GREMLIN Database
RBSK - Ribokinase
UniProt: P0A9J6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10818
Length: 309 (278)
Sequences: 22568 (16734)
Seq/√Len: 1003.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A263_T3.1041.00
74_R89_V2.6411.00
139_L164_A2.6051.00
59_A83_D2.4991.00
224_L230_W2.4931.00
231_A275_I2.4841.00
270_P273_E2.3301.00
264_A269_K2.3181.00
8_V135_A2.2761.00
66_D91_K2.2581.00
229_V257_F2.2551.00
154_K180_L2.1691.00
71_E89_V2.0941.00
63_C90_I2.0621.00
213_H232_S2.0531.00
51_A56_A2.0081.00
188_E224_L1.9771.00
9_V48_A1.9771.00
53_R80_D1.9371.00
156_A161_T1.9361.00
164_A262_I1.9271.00
264_A277_F1.9141.00
153_A163_V1.8941.00
256_T281_A1.8881.00
238_Q272_P1.8651.00
206_A237_G1.8331.00
49_V80_D1.8231.00
269_K273_E1.8051.00
162_I182_D1.7951.00
185_T258_N1.7941.00
78_A84_I1.7921.00
137_A162_I1.7911.00
267_E298_R1.7901.00
50_A259_G1.7541.00
209_A232_S1.7321.00
182_D218_R1.7021.00
229_V279_H1.6841.00
76_Q79_T1.6791.00
230_W239_R1.6531.00
231_A238_Q1.6441.00
63_C124_L1.6431.00
75_Q79_T1.6411.00
253_A286_V1.6411.00
282_A286_V1.6381.00
150_M176_E1.6381.00
137_A164_A1.6351.00
261_L274_A1.6321.00
74_R78_A1.6241.00
183_I219_T1.6181.00
272_P276_R1.6121.00
224_L239_R1.6121.00
260_A281_A1.6031.00
221_L261_L1.5571.00
211_V215_K1.5411.00
243_F280_A1.5391.00
150_M154_K1.5321.00
151_A154_K1.5291.00
155_I159_N1.5121.00
211_V214_E1.4961.00
219_T233_V1.4851.00
38_V72_S1.4761.00
249_D290_G1.4751.00
13_I62_A1.4711.00
240_V275_I1.4711.00
51_A263_T1.4711.00
231_A271_L1.4681.00
66_D71_E1.4671.00
71_E75_Q1.4531.00
137_A262_I1.4501.00
155_I158_Q1.4481.00
224_L227_R1.4431.00
7_L51_A1.4431.00
151_A155_I1.4421.00
233_V236_E1.4391.00
260_A277_F1.4381.00
40_F73_V1.4121.00
204_D207_K1.3801.00
162_I183_I1.3771.00
15_A72_S1.3761.00
167_P186_P1.3621.00
157_H182_D1.3561.00
166_N223_T1.3491.00
197_I211_V1.3391.00
133_A159_N1.3371.00
206_A210_Q1.3371.00
45_A77_L1.3331.00
66_D89_V1.3271.00
181_V184_I1.3261.00
157_H180_L1.3181.00
243_F276_R1.3161.00
245_V287_T1.3111.00
240_V279_H1.3101.00
210_Q214_E1.2991.00
70_G95_T1.2941.00
17_H36_Y1.2731.00
121_S124_L1.2661.00
57_N83_D1.2631.00
263_T267_E1.2591.00
76_Q80_D1.2501.00
40_F76_Q1.2441.00
74_R87_V1.2341.00
162_I218_R1.2261.00
229_V275_I1.2251.00
219_T261_L1.2251.00
219_T265_L1.2101.00
261_L265_L1.2081.00
224_L228_G1.1921.00
260_A278_A1.1921.00
122_P151_A1.1861.00
210_Q232_S1.1801.00
175_D215_K1.1801.00
72_S75_Q1.1731.00
264_A274_A1.1721.00
197_I207_K1.1711.00
219_T271_L1.1691.00
223_T257_F1.1611.00
243_F279_H1.1581.00
261_L278_A1.1571.00
52_G82_I1.1571.00
185_T223_T1.1561.00
17_H38_V1.1561.00
245_V286_V1.1451.00
273_E276_R1.1421.00
284_I287_T1.1411.00
284_I288_R1.1411.00
71_E74_R1.1401.00
54_S260_A1.1331.00
247_A286_V1.1261.00
243_F283_A1.1161.00
56_A266_L1.1051.00
191_A222_I1.1041.00
48_A58_I1.0981.00
232_S237_G1.0971.00
75_Q78_A1.0931.00
210_Q237_G1.0861.00
183_I261_L1.0861.00
154_K158_Q1.0851.00
51_A58_I1.0691.00
47_Q139_L1.0691.00
264_A267_E1.0681.00
