GREMLIN Database
PANE - 2-dehydropantoate 2-reductase
UniProt: P0A9J4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13271
Length: 303 (288)
Sequences: 5002 (3872)
Seq/√Len: 228.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_R279_T4.5901.00
242_I250_R4.4801.00
268_A275_V4.0241.00
218_E271_H3.5161.00
4_T64_S2.9861.00
2_K25_E2.9231.00
16_L28_G2.9051.00
207_I281_L2.8051.00
214_V275_V2.7881.00
187_T243_S2.7451.00
265_L279_T2.6091.00
261_N278_N2.4941.00
267_R270_A2.4311.00
141_P146_D2.3941.00
258_D286_K2.3871.00
76_V97_H2.2581.00
68_L94_L2.2461.00
246_L250_R2.2381.00
218_E267_R2.2291.00
275_V279_T2.2151.00
66_L94_L2.2041.00
242_I246_L2.1411.00
191_N250_R2.1301.00
141_P148_D2.0181.00
18_A21_K1.9351.00
42_V128_V1.9281.00
33_P36_Y1.8871.00
3_I155_I1.8751.00
206_Q277_E1.8361.00
6_L79_A1.8301.00
8_C28_G1.8171.00
174_W215_I1.7931.00
207_I277_E1.7731.00
136_I164_A1.7561.00
168_N171_A1.7541.00
193_P196_E1.7391.00
140_G169_I1.6661.00
138_H166_H1.6491.00
191_N246_L1.6451.00
32_V35_P1.6451.00
178_A211_V1.6361.00
3_I66_L1.6191.00
43_E131_H1.6161.00
180_N184_N1.6121.00
188_A249_I1.5951.00
114_L149_Y1.5911.00
267_R271_H1.5821.00
274_A279_T1.5771.00
153_A157_Q1.5691.00
77_S105_E1.5641.00
96_I116_G1.5631.00
181_C211_V1.5611.00
13_Q129_I1.5501.00
282_F286_K1.5491.00
24_H158_T1.5461.00
33_P37_C1.5341.00
265_L275_V1.5331.00
66_L152_L1.5231.00
189_I284_M1.5001.00
125_D128_V1.4981.00
217_R273_I1.4791.00
150_S154_D1.4691.00
257_I285_V1.4631.00
87_L91_T1.4501.00
191_N288_K1.4451.00
255_T285_V1.4431.00
81_K109_I1.4381.00
258_D282_F1.4351.00
261_N282_F1.4331.00
214_V264_L1.4251.00
40_N128_V1.4121.00
205_M228_R1.4071.00
166_H172_E1.3911.00
195_G239_A1.3871.00
50_N53_L1.3611.00
84_A109_I1.3491.00
286_K289_E1.3471.00
15_W96_I1.3451.00
14_L122_A1.3421.00
203_E280_R1.3421.00
118_T137_T1.3371.00
265_L282_F1.3281.00
88_P91_T1.3161.00
146_D150_S1.3111.00
279_T283_E1.3051.00
185_P245_M1.2621.00
30_L35_P1.2531.00
77_S108_N1.2511.00
258_D266_R1.2451.00
92_P148_D1.2431.00
42_V47_S1.2361.00
249_I255_T1.2361.00
268_A273_I1.2331.00
76_V102_T1.2301.00
103_I173_L1.2251.00
149_Y165_W1.2221.00
205_M209_E1.2151.00
280_R284_M1.2111.00
192_C196_E1.2051.00
154_D157_Q1.2041.00
42_V130_I1.2011.00
78_D81_K1.1991.00
81_K84_A1.1991.00
77_S81_K1.1871.00
27_Q64_S1.1861.00
78_D82_S1.1801.00
101_G104_E1.1731.00
57_D60_F1.1661.00
92_P114_L1.1641.00
263_F266_R1.1591.00
4_T29_W1.1541.00
5_V68_L1.1471.00
211_V264_L1.1451.00
229_D232_M1.1451.00
100_M263_F1.1421.00
21_K48_I1.1321.00
255_T289_E1.1251.00
4_T67_L1.1201.00
153_A165_W1.1181.00
207_I278_N1.1161.00
73_A259_Y1.1111.00
32_V36_Y1.1091.00
154_D158_T1.1071.00
218_E270_A1.1061.00
217_R271_H1.1051.00
30_L36_Y1.0971.00
266_R270_A1.0961.00
52_S55_A1.0951.00
13_Q39_V1.0861.00
263_F267_R1.0861.00
117_T173_L1.0831.00
95_L106_L1.0721.00
58_P61_L1.0701.00
11_L70_T1.0661.00
147_G150_S1.0661.00
120_H131_H1.0621.00
184_N245_M1.0451.00
185_P261_N1.0421.00
107_Q110_Q1.0341.00
189_I288_K1.0321.00
203_E277_E1.0281.00
66_L92_P1.0181.00
11_L118_T1.0151.00
193_P240_E1.0111.00
