CITE - ECOLI - GREMLIN Contacts

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CITE - Citrate lyase subunit beta

UniProt:	P0A9I1	Sequences: MISASLQQRKTRTRRSMLFVPGANAAMVSNSFIYPADALMFDLEDSVALREKDTARRMVYHALQHPLYRDIETIVRVNALDSEWGVNDLEAVVRGGADVVRLPKTDTAQDVLDIEKEILRIEKACGREPGSTGLLAAIESPLGITRAVEIAHASERLIGIALGAEDYVRNLRTERSPEGTELLFARCSILQAARSAGIQAFDTVYSDANNEAGFLQEAAHIKQLGFDGKSLINPRQIDLLHNLYAPTQKEVDHARRVVEAAEAAAREGLGVVSLNGKMVDGPVIDRARLVLSRAELSGIREE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13542
Length:	302 (270)
Sequences:	3790 (2516)
Seq/√Len:	153.1

ECOLI - CITE
HALSA - Q9HRM8
SULSO - Q97YR5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
256_R	275_N	4.308	1.00
231_L	240_L	4.203	1.00
205_Y	213_G	4.104	1.00
215_L	242_N	4.098	1.00
74_I	99_V	3.712	1.00
22_G	59_V	3.566	1.00
253_H	257_V	3.084	1.00
51_E	54_T	3.026	1.00
215_L	219_A	2.860	1.00
141_P	170_N	2.700	1.00
184_F	188_S	2.691	1.00
146_R	149_E	2.680	1.00
151_A	160_I	2.664	1.00
209_N	235_R	2.494	1.00
16_S	241_H	2.443	1.00
56_R	88_D	2.408	1.00
77_V	85_G	2.263	1.00
217_E	229_K	2.147	1.00
258_V	291_L	2.143	1.00
14_R	72_E	2.112	1.00
145_T	188_S	2.091	1.00
74_I	101_R	2.081	1.00
281_G	285_D	2.074	1.00
136_A	157_L	2.053	1.00
214_F	240_L	2.043	1.00
256_R	274_L	2.009	1.00
162_L	167_Y	1.996	1.00
285_D	288_R	1.975	1.00
247_T	250_E	1.958	1.00
262_E	288_R	1.923	1.00
238_D	242_N	1.913	1.00
208_A	273_S	1.905	1.00
106_D	142_L	1.899	1.00
102_L	114_I	1.863	1.00
57_R	61_H	1.850	1.00
23_A	51_E	1.847	1.00
167_Y	171_L	1.844	1.00
115_E	119_L	1.844	1.00
248_Q	252_D	1.818	1.00
41_F	59_V	1.794	1.00
257_V	274_L	1.787	1.00
222_K	250_E	1.772	1.00
218_A	243_L	1.727	1.00
87_N	90_E	1.688	1.00
115_E	156_R	1.675	1.00
107_T	110_D	1.673	1.00
112_L	153_A	1.663	1.00
202_D	229_K	1.654	1.00
133_G	158_I	1.626	1.00
274_L	279_V	1.614	1.00
23_A	48_A	1.581	1.00
109_Q	112_L	1.545	1.00
164_A	203_T	1.543	1.00
251_V	290_V	1.543	1.00
145_T	195_S	1.534	1.00
252_D	256_R	1.516	1.00
255_R	295_E	1.512	1.00
35_P	71_I	1.501	1.00
147_A	192_A	1.458	1.00
161_A	230_S	1.455	1.00
17_M	38_A	1.448	1.00
207_D	210_N	1.446	1.00
79_A	82_S	1.422	1.00
53_D	87_N	1.422	1.00
165_E	206_S	1.417	1.00
80_L	85_G	1.416	1.00
25_A	58_M	1.391	1.00
49_L	84_W	1.387	1.00
212_A	215_L	1.387	1.00
17_M	201_F	1.382	1.00
19_F	230_S	1.370	1.00
24_N	27_M	1.362	1.00
105_T	150_I	1.345	1.00
111_V	136_A	1.334	1.00
75_V	92_V	1.325	1.00
289_L	293_R	1.324	1.00
