GREMLIN Database
RNG - Ribonuclease G
UniProt: P0A9J0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11299
Length: 489 (463)
Sequences: 2281 (1259)
Seq/√Len: 58.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_R295_D5.7681.00
230_R258_E5.0081.00
66_A119_L4.9471.00
317_D356_H4.6261.00
132_F166_G4.2601.00
4_E230_R4.2061.00
364_L386_V4.0651.00
150_E153_R4.0501.00
288_S326_E3.8591.00
329_Q363_S3.8161.00
8_N234_D3.5411.00
405_C408_C3.3341.00
346_I388_M3.1731.00
43_K102_D3.1231.00
321_F356_H3.0071.00
356_H359_R2.9301.00
6_L266_I2.7891.00
111_P117_A2.7631.00
303_V331_I2.7511.00
301_T340_L2.7321.00
449_A473_V2.7291.00
160_E179_E2.7121.00
233_V242_L2.7041.00
279_A397_I2.6771.00
214_A241_A2.6441.00
335_L340_L2.6351.00
47_S59_D2.5891.00
307_T320_I2.5521.00
415_K423_E2.5361.00
321_F325_I2.5341.00
48_R65_A2.5001.00
291_Y308_G2.4461.00
158_V170_I2.4241.00
361_L386_V2.3201.00
368_L375_T2.3121.00
236_R259_H2.2741.00
150_E176_G2.2681.00
405_C412_G2.2531.00
239_Y243_L2.2461.00
203_P207_Y2.2351.00
177_V181_E2.2241.00
246_T257_L2.2161.00
104_M209_L2.2021.00
44_G58_V2.1981.00
224_A231_I2.1911.00
60_I66_A2.1701.00
73_I97_V2.1271.00
332_A367_A2.1031.00
130_L186_A2.1001.00
354_E357_R2.0831.00
36_G110_D2.0811.00
345_I385_L2.0711.00
290_G326_E2.0381.00
166_G190_K1.9801.00
368_L377_V1.9721.00
27_I276_I1.9631.00
183_A187_A1.9181.00
163_D190_K1.9131.00
408_C412_G1.8851.00
243_L254_T1.8721.00
329_Q367_A1.8621.00
363_S366_Q1.8581.00
406_P414_V1.8551.00
300_M385_L1.8541.00
260_Y265_P1.8441.00
405_C410_G1.8230.99
381_S387_E1.8170.99
444_A449_A1.8030.99
236_R240_E1.7930.99
178_G181_E1.7740.99
6_L19_I1.7740.99
367_A370_K1.7660.99
321_F359_R1.7590.99
130_L182_L1.7480.99
262_G269_L1.7410.99
168_F186_A1.7260.99
15_R273_E1.6930.99
23_I333_R1.6700.99
265_P273_E1.6650.99
380_F386_V1.6430.99
17_A24_L1.6390.99
158_V168_F1.6380.99
195_K199_R1.6350.99
6_L272_V1.6350.99
93_I96_L1.6320.99
104_M200_K1.6280.99
363_S367_A1.6260.99
107_V119_L1.6130.99
44_G103_L1.5950.99
179_E183_A1.5890.99
44_G119_L1.5830.99
335_L344_I1.5730.98
212_E221_R1.5710.98
315_N318_D1.5630.98
307_T323_T1.5600.98
5_L18_Y1.5570.98
127_S185_D1.5380.98
247_S254_T1.5290.98
280_L397_I1.5160.98
331_I346_I1.5130.98
344_I388_M1.5120.98
108_V120_T1.5050.98
285_E291_Y1.5050.98
20_D25_Q1.4970.98
439_R472_K1.4870.98
50_L53_M1.4680.98
283_K293_I1.4670.98
37_I40_N1.4440.97
292_L302_T1.4400.97
286_L290_G1.4390.97
15_R267_F1.4340.97