141_P144_Q1.0081.00
51_E54_T1.0051.00
273_I276_P1.0031.00
223_S226_D1.0031.00
57_D61_L1.0021.00
94_L116_G1.0011.00
123_R132_V0.9951.00
171_A175_R0.9901.00
139_I153_A0.9891.00
151_Y154_D0.9881.00
228_R232_M0.9791.00
275_V278_N0.9761.00
141_P149_Y0.9761.00
38_S41_L0.9731.00
103_I107_Q0.9721.00
48_I51_E0.9611.00
34_Q126_G0.9561.00
76_V95_L0.9501.00
40_N47_S0.9481.00
74_W254_H0.9451.00
3_I24_H0.9421.00
8_C16_L0.9391.00
202_Q206_Q0.9361.00
157_Q163_V0.9341.00
179_V234_V0.9311.00
186_L197_L0.9281.00
176_K244_S0.9241.00
277_E280_R0.9211.00
190_W284_M0.9201.00
98_N176_K0.9201.00
69_V93_I0.9181.00
92_P152_L0.9181.00
190_W203_E0.9181.00
191_N249_I0.9181.00
61_L64_S0.9171.00
231_V235_I0.9131.00
43_E46_G0.9070.99
214_V268_A0.9060.99
6_L67_L0.9000.99
194_N241_N0.9000.99
5_V26_V0.8910.99
206_Q279_T0.8870.99
123_R130_I0.8830.99
182_V208_C0.8820.99
198_R235_I0.8800.99
229_D233_Q0.8790.99
138_H172_E0.8760.99
196_E199_H0.8750.99
2_K62_A0.8750.99
122_A129_I0.8740.99
123_R247_Q0.8700.99
4_T86_T0.8680.99
72_K248_D0.8590.99
261_N264_L0.8580.99
75_Q78_D0.8570.99
24_H155_I0.8560.99
147_G151_Y0.8540.99
175_R223_S0.8470.99
138_H164_A0.8460.99
22_Q159_V0.8420.99
92_P112_P0.8420.99
230_Y233_Q0.8420.99
268_A274_A0.8410.99
2_K63_T0.8390.99
101_G266_R0.8350.99
14_L120_H0.8340.99
247_Q251_A0.8290.99
72_K176_K0.8290.99
177_L264_L0.8250.99
68_L96_I0.8240.99
186_L204_I0.8210.99
15_W118_T0.8200.99
8_C13_Q0.8200.99
213_A216_E0.8130.99
177_L260_I0.8110.99
67_L87_L0.8070.99
67_L91_T0.8050.99
269_R275_V0.8040.99
258_D262_G0.8040.99
6_L71_L0.8030.99
184_N244_S0.8010.99
49_F52_S0.7960.99
183_I234_V0.7940.99
209_E213_A0.7920.99
9_G12_G0.7910.99
63_T91_T0.7900.99
212_A216_E0.7890.99
41_L48_I0.7890.99
280_R283_E0.7880.99
238_T241_N0.7860.99
202_Q205_M0.7840.98
104_E108_N0.7840.98
101_G263_F0.7800.98
152_L156_L0.7790.98
17_T41_L0.7780.98
284_M288_K0.7760.98
179_V183_I0.7750.98
73_A102_T0.7740.98
242_I247_Q0.7730.98
95_L102_T0.7710.98
121_A132_V0.7640.98
254_H289_E0.7570.98
211_V214_V0.7560.98
266_R269_R0.7560.98
184_N188_A0.7540.98
248_D256_E0.7540.98
81_K85_S0.7520.98
181_C278_N0.7510.98
262_G282_F0.7510.98
214_V273_I0.7500.98
63_T88_P0.7490.98
185_P188_A0.7480.98
69_V95_L0.7480.98
116_G137_T0.7450.98
67_L93_I0.7430.98
215_I222_T0.7360.98
213_A217_R0.7360.98
102_T106_L0.7330.98
244_S248_D0.7320.98
262_G266_R0.7310.98
34_Q37_C0.7300.98
105_E108_N0.7270.98
206_Q283_E0.7230.97
225_E229_D0.7200.97
183_I241_N0.7200.97
72_K244_S0.7200.97
121_A238_T0.7180.97
265_L278_N0.7170.97
5_V16_L0.7170.97
175_R226_D0.7160.97
187_T197_L0.7140.97
233_Q237_A0.7120.97
72_K256_E0.7100.97
183_I194_N0.7090.97
15_W68_L0.7080.97
107_Q142_A0.7060.97
64_S67_L0.7050.97
14_L131_H0.7040.97
139_I163_V0.6980.97
233_Q236_D0.6980.97
6_L29_W0.6980.97
180_N260_I0.6950.97
248_D253_R0.6940.97
185_P281_L0.6920.97
203_E284_M0.6900.97
249_I288_K0.6890.97
48_I52_S0.6880.97
18_A159_V0.6860.97
153_A163_V0.6830.96
194_N238_T0.6800.96
268_A276_P0.6780.96
184_N260_I0.6770.96
79_A82_S0.6710.96
80_V109_I0.6690.96
184_N247_Q0.6690.96
20_C23_G0.6690.96
65_D90_T0.6670.96
