GREMLIN Database
PHOH - Protein PhoH
UniProt: P0A9K1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11734
Length: 354 (293)
Sequences: 3590 (1867)
Seq/√Len: 109.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_A331_G6.7791.00
271_V299_I4.4311.00
337_K351_H4.4041.00
282_A319_D3.5111.00
197_D269_N3.4581.00
292_L298_V3.3641.00
168_L345_L3.3201.00
181_W236_R3.3191.00
321_L334_R3.3151.00
201_V230_V3.1341.00
321_L332_I3.1121.00
329_M348_R2.8991.00
166_K331_G2.8421.00
164_E186_K2.6171.00
307_C318_S2.5931.00
157_L161_K2.5681.00
63_L113_D2.4941.00
172_T321_L2.3951.00
269_N295_N2.3831.00
189_E193_H2.3631.00
272_V296_V2.3171.00
166_K329_M2.2951.00
103_R107_K2.2861.00
325_E334_R2.2711.00
168_L300_V2.1941.00
170_F332_I2.1891.00
344_A348_R2.1871.00
162_A333_V2.1831.00
81_A102_A2.1781.00
274_L288_F2.1531.00
81_A92_S2.1351.00
155_A335_F2.1311.00
167_Q297_T2.0811.00
219_I261_Y2.0791.00
304_I318_S2.0701.00
272_V298_V2.0321.00
190_A195_D2.0321.00
92_S103_R1.9901.00
78_A102_A1.9811.00
327_D348_R1.9381.00
314_C322_E1.9351.00
191_L253_K1.9261.00
159_Y171_A1.9111.00
168_L330_V1.8331.00
218_D221_E1.8051.00
78_A81_A1.7551.00
163_I186_K1.7161.00
125_V129_V1.7101.00
163_I271_V1.7101.00
161_K165_S1.6781.00
92_S102_A1.6761.00
73_A126_T1.6631.00
235_V243_M1.6171.00
184_A273_I1.5921.00
160_L186_K1.5831.00
151_A160_L1.5821.00
348_R351_H1.5521.00
242_F245_Y1.5481.00
125_V128_L1.5421.00
319_D323_R1.5421.00
120_R124_S1.5341.00
171_A335_F1.5311.00
151_A157_L1.5121.00
172_T334_R1.5121.00
185_A237_R1.4881.00
59_A114_S1.4861.00
98_A102_A1.4801.00
246_C253_K1.4751.00
92_S99_V1.4471.00
128_L132_G1.4421.00
167_Q329_M1.4041.00
100_I103_R1.3851.00
95_R98_A1.3841.00
109_V128_L1.3841.00
244_Q250_E1.3771.00
121_E124_S1.3751.00
123_E127_S1.3441.00
172_T305_T1.3431.00
328_E348_R1.3421.00
62_G113_D1.3331.00
96_Q100_I1.3280.99
163_I299_I1.3210.99
172_T332_I1.2970.99
109_V125_V1.2750.99
210_E284_Q1.2660.99
74_H105_E1.2640.99
122_E126_T1.2540.99
78_A129_V1.2450.99
77_A129_V1.2400.99
126_T130_Q1.2340.99
135_E139_M1.2320.99
60_N64_Q1.2320.99
202_T257_A1.2220.99
146_T160_L1.2200.99
94_G99_V1.2180.99
230_V301_N1.2140.99
124_S128_L1.2130.99
187_A271_V1.2110.99
127_S131_M1.2110.99
102_A105_E1.2000.99
115_R118_K1.1950.99
152_R294_E1.1910.99
230_V273_I1.1860.99
243_M247_L1.1770.99
166_K190_A1.1770.99
158_H161_K1.1730.99
163_I297_T1.1570.99
241_S245_Y1.1540.99
163_I169_I1.1350.98
163_I171_A1.1330.98
127_S130_Q1.1310.98
172_T304_I1.1260.98
126_T129_V1.1180.98
121_E126_T1.1060.98
146_T189_E1.1010.98
79_N98_A1.1000.98
147_S269_N1.0960.98
307_C312_G1.0940.98
66_S69_S1.0860.98
69_S122_E1.0760.98
132_G135_E1.0680.98
159_Y182_I1.0650.98
134_V139_M1.0620.98
319_D322_E1.0540.97
152_R202_T1.0480.97
136_A139_M1.0470.97
198_R270_A1.0440.97
82_C93_M1.0410.97
269_N294_E1.0380.97
108_R111_R1.0320.97
112_R117_H1.0230.97
223_F239_G1.0200.97
240_A244_Q1.0150.97
154_E157_L1.0080.97
120_R125_V1.0060.97
132_G140_A1.0020.97
98_A101_K1.0000.96
109_V113_D0.9980.96
292_L345_L0.9880.96
169_I333_V0.9850.96
83_D92_S0.9820.96
64_Q90_V0.9810.96
64_Q85_Y0.9760.96
90_V106_A0.9700.96
121_E125_V0.9690.96
107_K111_R0.9640.96
283_A313_V0.9620.96
232_D265_R0.9600.96