13_E426_R1.4330.97
240_E243_L1.4280.97
20_D370_K1.4250.97
379_G387_E1.4210.97
43_K104_M1.4110.97
152_E156_K1.4030.97
8_N15_R1.4030.97
328_T348_F1.3990.97
268_D273_E1.3980.97
325_I363_S1.3850.97
366_Q369_S1.3760.96
403_N417_V1.3750.96
460_L473_V1.3580.96
96_L101_Q1.3570.96
102_D205_T1.3560.96
41_I303_V1.3490.96
345_I381_S1.3420.96
285_E309_A1.3330.96
24_L275_E1.3250.96
43_K205_T1.3130.95
20_D26_E1.3050.95
232_R266_I1.2870.95
44_G60_I1.2830.95
132_F190_K1.2720.94
424_I442_V1.2720.94
253_M256_K1.2720.94
132_F163_D1.2670.94
240_E244_E1.2660.94
287_K290_G1.2650.94
15_R426_R1.2630.94
134_P193_W1.2600.94
330_A334_Q1.2550.94
3_A20_D1.2530.94
153_R157_V1.2510.94
286_L326_E1.2500.94
188_Y245_F1.2460.94
266_I270_F1.2450.94
157_V179_E1.2420.94
296_Q301_T1.2380.94
361_L379_G1.2350.94
284_V294_I1.2300.93
441_L474_Q1.2260.93
443_Y474_Q1.2170.93
360_V363_S1.2060.93
235_S238_T1.2020.93
4_E232_R1.2020.93
382_A387_E1.1970.92
321_F360_V1.1870.92
47_S65_A1.1790.92
125_L193_W1.1770.92
439_R470_Q1.1670.91
276_I397_I1.1630.91
125_L192_V1.1620.91
188_Y192_V1.1620.91
53_M118_R1.1530.91
140_G155_K1.1520.91
305_I328_T1.1460.91
301_T387_E1.1460.91
271_D274_N1.1460.91
13_E31_R1.1410.91
427_E430_R1.1370.90
358_R362_H1.1320.90
360_V367_A1.1300.90
126_P221_R1.1280.90
204_Q207_Y1.1230.90
331_I335_L1.1220.90
170_I174_A1.1170.90
52_G312_G1.1110.89
278_R285_E1.1100.89
446_P450_E1.1080.89
44_G59_D1.1070.89
377_V388_M1.1060.89
20_D336_R1.0980.89
353_N356_H1.0970.89
309_A381_S1.0920.89
294_I340_L1.0800.88
97_V101_Q1.0800.88
339_N373_V1.0760.88
296_Q302_T1.0740.88
163_D166_G1.0730.88
92_D95_E1.0730.88
339_N393_T1.0710.88
302_T343_I1.0700.87
232_R270_F1.0620.87
58_V119_L1.0580.87
318_D322_N1.0570.87
141_V151_R1.0540.87
429_V466_F1.0530.87
30_E222_D1.0510.87
40_N208_Q1.0500.86
4_E22_G1.0420.86
8_N426_R1.0410.86
428_I440_F1.0400.86
133_M136_A1.0360.86
42_Y208_Q1.0330.86
139_V173_A1.0250.85
339_N372_R1.0220.85
325_I360_V1.0210.85
192_V210_Y1.0190.85
316_L319_T1.0170.85
296_Q396_S1.0160.85
56_A93_I1.0130.84
41_I123_I1.0090.84
114_T291_Y1.0050.84
8_N13_E1.0050.84
37_I107_V1.0050.84
222_D372_R1.0040.84
16_V24_L1.0030.84
287_K291_Y1.0020.84
358_R365_E0.9980.84
379_G382_A0.9940.83
198_E202_R0.9870.83
360_V364_L0.9870.83
111_P118_R0.9860.83
68_L73_I0.9850.83
67_F118_R0.9810.82
62_L117_A0.9790.82
402_C413_T0.9750.82
46_V272_V0.9670.82
373_V392_R0.9540.81
17_A276_I0.9530.81
458_H465_I0.9480.80
