PHOL - ECOLI - GREMLIN Contacts

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PHOL - PhoH-like protein

UniProt:	P0A9K3	Sequences: MNIDTREITLEPADNARLLSLCGPFDDNIKQLERRLGIEINRRDNHFKLTGRPICVTAAADILRSLYVDTAPMRGQIQDIEPEQIHLAIKEARVLEQSAESVPEYGKAVNIKTKRGVIKPRTPNQAQYIANILDHDITFGVGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTIEQMKMFLTRIGFNSKAVITGDVTQIDLPRNTKSGLRHAIEVLADVEEISFNFFHSEDVVRHPVVARIVNAYEAWEEAEQKRKAALAAERKREEQEQK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13656
Length:	346 (306)
Sequences:	3703 (1873)
Seq/√Len:	107.1

ECOLI - PHOL PHOH
BACSU - PHOL YLAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_N	298_S	6.880	1.00
238_F	266_V	4.435	1.00
304_S	318_N	4.397	1.00
249_I	286_H	3.457	1.00
288_I	301_F	3.415	1.00
166_R	236_D	3.334	1.00
259_I	265_A	3.301	1.00
150_Y	205_E	3.283	1.00
288_I	299_F	3.204	1.00
296_E	315_R	3.119	1.00
170_L	199_L	3.098	1.00
21_L	70_T	2.940	1.00
137_I	312_V	2.844	1.00
60_A	64_R	2.744	1.00
135_H	298_S	2.698	1.00
158_D	162_R	2.685	1.00
274_I	285_R	2.583	1.00
126_A	130_A	2.547	1.00
133_L	155_A	2.493	1.00
137_I	267_I	2.454	1.00
38_I	49_L	2.407	1.00
141_V	288_I	2.402	1.00
289_E	323_W	2.390	1.00
38_I	59_A	2.389	1.00
124_N	302_F	2.371	1.00
135_H	296_E	2.369	1.00
136_D	264_K	2.352	1.00
236_D	262_N	2.330	1.00
239_I	263_S	2.292	1.00
241_L	255_F	2.232	1.00
36_L	59_A	2.219	1.00
286_H	323_W	2.212	1.00
292_A	301_F	2.164	1.00
27_D	82_P	2.150	1.00
271_V	285_R	2.080	1.00
131_N	300_N	2.073	1.00
31_Q	86_H	2.039	1.00
311_P	315_R	2.037	1.00
188_L	228_Y	2.013	1.00
128_Y	140_G	1.983	1.00
239_I	265_A	1.966	1.00
49_L	60_A	1.946	1.00
81_E	84_Q	1.892	1.00
281_K	289_E	1.852	1.00
187_D	190_Q	1.852	1.00
139_F	299_F	1.847	1.00
66_L	85_I	1.834	1.00
137_I	297_I	1.813	1.00
130_A	134_D	1.769	1.00
294_V	315_R	1.768	1.00
315_R	318_N	1.717	1.00
132_I	155_A	1.711	1.00
107_K	133_L	1.711	1.00
35_R	89_I	1.678	1.00
66_L	88_A	1.641	1.00
160_L	220_V	1.636	1.00
140_G	302_F	1.632	1.00
17_R	70_T	1.631	1.00
153_V	240_I	1.623	1.00
57_T	60_A	1.613	1.00
204_F	212_V	1.605	1.00
17_R	71_A	1.592	1.00
129_I	155_A	1.577	1.00
290_V	323_W	1.567	1.00
132_I	238_F	1.564	1.00
32_L	62_I	1.562	1.00
213_E	217_E	1.541	1.00
49_L	59_A	1.521	1.00
20_S	70_T	1.519	1.00
141_V	301_F	1.506	1.00
141_V	299_F	1.489	1.00
120_P	129_I	1.481	1.00
37_G	55_C	1.476	1.00
