GREMLIN Database
GCVR - Glycine cleavage system transcriptional repressor
UniProt: P0A9I3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11149
Length: 190 (170)
Sequences: 821 (586)
Seq/√Len: 45.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_G77_L5.3931.00
98_V116_F4.0851.00
17_D20_G3.8541.00
98_V147_A3.8171.00
47_E82_K3.4111.00
35_N104_D3.0111.00
37_E55_S3.0041.00
17_D122_N2.4341.00
62_T65_E2.4191.00
119_H161_A2.3191.00
22_V48_F2.2331.00
21_I143_I2.1341.00
38_D136_E2.0840.99
41_L128_S2.0670.99
124_A148_H2.0620.99
9_L56_G2.0620.99
62_T66_S2.0550.99
23_N102_V1.7810.98
29_V52_M1.7450.98
15_G44_L1.7230.98
38_D53_L1.7110.98
114_A118_A1.6830.98
11_I79_I1.6550.97
27_R31_S1.6340.97
21_I48_F1.6130.97
29_V34_C1.6060.97
20_G48_F1.6020.97
41_L52_M1.5740.96
61_I65_E1.5670.96
100_V145_I1.5550.96
135_N138_A1.5450.96
104_D107_H1.5320.96
65_E83_R1.5210.96
31_S86_A1.4780.95
91_P151_A1.4580.95
163_K171_A1.4490.94
20_G122_N1.4390.94
109_I128_S1.4210.94
39_S128_S1.4120.94
29_V113_T1.4030.93
115_L165_L1.3990.93
33_G106_P1.3760.93
14_L47_E1.3640.92
99_Q144_Q1.3620.92
133_A141_L1.3380.92
163_K170_N1.3200.91
115_L119_H1.3160.91
40_R53_L1.3160.91
164_A168_E1.3070.91
131_Q142_H1.2920.90
12_T48_F1.2860.90
35_N130_T1.2650.89
34_C56_G1.2600.89
112_F125_E1.2460.88
16_A47_E1.2440.88
92_M151_A1.2380.88
116_F121_M1.2300.88
8_Y29_V1.2220.87
36_I50_F1.2070.87
41_L108_L1.1960.86
162_F166_C1.1890.86
105_S111_R1.1870.86
19_P126_L1.1630.85
100_V108_L1.1330.83
62_T90_P1.1300.83
101_D131_Q1.1260.83
69_P81_M1.1240.82
60_A63_L1.1160.82
103_A171_A1.0970.81
108_L128_S1.0860.80
109_I126_L1.0840.80
17_D44_L1.0840.80
25_I143_I1.0760.80
28_H37_E1.0670.79
57_S66_S1.0500.78
61_I69_P1.0470.78
7_H42_A1.0400.77
34_C141_L1.0370.77
31_S87_R1.0210.76
30_S110_E1.0060.75
10_V22_V0.9940.74
7_H83_R0.9930.74
107_H141_L0.9840.73
159_E163_K0.9800.73
102_V171_A0.9790.73
96_V155_A0.9770.73
40_R146_T0.9760.73
12_T110_E0.9730.72
28_H32_C0.9700.72
24_T120_H0.9650.72
14_L169_L0.9600.71
44_L122_N0.9590.71
125_E144_Q0.9390.70
38_D135_N0.9350.69
103_A108_L0.9330.69
91_P120_H0.9330.69
55_S112_F0.9250.68
118_A156_A0.9180.68
29_V54_L0.9170.68
44_L168_E0.9160.68
31_S156_A0.9160.68
20_G107_H0.9120.67
10_V50_F0.9110.67
56_G60_A0.9110.67
42_A51_I0.9040.67
102_V117_D0.9030.67
80_V158_I0.9030.67
33_G149_S0.9010.66
33_G156_A0.8910.65
162_F173_G0.8880.65
10_V47_E0.8870.65
113_T165_L0.8860.65
23_N122_N0.8820.65
41_L48_F0.8760.64
35_N108_L0.8740.64
17_D128_S0.8700.64
14_L49_T0.8680.63
17_D113_T0.8670.63
97_W127_V0.8590.63
32_C67_T0.8570.62
13_A84_T0.8480.62
85_T156_A0.8440.61
14_L150_P0.8230.59
36_I170_N0.8210.59
71_K169_L0.8170.59
8_Y147_A0.8160.59
132_P139_A0.8150.59
12_T68_L0.8090.58
36_I143_I0.7990.57
54_L106_P0.7990.57
17_D21_I0.7990.57
55_S125_E0.7980.57
157_N165_L0.7980.57
98_V175_I0.7980.57
129_R174_S0.7970.57
