PHOH - ECOLI - GREMLIN Contacts

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PHOH - Protein PhoH

UniProt:	P0A9K1	Sequences: MVTSCTGHVLDNQRATTRGVFSSGSHLVTLHFQPHPFFSCVTDAVNGARSRFSAFYPKANYGLQGSQPSDVRAHNRAANGACDEYKQLKVLSMGRQKAVIKARREAKRVLRRDSRSHKQREEESVTSLVQMGGVEAIGMARDSRDTSPILARNEAQLHYLKAIESKQLIFATGEAGCGKTWISAAKAAEALIHKDVDRIIVTRPVLQADEDLGFLPGDIAEKFAPYFRPVYDVLVRRLGASFMQYCLRPEIGKVEIAPFAYMRGRTFENAVVILDEAQNVTAAQMKMFLTRLGENVTVIVNGDITQCDLPRGVCSGLSDALERFEEDEMVGIVRFGKEDCVRSALCQRTLHAYS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11734
Length:	354 (293)
Sequences:	3590 (1867)
Seq/√Len:	109.1

ECOLI - PHOH PHOL
BACSU - YLAK PHOL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_A	331_G	6.779	1.00
271_V	299_I	4.431	1.00
337_K	351_H	4.404	1.00
282_A	319_D	3.511	1.00
197_D	269_N	3.458	1.00
292_L	298_V	3.364	1.00
168_L	345_L	3.320	1.00
181_W	236_R	3.319	1.00
321_L	334_R	3.315	1.00
201_V	230_V	3.134	1.00
321_L	332_I	3.112	1.00
329_M	348_R	2.899	1.00
166_K	331_G	2.842	1.00
164_E	186_K	2.617	1.00
307_C	318_S	2.593	1.00
157_L	161_K	2.568	1.00
63_L	113_D	2.494	1.00
172_T	321_L	2.395	1.00
269_N	295_N	2.383	1.00
189_E	193_H	2.363	1.00
272_V	296_V	2.317	1.00
166_K	329_M	2.295	1.00
103_R	107_K	2.286	1.00
325_E	334_R	2.271	1.00
168_L	300_V	2.194	1.00
170_F	332_I	2.189	1.00
344_A	348_R	2.187	1.00
162_A	333_V	2.183	1.00
81_A	102_A	2.178	1.00
274_L	288_F	2.153	1.00
81_A	92_S	2.135	1.00
155_A	335_F	2.131	1.00
167_Q	297_T	2.081	1.00
219_I	261_Y	2.079	1.00
304_I	318_S	2.070	1.00
272_V	298_V	2.032	1.00
190_A	195_D	2.032	1.00
92_S	103_R	1.990	1.00
78_A	102_A	1.981	1.00
327_D	348_R	1.938	1.00
314_C	322_E	1.935	1.00
191_L	253_K	1.926	1.00
159_Y	171_A	1.911	1.00
168_L	330_V	1.833	1.00
218_D	221_E	1.805	1.00
78_A	81_A	1.755	1.00
163_I	186_K	1.716	1.00
125_V	129_V	1.710	1.00
163_I	271_V	1.710	1.00
161_K	165_S	1.678	1.00
92_S	102_A	1.676	1.00
73_A	126_T	1.663	1.00
235_V	243_M	1.617	1.00
184_A	273_I	1.592	1.00
160_L	186_K	1.583	1.00
151_A	160_L	1.582	1.00
348_R	351_H	1.552	1.00
242_F	245_Y	1.548	1.00
125_V	128_L	1.542	1.00
319_D	323_R	1.542	1.00
120_R	124_S	1.534	1.00
171_A	335_F	1.531	1.00
151_A	157_L	1.512	1.00
172_T	334_R	1.512	1.00
185_A	237_R	1.488	1.00
59_A	114_S	1.486	1.00
98_A	102_A	1.480	1.00
246_C	253_K	1.475	1.00
