GREMLIN Database
PHEA - P-protein
UniProt: P0A9J8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10707
Length: 386 (351)
Sequences: 1264 (865)
Seq/√Len: 46.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K27_E4.7041.00
302_M344_L4.0951.00
20_K23_A4.0691.00
252_L270_E3.9711.00
142_I154_A3.6661.00
115_Y190_H3.3891.00
316_L320_N3.3161.00
10_L31_L3.2021.00
193_L253_G3.1811.00
300_L346_I3.1161.00
255_E268_R3.0611.00
204_N248_H2.9921.00
199_D202_T2.9431.00
320_N361_E2.8671.00
34_E37_K2.7131.00
205_T227_K2.6391.00
212_P234_T2.6171.00
17_L31_L2.6111.00
107_A151_A2.5981.00
217_S272_N2.5931.00
154_A283_L2.5141.00
318_L325_M2.4681.00
20_K27_E2.4171.00
171_D331_R2.4091.00
55_L81_I2.4061.00
236_A239_E2.3801.00
207_Y229_E2.3261.00
239_E243_Q2.3221.00
109_L233_S2.3111.00
203_I250_A2.2281.00
238_M263_L2.1751.00
23_A27_E2.1501.00
114_S235_S2.1321.00
321_H357_K2.1101.00
360_K363_G2.1021.00
7_L35_V2.0961.00
50_D54_D2.0781.00
205_T229_E2.0731.00
258_G265_V2.0601.00
299_T345_D2.0360.99
208_S234_T2.0080.99
193_L238_M1.9950.99
16_A20_K1.9930.99
197_T264_Q1.9920.99
10_L35_V1.9580.99
307_Q313_E1.9510.99
6_P9_A1.9050.99
346_I355_M1.9040.99
22_L59_L1.8650.99
13_K34_E1.8590.99
325_M346_I1.8580.99
19_E62_L1.8520.99
60_I74_T1.8360.99
299_T375_Y1.8270.99
111_P233_S1.8190.99
109_L116_S1.8100.99
194_V198_T1.8090.99
22_L62_L1.7870.99
208_S212_P1.7770.98
13_K16_A1.7680.98
221_N228_I1.7450.98
143_F154_A1.7140.98
22_L73_I1.6790.98
53_R57_E1.6560.98
117_H256_A1.6550.98
207_Y249_V1.6520.98
140_A175_H1.6390.97
314_A366_T1.6170.97
321_H361_E1.6080.97
108_F135_G1.5460.96
149_G285_R1.5410.96
183_E297_K1.5360.96
213_F228_I1.5320.96
190_H211_Q1.5320.96
124_A153_Y1.5240.96
304_T310_A1.5160.96
163_S166_I1.5150.96
147_E176_T1.4920.96
21_L68_L1.4900.95
205_T246_S1.4900.95
82_E85_V1.4830.95
120_A133_E1.4740.95
313_E319_R1.4340.94
189_D271_A1.4300.94
6_P34_E1.4270.94
232_E236_A1.4220.94
30_E33_V1.4090.94
190_H216_C1.4060.94
47_R85_V1.3970.94
188_I261_Y1.3910.93
10_L38_A1.3900.93
8_L12_E1.3870.93
180_I375_Y1.3820.93
321_H325_M1.3730.93
30_E34_E1.3620.93
116_S168_D1.3610.93
109_L114_S1.3540.92
17_L24_L1.3380.92
9_A12_E1.3370.92
143_F156_V1.3340.92
190_H212_P1.3330.92
325_M344_L1.3330.92
58_R62_L1.3300.92
163_S214_Q1.3150.91
56_L74_T1.3130.91
105_R132_I1.3120.91
123_Y282_V1.3120.91
196_G264_Q1.3030.91
298_T374_C1.2950.91
25_L76_L1.2950.91
325_M358_A1.2840.90
140_A144_N1.2800.90
55_L59_L1.2760.90
194_V266_L1.2720.90
219_F267_E1.2690.90
195_S247_P1.2560.89
202_T247_P1.2530.89
147_E177_S1.2520.89
46_V85_V1.2500.89
32_A84_S1.2430.89
59_L73_I1.2420.89
198_T264_Q1.2390.89
306_Q324_I1.2390.89
27_E30_E1.2330.88
107_A136_C1.2260.88
318_L346_I1.2200.88
144_N148_T1.2060.87
324_I347_Q1.1980.87
305_G310_A1.1960.87
108_F112_K1.1940.87
