GREMLIN Database
PHOL - PhoH-like protein
UniProt: P0A9K3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13656
Length: 346 (306)
Sequences: 3703 (1873)
Seq/√Len: 107.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_N298_S6.8801.00
238_F266_V4.4351.00
304_S318_N4.3971.00
249_I286_H3.4571.00
288_I301_F3.4151.00
166_R236_D3.3341.00
259_I265_A3.3011.00
150_Y205_E3.2831.00
288_I299_F3.2041.00
296_E315_R3.1191.00
170_L199_L3.0981.00
21_L70_T2.9401.00
137_I312_V2.8441.00
60_A64_R2.7441.00
135_H298_S2.6981.00
158_D162_R2.6851.00
274_I285_R2.5831.00
126_A130_A2.5471.00
133_L155_A2.4931.00
137_I267_I2.4541.00
38_I49_L2.4071.00
141_V288_I2.4021.00
289_E323_W2.3901.00
38_I59_A2.3891.00
124_N302_F2.3711.00
135_H296_E2.3691.00
136_D264_K2.3521.00
236_D262_N2.3301.00
239_I263_S2.2921.00
241_L255_F2.2321.00
36_L59_A2.2191.00
286_H323_W2.2121.00
292_A301_F2.1641.00
27_D82_P2.1501.00
271_V285_R2.0801.00
131_N300_N2.0731.00
31_Q86_H2.0391.00
311_P315_R2.0371.00
188_L228_Y2.0131.00
128_Y140_G1.9831.00
239_I265_A1.9661.00
49_L60_A1.9461.00
81_E84_Q1.8921.00
281_K289_E1.8521.00
187_D190_Q1.8521.00
139_F299_F1.8471.00
66_L85_I1.8341.00
137_I297_I1.8131.00
130_A134_D1.7691.00
294_V315_R1.7681.00
315_R318_N1.7171.00
132_I155_A1.7111.00
107_K133_L1.7111.00
35_R89_I1.6781.00
66_L88_A1.6411.00
160_L220_V1.6361.00
140_G302_F1.6321.00
17_R70_T1.6311.00
153_V240_I1.6231.00
57_T60_A1.6131.00
204_F212_V1.6051.00
17_R71_A1.5921.00
129_I155_A1.5771.00
290_V323_W1.5671.00
132_I238_F1.5641.00
32_L62_I1.5621.00
213_E217_E1.5411.00
49_L59_A1.5211.00
20_S70_T1.5191.00
141_V301_F1.5061.00
141_V299_F1.4891.00
120_P129_I1.4811.00
37_G55_C1.4761.00
14_D17_R1.4451.00
85_I89_I1.4391.00
210_E214_K1.4381.00
120_P126_A1.4341.00
159_A164_E1.4291.00
101_S104_E1.4221.00
26_D30_K1.4201.00
154_A206_M1.4191.00
22_C42_R1.3891.00
295_E315_R1.3871.00
286_H290_V1.3861.00
49_L56_V1.3851.00
83_E87_L1.3731.00
132_I266_V1.3541.00
156_A238_F1.3511.00
18_L22_C1.3200.99
115_R129_I1.2910.99
199_L240_I1.2660.99
127_Q130_A1.2530.99
215_L220_V1.2490.99
179_E251_Q1.2440.99
141_V271_V1.2260.99
64_R68_V1.2250.99
121_R261_F1.2220.99
132_I264_K1.2180.99
41_N50_T1.2160.99
132_I140_G1.2020.99
36_L89_I1.2010.99
17_R67_Y1.1970.99
62_I88_A1.1920.99
171_T224_A1.1800.99
51_G56_V1.1550.98
84_Q88_A1.1540.98
57_T61_D1.1460.98
141_V272_T1.1440.98
33_E36_L1.1420.98
199_L268_T1.1410.98
236_D261_F1.1330.98
61_D65_S1.1280.98