138_L156_A1.0541.00
13_I73_V1.0541.00
109_V112_I1.0531.00
219_T231_A1.0421.00
49_V53_R1.0401.00
56_A267_E1.0391.00
68_S71_E1.0381.00
207_K210_Q1.0381.00
140_M163_V1.0371.00
183_I265_L1.0331.00
256_T285_A1.0331.00
188_E227_R1.0251.00
247_A250_T1.0191.00
139_L262_I1.0151.00
52_G81_N1.0141.00
90_I93_E1.0101.00
50_A256_T1.0051.00
209_A222_I1.0041.00
279_H282_A1.0031.00
9_V44_G1.0031.00
165_L181_V0.9921.00
185_T261_L0.9851.00
147_E151_A0.9821.00
242_G279_H0.9801.00
59_A135_A0.9791.00
191_A208_A0.9771.00
126_E151_A0.9741.00
65_G95_T0.9701.00
17_H69_I0.9631.00
261_L271_L0.9631.00
18_I39_A0.9621.00
138_L161_T0.9601.00
59_A86_P0.9591.00
274_A278_A0.9581.00
51_A259_G0.9581.00
40_F72_S0.9521.00
93_E119_A0.9501.00
72_S76_Q0.9491.00
64_T70_G0.9491.00
139_L258_N0.9431.00
276_R280_A0.9391.00
13_I45_A0.9371.00
120_L125_V0.9361.00
54_S281_A0.9351.00
64_T74_R0.9241.00
67_D95_T0.9221.00
74_R84_I0.9131.00
19_L99_L0.9121.00
140_M153_A0.9111.00
130_E133_A0.9081.00
263_T298_R0.9081.00
52_G57_N0.9071.00
13_I60_F0.9061.00
109_V113_H0.9051.00
59_A131_R0.9051.00
135_A161_T0.9041.00
263_T277_F0.9011.00
8_V61_I0.9011.00
17_H97_V0.9011.00
247_A287_T0.8991.00
236_E272_P0.8961.00
64_T87_V0.8961.00
195_T208_A0.8901.00
166_N185_T0.8821.00
188_E192_E0.8791.00
84_I87_V0.8711.00
154_K176_E0.8711.00
269_K277_F0.8691.00
33_G111_G0.8691.00
227_R239_R0.8681.00
207_K211_V0.8641.00
209_A220_V0.8621.00
179_A216_G0.8601.00
64_T89_V0.8591.00
10_L138_L0.8541.00
111_G114_A0.8501.00
187_N190_E0.8461.00
228_G242_G0.8431.00
248_V289_K0.8411.00
240_V276_R0.8391.00
265_L274_A0.8381.00
45_A292_Q0.8341.00
63_C88_S0.8321.00
176_E179_A0.8291.00
270_P274_A0.8271.00
238_Q275_I0.8261.00
90_I119_A0.8231.00
73_V95_T0.8171.00
88_S124_L0.8151.00
186_P191_A0.8141.00
148_S152_A0.8121.00
257_F279_H0.8111.00
66_D92_G0.8051.00
108_N112_I0.8031.00
47_Q258_N0.8011.00
213_H233_V0.8001.00
16_D41_G0.7981.00
7_L266_L0.7961.00
245_V283_A0.7951.00
166_N186_P0.7951.00
256_T282_A0.7941.00
260_A264_A0.7931.00
10_L152_A0.7901.00
14_N96_G0.7901.00
240_V272_P0.7861.00
256_T260_A0.7861.00
74_R88_S0.7841.00
233_V271_L0.7841.00
140_M149_V0.7811.00
210_Q213_H0.7781.00
132_I135_A0.7761.00
137_A266_L0.7731.00
178_L181_V0.7711.00
124_L127_A0.7691.00
120_L124_L0.7651.00
48_A60_F0.7611.00
38_V69_I0.7561.00
52_G58_I0.7551.00
206_A239_R0.7531.00
171_R175_D0.7521.00
164_A185_T0.7511.00
112_I115_G0.7511.00
280_A284_I0.7491.00
246_Q287_T0.7461.00
142_L165_L0.7441.00
150_M180_L0.7401.00
131_R135_A0.7391.00
8_V59_A0.7391.00
213_H234_N0.7331.00
279_H283_A0.7311.00
59_A85_T0.7301.00
209_A213_H0.7241.00
132_I161_T0.7241.00
277_F298_R0.7231.00
230_W237_G0.7231.00
15_A38_V0.7221.00
111_G115_G0.7191.00
282_A285_A0.7151.00
221_L231_A0.7141.00
15_A69_I0.7111.00
116_A119_A0.7091.00
153_A180_L0.7081.00
86_P131_R0.7031.00
49_V292_Q0.7001.00
69_I97_V0.6971.00
164_A183_I0.6951.00
233_V238_Q0.6931.00
107_E110_I0.6921.00
100_I110_I0.6901.00
146_L173_L0.6881.00
122_P147_E0.6861.00
76_Q292_Q0.6841.00