69_H316_L0.9470.80
328_T363_S0.9470.80
362_H366_Q0.9460.80
99_Q397_I0.9460.80
364_L388_M0.9420.80
463_V467_V0.9400.80
234_D260_Y0.9390.80
239_Y259_H0.9390.80
46_V49_V0.9370.79
36_G40_N0.9330.79
50_L311_V0.9310.79
56_A97_V0.9290.79
417_V448_V0.9280.79
68_L121_T0.9210.78
12_S422_Y0.9200.78
222_D350_D0.9200.78
337_L410_G0.9150.78
157_V160_E0.9150.78
343_I383_L0.9140.78
245_F250_I0.9140.78
325_I359_R0.9120.78
125_L332_A0.9110.78
378_N392_R0.9090.77
288_S322_N0.9040.77
69_H72_D0.9010.77
292_L418_E0.9000.77
45_R102_D0.8960.76
419_T426_R0.8940.76
61_G64_K0.8940.76
220_L242_L0.8910.76
46_V97_V0.8880.76
59_D65_A0.8870.76
454_G457_S0.8860.76
126_P131_V0.8850.75
105_V119_L0.8820.75
307_T312_G0.8800.75
8_N273_E0.8800.75
73_I121_T0.8790.75
196_V340_L0.8670.74
254_T257_L0.8640.74
432_H469_K0.8630.74
455_E463_V0.8530.73
343_I350_D0.8520.73
126_P132_F0.8470.72
62_L276_I0.8470.72
162_C168_F0.8460.72
50_L118_R0.8440.72
69_H118_R0.8420.72
381_S392_R0.8410.72
192_V245_F0.8410.72
316_L320_I0.8400.72
359_R363_S0.8380.71
67_F72_D0.8360.71
145_I154_L0.8360.71
332_A368_L0.8320.71
9_V238_T0.8320.71
58_V355_D0.8310.71
46_V305_I0.8300.71
465_I470_Q0.8290.71
120_T218_R0.8260.70
451_A456_E0.8250.70
151_R218_R0.8240.70
104_M195_K0.8200.70
200_K209_L0.8170.69
184_S248_E0.8160.69
58_V68_L0.8160.69
161_Y183_A0.8140.69
53_M307_T0.8130.69
360_V380_F0.8110.69
249_Y339_N0.8100.69
421_C452_L0.8100.69
182_L377_V0.8090.69
130_L235_S0.8070.68
284_V337_L0.8060.68
383_L391_K0.8060.68
296_Q398_E0.8050.68
243_L255_S0.8050.68
295_D301_T0.8050.68
4_E209_L0.8050.68
112_L392_R0.8010.68
330_A333_R0.7990.68
154_L158_V0.7990.68
239_Y257_L0.7960.67
197_M201_K0.7960.67
126_P159_A0.7940.67
296_Q340_L0.7930.67
361_L383_L0.7920.67
132_F165_Q0.7910.67
275_E278_R0.7890.67
137_S162_C0.7880.67
243_L257_L0.7880.67
292_L333_R0.7830.66
52_G319_T0.7810.66
53_M391_K0.7800.66
17_A27_I0.7790.66
444_A473_V0.7750.65
250_I253_M0.7730.65
268_D430_R0.7720.65
31_R419_T0.7690.65
152_E362_H0.7690.65
343_I385_L0.7670.65
157_V170_I0.7660.64
128_R336_R0.7660.64
275_E280_L0.7660.64
128_R250_I0.7640.64
452_L463_V0.7630.64
277_Q281_E0.7600.64
221_R350_D0.7590.64
464_E470_Q0.7590.64
335_L387_E0.7590.64
67_F383_L0.7570.64
467_V470_Q0.7540.63
438_D441_L0.7540.63
75_P122_D0.7530.63
284_V334_Q0.7470.62
188_Y210_Y0.7460.62
357_R380_F0.7420.62
365_E377_V0.7410.62
19_I445_S0.7370.61
274_N277_Q0.7340.61
223_F256_K0.7330.61
61_G116_G0.7300.61