139_F172_L1.1870.86
37_K41_L1.1730.86
191_C255_E1.1620.85
21_L31_L1.1550.85
313_E316_L1.1550.85
336_N339_E1.1420.84
233_S236_A1.1300.84
25_L73_I1.1220.83
198_T202_T1.1150.83
246_S249_V1.1150.83
26_A63_G1.1120.83
76_L80_I1.1040.82
173_L301_L1.1030.82
39_K51_R1.1020.82
156_V169_V1.0960.82
306_Q339_E1.0920.81
124_A282_V1.0910.81
206_V213_F1.0840.81
199_D264_Q1.0830.81
185_T277_F1.0720.80
123_Y182_G1.0690.80
193_L263_L1.0690.80
345_D372_L1.0660.80
210_P231_T1.0570.79
146_V283_L1.0390.78
59_L85_V1.0340.78
118_L254_S1.0320.78
253_G310_A1.0270.77
136_C150_Q1.0250.77
282_V359_L1.0210.77
139_F169_V1.0190.77
160_N276_N1.0170.77
105_R151_A1.0160.76
145_Q150_Q1.0100.76
193_L261_Y1.0070.76
73_I76_L1.0030.76
36_G165_A1.0010.75
206_V224_P0.9940.75
217_S221_N0.9880.74
197_T266_L0.9850.74
207_Y246_S0.9780.74
54_D291_S0.9730.73
255_E259_T0.9720.73
326_T346_I0.9720.73
11_R51_R0.9700.73
188_I313_E0.9700.73
194_V264_Q0.9680.73
13_K31_L0.9580.72
15_S51_R0.9570.72
180_I281_V0.9520.72
223_Y226_W0.9480.71
63_G67_H0.9470.71
325_M330_S0.9420.71
345_D375_Y0.9410.71
56_L60_I0.9370.70
59_L62_L0.9320.70
175_H218_K0.9270.70
348_A355_M0.9230.69
318_L358_A0.9210.69
118_L256_A0.9200.69
311_L328_L0.9200.69
287_A350_L0.9180.69
26_A65_A0.9140.69
146_V154_A0.9110.68
10_L34_E0.9050.68
114_S233_S0.9040.68
318_L362_L0.9040.68
273_Q343_Y0.9040.68
329_E345_D0.8990.67
113_G117_H0.8990.67
179_S287_A0.8950.67
112_K117_H0.8900.66
57_E61_T0.8900.66
312_V316_L0.8890.66
234_T324_I0.8880.66
48_D81_I0.8820.66
347_Q377_S0.8800.66
166_I237_A0.8790.65
240_K246_S0.8780.65
188_I254_S0.8760.65
80_I83_D0.8760.65
6_P38_A0.8740.65
31_L35_V0.8720.65
218_K272_N0.8700.65
16_A27_E0.8690.65
168_D209_H0.8690.65
134_S151_A0.8660.64
190_H276_N0.8650.64
174_Q341_M0.8640.64
146_V178_L0.8640.64
193_L258_G0.8630.64
38_A42_S0.8630.64
33_V37_K0.8580.64
302_M314_A0.8530.63
216_C252_L0.8420.62
112_K161_T0.8400.62
36_G75_R0.8390.62
290_V351_E0.8340.61
238_M306_Q0.8340.61
328_L335_G0.8330.61
12_E16_A0.8330.61
160_N278_T0.8310.61
25_L80_I0.8300.61
207_Y213_F0.8280.61
206_V330_S0.8260.61
193_L265_V0.8180.60
26_A64_K0.8170.60
191_C269_I0.8150.60
312_V365_I0.8120.59
345_D358_A0.8120.59
29_R84_S0.8090.59
296_A349_N0.8090.59
188_I202_T0.8070.59
84_S156_V0.8070.59
330_S339_E0.8050.59
19_E58_R0.8050.59
231_T236_A0.7990.58
333_I341_M0.7970.58
321_H358_A0.7950.58
349_N374_C0.7940.58
26_A67_H0.7910.57
44_R48_D0.7900.57
296_A374_C0.7870.57
272_N374_C0.7760.56
131_F145_Q0.7740.56
11_R52_E0.7740.56
204_N246_S0.7690.55
210_P230_Y0.7670.55
213_F230_Y0.7660.55
308_A325_M0.7640.55
219_F223_Y0.7610.54
22_L63_G0.7550.54
229_E249_V0.7540.54
303_A368_S0.7520.53
198_T246_S0.7510.53
253_G338_W0.7470.53
115_Y187_T0.7440.53
102_H105_R0.7420.53
118_L122_Q0.7410.52
180_I372_L0.7400.52
20_K24_L0.7400.52