103_I115_M0.6670.96
4_T27_Q0.6650.96
166_H169_I0.6640.96
79_A83_L0.6620.96
30_L34_Q0.6620.96
49_F53_L0.6600.96
63_T90_T0.6580.96
195_G199_H0.6580.96
157_Q162_D0.6560.96
216_E221_H0.6560.96
124_R127_N0.6510.95
261_N265_L0.6490.95
97_H102_T0.6490.95
102_T173_L0.6470.95
208_C228_R0.6470.95
25_E54_T0.6440.95
213_A273_I0.6420.95
53_L56_N0.6400.95
52_S56_N0.6400.95
269_R274_A0.6370.95
199_H239_A0.6340.95
98_N244_S0.6320.95
115_M173_L0.6300.94
15_W137_T0.6280.94
115_M142_A0.6270.94
136_I162_D0.6270.94
218_E273_I0.6230.94
188_A255_T0.6220.94
170_R218_E0.6210.94
183_I235_I0.6210.94
213_A274_A0.6200.94
20_C28_G0.6200.94
17_T20_C0.6160.94
226_D229_D0.6150.94
100_M177_L0.6150.94
264_L278_N0.6150.94
209_E224_A0.6140.94
21_K49_F0.6140.94
40_N49_F0.6120.94
80_V106_L0.6120.94
104_E107_Q0.6120.94
6_L82_S0.6110.93
181_C260_I0.6100.93
178_A212_A0.6090.93
176_K248_D0.6080.93
264_L275_V0.6070.93
96_I118_T0.6070.93
94_L114_L0.6040.93
2_K65_D0.6040.93
27_Q54_T0.6040.93
139_I165_W0.5980.93
177_L180_N0.5960.93
124_R129_I0.5950.93
231_V234_V0.5940.93
114_L141_P0.5930.92
150_S165_W0.5930.92
14_L18_A0.5920.92
216_E224_A0.5920.92
176_K184_N0.5880.92
72_K98_N0.5880.92
13_Q28_G0.5880.92
186_L207_I0.5870.92
150_S153_A0.5860.92
142_A170_R0.5840.92
197_L204_I0.5830.92
170_R173_L0.5800.92
32_V37_C0.5800.92
178_A227_L0.5790.92
180_N244_S0.5750.91
188_A246_L0.5740.91
182_V186_L0.5720.91
87_L111_Q0.5710.91
15_W70_T0.5700.91
15_W18_A0.5690.91
14_L135_G0.5690.91
98_N256_E0.5680.91
180_N247_Q0.5660.91
71_L76_V0.5660.91
244_S256_E0.5650.91
31_R75_Q0.5640.90
98_N180_N0.5640.90
195_G240_E0.5610.90
117_T172_E0.5580.90
210_E276_P0.5570.90
188_A192_C0.5560.90
51_E55_A0.5550.90
264_L268_A0.5550.90
192_C197_L0.5550.90
194_N243_S0.5530.90
71_L75_Q0.5530.90
115_M140_G0.5530.90
20_C51_E0.5500.89
50_N54_T0.5500.89
118_T135_G0.5490.89
69_V106_L0.5410.89
73_A76_V0.5410.89
185_P285_V0.5410.89
121_A241_N0.5390.88
257_I286_K0.5390.88
37_C126_G0.5380.88
175_R230_Y0.5370.88
185_P207_I0.5360.88
40_N50_N0.5340.88
148_D151_Y0.5340.88
245_M248_D0.5340.88
245_M255_T0.5320.88
35_P55_A0.5280.87
96_I137_T0.5250.87
95_L113_L0.5240.87
2_K27_Q0.5230.87
8_C30_L0.5230.87
32_V126_G0.5210.87
249_I285_V0.5200.87
285_V289_E0.5180.86
139_I149_Y0.5180.86
120_H135_G0.5180.86
115_M169_I0.5170.86
204_I235_I0.5170.86
182_V185_P0.5140.86
187_T246_L0.5130.86
144_Q148_D0.5130.86
10_A124_R0.5110.86
89_V111_Q0.5100.86
75_Q254_H0.5080.85
101_G105_E0.5070.85
63_T89_V0.5040.85
9_G98_N0.5020.85
100_M173_L0.5020.85
193_P242_I0.5010.85
195_G246_L0.5000.84
197_L235_I0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ks9A 1 0.9604 100 0.368 Contact Map
3wfiA 2 0.9703 100 0.369 Contact Map
2ew2A 2 0.9703 100 0.377 Contact Map
3egoA 2 0.9241 100 0.415 Contact Map
3ghyA 2 0.9637 100 0.419 Contact Map
3hn2A 2 0.9571 100 0.419 Contact Map
3i83A 2 0.9835 100 0.42 Contact Map
3hwrA 2 0.9505 100 0.421 Contact Map
4ol9A 2 0.9406 100 0.422 Contact Map
2qytA 1 0.8779 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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