64_K116_G0.7290.61
298_E306_N0.7280.60
66_A367_A0.7270.60
411_R444_A0.7250.60
128_R131_V0.7240.60
45_R206_R0.7220.60
438_D469_K0.7210.60
18_Y26_E0.7200.60
98_R101_Q0.7200.60
68_L357_R0.7190.60
218_R221_R0.7190.60
111_P394_R0.7170.59
117_A316_L0.7160.59
361_L381_S0.7160.59
50_L307_T0.7140.59
470_Q474_Q0.7140.59
354_E358_R0.7140.59
141_V181_E0.7130.59
264_Q269_L0.7110.59
158_V186_A0.7100.59
442_V473_V0.7070.58
172_T371_D0.7050.58
307_T319_T0.7050.58
450_E453_K0.7050.58
3_A227_E0.7050.58
126_P173_A0.7050.58
240_E246_T0.7040.58
53_M117_A0.7040.58
161_Y186_A0.7030.58
325_I329_Q0.7020.58
219_V380_F0.7020.58
460_L464_E0.6990.57
442_V449_A0.6990.57
11_P51_P0.6980.57
26_E372_R0.6960.57
305_I322_N0.6960.57
60_I65_A0.6960.57
123_I196_V0.6950.57
31_R66_A0.6920.57
133_M360_V0.6920.57
168_F190_K0.6910.57
125_L196_V0.6890.56
67_F193_W0.6890.56
231_I269_L0.6870.56
375_T387_E0.6870.56
449_A452_L0.6860.56
71_S333_R0.6860.56
164_E209_L0.6850.56
237_L366_Q0.6850.56
55_A316_L0.6840.56
266_I399_H0.6840.56
462_E466_F0.6810.55
428_I467_V0.6800.55
290_G323_T0.6800.55
420_V448_V0.6790.55
195_K198_E0.6790.55
161_Y277_Q0.6780.55
459_S462_E0.6780.55
211_G231_I0.6760.55
343_I381_S0.6740.55
242_L246_T0.6730.55
317_D353_N0.6720.54
461_A468_G0.6720.54
156_K160_E0.6710.54
112_L118_R0.6700.54
432_H440_F0.6690.54
70_A95_E0.6690.54
458_H470_Q0.6690.54
312_G391_K0.6690.54
92_D160_E0.6680.54
404_E407_T0.6660.54
137_S165_Q0.6630.53
16_V339_N0.6630.53
301_T400_V0.6620.53
378_N383_L0.6590.53
238_T241_A0.6580.53
53_M316_L0.6570.53
224_A253_M0.6570.53
438_D465_I0.6560.53
199_R257_L0.6550.53
442_V452_L0.6550.53
232_R330_A0.6550.53
125_L309_A0.6530.52
16_V28_H0.6520.52
231_I256_K0.6510.52
292_L437_S0.6500.52
453_K456_E0.6480.52
237_L241_A0.6470.52
361_L365_E0.6460.52
244_E248_E0.6460.52
111_P212_E0.6450.51
49_V97_V0.6420.51
37_I110_D0.6420.51
294_I297_T0.6390.51
462_E465_I0.6390.51
116_G134_P0.6380.51
162_C186_A0.6370.51
133_M138_H0.6370.51
294_I334_Q0.6370.51
455_E467_V0.6350.50
141_V145_I0.6340.50
147_S150_E0.6320.50
451_A454_G0.6320.50
131_V287_K0.6310.50
343_I391_K0.6310.50
117_A305_I0.6300.50
310_F319_T0.6300.50
35_R211_G0.6300.50
167_G231_I0.6300.50
167_G388_M0.6290.50
38_V393_T0.6290.50
203_P315_N0.6270.49
191_R313_H0.6260.49
48_R99_Q0.6240.49
104_M120_T0.6230.49
49_V158_V0.6230.49
26_E39_G0.6220.49
88_F91_R0.6200.49
69_H231_I0.6200.49
418_E455_E0.6200.49
46_V58_V0.6190.49
131_V221_R0.6190.49