103_A133_A0.7960.57
65_E72_G0.7900.56
34_C54_L0.7890.56
15_G36_I0.7820.55
157_N161_A0.7770.55
167_T170_N0.7740.55
22_V109_I0.7720.54
10_V41_L0.7710.54
9_L12_T0.7680.54
11_I169_L0.7670.54
41_L129_R0.7590.53
68_L158_I0.7590.53
85_T142_H0.7480.52
119_H158_I0.7340.51
22_V113_T0.7300.50
20_G35_N0.7270.50
70_L86_A0.7170.49
63_L69_P0.7120.49
112_F175_I0.7120.49
18_R21_I0.7060.48
149_S155_A0.7040.48
34_C165_L0.7020.48
109_I141_L0.7010.48
125_E176_N0.6960.47
28_H67_T0.6940.47
81_M93_P0.6890.46
87_R92_M0.6870.46
55_S174_S0.6840.46
22_V41_L0.6820.46
19_P122_N0.6660.44
78_L147_A0.6650.44
41_L105_S0.6630.44
54_L68_L0.6570.43
125_E128_S0.6540.43
59_N120_H0.6540.43
151_A164_A0.6520.43
10_V51_I0.6510.43
42_A144_Q0.6440.42
132_P135_N0.6430.42
147_A175_I0.6430.42
63_L70_L0.6410.42
31_S42_A0.6400.42
15_G126_L0.6400.42
39_S126_L0.6390.42
44_L123_I0.6380.41
12_T159_E0.6380.41
154_D157_N0.6370.41
22_V40_R0.6350.41
40_R125_E0.6330.41
25_I72_G0.6310.41
63_L83_R0.6290.41
11_I139_A0.6180.40
128_S177_V0.6170.40
133_A172_Q0.6160.39
92_M95_S0.6160.39
156_A177_V0.6050.38
55_S145_I0.6040.38
17_D48_F0.6030.38
10_V130_T0.6020.38
149_S154_D0.5960.38
15_G53_L0.5950.37
11_I135_N0.5930.37
65_E69_P0.5920.37
22_V128_S0.5920.37
111_R168_E0.5920.37
131_Q140_Q0.5920.37
36_I105_S0.5920.37
38_D44_L0.5900.37
46_E128_S0.5900.37
132_P136_E0.5890.37
102_V141_L0.5860.37
19_P77_L0.5830.36
77_L80_V0.5780.36
25_I87_R0.5730.36
92_M152_S0.5720.35
89_R151_A0.5710.35
138_A172_Q0.5710.35
103_A165_L0.5650.35
93_P148_H0.5650.35
116_F130_T0.5620.35
72_G105_S0.5610.34
11_I22_V0.5590.34
22_V51_I0.5580.34
40_R168_E0.5570.34
133_A163_K0.5550.34
125_E146_T0.5500.33
27_R117_D0.5470.33
48_F107_H0.5470.33
99_Q146_T0.5460.33
119_H154_D0.5430.33
118_A159_E0.5430.33
135_N140_Q0.5400.33
52_M138_A0.5370.32
26_T88_P0.5330.32
12_T20_G0.5310.32
102_V166_C0.5310.32
151_A156_A0.5310.32
102_V122_N0.5270.32
29_V40_R0.5260.31
14_L109_I0.5240.31
79_I155_A0.5240.31
37_E44_L0.5220.31
60_A71_K0.5210.31
66_S89_R0.5210.31
31_S110_E0.5180.31
147_A165_L0.5170.31
96_V147_A0.5170.31
95_S124_A0.5160.31
88_P120_H0.5140.30
108_L139_A0.5140.30
21_I113_T0.5140.30
85_T93_P0.5120.30
26_T141_L0.5120.30
10_V84_T0.5080.30
56_G61_I0.5060.30
94_A149_S0.5040.30
22_V132_P0.5040.30
20_G46_E0.5010.29
9_L81_M0.5010.29
23_N29_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nyiA 2 0.8947 100 0.442 Contact Map
1u8sA 2 0.9053 100 0.455 Contact Map
3p96A 2 0.9368 99.9 0.575 Contact Map
3o1lA 3 0.8053 99.6 0.703 Contact Map
3louA 3 0.7737 99.5 0.713 Contact Map
3nrbA 4 0.7895 99.5 0.713 Contact Map
3n0vA 4 0.7737 99.5 0.715 Contact Map
3w7bA 3 0.7895 99.5 0.718 Contact Map
3obiA 4 0.7842 99.5 0.719 Contact Map
2re1A 2 0.7421 98.8 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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