92_S	99_V	1.447	1.00
128_L	132_G	1.442	1.00
167_Q	329_M	1.404	1.00
100_I	103_R	1.385	1.00
95_R	98_A	1.384	1.00
109_V	128_L	1.384	1.00
244_Q	250_E	1.377	1.00
121_E	124_S	1.375	1.00
123_E	127_S	1.344	1.00
172_T	305_T	1.343	1.00
328_E	348_R	1.342	1.00
62_G	113_D	1.333	1.00
96_Q	100_I	1.328	0.99
163_I	299_I	1.321	0.99
172_T	332_I	1.297	0.99
109_V	125_V	1.275	0.99
210_E	284_Q	1.266	0.99
74_H	105_E	1.264	0.99
122_E	126_T	1.254	0.99
78_A	129_V	1.245	0.99
77_A	129_V	1.240	0.99
126_T	130_Q	1.234	0.99
135_E	139_M	1.232	0.99
60_N	64_Q	1.232	0.99
202_T	257_A	1.222	0.99
146_T	160_L	1.220	0.99
94_G	99_V	1.218	0.99
230_V	301_N	1.214	0.99
124_S	128_L	1.213	0.99
187_A	271_V	1.211	0.99
127_S	131_M	1.211	0.99
102_A	105_E	1.200	0.99
115_R	118_K	1.195	0.99
152_R	294_E	1.191	0.99
230_V	273_I	1.186	0.99
243_M	247_L	1.177	0.99
166_K	190_A	1.177	0.99
158_H	161_K	1.173	0.99
163_I	297_T	1.157	0.99
241_S	245_Y	1.154	0.99
163_I	169_I	1.135	0.98
163_I	171_A	1.133	0.98
127_S	130_Q	1.131	0.98
172_T	304_I	1.126	0.98
126_T	129_V	1.118	0.98
121_E	126_T	1.106	0.98
146_T	189_E	1.101	0.98
79_N	98_A	1.100	0.98
147_S	269_N	1.096	0.98
307_C	312_G	1.094	0.98
66_S	69_S	1.086	0.98
69_S	122_E	1.076	0.98
132_G	135_E	1.068	0.98
159_Y	182_I	1.065	0.98
134_V	139_M	1.062	0.98
319_D	322_E	1.054	0.97
152_R	202_T	1.048	0.97
136_A	139_M	1.047	0.97
198_R	270_A	1.044	0.97
82_C	93_M	1.041	0.97
269_N	294_E	1.038	0.97
108_R	111_R	1.032	0.97
112_R	117_H	1.023	0.97
223_F	239_G	1.020	0.97
240_A	244_Q	1.015	0.97
154_E	157_L	1.008	0.97
120_R	125_V	1.006	0.97
132_G	140_A	1.002	0.97
98_A	101_K	1.000	0.96
109_V	113_D	0.998	0.96
292_L	345_L	0.988	0.96
169_I	333_V	0.985	0.96
83_D	92_S	0.982	0.96
64_Q	90_V	0.981	0.96
64_Q	85_Y	0.976	0.96
90_V	106_A	0.970	0.96
121_E	125_V	0.969	0.96
107_K	111_R	0.964	0.96
283_A	313_V	0.962	0.96
232_D	265_R	0.960	0.96
235_V	244_Q	0.954	0.95
268_E	294_E	0.950	0.95
239_G	243_M	0.945	0.95
75_N	78_A	0.939	0.95
214_F	227_F	0.935	0.95
184_A	233_V	0.934	0.95
304_I	321_L	0.932	0.95
59_A	113_D	0.931	0.95
234_L	254_V	0.928	0.95
187_A	199_I	0.920	0.94
75_N	81_A	0.918	0.94
149_I	237_R	0.918	0.94
123_E	126_T	0.916	0.94
204_P	259_F	0.913	0.94
169_I	331_G	0.905	0.94
183_S	301_N	0.903	0.94
113_D	116_S	0.899	0.94
96_Q	99_V	0.898	0.94
122_E	125_V	0.892	0.93
