GREMLIN Database
NIRD - Nitrite reductase (NADH) small subunit
UniProt: P0A9I8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10655
Length: 108 (103)
Sequences: 1043 (652)
Seq/√Len: 64.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_L92_V3.6041.00
65_E78_R3.4871.00
43_S93_K3.2561.00
6_D103_V3.0311.00
98_R105_Q2.9821.00
61_E64_G2.6721.00
76_R86_E2.2831.00
62_H76_R2.2651.00
49_F72_L2.1971.00
67_W76_R2.1861.00
27_Q52_S2.0481.00
9_K12_D2.0081.00
45_I52_S1.9961.00
48_F77_F1.9931.00
42_I92_V1.9671.00
39_V97_A1.9061.00
39_V99_V1.8601.00
49_F73_K1.8051.00
78_R81_D1.8041.00
44_N55_S1.6840.99
100_K105_Q1.6330.99
45_I50_E1.6300.99
62_H86_E1.6110.99
6_D105_Q1.5800.99
13_I17_T1.5420.99
65_E83_L1.5300.99
65_E80_S1.5160.99
99_V104_V1.5140.99
31_F68_V1.4750.98
9_K103_V1.4560.98
26_E43_S1.4370.98
48_F90_F1.3740.97
38_Q80_S1.3710.97
69_A76_R1.3420.97
32_R37_D1.3060.96
4_W98_R1.2980.96
27_Q44_N1.2750.96
62_H67_W1.2050.94
7_I21_A1.1870.94
10_I39_V1.1860.94
13_I32_R1.1830.94
48_F87_D1.1660.93
83_L91_S1.1560.93
18_G31_F1.1060.91
14_L58_L1.0470.89
42_I54_L1.0330.88
21_A28_V0.9940.86
7_I106_L0.9830.86
33_P36_S0.9620.84
20_C55_S0.9500.83
7_I23_L0.9490.83
10_I99_V0.9360.83
36_S59_I0.9320.82
48_F75_Q0.9320.82
7_I30_I0.9210.82
60_A67_W0.9000.80
45_I49_F0.8940.80
99_V102_G0.8660.77
46_D70_S0.8650.77
6_D9_K0.8560.77
21_A39_V0.8490.76
43_S95_Y0.8420.75
8_C46_D0.8360.75
10_I32_R0.8310.74
8_C30_I0.8230.74
53_V72_L0.8160.73
8_C13_I0.7980.71
33_P40_F0.7980.71
14_L17_T0.7710.69
30_I97_A0.7540.67
69_A77_F0.7430.66
61_E78_R0.7350.65
35_H38_Q0.7320.65
17_T55_S0.7290.64
19_V44_N0.7280.64
33_P66_L0.7250.64
63_Q80_S0.7230.64
52_S67_W0.7210.64
11_D102_G0.7140.63
23_L106_L0.7130.63
10_I15_P0.7050.62
39_V43_S0.7030.62
60_A66_L0.7020.62
13_I64_G0.6930.61
16_E33_P0.6900.60
10_I37_D0.6870.60
33_P42_I0.6820.59
33_P59_I0.6760.59
28_V37_D0.6750.58
20_C27_Q0.6750.58
37_D94_H0.6740.58
26_E95_Y0.6680.58
61_E67_W0.6650.57
8_C104_V0.6540.56
20_C28_V0.6490.56
23_L28_V0.6470.55
68_V92_V0.6390.54
24_G35_H0.6380.54
16_E35_H0.6300.53
16_E58_L0.6270.53
16_E59_I0.6250.53
10_I13_I0.6210.52
67_W86_E0.6140.51
50_E96_E0.6140.51
49_F75_Q0.6110.51
17_T32_R0.6100.51
14_L19_V0.6090.51
77_F84_C0.6090.51
21_A30_I0.6080.51
30_I64_G0.6020.50
15_P51_S0.6000.50
6_D96_E0.5880.48
8_C75_Q0.5830.48
16_E19_V0.5800.48
9_K102_G0.5790.47
17_T20_C0.5770.47
77_F87_D0.5760.47
16_E72_L0.5750.47
35_H61_E0.5750.47
32_R106_L0.5730.47
33_P81_D0.5690.46
88_E101_D0.5660.46
13_I39_V0.5650.46
30_I75_Q0.5620.45
8_C22_L0.5570.45
4_W105_Q0.5560.45
18_G79_L0.5540.45
67_W73_K0.5540.45
52_S61_E0.5530.44
64_G87_D0.5520.44
70_S75_Q0.5520.44
27_Q56_R0.5480.44
61_E66_L0.5480.44
18_G68_V0.5470.44
5_K105_Q0.5460.44
13_I72_L0.5450.44
15_P89_Q0.5410.43
12_D26_E0.5390.43
46_D78_R0.5380.43
87_D90_F0.5370.43
65_E86_E0.5290.42
10_I102_G0.5230.41
30_I95_Y0.5220.41
33_P52_S0.5170.40
35_H58_L0.5130.40
58_L61_E0.5120.40
48_F84_C0.5110.40
89_Q92_V0.5060.39
35_H66_L0.5050.39
26_E93_K0.5050.39
16_E44_N0.5040.39
14_L32_R0.5040.39
19_V22_L0.5000.38
8_C25_D0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jzaA 1 0.9907 99.9 0.532 Contact Map
2jo6A 1 0.9907 99.9 0.534 Contact Map
3c0dA 1 0.9815 99.9 0.54 Contact Map
4aivA 1 0.9722 99.8 0.572 Contact Map
2de6D 1 0.9074 99.8 0.59 Contact Map
2i7fA 1 0.9167 99.8 0.593 Contact Map
3gceA 1 0.9259 99.8 0.596 Contact Map
1fqtA 2 0.9259 99.8 0.597 Contact Map
3d89A 1 0.963 99.8 0.606 Contact Map
1vm9A 1 0.9259 99.7 0.61 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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