255_R	259_E	1.306	1.00
138_I	147_A	1.303	1.00
214_F	239_L	1.299	1.00
209_N	273_S	1.293	1.00
86_V	117_E	1.290	1.00
54_T	58_M	1.285	1.00
84_W	87_N	1.270	1.00
15_R	241_H	1.267	1.00
174_E	223_Q	1.256	1.00
218_A	229_K	1.254	1.00
215_L	243_L	1.242	1.00
148_V	188_S	1.240	1.00
183_L	187_C	1.234	1.00
221_I	244_Y	1.231	1.00
142_L	146_R	1.218	1.00
148_V	195_S	1.189	1.00
253_H	290_V	1.180	1.00
169_R	285_D	1.177	1.00
145_T	148_V	1.174	1.00
143_G	147_A	1.164	1.00
17_M	40_M	1.164	1.00
288_R	292_S	1.162	1.00
101_R	161_A	1.160	1.00
144_I	185_A	1.154	1.00
138_I	144_I	1.153	1.00
38_A	74_I	1.147	1.00
135_L	161_A	1.145	1.00
284_I	288_R	1.145	1.00
211_E	215_L	1.144	1.00
136_A	150_I	1.116	0.99
118_I	134_L	1.094	0.99
165_E	282_P	1.092	0.99
186_R	202_D	1.088	0.99
108_A	149_E	1.081	0.99
28_V	41_F	1.076	0.99
251_V	291_L	1.069	0.99
59_V	75_V	1.069	0.99
86_V	90_E	1.065	0.99
60_Y	91_A	1.061	0.99
200_A	227_D	1.056	0.99
61_H	65_H	1.056	0.99
183_L	224_L	1.037	0.99
147_A	151_A	1.035	0.99
281_G	288_R	1.033	0.99
261_A	284_I	1.026	0.99
45_D	104_K	1.024	0.99
210_N	213_G	1.016	0.99
174_E	250_E	1.011	0.99
205_Y	217_E	1.001	0.99
239_L	243_L	0.993	0.99
201_F	230_S	0.992	0.99
253_H	277_K	0.977	0.99
82_S	85_G	0.973	0.99
259_E	262_E	0.972	0.99
253_H	275_N	0.972	0.99
28_V	62_A	0.972	0.99
100_V	118_I	0.971	0.99
53_D	57_R	0.970	0.99
262_E	266_R	0.967	0.99
206_S	278_M	0.956	0.98
184_F	187_C	0.953	0.98
211_E	235_R	0.952	0.98
194_R	227_D	0.952	0.98
189_I	200_A	0.947	0.98
172_R	289_L	0.945	0.98
97_A	132_T	0.942	0.98
167_Y	191_Q	0.930	0.98
32_F	62_A	0.930	0.98
142_L	152_H	0.929	0.98
193_A	200_A	0.921	0.98
271_V	280_D	0.920	0.98
251_V	294_A	0.920	0.98
118_I	132_T	0.919	0.98
94_R	97_A	0.919	0.98
214_F	218_A	0.919	0.98
54_T	57_R	0.914	0.98
148_V	152_H	0.912	0.98
165_E	283_V	0.902	0.98
246_P	251_V	0.896	0.98
214_F	236_Q	0.896	0.98
212_A	216_Q	0.892	0.98
29_S	32_F	0.888	0.97
108_A	112_L	0.883	0.97
107_T	146_R	0.883	0.97
34_Y	237_I	0.880	0.97
108_A	153_A	0.880	0.97
190_L	226_F	0.879	0.97
258_V	261_A	0.878	0.97
160_I	193_A	0.877	0.97
19_F	204_V	0.874	0.97
218_A	244_Y	0.873	0.97
184_F	191_Q	0.873	0.97
85_G	114_I	0.861	0.97
159_G	193_A	0.861	0.97
183_L	220_H	0.858	0.97
216_Q	220_H	0.857	0.97
168_V	182_L	0.857	0.97
47_V	55_A	0.855	0.97
93_V	132_T	0.855	0.97
110_D	113_D	0.853	0.97
139_E	166_D	0.851	0.97
249_K	252_D	0.850	0.97
215_L	239_L	0.850	0.97
119_L	156_R	0.846	0.97
