PHEA - ECOLI - GREMLIN Contacts

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PHEA - P-protein

UniProt:	P0A9J8	Sequences: MTSENPLLALREKISALDEKLLALLAERRELAVEVGKAKLLSHRPVRDIDRERDLLERLITLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQHLNKINPHSARIAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENTSSGAINDVYDLLQHTSLSIVGEMTLTIDHCLLVSGTTDLSTINTVYSHPQPFQQCSKFLNRYPHWKIEYTESTSAAMEKVAQAKSPHVAALGSEAGGTLYGLQVLERIEANQRQNFTRFVVLARKAINVSDQVPAKTTLLMATGQQAGALVEALLVLRNHNLIMTRLESRPIHGNPWEEMFYLDIQANLESAEMQKALKELGEITRSMKVLGCYPSENVVPVDPT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10707
Length:	386 (351)
Sequences:	1264 (865)
Seq/√Len:	46.1

ECOLI - PHEA
BACSU - PHEA
HALSA - Q9HN73
SULSO - Q980P2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_K	27_E	4.704	1.00
302_M	344_L	4.095	1.00
20_K	23_A	4.069	1.00
252_L	270_E	3.971	1.00
142_I	154_A	3.666	1.00
115_Y	190_H	3.389	1.00
316_L	320_N	3.316	1.00
10_L	31_L	3.202	1.00
193_L	253_G	3.181	1.00
300_L	346_I	3.116	1.00
255_E	268_R	3.061	1.00
204_N	248_H	2.992	1.00
199_D	202_T	2.943	1.00
320_N	361_E	2.867	1.00
34_E	37_K	2.713	1.00
205_T	227_K	2.639	1.00
212_P	234_T	2.617	1.00
17_L	31_L	2.611	1.00
107_A	151_A	2.598	1.00
217_S	272_N	2.593	1.00
154_A	283_L	2.514	1.00
318_L	325_M	2.468	1.00
20_K	27_E	2.417	1.00
171_D	331_R	2.409	1.00
55_L	81_I	2.406	1.00
236_A	239_E	2.380	1.00
207_Y	229_E	2.326	1.00
239_E	243_Q	2.322	1.00
109_L	233_S	2.311	1.00
203_I	250_A	2.228	1.00
238_M	263_L	2.175	1.00
23_A	27_E	2.150	1.00
114_S	235_S	2.132	1.00
321_H	357_K	2.110	1.00
360_K	363_G	2.102	1.00
7_L	35_V	2.096	1.00
50_D	54_D	2.078	1.00
205_T	229_E	2.073	1.00
258_G	265_V	2.060	1.00
299_T	345_D	2.036	0.99
208_S	234_T	2.008	0.99
193_L	238_M	1.995	0.99
16_A	20_K	1.993	0.99
197_T	264_Q	1.992	0.99
10_L	35_V	1.958	0.99
307_Q	313_E	1.951	0.99
6_P	9_A	1.905	0.99
346_I	355_M	1.904	0.99
22_L	59_L	1.865	0.99
13_K	34_E	1.859	0.99
325_M	346_I	1.858	0.99
19_E	62_L	1.852	0.99
60_I	74_T	1.836	0.99
299_T	375_Y	1.827	0.99
111_P	233_S	1.819	0.99
109_L	116_S	1.810	0.99
194_V	198_T	1.809	0.99
22_L	62_L	1.787	0.99
208_S	212_P	1.777	0.98
13_K	16_A	1.768	0.98
221_N	228_I	1.745	0.98
143_F	154_A	1.714	0.98
22_L	73_I	1.679	0.98
53_R	57_E	1.656	0.98
117_H	256_A	1.655	0.98
207_Y	249_V	1.652	0.98
140_A	175_H	1.639	0.97
314_A	366_T	1.617	0.97
321_H	361_E	1.608	0.97
108_F	135_G	1.546	0.96
149_G	285_R	1.541	0.96
183_E	297_K	1.536	0.96
213_F	228_I	1.532	0.96
190_H	211_Q	1.532	0.96
124_A	153_Y	1.524	0.96
304_T	310_A	1.516	0.96
163_S	166_I	1.515	0.96
147_E	176_T	1.492	0.96
21_L	68_L	1.490	0.95
205_T	246_S	1.490	0.95
82_E	85_V	1.483	0.95
120_A	133_E	1.474	0.95
313_E	319_R	1.434	0.94