186_K	190_A	0.890	0.93
163_I	190_A	0.890	0.93
199_I	230_V	0.889	0.93
137_I	141_R	0.887	0.93
161_K	164_E	0.885	0.93
324_F	330_V	0.884	0.93
207_Q	260_A	0.880	0.93
84_E	93_M	0.877	0.93
128_L	140_A	0.876	0.93
74_H	106_A	0.868	0.92
139_M	142_D	0.867	0.92
184_A	243_M	0.865	0.92
84_E	91_L	0.863	0.92
77_A	133_G	0.863	0.92
202_T	347_Q	0.863	0.92
71_V	106_A	0.857	0.92
318_S	322_E	0.857	0.92
321_L	325_E	0.856	0.92
187_A	201_V	0.853	0.92
107_K	110_L	0.849	0.92
282_A	314_C	0.847	0.92
128_L	131_M	0.847	0.92
314_C	319_D	0.844	0.91
105_E	128_L	0.843	0.91
272_V	292_L	0.838	0.91
104_R	135_E	0.837	0.91
104_R	108_R	0.837	0.91
125_V	132_G	0.834	0.91
130_Q	133_G	0.833	0.91
226_Y	260_A	0.831	0.91
130_Q	134_V	0.828	0.91
67_Q	70_D	0.816	0.90
211_D	335_F	0.815	0.90
231_Y	235_V	0.813	0.90
162_A	169_I	0.808	0.90
112_R	116_S	0.807	0.89
135_E	140_A	0.805	0.89
73_A	76_R	0.804	0.89
59_A	110_L	0.803	0.89
198_R	235_V	0.791	0.88
169_I	221_E	0.790	0.88
94_G	352_A	0.786	0.88
124_S	130_Q	0.777	0.88
146_T	192_I	0.776	0.88
94_G	102_A	0.775	0.87
212_L	226_Y	0.774	0.87
155_A	158_H	0.771	0.87
134_V	140_A	0.770	0.87
100_I	104_R	0.768	0.87
220_A	298_V	0.765	0.87
124_S	127_S	0.764	0.87
155_A	192_I	0.760	0.86
81_A	98_A	0.758	0.86
100_I	136_A	0.756	0.86
153_N	335_F	0.755	0.86
76_R	328_E	0.748	0.86
113_D	117_H	0.746	0.85
120_R	123_E	0.743	0.85
121_E	129_V	0.743	0.85
180_T	345_L	0.742	0.85
150_L	261_Y	0.740	0.85
333_V	336_G	0.740	0.85
188_A	234_L	0.738	0.85
323_R	327_D	0.736	0.85
190_A	271_V	0.735	0.85
120_R	132_G	0.735	0.85
136_A	140_A	0.732	0.84
108_R	112_R	0.731	0.84
132_G	137_I	0.727	0.84
285_M	300_V	0.723	0.84
238_L	246_C	0.721	0.83
262_M	284_Q	0.721	0.83
162_A	166_K	0.716	0.83
60_N	85_Y	0.716	0.83
74_H	129_V	0.715	0.83
64_Q	79_N	0.715	0.83
129_V	133_G	0.714	0.83
138_G	141_R	0.712	0.83
117_H	121_E	0.709	0.82
320_A	323_R	0.708	0.82
72_R	96_Q	0.707	0.82
183_S	299_I	0.705	0.82
66_S	73_A	0.703	0.82
111_R	114_S	0.699	0.81
211_D	350_L	0.696	0.81
143_S	146_T	0.696	0.81
58_K	75_N	0.694	0.81
225_P	290_T	0.693	0.81
112_R	115_R	0.690	0.81
320_A	353_Y	0.690	0.81
184_A	238_L	0.688	0.80
204_P	303_D	0.687	0.80
64_Q	148_P	0.681	0.80
177_C	340_C	0.680	0.80
145_D	197_D	0.680	0.80
149_I	152_R	0.680	0.80
132_G	139_M	0.678	0.80
243_M	246_C	0.675	0.79