14_D	17_R	1.445	1.00
85_I	89_I	1.439	1.00
210_E	214_K	1.438	1.00
120_P	126_A	1.434	1.00
159_A	164_E	1.429	1.00
101_S	104_E	1.422	1.00
26_D	30_K	1.420	1.00
154_A	206_M	1.419	1.00
22_C	42_R	1.389	1.00
295_E	315_R	1.387	1.00
286_H	290_V	1.386	1.00
49_L	56_V	1.385	1.00
83_E	87_L	1.373	1.00
132_I	266_V	1.354	1.00
156_A	238_F	1.351	1.00
18_L	22_C	1.320	0.99
115_R	129_I	1.291	0.99
199_L	240_I	1.266	0.99
127_Q	130_A	1.253	0.99
215_L	220_V	1.249	0.99
179_E	251_Q	1.244	0.99
141_V	271_V	1.226	0.99
64_R	68_V	1.225	0.99
121_R	261_F	1.222	0.99
132_I	264_K	1.218	0.99
41_N	50_T	1.216	0.99
132_I	140_G	1.202	0.99
36_L	89_I	1.201	0.99
17_R	67_Y	1.197	0.99
62_I	88_A	1.192	0.99
171_T	224_A	1.180	0.99
51_G	56_V	1.155	0.98
84_Q	88_A	1.154	0.98
57_T	61_D	1.146	0.98
141_V	272_T	1.144	0.98
33_E	36_L	1.142	0.98
199_L	268_T	1.141	0.98
236_D	261_F	1.133	0.98
61_D	65_S	1.128	0.98
101_S	105_Y	1.125	0.98
22_C	47_F	1.117	0.98
116_G	236_D	1.110	0.98
86_H	89_I	1.108	0.98
167_R	237_A	1.101	0.98
85_I	88_A	1.097	0.98
24_P	27_D	1.097	0.98
211_K	214_K	1.085	0.98
192_V	208_G	1.080	0.98
293_D	322_A	1.078	0.98
59_A	62_I	1.074	0.98
128_Y	151_L	1.073	0.98
208_G	212_V	1.059	0.97
83_E	86_H	1.056	0.97
304_S	321_E	1.044	0.97
115_R	158_D	1.043	0.97
259_I	312_V	1.033	0.97
204_F	213_E	1.032	0.97
212_V	216_I	1.029	0.97
88_A	91_E	1.027	0.97
32_L	63_L	1.027	0.97
287_A	323_W	1.027	0.97
80_I	84_Q	1.022	0.97
203_L	221_I	1.021	0.97
85_I	90_K	1.021	0.97
65_S	68_V	1.013	0.97
39_E	50_T	1.012	0.97
13_A	16_A	1.004	0.96
155_A	159_A	1.002	0.96
65_S	69_D	0.997	0.96
108_A	119_K	0.993	0.96
42_R	47_F	0.992	0.96
32_L	89_I	0.991	0.96
47_F	63_L	0.984	0.96
271_V	288_I	0.983	0.96
249_I	323_W	0.982	0.96
88_A	92_A	0.975	0.96
58_A	93_R	0.971	0.96
121_R	171_T	0.964	0.95
201_D	232_R	0.959	0.95
94_V	305_E	0.958	0.95
176_E	227_A	0.950	0.95
55_C	59_A	0.946	0.95
250_E	280_T	0.946	0.95
173_P	226_L	0.944	0.95
20_S	79_D	0.942	0.95
25_F	28_N	0.941	0.95
183_F	196_L	0.941	0.95
168_I	199_L	0.937	0.95
249_I	281_K	0.931	0.94
40_I	49_L	0.927	0.94
62_I	92_A	0.922	0.94
291_L	297_I	0.911	0.94
159_A	165_I	0.902	0.93
26_D	211_K	0.901	0.93
91_E	94_V	0.898	0.93
22_C	29_I	0.896	0.93
80_I	86_H	0.894	0.93
156_A	170_L	0.893	0.93
136_D	296_E	0.891	0.93
286_H	289_E	0.888	0.93
156_A	168_I	0.887	0.93
153_V	202_A	0.886	0.93
285_R	289_E	0.886	0.93