189_D	271_A	1.430	0.94
6_P	34_E	1.427	0.94
232_E	236_A	1.422	0.94
30_E	33_V	1.409	0.94
190_H	216_C	1.406	0.94
47_R	85_V	1.397	0.94
188_I	261_Y	1.391	0.93
10_L	38_A	1.390	0.93
8_L	12_E	1.387	0.93
180_I	375_Y	1.382	0.93
321_H	325_M	1.373	0.93
30_E	34_E	1.362	0.93
116_S	168_D	1.361	0.93
109_L	114_S	1.354	0.92
17_L	24_L	1.338	0.92
9_A	12_E	1.337	0.92
143_F	156_V	1.334	0.92
190_H	212_P	1.333	0.92
325_M	344_L	1.333	0.92
58_R	62_L	1.330	0.92
163_S	214_Q	1.315	0.91
56_L	74_T	1.313	0.91
105_R	132_I	1.312	0.91
123_Y	282_V	1.312	0.91
196_G	264_Q	1.303	0.91
298_T	374_C	1.295	0.91
25_L	76_L	1.295	0.91
325_M	358_A	1.284	0.90
140_A	144_N	1.280	0.90
55_L	59_L	1.276	0.90
194_V	266_L	1.272	0.90
219_F	267_E	1.269	0.90
195_S	247_P	1.256	0.89
202_T	247_P	1.253	0.89
147_E	177_S	1.252	0.89
46_V	85_V	1.250	0.89
32_A	84_S	1.243	0.89
59_L	73_I	1.242	0.89
198_T	264_Q	1.239	0.89
306_Q	324_I	1.239	0.89
27_E	30_E	1.233	0.88
107_A	136_C	1.226	0.88
318_L	346_I	1.220	0.88
144_N	148_T	1.206	0.87
324_I	347_Q	1.198	0.87
305_G	310_A	1.196	0.87
108_F	112_K	1.194	0.87
139_F	172_L	1.187	0.86
37_K	41_L	1.173	0.86
191_C	255_E	1.162	0.85
21_L	31_L	1.155	0.85
313_E	316_L	1.155	0.85
336_N	339_E	1.142	0.84
233_S	236_A	1.130	0.84
25_L	73_I	1.122	0.83
198_T	202_T	1.115	0.83
246_S	249_V	1.115	0.83
26_A	63_G	1.112	0.83
76_L	80_I	1.104	0.82
173_L	301_L	1.103	0.82
39_K	51_R	1.102	0.82
156_V	169_V	1.096	0.82
306_Q	339_E	1.092	0.81
124_A	282_V	1.091	0.81
206_V	213_F	1.084	0.81
199_D	264_Q	1.083	0.81
185_T	277_F	1.072	0.80
123_Y	182_G	1.069	0.80
193_L	263_L	1.069	0.80
345_D	372_L	1.066	0.80
210_P	231_T	1.057	0.79
146_V	283_L	1.039	0.78
59_L	85_V	1.034	0.78
118_L	254_S	1.032	0.78
253_G	310_A	1.027	0.77
136_C	150_Q	1.025	0.77
282_V	359_L	1.021	0.77
139_F	169_V	1.019	0.77
160_N	276_N	1.017	0.77
105_R	151_A	1.016	0.76
145_Q	150_Q	1.010	0.76
193_L	261_Y	1.007	0.76
73_I	76_L	1.003	0.76
36_G	165_A	1.001	0.75
206_V	224_P	0.994	0.75
217_S	221_N	0.988	0.74
197_T	266_L	0.985	0.74
207_Y	246_S	0.978	0.74
54_D	291_S	0.973	0.73
255_E	259_T	0.972	0.73
326_T	346_I	0.972	0.73
11_R	51_R	0.970	0.73
188_I	313_E	0.970	0.73
194_V	264_Q	0.968	0.73
13_K	31_L	0.958	0.72
15_S	51_R	0.957	0.72
180_I	281_V	0.952	0.72
223_Y	226_W	0.948	0.71
63_G	67_H	0.947	0.71
325_M	330_S	0.942	0.71
345_D	375_Y	0.941	0.71
56_L	60_I	0.937	0.70
59_L	62_L	0.932	0.70
175_H	218_K	0.927	0.70
348_A	355_M	0.923	0.69
318_L	358_A	0.921	0.69
118_L	256_A	0.920	0.69
311_L	328_L	0.920	0.69
287_A	350_L	0.918	0.69
26_A	65_A	0.914	0.69
146_V	154_A	0.911	0.68
10_L	34_E	0.905	0.68
114_S	233_S	0.904	0.68
318_L	362_L	0.904	0.68
273_Q	343_Y	0.904	0.68
329_E	345_D	0.899	0.67