335_F	338_E	0.675	0.79
146_T	335_F	0.673	0.79
318_S	321_L	0.672	0.79
131_M	154_E	0.671	0.79
210_E	262_M	0.670	0.79
220_A	268_E	0.666	0.78
188_A	237_R	0.666	0.78
152_R	269_N	0.664	0.78
218_D	239_G	0.663	0.78
75_N	245_Y	0.663	0.78
328_E	344_A	0.656	0.77
261_Y	337_K	0.655	0.77
219_I	258_P	0.650	0.77
115_R	336_G	0.650	0.77
302_G	317_L	0.650	0.77
85_Y	90_V	0.649	0.76
87_Q	91_L	0.647	0.76
329_M	344_A	0.646	0.76
347_Q	351_H	0.645	0.76
69_S	73_A	0.645	0.76
99_V	102_A	0.644	0.76
160_L	182_I	0.643	0.76
322_E	334_R	0.641	0.76
68_P	72_R	0.641	0.76
289_L	320_A	0.640	0.75
83_D	106_A	0.639	0.75
204_P	258_P	0.639	0.75
116_S	333_V	0.636	0.75
282_A	323_R	0.634	0.75
114_S	117_H	0.633	0.75
283_A	305_T	0.630	0.74
236_R	268_E	0.629	0.74
202_T	206_L	0.627	0.74
125_V	131_M	0.626	0.74
100_I	121_E	0.626	0.74
321_L	331_G	0.622	0.73
319_D	353_Y	0.621	0.73
153_N	236_R	0.620	0.73
65_G	68_P	0.620	0.73
92_S	109_V	0.619	0.73
124_S	132_G	0.618	0.73
160_L	164_E	0.617	0.73
136_A	321_L	0.615	0.73
95_R	107_K	0.614	0.72
99_V	103_R	0.614	0.72
219_I	255_E	0.611	0.72
191_L	238_L	0.611	0.72
131_M	134_V	0.610	0.72
59_A	62_G	0.610	0.72
191_L	256_I	0.609	0.72
224_A	298_V	0.607	0.72
205_V	227_F	0.604	0.71
135_E	141_R	0.602	0.71
216_P	225_P	0.601	0.71
111_R	115_R	0.600	0.71
318_S	335_F	0.598	0.70
143_S	151_A	0.597	0.70
134_V	142_D	0.597	0.70
112_R	194_K	0.596	0.70
105_E	132_G	0.593	0.70
202_T	239_G	0.590	0.69
223_F	226_Y	0.590	0.69
235_V	252_G	0.589	0.69
220_A	224_A	0.589	0.69
100_I	135_E	0.589	0.69
90_V	112_R	0.587	0.69
153_N	202_T	0.582	0.68
150_L	246_C	0.581	0.68
130_Q	135_E	0.580	0.68
131_M	136_A	0.580	0.68
263_R	308_D	0.577	0.68
59_A	88_L	0.576	0.68
154_E	158_H	0.576	0.68
108_R	139_M	0.574	0.67
224_A	257_A	0.572	0.67
105_E	109_V	0.572	0.67
231_Y	260_A	0.571	0.67
126_T	132_G	0.570	0.67
109_V	120_R	0.569	0.67
165_S	331_G	0.569	0.67
101_K	104_R	0.568	0.67
136_A	141_R	0.568	0.67
57_P	70_D	0.567	0.66
181_W	233_V	0.567	0.66
72_R	161_K	0.566	0.66
66_S	70_D	0.566	0.66
285_M	289_L	0.565	0.66
123_E	135_E	0.565	0.66
114_S	295_N	0.563	0.66
98_A	104_R	0.562	0.66
130_Q	142_D	0.562	0.66
177_C	300_V	0.561	0.66
322_E	325_E	0.561	0.66
103_R	109_V	0.560	0.65
134_V	141_R	0.559	0.65
189_E	192_I	0.557	0.65
202_T	259_F	0.557	0.65
170_F	280_V	0.557	0.65
188_A	193_H	0.557	0.65
