1.794	1.00
52_K	114_L	1.775	1.00
41_T	50_L	1.767	1.00
58_D	100_E	1.761	1.00
135_T	164_V	1.743	1.00
165_D	200_E	1.721	1.00
32_V	61_V	1.714	1.00
127_S	174_Q	1.694	1.00
92_I	146_F	1.676	1.00
39_A	106_A	1.673	1.00
62_N	100_E	1.670	1.00
52_K	56_E	1.658	1.00
141_D	153_E	1.649	1.00
137_Q	141_D	1.627	1.00
95_T	209_I	1.614	1.00
160_E	163_K	1.520	1.00
33_E	37_S	1.474	1.00
58_D	62_N	1.463	1.00
63_M	67_A	1.462	1.00
161_D	200_E	1.440	1.00
91_V	216_Y	1.425	1.00
144_D	153_E	1.398	1.00
179_M	186_I	1.395	1.00
102_I	202_I	1.395	1.00
27_T	64_M	1.368	1.00
171_I	196_A	1.366	1.00
36_L	202_I	1.362	1.00
108_K	198_S	1.354	1.00
135_T	199_I	1.350	1.00
109_I	195_C	1.349	1.00
25_V	92_I	1.346	1.00
163_K	166_Q	1.340	1.00
142_V	206_C	1.334	1.00
138_M	203_G	1.324	1.00
139_L	206_C	1.306	1.00
142_V	213_I	1.303	1.00
30_G	33_E	1.292	1.00
48_S	117_F	1.280	1.00
154_A	214_F	1.274	1.00
150_D	153_E	1.266	1.00
21_I	75_I	1.263	1.00
200_E	204_D	1.240	1.00
39_A	113_A	1.239	1.00
57_G	60_N	1.226	1.00
102_I	139_L	1.226	1.00
161_D	204_D	1.221	1.00
28_M	65_E	1.215	1.00
55_I	58_D	1.200	1.00
11_S	79_R	1.200	1.00
152_D	155_V	1.196	1.00
72_C	89_V	1.182	1.00
156_R	160_E	1.179	1.00
54_V	110_C	1.173	1.00
74_R	78_K	1.170	1.00
47_D	50_L	1.170	1.00
134_H	137_Q	1.165	1.00
75_I	89_V	1.161	1.00
151_I	217_V	1.157	1.00
208_N	211_E	1.155	1.00
134_H	160_E	1.154	1.00
35_Q	54_V	1.149	1.00
33_E	136_I	1.142	1.00
42_A	54_V	1.135	1.00
155_V	214_F	1.109	1.00
24_Q	27_T	1.099	1.00
137_Q	160_E	1.098	1.00
34_Q	38_D	1.098	1.00
153_E	156_R	1.092	1.00
53_R	57_G	1.092	1.00
112_T	191_T	1.089	1.00
24_Q	67_A	1.087	1.00
88_L	149_M	1.081	1.00
168_Y	196_A	1.076	1.00
32_V	103_G	1.073	1.00
148_R	153_E	1.059	1.00
65_E	94_K	1.055	1.00
35_Q	57_G	1.054	1.00
162_K	165_D	1.050	1.00
101_R	201_R	1.043	1.00
51_A	114_L	1.033	1.00
144_D	147_A	1.032	1.00
145_A	157_I	1.028	1.00
32_V	102_I	1.025	1.00
58_D	107_D	1.024	1.00
67_A	71_A	1.024	1.00
17_E	71_A	1.013	1.00
135_T	206_C	1.011	1.00
115_E	191_T	1.004	1.00
126_V	129_E	1.003	1.00
175_L	189_V	1.003	1.00
130_S	163_K	1.002	1.00
73_V	215_Y	0.999	1.00
134_H	164_V	0.987	1.00
14_F	75_I	0.981	1.00
127_S	170_G	0.978	1.00
22_R	88_L	0.966	1.00
72_C	93_S	0.962	1.00
31_M	61_V	0.952	1.00
48_S	114_L	0.950	1.00
28_M	64_M	0.949	1.00
31_M	60_N	0.949	1.00
72_C	96_I	0.947	1.00
73_V	90_M	0.943	1.00
121_H	124_L	0.943	1.00
55_I	114_L	0.941	1.00