113_G	117_H	0.899	0.67
179_S	287_A	0.895	0.67
112_K	117_H	0.890	0.66
57_E	61_T	0.890	0.66
312_V	316_L	0.889	0.66
234_T	324_I	0.888	0.66
48_D	81_I	0.882	0.66
347_Q	377_S	0.880	0.66
166_I	237_A	0.879	0.65
240_K	246_S	0.878	0.65
188_I	254_S	0.876	0.65
80_I	83_D	0.876	0.65
6_P	38_A	0.874	0.65
31_L	35_V	0.872	0.65
218_K	272_N	0.870	0.65
16_A	27_E	0.869	0.65
168_D	209_H	0.869	0.65
134_S	151_A	0.866	0.64
190_H	276_N	0.865	0.64
174_Q	341_M	0.864	0.64
146_V	178_L	0.864	0.64
193_L	258_G	0.863	0.64
38_A	42_S	0.863	0.64
33_V	37_K	0.858	0.64
302_M	314_A	0.853	0.63
216_C	252_L	0.842	0.62
112_K	161_T	0.840	0.62
36_G	75_R	0.839	0.62
290_V	351_E	0.834	0.61
238_M	306_Q	0.834	0.61
328_L	335_G	0.833	0.61
12_E	16_A	0.833	0.61
160_N	278_T	0.831	0.61
25_L	80_I	0.830	0.61
207_Y	213_F	0.828	0.61
206_V	330_S	0.826	0.61
193_L	265_V	0.818	0.60
26_A	64_K	0.817	0.60
191_C	269_I	0.815	0.60
312_V	365_I	0.812	0.59
345_D	358_A	0.812	0.59
29_R	84_S	0.809	0.59
296_A	349_N	0.809	0.59
188_I	202_T	0.807	0.59
84_S	156_V	0.807	0.59
330_S	339_E	0.805	0.59
19_E	58_R	0.805	0.59
231_T	236_A	0.799	0.58
333_I	341_M	0.797	0.58
321_H	358_A	0.795	0.58
349_N	374_C	0.794	0.58
26_A	67_H	0.791	0.57
44_R	48_D	0.790	0.57
296_A	374_C	0.787	0.57
272_N	374_C	0.776	0.56
131_F	145_Q	0.774	0.56
11_R	52_E	0.774	0.56
204_N	246_S	0.769	0.55
210_P	230_Y	0.767	0.55
213_F	230_Y	0.766	0.55
308_A	325_M	0.764	0.55
219_F	223_Y	0.761	0.54
22_L	63_G	0.755	0.54
229_E	249_V	0.754	0.54
303_A	368_S	0.752	0.53
198_T	246_S	0.751	0.53
253_G	338_W	0.747	0.53
115_Y	187_T	0.744	0.53
102_H	105_R	0.742	0.53
118_L	122_Q	0.741	0.52
180_I	372_L	0.740	0.52
20_K	24_L	0.740	0.52
295_P	377_S	0.739	0.52
35_V	39_K	0.737	0.52
159_E	340_E	0.737	0.52
197_T	246_S	0.735	0.52
109_L	235_S	0.734	0.52
55_L	58_R	0.728	0.51
35_V	51_R	0.727	0.51
116_S	339_E	0.725	0.51
29_R	48_D	0.723	0.51
361_E	365_I	0.721	0.50
11_R	39_K	0.720	0.50
204_N	227_K	0.720	0.50
191_C	265_V	0.719	0.50
140_A	168_D	0.718	0.50
332_P	340_E	0.716	0.50
155_V	226_W	0.715	0.50
115_Y	211_Q	0.713	0.50
165_A	329_E	0.712	0.50
25_L	206_V	0.710	0.49
39_K	52_E	0.710	0.49
201_S	285_R	0.708	0.49
166_I	212_P	0.705	0.49
22_L	58_R	0.705	0.49
193_L	251_A	0.704	0.49
117_H	121_R	0.703	0.49
8_L	22_L	0.698	0.48
348_A	352_S	0.696	0.48
167_N	237_A	0.696	0.48
231_T	240_K	0.696	0.48
108_F	338_W	0.696	0.48
215_Q	276_N	0.693	0.48
181_V	284_A	0.693	0.48
23_A	243_Q	0.693	0.48
257_G	340_E	0.692	0.48
289_N	351_E	0.691	0.47
153_Y	288_I	0.690	0.47
40_L	46_V	0.690	0.47
241_V	247_P	0.688	0.47
78_Q	85_V	0.688	0.47
56_L	77_F	0.685	0.47
78_Q	82_E	0.685	0.47
162_S	169_V	0.685	0.47
105_R	152_D	0.683	0.47
17_L	155_V	0.681	0.47
24_L	328_L	0.678	0.46