97_Q	100_E	0.882	0.93
281_K	286_H	0.881	0.93
132_I	159_A	0.878	0.93
239_I	259_I	0.878	0.93
207_L	215_L	0.875	0.92
152_A	268_T	0.874	0.92
35_R	93_R	0.874	0.92
118_I	206_M	0.872	0.92
61_D	92_A	0.870	0.92
235_N	261_F	0.867	0.92
167_R	204_F	0.861	0.92
171_T	314_A	0.860	0.92
33_E	214_K	0.859	0.92
40_I	63_L	0.857	0.92
98_S	101_S	0.857	0.92
229_M	251_Q	0.856	0.92
180_K	302_F	0.840	0.91
62_I	85_I	0.838	0.91
181_L	195_Y	0.836	0.91
24_P	30_K	0.834	0.90
64_R	67_Y	0.830	0.90
123_P	126_A	0.825	0.90
66_L	80_I	0.825	0.90
195_Y	227_A	0.822	0.90
78_Q	84_Q	0.822	0.90
130_A	133_L	0.821	0.90
288_I	292_A	0.820	0.90
136_D	295_E	0.813	0.89
81_E	86_H	0.812	0.89
200_Y	204_F	0.808	0.89
58_A	322_A	0.802	0.89
33_E	38_I	0.799	0.89
122_T	302_F	0.799	0.89
52_R	55_C	0.799	0.89
36_L	55_C	0.796	0.88
209_F	213_E	0.796	0.88
149_T	312_V	0.795	0.88
61_D	64_R	0.794	0.88
131_N	135_H	0.792	0.88
86_H	90_K	0.792	0.88
124_N	127_Q	0.785	0.88
25_F	32_L	0.780	0.87
90_K	93_R	0.780	0.87
157_V	203_L	0.777	0.87
287_A	320_Y	0.777	0.87
90_K	94_V	0.769	0.87
157_V	206_M	0.767	0.86
179_E	229_M	0.766	0.86
14_D	68_V	0.764	0.86
287_A	290_V	0.764	0.86
274_I	279_N	0.760	0.86
118_I	121_R	0.754	0.85
16_A	19_L	0.742	0.85
204_F	219_N	0.738	0.84
82_P	85_I	0.733	0.84
65_S	110_N	0.733	0.84
69_D	78_Q	0.730	0.84
153_V	207_L	0.730	0.84
146_T	307_V	0.728	0.83
38_I	55_C	0.726	0.83
31_Q	34_R	0.724	0.83
153_V	212_V	0.722	0.83
87_L	314_A	0.718	0.83
120_P	161_E	0.718	0.83
134_D	298_S	0.714	0.82
194_P	257_T	0.708	0.82
300_N	303_H	0.708	0.82
70_T	80_I	0.707	0.82
39_E	65_S	0.704	0.81
110_N	158_D	0.702	0.81
318_N	321_E	0.702	0.81
252_M	267_I	0.701	0.81
298_S	301_F	0.699	0.81
25_F	42_R	0.696	0.81
156_A	159_A	0.696	0.81
146_T	317_V	0.694	0.80
173_P	270_D	0.694	0.80
230_R	275_D	0.694	0.80
139_F	247_T	0.690	0.80
123_P	127_Q	0.685	0.80
210_E	218_R	0.684	0.79
104_E	107_K	0.681	0.79
59_A	63_L	0.678	0.79
76_Q	80_I	0.678	0.79
84_Q	87_L	0.676	0.79
41_N	48_K	0.675	0.79
302_F	305_E	0.674	0.78
34_R	295_E	0.673	0.78
94_V	97_Q	0.671	0.78
173_P	225_P	0.669	0.78
205_E	235_N	0.666	0.78
66_L	70_T	0.665	0.78
60_A	63_L	0.664	0.77
78_Q	105_Y	0.664	0.77
129_I	151_L	0.663	0.77
26_D	42_R	0.662	0.77
188_L	225_P	0.662	0.77
285_R	302_F	0.660	0.77
250_E	272_T	0.660	0.77
193_D	224_A	0.660	0.77
121_R	236_D	0.659	0.77
285_R	288_I	0.655	0.76