101_S105_Y1.1250.98
22_C47_F1.1170.98
116_G236_D1.1100.98
86_H89_I1.1080.98
167_R237_A1.1010.98
85_I88_A1.0970.98
24_P27_D1.0970.98
211_K214_K1.0850.98
192_V208_G1.0800.98
293_D322_A1.0780.98
59_A62_I1.0740.98
128_Y151_L1.0730.98
208_G212_V1.0590.97
83_E86_H1.0560.97
304_S321_E1.0440.97
115_R158_D1.0430.97
259_I312_V1.0330.97
204_F213_E1.0320.97
212_V216_I1.0290.97
88_A91_E1.0270.97
32_L63_L1.0270.97
287_A323_W1.0270.97
80_I84_Q1.0220.97
203_L221_I1.0210.97
85_I90_K1.0210.97
65_S68_V1.0130.97
39_E50_T1.0120.97
13_A16_A1.0040.96
155_A159_A1.0020.96
65_S69_D0.9970.96
108_A119_K0.9930.96
42_R47_F0.9920.96
32_L89_I0.9910.96
47_F63_L0.9840.96
271_V288_I0.9830.96
249_I323_W0.9820.96
88_A92_A0.9750.96
58_A93_R0.9710.96
121_R171_T0.9640.95
201_D232_R0.9590.95
94_V305_E0.9580.95
176_E227_A0.9500.95
55_C59_A0.9460.95
250_E280_T0.9460.95
173_P226_L0.9440.95
20_S79_D0.9420.95
25_F28_N0.9410.95
183_F196_L0.9410.95
168_I199_L0.9370.95
249_I281_K0.9310.94
40_I49_L0.9270.94
62_I92_A0.9220.94
291_L297_I0.9110.94
159_A165_I0.9020.93
26_D211_K0.9010.93
91_E94_V0.8980.93
22_C29_I0.8960.93
80_I86_H0.8940.93
156_A170_L0.8930.93
136_D296_E0.8910.93
286_H289_E0.8880.93
156_A168_I0.8870.93
153_V202_A0.8860.93
285_R289_E0.8860.93
97_Q100_E0.8820.93
281_K286_H0.8810.93
132_I159_A0.8780.93
239_I259_I0.8780.93
207_L215_L0.8750.92
152_A268_T0.8740.92
35_R93_R0.8740.92
118_I206_M0.8720.92
61_D92_A0.8700.92
235_N261_F0.8670.92
167_R204_F0.8610.92
171_T314_A0.8600.92
33_E214_K0.8590.92
40_I63_L0.8570.92
98_S101_S0.8570.92
229_M251_Q0.8560.92
180_K302_F0.8400.91
62_I85_I0.8380.91
181_L195_Y0.8360.91
24_P30_K0.8340.90
64_R67_Y0.8300.90
123_P126_A0.8250.90
66_L80_I0.8250.90
195_Y227_A0.8220.90
78_Q84_Q0.8220.90
130_A133_L0.8210.90
288_I292_A0.8200.90
136_D295_E0.8130.89
81_E86_H0.8120.89
200_Y204_F0.8080.89
58_A322_A0.8020.89
33_E38_I0.7990.89
122_T302_F0.7990.89
52_R55_C0.7990.89
36_L55_C0.7960.88
209_F213_E0.7960.88
149_T312_V0.7950.88
61_D64_R0.7940.88
131_N135_H0.7920.88
86_H90_K0.7920.88
124_N127_Q0.7850.88
25_F32_L0.7800.87
90_K93_R0.7800.87
157_V203_L0.7770.87
287_A320_Y0.7770.87
90_K94_V0.7690.87
157_V206_M0.7670.86
179_E229_M0.7660.86
14_D68_V0.7640.86
287_A290_V0.7640.86
274_I279_N0.7600.86
118_I121_R0.7540.85
16_A19_L0.7420.85
204_F219_N0.7380.84
82_P85_I0.7330.84
65_S110_N0.7330.84
69_D78_Q0.7300.84
153_V207_L0.7300.84
146_T307_V0.7280.83
38_I55_C0.7260.83
31_Q34_R0.7240.83
153_V212_V0.7220.83