205_T	249_V	0.677	0.46
123_Y	338_W	0.676	0.46
111_P	236_A	0.675	0.46
311_L	324_I	0.675	0.46
156_V	275_Q	0.674	0.46
187_T	271_A	0.671	0.46
153_Y	181_V	0.670	0.45
81_I	141_D	0.670	0.45
215_Q	278_T	0.669	0.45
174_Q	301_L	0.669	0.45
117_H	314_A	0.666	0.45
37_K	40_L	0.665	0.45
79_L	82_E	0.665	0.45
349_N	352_S	0.665	0.45
200_L	219_F	0.664	0.45
15_S	55_L	0.664	0.45
304_T	314_A	0.662	0.45
36_G	46_V	0.661	0.45
84_S	182_G	0.661	0.45
182_G	327_R	0.660	0.44
243_Q	246_S	0.660	0.44
175_H	370_K	0.655	0.44
297_K	326_T	0.653	0.44
212_P	254_S	0.653	0.44
160_N	215_Q	0.652	0.44
355_M	358_A	0.651	0.44
168_D	217_S	0.649	0.43
191_C	268_R	0.648	0.43
10_L	218_K	0.648	0.43
188_I	276_N	0.647	0.43
317_V	361_E	0.647	0.43
139_F	170_Y	0.646	0.43
306_Q	333_I	0.646	0.43
299_T	355_M	0.645	0.43
60_I	70_A	0.645	0.43
193_L	222_R	0.644	0.43
76_L	133_E	0.643	0.43
117_H	236_A	0.643	0.43
297_K	345_D	0.643	0.43
7_L	11_R	0.638	0.42
301_L	308_A	0.637	0.42
173_L	283_L	0.636	0.42
48_D	55_L	0.634	0.42
19_E	23_A	0.633	0.42
133_E	166_I	0.632	0.42
196_G	262_G	0.632	0.42
218_K	222_R	0.632	0.42
114_S	163_S	0.631	0.42
206_V	226_W	0.630	0.42
68_L	72_Y	0.628	0.41
124_A	348_A	0.627	0.41
198_T	247_P	0.626	0.41
200_L	267_E	0.625	0.41
352_S	355_M	0.624	0.41
323_L	346_I	0.622	0.41
331_R	338_W	0.617	0.40
277_F	337_P	0.617	0.40
168_D	272_N	0.617	0.40
36_G	77_F	0.616	0.40
208_S	213_F	0.616	0.40
301_L	368_S	0.615	0.40
197_T	248_H	0.614	0.40
108_F	255_E	0.612	0.40
241_V	246_S	0.607	0.39
194_V	197_T	0.606	0.39
294_V	349_N	0.604	0.39
85_V	123_Y	0.603	0.39
352_S	374_C	0.602	0.39
125_A	183_E	0.600	0.39
27_E	34_E	0.599	0.39
257_G	297_K	0.598	0.39
21_L	43_H	0.596	0.38
6_P	41_L	0.595	0.38
120_A	155_V	0.594	0.38
235_S	261_Y	0.592	0.38
169_V	352_S	0.592	0.38
357_K	361_E	0.591	0.38
37_K	120_A	0.590	0.38
115_Y	337_P	0.590	0.38
136_C	145_Q	0.586	0.37
143_F	283_L	0.586	0.37
49_I	53_R	0.585	0.37
131_F	154_A	0.585	0.37
206_V	318_L	0.584	0.37
142_I	283_L	0.584	0.37
11_R	14_I	0.584	0.37
215_Q	280_F	0.581	0.37
327_R	344_L	0.581	0.37
195_S	242_A	0.579	0.37
46_V	165_A	0.576	0.37
170_Y	329_E	0.575	0.36
192_L	197_T	0.574	0.36
21_L	202_T	0.573	0.36
205_T	248_H	0.573	0.36
255_E	265_V	0.573	0.36
14_I	32_A	0.572	0.36
353_A	356_Q	0.571	0.36
127_H	170_Y	0.570	0.36
73_I	77_F	0.569	0.36
29_R	85_V	0.566	0.36
35_V	46_V	0.566	0.36
319_R	330_S	0.565	0.36
16_A	19_E	0.565	0.36
12_E	19_E	0.565	0.36
55_L	79_L	0.565	0.36
63_G	80_I	0.565	0.36
112_K	260_L	0.564	0.35
356_Q	360_K	0.564	0.35
255_E	264_Q	0.563	0.35
158_I	235_S	0.563	0.35
182_G	338_W	0.562	0.35
120_A	131_F	0.562	0.35
168_D	281_V	0.562	0.35
165_A	168_D	0.562	0.35
209_H	276_N	0.561	0.35
300_L	355_M	0.561	0.35