206_M	216_I	0.654	0.76
178_G	222_E	0.652	0.76
292_A	315_R	0.652	0.76
193_D	233_T	0.651	0.76
18_L	42_R	0.650	0.76
150_Y	202_A	0.650	0.76
87_L	123_P	0.650	0.76
76_Q	102_V	0.648	0.76
22_C	117_V	0.646	0.75
173_P	198_P	0.645	0.75
197_R	210_E	0.645	0.75
111_I	158_D	0.644	0.75
269_G	284_L	0.644	0.75
189_S	265_A	0.643	0.75
62_I	89_I	0.640	0.75
152_A	266_V	0.640	0.75
122_T	205_E	0.639	0.75
114_K	166_R	0.639	0.75
138_T	298_S	0.637	0.74
133_L	158_D	0.636	0.74
290_V	294_V	0.636	0.74
296_E	311_P	0.636	0.74
91_E	123_P	0.635	0.74
318_N	322_A	0.635	0.74
181_L	228_Y	0.633	0.74
158_D	161_E	0.631	0.74
289_E	301_F	0.630	0.74
171_T	208_G	0.628	0.73
200_Y	227_A	0.628	0.73
208_G	228_Y	0.627	0.73
58_A	92_A	0.625	0.73
119_K	228_Y	0.624	0.73
152_A	181_L	0.622	0.73
115_R	302_F	0.621	0.73
225_P	268_T	0.618	0.72
19_L	45_N	0.618	0.72
192_V	195_Y	0.618	0.72
252_M	256_L	0.615	0.72
280_T	321_E	0.613	0.72
64_R	134_D	0.612	0.72
61_D	281_K	0.611	0.71
171_T	226_L	0.611	0.71
112_K	115_R	0.611	0.71
62_I	65_S	0.610	0.71
176_E	179_E	0.609	0.71
129_I	133_L	0.607	0.71
228_Y	304_S	0.607	0.71
179_E	282_S	0.603	0.70
295_E	311_P	0.603	0.70
111_I	117_V	0.601	0.70
26_D	41_N	0.601	0.70
119_K	215_L	0.601	0.70
143_P	179_E	0.600	0.70
19_L	39_E	0.598	0.70
136_D	211_K	0.595	0.69
187_D	208_G	0.590	0.69
160_L	223_V	0.590	0.69
249_I	317_V	0.589	0.69
61_D	103_P	0.588	0.68
55_C	58_A	0.587	0.68
87_L	91_E	0.584	0.68
58_A	61_D	0.583	0.68
185_P	194_P	0.583	0.68
66_L	217_E	0.583	0.68
223_V	278_R	0.582	0.68
153_V	307_V	0.578	0.67
13_A	19_L	0.577	0.67
51_G	319_A	0.575	0.67
139_F	229_M	0.573	0.67
234_L	237_A	0.572	0.66
88_A	192_V	0.571	0.66
31_Q	85_I	0.571	0.66
228_Y	247_T	0.570	0.66
43_R	205_E	0.569	0.66
126_A	129_I	0.569	0.66
318_N	323_W	0.569	0.66
87_L	90_K	0.569	0.66
78_Q	106_G	0.568	0.66
188_L	222_E	0.568	0.66
314_A	318_N	0.568	0.66
100_E	103_P	0.567	0.66
30_K	33_E	0.566	0.66
171_T	175_V	0.566	0.66
67_Y	150_Y	0.565	0.65
83_E	89_I	0.565	0.65
97_Q	102_V	0.565	0.65
174_A	196_L	0.563	0.65
80_I	85_I	0.563	0.65
26_D	206_M	0.563	0.65
138_T	300_N	0.561	0.65
27_D	117_V	0.561	0.65
177_A	254_M	0.561	0.65
19_L	219_N	0.561	0.65
25_F	46_H	0.560	0.65
183_F	187_D	0.559	0.65
124_N	303_H	0.559	0.65
249_I	290_V	0.558	0.64
101_S	169_L	0.558	0.64
307_V	317_V	0.557	0.64
53_P	57_T	0.556	0.64
267_I	287_A	0.555	0.64
24_P	180_K	0.554	0.64