235_V244_Q0.9540.95
268_E294_E0.9500.95
239_G243_M0.9450.95
75_N78_A0.9390.95
214_F227_F0.9350.95
184_A233_V0.9340.95
304_I321_L0.9320.95
59_A113_D0.9310.95
234_L254_V0.9280.95
187_A199_I0.9200.94
75_N81_A0.9180.94
149_I237_R0.9180.94
123_E126_T0.9160.94
204_P259_F0.9130.94
169_I331_G0.9050.94
183_S301_N0.9030.94
113_D116_S0.8990.94
96_Q99_V0.8980.94
122_E125_V0.8920.93
186_K190_A0.8900.93
163_I190_A0.8900.93
199_I230_V0.8890.93
137_I141_R0.8870.93
161_K164_E0.8850.93
324_F330_V0.8840.93
207_Q260_A0.8800.93
84_E93_M0.8770.93
128_L140_A0.8760.93
74_H106_A0.8680.92
139_M142_D0.8670.92
184_A243_M0.8650.92
84_E91_L0.8630.92
77_A133_G0.8630.92
202_T347_Q0.8630.92
71_V106_A0.8570.92
318_S322_E0.8570.92
321_L325_E0.8560.92
187_A201_V0.8530.92
107_K110_L0.8490.92
282_A314_C0.8470.92
128_L131_M0.8470.92
314_C319_D0.8440.91
105_E128_L0.8430.91
272_V292_L0.8380.91
104_R135_E0.8370.91
104_R108_R0.8370.91
125_V132_G0.8340.91
130_Q133_G0.8330.91
226_Y260_A0.8310.91
130_Q134_V0.8280.91
67_Q70_D0.8160.90
211_D335_F0.8150.90
231_Y235_V0.8130.90
162_A169_I0.8080.90
112_R116_S0.8070.89
135_E140_A0.8050.89
73_A76_R0.8040.89
59_A110_L0.8030.89
198_R235_V0.7910.88
169_I221_E0.7900.88
94_G352_A0.7860.88
124_S130_Q0.7770.88
146_T192_I0.7760.88
94_G102_A0.7750.87
212_L226_Y0.7740.87
155_A158_H0.7710.87
134_V140_A0.7700.87
100_I104_R0.7680.87
220_A298_V0.7650.87
124_S127_S0.7640.87
155_A192_I0.7600.86
81_A98_A0.7580.86
100_I136_A0.7560.86
153_N335_F0.7550.86
76_R328_E0.7480.86
113_D117_H0.7460.85
120_R123_E0.7430.85
121_E129_V0.7430.85
180_T345_L0.7420.85
150_L261_Y0.7400.85
333_V336_G0.7400.85
188_A234_L0.7380.85
323_R327_D0.7360.85
190_A271_V0.7350.85
120_R132_G0.7350.85
136_A140_A0.7320.84
108_R112_R0.7310.84
132_G137_I0.7270.84
285_M300_V0.7230.84
238_L246_C0.7210.83
262_M284_Q0.7210.83
162_A166_K0.7160.83
60_N85_Y0.7160.83
74_H129_V0.7150.83
64_Q79_N0.7150.83
129_V133_G0.7140.83
138_G141_R0.7120.83
117_H121_E0.7090.82
320_A323_R0.7080.82
72_R96_Q0.7070.82
183_S299_I0.7050.82
66_S73_A0.7030.82
111_R114_S0.6990.81
211_D350_L0.6960.81
143_S146_T0.6960.81
58_K75_N0.6940.81
225_P290_T0.6930.81
112_R115_R0.6900.81
320_A353_Y0.6900.81
184_A238_L0.6880.80
204_P303_D0.6870.80
64_Q148_P0.6810.80
177_C340_C0.6800.80
145_D197_D0.6800.80
149_I152_R0.6800.80
132_G139_M0.6780.80
243_M246_C0.6750.79
335_F338_E0.6750.79
146_T335_F0.6730.79
318_S321_L0.6720.79
131_M154_E0.6710.79
210_E262_M0.6700.79
220_A268_E0.6660.78
188_A237_R0.6660.78
152_R269_N0.6640.78
218_D239_G0.6630.78
75_N245_Y0.6630.78
328_E344_A0.6560.77
261_Y337_K0.6550.77
219_I258_P0.6500.77
115_R336_G0.6500.77
302_G317_L0.6500.77
85_Y90_V0.6490.76
87_Q91_L0.6470.76
329_M344_A0.6460.76
347_Q351_H0.6450.76
69_S73_A0.6450.76
99_V102_A0.6440.76
160_L182_I0.6430.76
322_E334_R0.6410.76
68_P72_R0.6410.76
289_L320_A0.6400.75
83_D106_A0.6390.75
204_P258_P0.6390.75
116_S333_V0.6360.75
282_A323_R0.6340.75
114_S117_H0.6330.75
283_A305_T0.6300.74
236_R268_E0.6290.74
202_T206_L0.6270.74
125_V131_M0.6260.74
100_I121_E0.6260.74
321_L331_G0.6220.73
319_D353_Y0.6210.73
153_N236_R0.6200.73
65_G68_P0.6200.73
92_S109_V0.6190.73
124_S132_G0.6180.73
160_L164_E0.6170.73