133_R	137_Q	0.935	1.00
59_K	62_N	0.933	1.00
138_M	164_V	0.929	1.00
49_D	52_K	0.928	1.00
200_E	203_G	0.923	1.00
25_V	96_I	0.922	1.00
42_A	51_A	0.921	1.00
50_L	53_R	0.914	1.00
131_L	168_Y	0.914	1.00
21_I	89_V	0.913	1.00
151_I	214_F	0.902	1.00
113_A	195_C	0.897	1.00
46_Q	116_K	0.873	0.99
65_E	96_I	0.869	0.99
94_K	97_A	0.869	0.99
20_S	71_A	0.865	0.99
12_G	15_N	0.862	0.99
47_D	51_A	0.861	0.99
22_R	149_M	0.858	0.99
38_D	41_T	0.855	0.99
177_T	180_M	0.855	0.99
21_I	72_C	0.851	0.99
28_M	61_V	0.850	0.99
37_S	140_H	0.850	0.99
166_Q	170_G	0.848	0.99
130_S	133_R	0.841	0.99
136_I	140_H	0.840	0.99
30_G	144_D	0.837	0.99
42_A	113_A	0.830	0.99
48_S	52_K	0.827	0.99
68_I	97_A	0.827	0.99
30_G	147_A	0.819	0.99
150_D	154_A	0.812	0.99
140_H	144_D	0.810	0.99
19_E	23_T	0.807	0.99
15_N	19_E	0.806	0.99
36_L	106_A	0.806	0.99
26_M	143_L	0.804	0.99
53_R	56_E	0.796	0.99
145_A	154_A	0.791	0.99
165_D	203_G	0.787	0.99
14_F	18_L	0.786	0.99
174_Q	178_Y	0.785	0.99
179_M	193_L	0.782	0.99
55_I	110_C	0.781	0.99
54_V	57_G	0.780	0.99
42_A	46_Q	0.764	0.99
123_P	126_V	0.759	0.99
98_E	105_V	0.754	0.98
25_V	95_T	0.753	0.98
100_E	208_N	0.752	0.98
151_I	155_V	0.751	0.98
173_R	177_T	0.748	0.98
60_N	63_M	0.745	0.98
94_K	212_F	0.741	0.98
92_I	95_T	0.740	0.98
71_A	74_R	0.737	0.98
40_I	199_I	0.735	0.98
206_C	213_I	0.732	0.98
167_E	170_G	0.729	0.98
90_M	93_S	0.728	0.98
31_M	64_M	0.727	0.98
127_S	130_S	0.726	0.98
28_M	96_I	0.726	0.98
77_A	86_L	0.726	0.98
98_E	212_F	0.725	0.98
134_H	167_E	0.724	0.98
207_Q	211_E	0.723	0.98
197_R	205_R	0.722	0.98
172_V	193_L	0.721	0.98
45_N	50_L	0.721	0.98
19_E	22_R	0.720	0.98
78_K	83_A	0.719	0.98
27_T	31_M	0.718	0.98
111_R	169_E	0.717	0.98
112_T	195_C	0.714	0.98
180_M	184_R	0.714	0.98
126_V	130_S	0.709	0.98
13_Q	16_A	0.706	0.98
51_A	110_C	0.706	0.98
131_L	167_E	0.699	0.98
172_V	176_M	0.693	0.97
32_V	106_A	0.685	0.97
155_V	159_R	0.682	0.97
105_V	202_I	0.682	0.97
132_G	199_I	0.681	0.97
138_M	206_C	0.679	0.97
42_A	50_L	0.678	0.97
35_Q	39_A	0.676	0.97
105_V	205_R	0.675	0.97
43_M	195_C	0.671	0.97
105_V	198_S	0.671	0.97
24_Q	68_I	0.664	0.97
141_D	144_D	0.664	0.97
102_I	206_C	0.663	0.97
179_M	189_V	0.661	0.97
190_L	193_L	0.659	0.96
124_L	184_R	0.659	0.96
37_S	41_T	0.658	0.96
116_K	188_S	0.654	0.96
39_A	109_I	0.653	0.96
69_D	94_K	0.652	0.96
157_I	160_E	0.650	0.96
78_K	81_P	0.648	0.96