62_G	158_H	0.556	0.65
95_R	118_K	0.556	0.65
126_T	135_E	0.555	0.65
314_C	351_H	0.555	0.65
282_A	350_L	0.554	0.65
101_K	133_G	0.553	0.65
102_A	106_A	0.549	0.64
331_G	334_R	0.548	0.64
282_A	313_V	0.548	0.64
131_M	325_E	0.547	0.64
256_I	311_R	0.546	0.64
157_L	160_L	0.544	0.63
68_P	242_F	0.543	0.63
106_A	110_L	0.543	0.63
325_E	348_R	0.540	0.63
129_V	132_G	0.539	0.63
258_P	301_N	0.538	0.62
164_E	189_E	0.538	0.62
204_P	229_P	0.536	0.62
101_K	138_G	0.535	0.62
311_R	314_C	0.535	0.62
101_K	132_G	0.534	0.62
63_L	66_S	0.533	0.62
86_K	236_R	0.533	0.62
177_C	350_L	0.531	0.61
97_K	133_G	0.531	0.61
241_S	251_I	0.531	0.61
123_E	195_D	0.531	0.61
104_R	134_V	0.528	0.61
181_W	237_R	0.528	0.61
340_C	350_L	0.528	0.61
74_H	77_A	0.527	0.61
127_S	347_Q	0.526	0.61
166_K	195_D	0.526	0.61
194_K	269_N	0.525	0.61
151_A	154_E	0.523	0.60
120_R	128_L	0.523	0.60
167_Q	343_S	0.522	0.60
121_E	136_A	0.522	0.60
239_G	261_Y	0.520	0.60
59_A	66_S	0.518	0.60
68_P	274_L	0.517	0.59
323_R	350_L	0.517	0.59
183_S	212_L	0.516	0.59
126_T	142_D	0.515	0.59
111_R	136_A	0.515	0.59
207_Q	210_E	0.515	0.59
84_E	87_Q	0.515	0.59
155_A	336_G	0.514	0.59
110_L	261_Y	0.513	0.59
196_V	199_I	0.513	0.59
122_E	132_G	0.512	0.59
105_E	115_R	0.511	0.59
87_Q	92_S	0.511	0.59
127_S	133_G	0.511	0.59
135_E	138_G	0.510	0.58
60_N	335_F	0.509	0.58
121_E	133_G	0.509	0.58
104_R	115_R	0.509	0.58
235_V	283_A	0.508	0.58
163_I	182_I	0.508	0.58
76_R	326_E	0.507	0.58
59_A	64_Q	0.506	0.58
107_K	115_R	0.506	0.58
283_A	298_V	0.505	0.58
145_D	251_I	0.505	0.58
127_S	139_M	0.505	0.58
58_K	61_Y	0.505	0.58
210_E	315_S	0.505	0.58
267_F	270_A	0.504	0.57
174_E	210_E	0.504	0.57
138_G	157_L	0.502	0.57
168_L	235_V	0.502	0.57
174_E	262_M	0.502	0.57
171_A	292_L	0.501	0.57
122_E	145_D	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b85A	3	0.5311	100	0.758	Contact Map
3upuA	1	0.5226	99.7	0.846	Contact Map
3lfuA	1	0.5706	99.6	0.86	Contact Map
3e1sA	1	0.7599	99.6	0.864	Contact Map
4c2uA	1	0.5763	99.6	0.865	Contact Map
1w36D	1	0.8814	99.5	0.87	Contact Map
2wjyA	1	0.9266	99.5	0.874	Contact Map
2gk6A	1	0.8983	99.4	0.876	Contact Map
4c2tA	1	0.5763	99.4	0.876	Contact Map
1uaaA	2	0.5537	99.4	0.876	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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