99_A	134_D	0.552	0.64
248_T	251_Q	0.552	0.64
29_I	63_L	0.551	0.64
93_R	105_Y	0.550	0.63
173_P	197_R	0.549	0.63
204_F	250_E	0.549	0.63
175_V	233_T	0.549	0.63
286_H	320_Y	0.548	0.63
15_N	55_C	0.547	0.63
62_I	76_Q	0.546	0.63
177_A	229_M	0.546	0.63
169_L	237_A	0.545	0.63
189_S	193_D	0.545	0.63
24_P	42_R	0.544	0.63
61_D	135_H	0.544	0.63
163_Q	322_A	0.544	0.63
30_K	161_E	0.543	0.62
272_T	321_E	0.541	0.62
278_R	281_K	0.541	0.62
146_T	267_I	0.540	0.62
35_R	90_K	0.539	0.62
212_V	215_L	0.539	0.62
78_Q	81_E	0.538	0.62
251_Q	282_S	0.536	0.61
184_L	232_R	0.536	0.61
55_C	93_R	0.536	0.61
106_G	130_A	0.535	0.61
238_F	263_S	0.534	0.61
197_R	222_E	0.534	0.61
60_A	288_I	0.533	0.61
20_S	39_E	0.532	0.61
184_L	201_D	0.532	0.61
29_I	127_Q	0.532	0.61
127_Q	305_E	0.530	0.61
143_P	229_M	0.530	0.61
32_L	36_L	0.529	0.60
176_E	195_Y	0.528	0.60
101_S	107_K	0.528	0.60
63_L	67_Y	0.528	0.60
132_I	138_T	0.527	0.60
289_E	292_A	0.527	0.60
61_D	289_E	0.526	0.60
98_S	106_G	0.525	0.60
140_G	259_I	0.523	0.60
166_R	204_F	0.522	0.59
88_A	219_N	0.522	0.59
124_N	161_E	0.520	0.59
57_T	71_A	0.520	0.59
224_A	239_I	0.519	0.59
132_I	151_L	0.519	0.59
27_D	31_Q	0.518	0.59
159_A	238_F	0.517	0.59
81_E	85_I	0.517	0.59
61_D	98_S	0.516	0.59
290_V	317_V	0.516	0.59
189_S	235_N	0.515	0.58
76_Q	106_G	0.513	0.58
30_K	323_W	0.512	0.58
112_K	120_P	0.512	0.58
27_D	46_H	0.512	0.58
138_T	190_Q	0.512	0.58
37_G	127_Q	0.511	0.58
26_D	253_K	0.511	0.58
68_V	102_V	0.510	0.58
95_L	98_S	0.510	0.58
180_K	189_S	0.509	0.57
198_P	224_A	0.509	0.57
19_L	36_L	0.508	0.57
276_L	297_I	0.507	0.57
150_Y	206_M	0.506	0.57
31_Q	35_R	0.506	0.57
32_L	35_R	0.506	0.57
179_E	239_I	0.506	0.57
22_C	158_D	0.504	0.57
213_E	300_N	0.504	0.57
122_T	171_T	0.502	0.56
82_P	119_K	0.501	0.56
166_R	208_G	0.500	0.56
267_I	298_S	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b85A	3	0.5434	100	0.742	Contact Map
3upuA	1	0.6069	99.7	0.842	Contact Map
3e1sA	1	0.8555	99.6	0.86	Contact Map
3lfuA	1	0.6532	99.6	0.861	Contact Map
4c2uA	1	0.6532	99.6	0.862	Contact Map
2wjyA	1	0.9538	99.5	0.869	Contact Map
2xzlA	1	0.9306	99.4	0.871	Contact Map
2gk6A	1	0.9277	99.4	0.872	Contact Map
1w36D	1	0.922	99.4	0.872	Contact Map
4c2tA	1	0.659	99.4	0.873	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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