19_I24_L0.6150.48
73_I96_L0.6150.48
49_V301_T0.6150.48
359_R414_V0.6150.48
144_R447_A0.6140.48
421_C450_E0.6140.48
231_I340_L0.6130.48
17_A267_F0.6120.48
16_V219_V0.6110.48
430_R435_Y0.6100.48
125_L264_Q0.6100.48
46_V381_S0.6080.47
417_V420_V0.6080.47
139_V158_V0.6080.47
39_G272_V0.6080.47
59_D229_D0.6070.47
13_E419_T0.6070.47
255_S261_T0.6060.47
23_I329_Q0.6050.47
64_K374_K0.6050.47
173_A185_D0.6040.47
425_M431_V0.6040.47
403_N406_P0.6020.47
447_A459_S0.6020.47
344_I465_I0.6010.47
404_E428_I0.6010.47
45_R205_T0.6000.46
395_E399_H0.5980.46
120_T464_E0.5980.46
124_T172_T0.5980.46
281_E411_R0.5970.46
180_A183_A0.5970.46
264_Q353_N0.5970.46
144_R279_A0.5960.46
284_V377_V0.5960.46
6_L232_R0.5950.46
147_S350_D0.5950.46
236_R466_F0.5940.46
227_E256_K0.5920.46
266_I374_K0.5890.45
120_T376_S0.5890.45
358_R439_R0.5880.45
230_R270_F0.5880.45
4_E72_D0.5860.45
369_S449_A0.5850.45
438_D462_E0.5850.45
161_Y168_F0.5850.45
295_D302_T0.5840.45
110_D174_A0.5840.45
40_N110_D0.5840.45
69_H389_T0.5840.45
117_A311_V0.5840.45
104_M207_Y0.5830.45
187_A190_K0.5830.45
194_T198_E0.5820.44
140_G380_F0.5820.44
128_R222_D0.5820.44
242_L257_L0.5810.44
251_P336_R0.5800.44
150_E157_V0.5790.44
220_L339_N0.5790.44
100_G358_R0.5790.44
10_T209_L0.5790.44
149_S254_T0.5790.44
440_F471_V0.5790.44
26_E336_R0.5770.44
246_T254_T0.5770.44
409_H432_H0.5770.44
307_T391_K0.5760.44
56_A389_T0.5760.44
149_S187_A0.5750.44
305_I468_G0.5740.44
187_A244_E0.5730.44
56_A70_A0.5730.44
161_Y182_L0.5710.43
103_L365_E0.5700.43
123_I262_G0.5700.43
398_E413_T0.5690.43
91_R292_L0.5680.43
163_D224_A0.5680.43
218_R222_D0.5680.43
331_I354_E0.5670.43
8_N341_G0.5660.43
458_H472_K0.5660.43
129_Y222_D0.5660.43
458_H461_A0.5650.43
420_V431_V0.5650.43
290_G344_I0.5640.43
305_I327_A0.5640.43
334_Q338_R0.5630.42
52_G310_F0.5620.42
184_S229_D0.5610.42
465_I469_K0.5610.42
312_G319_T0.5590.42
143_Q374_K0.5590.42
186_A190_K0.5560.42
268_D403_N0.5550.42
154_L157_V0.5540.41
450_E456_E0.5540.41
105_V428_I0.5530.41
433_H470_Q0.5520.41
92_D96_L0.5520.41
54_Q94_S0.5510.41
335_L388_M0.5510.41
235_S466_F0.5500.41
240_E254_T0.5490.41
404_E409_H0.5490.41
98_R346_I0.5490.41
441_L472_K0.5480.41
231_I249_Y0.5480.41
465_I468_G0.5470.41
236_R261_T0.5470.41
153_R241_A0.5470.41
422_Y426_R0.5470.41
417_V458_H0.5470.41
333_R337_L0.5460.41
76_H197_M0.5460.41
337_L412_G0.5450.40
449_A472_K0.5450.40
97_V192_V0.5450.40
427_E435_Y0.5450.40