295_P377_S0.7390.52
35_V39_K0.7370.52
159_E340_E0.7370.52
197_T246_S0.7350.52
109_L235_S0.7340.52
55_L58_R0.7280.51
35_V51_R0.7270.51
116_S339_E0.7250.51
29_R48_D0.7230.51
361_E365_I0.7210.50
11_R39_K0.7200.50
204_N227_K0.7200.50
191_C265_V0.7190.50
140_A168_D0.7180.50
332_P340_E0.7160.50
155_V226_W0.7150.50
115_Y211_Q0.7130.50
165_A329_E0.7120.50
25_L206_V0.7100.49
39_K52_E0.7100.49
201_S285_R0.7080.49
166_I212_P0.7050.49
22_L58_R0.7050.49
193_L251_A0.7040.49
117_H121_R0.7030.49
8_L22_L0.6980.48
348_A352_S0.6960.48
167_N237_A0.6960.48
231_T240_K0.6960.48
108_F338_W0.6960.48
215_Q276_N0.6930.48
181_V284_A0.6930.48
23_A243_Q0.6930.48
257_G340_E0.6920.48
289_N351_E0.6910.47
153_Y288_I0.6900.47
40_L46_V0.6900.47
241_V247_P0.6880.47
78_Q85_V0.6880.47
56_L77_F0.6850.47
78_Q82_E0.6850.47
162_S169_V0.6850.47
105_R152_D0.6830.47
17_L155_V0.6810.47
24_L328_L0.6780.46
205_T249_V0.6770.46
123_Y338_W0.6760.46
111_P236_A0.6750.46
311_L324_I0.6750.46
156_V275_Q0.6740.46
187_T271_A0.6710.46
153_Y181_V0.6700.45
81_I141_D0.6700.45
215_Q278_T0.6690.45
174_Q301_L0.6690.45
117_H314_A0.6660.45
37_K40_L0.6650.45
79_L82_E0.6650.45
349_N352_S0.6650.45
200_L219_F0.6640.45
15_S55_L0.6640.45
304_T314_A0.6620.45
36_G46_V0.6610.45
84_S182_G0.6610.45
182_G327_R0.6600.44
243_Q246_S0.6600.44
175_H370_K0.6550.44
297_K326_T0.6530.44
212_P254_S0.6530.44
160_N215_Q0.6520.44
355_M358_A0.6510.44
168_D217_S0.6490.43
191_C268_R0.6480.43
10_L218_K0.6480.43
188_I276_N0.6470.43
317_V361_E0.6470.43
139_F170_Y0.6460.43
306_Q333_I0.6460.43
299_T355_M0.6450.43
60_I70_A0.6450.43
193_L222_R0.6440.43
76_L133_E0.6430.43
117_H236_A0.6430.43
297_K345_D0.6430.43
7_L11_R0.6380.42
301_L308_A0.6370.42
173_L283_L0.6360.42
48_D55_L0.6340.42
19_E23_A0.6330.42
133_E166_I0.6320.42
196_G262_G0.6320.42
218_K222_R0.6320.42
114_S163_S0.6310.42
206_V226_W0.6300.42
68_L72_Y0.6280.41
124_A348_A0.6270.41
198_T247_P0.6260.41
200_L267_E0.6250.41
352_S355_M0.6240.41
323_L346_I0.6220.41
331_R338_W0.6170.40
277_F337_P0.6170.40
168_D272_N0.6170.40
36_G77_F0.6160.40
208_S213_F0.6160.40
301_L368_S0.6150.40
197_T248_H0.6140.40
108_F255_E0.6120.40
241_V246_S0.6070.39
194_V197_T0.6060.39
294_V349_N0.6040.39
85_V123_Y0.6030.39
352_S374_C0.6020.39
125_A183_E0.6000.39
27_E34_E0.5990.39
257_G297_K0.5980.39
21_L43_H0.5960.38
6_P41_L0.5950.38
120_A155_V0.5940.38
235_S261_Y0.5920.38
169_V352_S0.5920.38
357_K361_E0.5910.38
37_K120_A0.5900.38
115_Y337_P0.5900.38
136_C145_Q0.5860.37
143_F283_L0.5860.37
49_I53_R0.5850.37
131_F154_A0.5850.37
206_V318_L0.5840.37
142_I283_L0.5840.37
11_R14_I0.5840.37
215_Q280_F0.5810.37
327_R344_L0.5810.37
195_S242_A0.5790.37
46_V165_A0.5760.37
170_Y329_E0.5750.36
192_L197_T0.5740.36
21_L202_T0.5730.36
205_T248_H0.5730.36
255_E265_V0.5730.36