174_Q	177_T	0.647	0.96
127_S	178_Y	0.647	0.96
130_S	167_E	0.645	0.96
50_L	54_V	0.645	0.96
69_D	212_F	0.642	0.96
101_R	205_R	0.642	0.96
182_D	185_T	0.639	0.96
46_Q	120_Q	0.637	0.96
96_I	212_F	0.633	0.96
35_Q	106_A	0.633	0.96
72_C	76_I	0.631	0.96
131_L	199_I	0.629	0.95
100_E	103_G	0.626	0.95
162_K	207_Q	0.612	0.95
168_Y	172_V	0.612	0.95
138_M	161_D	0.610	0.95
101_R	208_N	0.607	0.94
132_G	136_I	0.603	0.94
155_V	218_K	0.599	0.94
40_I	44_H	0.598	0.94
186_I	189_V	0.598	0.94
51_A	55_I	0.598	0.94
185_T	189_V	0.596	0.94
35_Q	103_G	0.592	0.94
88_L	216_Y	0.592	0.94
106_A	202_I	0.591	0.94
206_C	210_C	0.590	0.94
124_L	192_A	0.590	0.94
105_V	168_Y	0.589	0.94
112_T	198_S	0.587	0.93
95_T	212_F	0.586	0.93
170_G	173_R	0.584	0.93
152_D	156_R	0.583	0.93
161_D	203_G	0.582	0.93
20_S	24_Q	0.580	0.93
42_A	47_D	0.580	0.93
129_E	133_R	0.577	0.93
40_I	128_L	0.576	0.93
108_K	112_T	0.575	0.93
46_Q	117_F	0.575	0.93
22_R	147_A	0.571	0.93
124_L	175_L	0.568	0.92
130_S	134_H	0.567	0.92
27_T	30_G	0.566	0.92
180_M	187_P	0.565	0.92
65_E	69_D	0.564	0.92
77_A	81_P	0.564	0.92
178_Y	181_E	0.563	0.92
115_E	119_Q	0.556	0.92
66_V	69_D	0.554	0.91
122_Q	125_L	0.553	0.91
158_Y	211_E	0.553	0.91
33_E	147_A	0.552	0.91
14_F	17_E	0.552	0.91
72_C	212_F	0.545	0.91
55_I	107_D	0.545	0.91
34_Q	37_S	0.542	0.90
69_D	72_C	0.536	0.90
29_G	99_L	0.535	0.90
135_T	202_I	0.534	0.90
158_Y	207_Q	0.534	0.90
139_L	142_V	0.533	0.90
99_L	139_L	0.533	0.90
83_A	87_R	0.530	0.89
83_A	86_L	0.527	0.89
81_P	86_L	0.525	0.89
51_A	58_D	0.525	0.89
203_G	211_E	0.524	0.89
104_D	208_N	0.524	0.89
121_H	178_Y	0.523	0.89
93_S	96_I	0.522	0.89
68_I	96_I	0.518	0.88
123_P	178_Y	0.516	0.88
194_F	197_R	0.512	0.88
34_Q	57_G	0.512	0.88
137_Q	163_K	0.509	0.88
23_T	27_T	0.509	0.88
17_E	79_R	0.507	0.87
11_S	82_T	0.507	0.87
108_K	207_Q	0.502	0.87
51_A	113_A	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q25A	2	0.8714	100	0.207	Contact Map
1sumB	2	0.9336	100	0.211	Contact Map
1xwmA	2	0.8797	100	0.221	Contact Map
2i0mA	2	0.8589	100	0.223	Contact Map
1t72A	5	0.8672	100	0.259	Contact Map
2oltA	5	0.8257	99.9	0.5	Contact Map
3l39A	3	0.8257	99.6	0.68	Contact Map
1vctA	3	0.7593	97.3	0.848	Contact Map
1krqA	6	0.6639	25.3	0.938	Contact Map
1eumA	6	0.6473	24.7	0.939	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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