228_G239_R0.6831.00
27_P107_E0.6801.00
7_L137_A0.6781.00
257_F275_I0.6771.00
26_T29_E0.6761.00
110_I114_A0.6761.00
123_A126_E0.6731.00
54_S263_T0.6721.00
226_S244_R0.6711.00
43_K168_A0.6691.00
191_A212_L0.6631.00
37_Q289_K0.6601.00
101_F111_G0.6581.00
179_A215_K0.6571.00
80_D297_W0.6561.00
103_N107_E0.6561.00
205_A224_L0.6561.00
100_I251_I0.6541.00
257_F278_A0.6541.00
233_V237_G0.6531.00
175_D179_A0.6511.00
54_S277_F0.6491.00
206_A230_W0.6481.00
19_L36_Y0.6471.00
138_L152_A0.6461.00
205_A208_A0.6431.00
147_E150_M0.6411.00
146_L150_M0.6391.00
164_A258_N0.6371.00
269_K274_A0.6371.00
206_A232_S0.6361.00
131_R134_N0.6351.00
197_I208_A0.6311.00
257_F282_A0.6311.00
122_P126_E0.6311.00
85_T131_R0.6291.00
197_I204_D0.6211.00
229_V240_V0.6191.00
27_P103_N0.6151.00
41_G46_N0.6141.00
209_A237_G0.6131.00
48_A82_I0.6131.00
8_V131_R0.6091.00
206_A209_A0.6081.00
172_E175_D0.6041.00
101_F109_V0.6031.00
123_A127_A0.6021.00
139_L142_L0.6011.00
19_L33_G0.6001.00
122_P148_S0.6001.00
110_I113_H0.5991.00
275_I279_H0.5981.00
208_A212_L0.5961.00
156_A163_V0.5951.00
127_A155_I0.5941.00
191_A205_A0.5941.00
150_M153_A0.5941.00
62_A87_V0.5931.00
163_V181_V0.5921.00
240_V243_F0.5911.00
217_I220_V0.5901.00
57_N136_S0.5891.00
12_S143_E0.5861.00
57_N266_L0.5811.00
88_S127_A0.5791.00
184_I220_V0.5761.00
137_A183_I0.5741.00
71_E78_A0.5731.00
221_L257_F0.5721.00
213_H217_I0.5711.00
45_A60_F0.5691.00
136_S161_T0.5691.00
259_G263_T0.5681.00
189_T193_K0.5661.00
51_A262_I0.5591.00
54_S259_G0.5561.00
86_P89_V0.5551.00
47_Q262_I0.5541.00
152_A156_A0.5521.00
265_L268_E0.5511.00
216_G220_V0.5481.00
98_A112_I0.5471.00
273_E277_F0.5461.00
185_T221_L0.5421.00
67_D70_G0.5421.00
96_G117_N0.5391.00
122_P125_V0.5381.00
137_A265_L0.5381.00
251_I291_A0.5371.00
52_G80_D0.5351.00
127_A130_E0.5351.00
40_F292_Q0.5351.00
205_A209_A0.5341.00
114_A118_A0.5341.00
77_L82_I0.5341.00
170_A193_K0.5331.00
172_E176_E0.5331.00
225_G250_T0.5301.00
226_S247_A0.5291.00
108_N115_G0.5291.00
271_L274_A0.5291.00
68_S72_S0.5281.00
108_N113_H0.5271.00
213_H216_G0.5251.00
108_N114_A0.5241.00
30_T43_K0.5231.00
85_T88_S0.5231.00
166_N255_D0.5221.00
98_A101_F0.5211.00
136_S162_I0.5201.00
213_H235_G0.5171.00
139_L143_E0.5171.00
43_K143_E0.5151.00
109_V115_G0.5151.00
150_M173_L0.5141.00
182_D219_T0.5121.00
107_E113_H0.5121.00
12_S168_A0.5111.00
271_L275_I0.5101.00
46_N291_A0.5091.00
130_E134_N0.5091.00
188_E225_G0.5051.00
181_V217_I0.5031.00
32_T114_A0.5031.00
192_E203_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkdA 2 0.9903 100 0.155 Contact Map
2rbcA 2 0.9676 100 0.168 Contact Map
2fv7A 2 0.9806 100 0.177 Contact Map
4xdaA 2 0.9903 100 0.183 Contact Map
3ry7A 2 0.9741 100 0.183 Contact Map
1vm7A 2 0.9612 100 0.191 Contact Map
3vasA 1 0.9644 100 0.202 Contact Map
3ljsA 2 0.945 100 0.209 Contact Map
3kzhA 2 0.9871 100 0.211 Contact Map
3ikhA 2 0.9191 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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