468_G471_V0.5440.40
343_I389_T0.5430.40
138_H392_R0.5430.40
100_G381_S0.5430.40
294_I330_A0.5420.40
276_I341_G0.5420.40
442_V446_P0.5420.40
272_V409_H0.5410.40
8_N17_A0.5390.40
308_G313_H0.5390.40
18_Y448_V0.5390.40
47_S58_V0.5390.40
343_I361_L0.5380.40
325_I367_A0.5370.40
208_Q211_G0.5370.40
109_K172_T0.5370.40
461_A474_Q0.5360.40
436_D467_V0.5350.39
66_A107_V0.5350.39
461_A465_I0.5350.39
418_E422_Y0.5350.39
307_T316_L0.5340.39
277_Q452_L0.5340.39
40_N54_Q0.5330.39
293_I306_N0.5330.39
440_F458_H0.5320.39
46_V368_L0.5320.39
232_R258_E0.5310.39
129_Y418_E0.5300.39
287_K326_E0.5300.39
53_M310_F0.5280.39
437_S459_S0.5280.39
417_V445_S0.5270.39
359_R442_V0.5270.39
134_P167_G0.5260.38
36_G395_E0.5240.38
145_I333_R0.5240.38
30_E131_V0.5240.38
333_R340_L0.5230.38
303_V381_S0.5230.38
359_R366_Q0.5220.38
143_Q469_K0.5210.38
194_T241_A0.5200.38
460_L470_Q0.5200.38
128_R185_D0.5190.38
55_A72_D0.5190.38
5_L357_R0.5190.38
55_A319_T0.5180.38
107_V245_F0.5180.38
15_R275_E0.5180.38
90_V95_E0.5180.38
110_D307_T0.5170.38
431_V443_Y0.5160.37
314_R323_T0.5160.37
53_M386_V0.5160.37
310_F391_K0.5150.37
107_V177_V0.5150.37
198_E386_V0.5150.37
152_E276_I0.5150.37
155_K178_G0.5150.37
158_V472_K0.5150.37
305_I346_I0.5130.37
130_L158_V0.5130.37
162_C300_M0.5130.37
228_L387_E0.5120.37
50_L316_L0.5120.37
168_F335_L0.5110.37
65_A295_D0.5110.37
217_Q360_V0.5110.37
158_V294_I0.5110.37
467_V472_K0.5100.37
247_S438_D0.5100.37
52_G323_T0.5100.37
458_H463_V0.5100.37
41_I209_L0.5100.37
198_E201_K0.5090.37
457_S463_V0.5090.37
364_L375_T0.5090.37
101_Q158_V0.5090.37
337_L353_N0.5090.37
220_L224_A0.5080.37
79_C88_F0.5080.37
76_H125_L0.5080.37
24_L459_S0.5070.36
134_P212_E0.5070.36
454_G464_E0.5060.36
449_A454_G0.5050.36
151_R286_L0.5050.36
178_G243_L0.5050.36
364_L380_F0.5050.36
141_V396_S0.5050.36
422_Y456_E0.5040.36
439_R469_K0.5020.36
136_A233_V0.5020.36
414_V449_A0.5000.36
240_E259_H0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bx2L 3 0.9571 100 0.105 Contact Map
4oxpA 1 0.3681 100 0.653 Contact Map
3cw2C 1 0.4703 99.9 0.847 Contact Map
3aevA 1 0.3211 99.2 0.914 Contact Map
4nngA 1 0.319 99 0.921 Contact Map
1kl9A 2 0.3047 98.1 0.94 Contact Map
1wi5A 1 0.2352 97.9 0.944 Contact Map
2k52A 1 0.1513 97.9 0.944 Contact Map
2ja9A 2 0.3354 97.9 0.944 Contact Map
4aidA 3 0.0041 97.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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