87_L314_A0.7180.83
120_P161_E0.7180.83
134_D298_S0.7140.82
194_P257_T0.7080.82
300_N303_H0.7080.82
70_T80_I0.7070.82
39_E65_S0.7040.81
110_N158_D0.7020.81
318_N321_E0.7020.81
252_M267_I0.7010.81
298_S301_F0.6990.81
25_F42_R0.6960.81
156_A159_A0.6960.81
146_T317_V0.6940.80
173_P270_D0.6940.80
230_R275_D0.6940.80
139_F247_T0.6900.80
123_P127_Q0.6850.80
210_E218_R0.6840.79
104_E107_K0.6810.79
59_A63_L0.6780.79
76_Q80_I0.6780.79
84_Q87_L0.6760.79
41_N48_K0.6750.79
302_F305_E0.6740.78
34_R295_E0.6730.78
94_V97_Q0.6710.78
173_P225_P0.6690.78
205_E235_N0.6660.78
66_L70_T0.6650.78
60_A63_L0.6640.77
78_Q105_Y0.6640.77
129_I151_L0.6630.77
26_D42_R0.6620.77
188_L225_P0.6620.77
285_R302_F0.6600.77
250_E272_T0.6600.77
193_D224_A0.6600.77
121_R236_D0.6590.77
285_R288_I0.6550.76
206_M216_I0.6540.76
178_G222_E0.6520.76
292_A315_R0.6520.76
193_D233_T0.6510.76
18_L42_R0.6500.76
150_Y202_A0.6500.76
87_L123_P0.6500.76
76_Q102_V0.6480.76
22_C117_V0.6460.75
173_P198_P0.6450.75
197_R210_E0.6450.75
111_I158_D0.6440.75
269_G284_L0.6440.75
189_S265_A0.6430.75
62_I89_I0.6400.75
152_A266_V0.6400.75
122_T205_E0.6390.75
114_K166_R0.6390.75
138_T298_S0.6370.74
133_L158_D0.6360.74
290_V294_V0.6360.74
296_E311_P0.6360.74
91_E123_P0.6350.74
318_N322_A0.6350.74
181_L228_Y0.6330.74
158_D161_E0.6310.74
289_E301_F0.6300.74
171_T208_G0.6280.73
200_Y227_A0.6280.73
208_G228_Y0.6270.73
58_A92_A0.6250.73
119_K228_Y0.6240.73
152_A181_L0.6220.73
115_R302_F0.6210.73
225_P268_T0.6180.72
19_L45_N0.6180.72
192_V195_Y0.6180.72
252_M256_L0.6150.72
280_T321_E0.6130.72
64_R134_D0.6120.72
61_D281_K0.6110.71
171_T226_L0.6110.71
112_K115_R0.6110.71
62_I65_S0.6100.71
176_E179_E0.6090.71
129_I133_L0.6070.71
228_Y304_S0.6070.71
179_E282_S0.6030.70
295_E311_P0.6030.70
111_I117_V0.6010.70
26_D41_N0.6010.70
119_K215_L0.6010.70
143_P179_E0.6000.70
19_L39_E0.5980.70
136_D211_K0.5950.69
187_D208_G0.5900.69
160_L223_V0.5900.69
249_I317_V0.5890.69
61_D103_P0.5880.68
55_C58_A0.5870.68
87_L91_E0.5840.68
58_A61_D0.5830.68
185_P194_P0.5830.68
66_L217_E0.5830.68
223_V278_R0.5820.68
153_V307_V0.5780.67
13_A19_L0.5770.67
51_G319_A0.5750.67
139_F229_M0.5730.67
234_L237_A0.5720.66
88_A192_V0.5710.66
31_Q85_I0.5710.66
228_Y247_T0.5700.66
43_R205_E0.5690.66
126_A129_I0.5690.66
318_N323_W0.5690.66
87_L90_K0.5690.66
78_Q106_G0.5680.66
188_L222_E0.5680.66
314_A318_N0.5680.66
100_E103_P0.5670.66
30_K33_E0.5660.66
171_T175_V0.5660.66