14_I32_A0.5720.36
353_A356_Q0.5710.36
127_H170_Y0.5700.36
73_I77_F0.5690.36
29_R85_V0.5660.36
35_V46_V0.5660.36
319_R330_S0.5650.36
16_A19_E0.5650.36
12_E19_E0.5650.36
55_L79_L0.5650.36
63_G80_I0.5650.36
112_K260_L0.5640.35
356_Q360_K0.5640.35
255_E264_Q0.5630.35
158_I235_S0.5630.35
182_G338_W0.5620.35
120_A131_F0.5620.35
168_D281_V0.5620.35
165_A168_D0.5620.35
209_H276_N0.5610.35
300_L355_M0.5610.35
291_S294_V0.5600.35
208_S278_T0.5560.35
70_A351_E0.5560.35
162_S211_Q0.5560.35
173_L281_V0.5550.35
175_H346_I0.5550.35
35_V47_R0.5540.35
238_M340_E0.5540.35
29_R82_E0.5540.35
203_I313_E0.5510.34
365_I369_M0.5490.34
318_L322_N0.5490.34
309_G315_L0.5490.34
53_R62_L0.5490.34
37_K351_E0.5480.34
167_N327_R0.5460.34
36_G40_L0.5450.34
195_S246_S0.5450.34
7_L51_R0.5440.34
14_I39_K0.5430.34
211_Q276_N0.5430.34
291_S349_N0.5430.34
217_S328_L0.5420.33
225_H262_G0.5410.33
229_E235_S0.5400.33
48_D86_L0.5400.33
50_D301_L0.5360.33
120_A226_W0.5360.33
12_E20_K0.5360.33
168_D173_L0.5340.33
8_L212_P0.5340.33
108_F131_F0.5340.33
243_Q266_L0.5330.33
220_L270_E0.5320.33
259_T277_F0.5320.33
189_D269_I0.5320.33
229_E240_K0.5290.32
116_S233_S0.5280.32
218_K221_N0.5270.32
209_H328_L0.5270.32
188_I280_F0.5270.32
139_F271_A0.5260.32
72_Y75_R0.5260.32
112_K239_E0.5250.32
227_K239_E0.5230.32
179_S286_K0.5230.32
272_N334_H0.5230.32
218_K282_V0.5230.32
108_F133_E0.5220.32
160_N188_I0.5220.32
217_S311_L0.5210.32
158_I287_A0.5200.32
55_L62_L0.5200.32
11_R81_I0.5190.31
22_L65_A0.5180.31
122_Q184_M0.5170.31
188_I212_P0.5160.31
165_A345_D0.5160.31
190_H254_S0.5160.31
45_P60_I0.5150.31
19_E55_L0.5150.31
141_D223_Y0.5140.31
141_D144_N0.5140.31
194_V249_V0.5140.31
46_V102_H0.5140.31
52_E56_L0.5130.31
297_K327_R0.5130.31
181_V277_F0.5120.31
31_L181_V0.5100.31
9_A13_K0.5100.31
146_V174_Q0.5100.31
15_S39_K0.5090.31
135_G326_T0.5090.31
262_G371_V0.5090.31
154_A173_L0.5080.31
314_A317_V0.5080.31
298_T323_L0.5080.31
136_C141_D0.5080.31
78_Q146_V0.5070.30
287_A306_Q0.5060.30
282_V330_S0.5060.30
32_A182_G0.5060.30
82_E92_L0.5050.30
171_D332_P0.5050.30
35_V260_L0.5040.30
136_C172_L0.5040.30
79_L125_A0.5030.30
314_A355_M0.5030.30
106_I257_G0.5020.30
109_L298_T0.5020.30
139_F143_F0.5010.30
243_Q307_Q0.5010.30
105_R134_S0.5000.30
38_A41_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qmxA 3 0.7021 100 0.3 Contact Map
3mwbA 3 0.7254 100 0.306 Contact Map
4lubA 2 0.487 100 0.314 Contact Map
3luyA 2 0.7254 100 0.328 Contact Map
2qmwA 2 0.6813 100 0.332 Contact Map
1phzA 2 0.2694 100 0.795 Contact Map
2mdaA 2 0.2358 99.9 0.822 Contact Map
1ecmA 3 0.2487 99.9 0.824 Contact Map
3nvtA 4 0.8057 99.9 0.826 Contact Map
3rmiA 2 0.2591 99.8 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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