291_S	294_V	0.560	0.35
208_S	278_T	0.556	0.35
70_A	351_E	0.556	0.35
162_S	211_Q	0.556	0.35
173_L	281_V	0.555	0.35
175_H	346_I	0.555	0.35
35_V	47_R	0.554	0.35
238_M	340_E	0.554	0.35
29_R	82_E	0.554	0.35
203_I	313_E	0.551	0.34
365_I	369_M	0.549	0.34
318_L	322_N	0.549	0.34
309_G	315_L	0.549	0.34
53_R	62_L	0.549	0.34
37_K	351_E	0.548	0.34
167_N	327_R	0.546	0.34
36_G	40_L	0.545	0.34
195_S	246_S	0.545	0.34
7_L	51_R	0.544	0.34
14_I	39_K	0.543	0.34
211_Q	276_N	0.543	0.34
291_S	349_N	0.543	0.34
217_S	328_L	0.542	0.33
225_H	262_G	0.541	0.33
229_E	235_S	0.540	0.33
48_D	86_L	0.540	0.33
50_D	301_L	0.536	0.33
120_A	226_W	0.536	0.33
12_E	20_K	0.536	0.33
168_D	173_L	0.534	0.33
8_L	212_P	0.534	0.33
108_F	131_F	0.534	0.33
243_Q	266_L	0.533	0.33
220_L	270_E	0.532	0.33
259_T	277_F	0.532	0.33
189_D	269_I	0.532	0.33
229_E	240_K	0.529	0.32
116_S	233_S	0.528	0.32
218_K	221_N	0.527	0.32
209_H	328_L	0.527	0.32
188_I	280_F	0.527	0.32
139_F	271_A	0.526	0.32
72_Y	75_R	0.526	0.32
112_K	239_E	0.525	0.32
227_K	239_E	0.523	0.32
179_S	286_K	0.523	0.32
272_N	334_H	0.523	0.32
218_K	282_V	0.523	0.32
108_F	133_E	0.522	0.32
160_N	188_I	0.522	0.32
217_S	311_L	0.521	0.32
158_I	287_A	0.520	0.32
55_L	62_L	0.520	0.32
11_R	81_I	0.519	0.31
22_L	65_A	0.518	0.31
122_Q	184_M	0.517	0.31
188_I	212_P	0.516	0.31
165_A	345_D	0.516	0.31
190_H	254_S	0.516	0.31
45_P	60_I	0.515	0.31
19_E	55_L	0.515	0.31
141_D	223_Y	0.514	0.31
141_D	144_N	0.514	0.31
194_V	249_V	0.514	0.31
46_V	102_H	0.514	0.31
52_E	56_L	0.513	0.31
297_K	327_R	0.513	0.31
181_V	277_F	0.512	0.31
31_L	181_V	0.510	0.31
9_A	13_K	0.510	0.31
146_V	174_Q	0.510	0.31
15_S	39_K	0.509	0.31
135_G	326_T	0.509	0.31
262_G	371_V	0.509	0.31
154_A	173_L	0.508	0.31
314_A	317_V	0.508	0.31
298_T	323_L	0.508	0.31
136_C	141_D	0.508	0.31
78_Q	146_V	0.507	0.30
287_A	306_Q	0.506	0.30
282_V	330_S	0.506	0.30
32_A	182_G	0.506	0.30
82_E	92_L	0.505	0.30
171_D	332_P	0.505	0.30
35_V	260_L	0.504	0.30
136_C	172_L	0.504	0.30
79_L	125_A	0.503	0.30
314_A	355_M	0.503	0.30
106_I	257_G	0.502	0.30
109_L	298_T	0.502	0.30
139_F	143_F	0.501	0.30
243_Q	307_Q	0.501	0.30
105_R	134_S	0.500	0.30
38_A	41_L	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qmxA	3	0.7021	100	0.3	Contact Map
3mwbA	3	0.7254	100	0.306	Contact Map
4lubA	2	0.487	100	0.314	Contact Map
3luyA	2	0.7254	100	0.328	Contact Map
2qmwA	2	0.6813	100	0.332	Contact Map
1phzA	2	0.2694	100	0.795	Contact Map
2mdaA	2	0.2358	99.9	0.822	Contact Map
1ecmA	3	0.2487	99.9	0.824	Contact Map
3nvtA	4	0.8057	99.9	0.826	Contact Map
3rmiA	2	0.2591	99.8	0.846	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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