67_Y150_Y0.5650.65
83_E89_I0.5650.65
97_Q102_V0.5650.65
174_A196_L0.5630.65
80_I85_I0.5630.65
26_D206_M0.5630.65
138_T300_N0.5610.65
27_D117_V0.5610.65
177_A254_M0.5610.65
19_L219_N0.5610.65
25_F46_H0.5600.65
183_F187_D0.5590.65
124_N303_H0.5590.65
249_I290_V0.5580.64
101_S169_L0.5580.64
307_V317_V0.5570.64
53_P57_T0.5560.64
267_I287_A0.5550.64
24_P180_K0.5540.64
99_A134_D0.5520.64
248_T251_Q0.5520.64
29_I63_L0.5510.64
93_R105_Y0.5500.63
173_P197_R0.5490.63
204_F250_E0.5490.63
175_V233_T0.5490.63
286_H320_Y0.5480.63
15_N55_C0.5470.63
62_I76_Q0.5460.63
177_A229_M0.5460.63
169_L237_A0.5450.63
189_S193_D0.5450.63
24_P42_R0.5440.63
61_D135_H0.5440.63
163_Q322_A0.5440.63
30_K161_E0.5430.62
272_T321_E0.5410.62
278_R281_K0.5410.62
146_T267_I0.5400.62
35_R90_K0.5390.62
212_V215_L0.5390.62
78_Q81_E0.5380.62
251_Q282_S0.5360.61
184_L232_R0.5360.61
55_C93_R0.5360.61
106_G130_A0.5350.61
238_F263_S0.5340.61
197_R222_E0.5340.61
60_A288_I0.5330.61
20_S39_E0.5320.61
184_L201_D0.5320.61
29_I127_Q0.5320.61
127_Q305_E0.5300.61
143_P229_M0.5300.61
32_L36_L0.5290.60
176_E195_Y0.5280.60
101_S107_K0.5280.60
63_L67_Y0.5280.60
132_I138_T0.5270.60
289_E292_A0.5270.60
61_D289_E0.5260.60
98_S106_G0.5250.60
140_G259_I0.5230.60
166_R204_F0.5220.59
88_A219_N0.5220.59
124_N161_E0.5200.59
57_T71_A0.5200.59
224_A239_I0.5190.59
132_I151_L0.5190.59
27_D31_Q0.5180.59
159_A238_F0.5170.59
81_E85_I0.5170.59
61_D98_S0.5160.59
290_V317_V0.5160.59
189_S235_N0.5150.58
76_Q106_G0.5130.58
30_K323_W0.5120.58
112_K120_P0.5120.58
27_D46_H0.5120.58
138_T190_Q0.5120.58
37_G127_Q0.5110.58
26_D253_K0.5110.58
68_V102_V0.5100.58
95_L98_S0.5100.58
180_K189_S0.5090.57
198_P224_A0.5090.57
19_L36_L0.5080.57
276_L297_I0.5070.57
150_Y206_M0.5060.57
31_Q35_R0.5060.57
32_L35_R0.5060.57
179_E239_I0.5060.57
22_C158_D0.5040.57
213_E300_N0.5040.57
122_T171_T0.5020.56
82_P119_K0.5010.56
166_R208_G0.5000.56
267_I298_S0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b85A 3 0.5434 100 0.742 Contact Map
3upuA 1 0.6069 99.7 0.842 Contact Map
3e1sA 1 0.8555 99.6 0.86 Contact Map
3lfuA 1 0.6532 99.6 0.861 Contact Map
4c2uA 1 0.6532 99.6 0.862 Contact Map
2wjyA 1 0.9538 99.5 0.869 Contact Map
2xzlA 1 0.9306 99.4 0.871 Contact Map
2gk6A 1 0.9277 99.4 0.872 Contact Map
1w36D 1 0.922 99.4 0.872 Contact Map
4c2tA 1 0.659 99.4 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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