136_A321_L0.6150.73
95_R107_K0.6140.72
99_V103_R0.6140.72
219_I255_E0.6110.72
191_L238_L0.6110.72
131_M134_V0.6100.72
59_A62_G0.6100.72
191_L256_I0.6090.72
224_A298_V0.6070.72
205_V227_F0.6040.71
135_E141_R0.6020.71
216_P225_P0.6010.71
111_R115_R0.6000.71
318_S335_F0.5980.70
143_S151_A0.5970.70
134_V142_D0.5970.70
112_R194_K0.5960.70
105_E132_G0.5930.70
202_T239_G0.5900.69
223_F226_Y0.5900.69
235_V252_G0.5890.69
220_A224_A0.5890.69
100_I135_E0.5890.69
90_V112_R0.5870.69
153_N202_T0.5820.68
150_L246_C0.5810.68
130_Q135_E0.5800.68
131_M136_A0.5800.68
263_R308_D0.5770.68
59_A88_L0.5760.68
154_E158_H0.5760.68
108_R139_M0.5740.67
224_A257_A0.5720.67
105_E109_V0.5720.67
231_Y260_A0.5710.67
126_T132_G0.5700.67
109_V120_R0.5690.67
165_S331_G0.5690.67
101_K104_R0.5680.67
136_A141_R0.5680.67
57_P70_D0.5670.66
181_W233_V0.5670.66
72_R161_K0.5660.66
66_S70_D0.5660.66
285_M289_L0.5650.66
123_E135_E0.5650.66
114_S295_N0.5630.66
98_A104_R0.5620.66
130_Q142_D0.5620.66
177_C300_V0.5610.66
322_E325_E0.5610.66
103_R109_V0.5600.65
134_V141_R0.5590.65
189_E192_I0.5570.65
202_T259_F0.5570.65
170_F280_V0.5570.65
188_A193_H0.5570.65
62_G158_H0.5560.65
95_R118_K0.5560.65
126_T135_E0.5550.65
314_C351_H0.5550.65
282_A350_L0.5540.65
101_K133_G0.5530.65
102_A106_A0.5490.64
331_G334_R0.5480.64
282_A313_V0.5480.64
131_M325_E0.5470.64
256_I311_R0.5460.64
157_L160_L0.5440.63
68_P242_F0.5430.63
106_A110_L0.5430.63
325_E348_R0.5400.63
129_V132_G0.5390.63
258_P301_N0.5380.62
164_E189_E0.5380.62
204_P229_P0.5360.62
101_K138_G0.5350.62
311_R314_C0.5350.62
101_K132_G0.5340.62
63_L66_S0.5330.62
86_K236_R0.5330.62
177_C350_L0.5310.61
97_K133_G0.5310.61
241_S251_I0.5310.61
123_E195_D0.5310.61
104_R134_V0.5280.61
181_W237_R0.5280.61
340_C350_L0.5280.61
74_H77_A0.5270.61
127_S347_Q0.5260.61
166_K195_D0.5260.61
194_K269_N0.5250.61
151_A154_E0.5230.60
120_R128_L0.5230.60
167_Q343_S0.5220.60
121_E136_A0.5220.60
239_G261_Y0.5200.60
59_A66_S0.5180.60
68_P274_L0.5170.59
323_R350_L0.5170.59
183_S212_L0.5160.59
126_T142_D0.5150.59
111_R136_A0.5150.59
207_Q210_E0.5150.59
84_E87_Q0.5150.59
155_A336_G0.5140.59
110_L261_Y0.5130.59
196_V199_I0.5130.59
122_E132_G0.5120.59
105_E115_R0.5110.59
87_Q92_S0.5110.59
127_S133_G0.5110.59
135_E138_G0.5100.58
60_N335_F0.5090.58
121_E133_G0.5090.58
104_R115_R0.5090.58
235_V283_A0.5080.58
163_I182_I0.5080.58
76_R326_E0.5070.58
59_A64_Q0.5060.58
107_K115_R0.5060.58
283_A298_V0.5050.58
145_D251_I0.5050.58
127_S139_M0.5050.58
58_K61_Y0.5050.58
210_E315_S0.5050.58
267_F270_A0.5040.57
174_E210_E0.5040.57
138_G157_L0.5020.57
168_L235_V0.5020.57
174_E262_M0.5020.57
171_A292_L0.5010.57
122_E145_D0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b85A 3 0.5311 100 0.758 Contact Map
3upuA 1 0.5226 99.7 0.846 Contact Map
3lfuA 1 0.5706 99.6 0.86 Contact Map
3e1sA 1 0.7599 99.6 0.864 Contact Map
4c2uA 1 0.5763 99.6 0.865 Contact Map
1w36D 1 0.8814 99.5 0.87 Contact Map
2wjyA 1 0.9266 99.5 0.874 Contact Map
2gk6A 1 0.8983 99.4 0.876 Contact Map
4c2tA 1 0.5763 99.4 0.876 Contact Map
1uaaA 2 0.5537 99.4 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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