60_Y	64_Q	0.843	0.97
25_A	28_V	0.838	0.96
30_N	33_I	0.837	0.96
107_T	150_I	0.836	0.96
89_L	114_I	0.836	0.96
180_T	220_H	0.833	0.96
144_I	191_Q	0.832	0.96
29_S	65_H	0.830	0.96
161_A	228_G	0.829	0.96
162_L	185_A	0.824	0.96
35_P	238_D	0.821	0.96
138_I	150_I	0.820	0.96
44_E	104_K	0.819	0.96
180_T	183_L	0.819	0.96
93_V	118_I	0.817	0.96
14_R	38_A	0.816	0.96
202_D	221_I	0.801	0.95
176_S	181_E	0.794	0.95
207_D	277_K	0.794	0.95
90_E	117_E	0.794	0.95
72_E	98_D	0.791	0.95
135_L	159_G	0.789	0.95
205_Y	236_Q	0.786	0.95
188_S	191_Q	0.777	0.95
205_Y	229_K	0.774	0.94
288_R	295_E	0.769	0.94
58_M	61_H	0.769	0.94
170_N	194_R	0.767	0.94
292_S	295_E	0.766	0.94
168_V	173_T	0.766	0.94
77_V	102_L	0.763	0.94
251_V	255_R	0.763	0.94
165_E	278_M	0.761	0.94
167_Y	185_A	0.759	0.94
81_D	85_G	0.759	0.94
144_I	147_A	0.758	0.94
152_H	196_A	0.758	0.94
52_K	78_N	0.757	0.94
75_V	91_A	0.757	0.94
144_I	167_Y	0.756	0.94
17_M	74_I	0.756	0.94
158_I	199_Q	0.754	0.94
89_L	100_V	0.749	0.93
77_V	114_I	0.749	0.93
20_V	39_L	0.747	0.93
44_E	166_D	0.745	0.93
200_A	280_D	0.744	0.93
282_P	286_R	0.741	0.93
159_G	201_F	0.739	0.93
255_R	291_L	0.738	0.93
140_S	170_N	0.736	0.93
26_A	29_S	0.733	0.93
237_I	241_H	0.732	0.93
67_L	98_D	0.729	0.92
153_A	156_R	0.729	0.92
40_M	101_R	0.724	0.92
102_L	105_T	0.723	0.92
176_S	223_Q	0.720	0.92
135_L	201_F	0.719	0.92
218_A	240_L	0.718	0.92
31_S	41_F	0.715	0.92
32_F	73_T	0.714	0.92
44_E	139_E	0.714	0.92
201_F	228_G	0.714	0.92
28_V	58_M	0.713	0.92
273_S	276_G	0.712	0.92
102_L	111_V	0.703	0.91
252_D	255_R	0.703	0.91
14_R	17_M	0.701	0.91
187_C	190_L	0.700	0.91
261_A	272_V	0.697	0.91
100_V	132_T	0.696	0.91
280_D	283_V	0.695	0.91
114_I	134_L	0.695	0.91
138_I	189_I	0.695	0.91
142_L	195_S	0.693	0.90
52_K	84_W	0.691	0.90
108_A	146_R	0.690	0.90
35_P	237_I	0.690	0.90
25_A	29_S	0.689	0.90
202_D	217_E	0.689	0.90
17_M	135_L	0.686	0.90
88_D	92_V	0.685	0.90
48_A	51_E	0.685	0.90
15_R	37_D	0.681	0.90
291_L	295_E	0.679	0.90
141_P	171_L	0.677	0.89
211_E	239_L	0.676	0.89
147_A	188_S	0.675	0.89
222_K	243_L	0.674	0.89
162_L	189_I	0.674	0.89
47_V	52_K	0.671	0.89
219_A	223_Q	0.669	0.89
21_P	233_N	0.669	0.89
141_P	195_S	0.665	0.89
14_R	199_Q	0.663	0.88
178_E	223_Q	0.663	0.88
106_D	143_G	0.662	0.88
165_E	280_D	0.662	0.88
218_A	222_K	0.662	0.88
163_G	166_D	0.656	0.88
199_Q	227_D	0.656	0.88
286_R	290_V	0.653	0.88
113_D	116_K	0.650	0.87
253_H	274_L	0.646	0.87
19_F	164_A	0.645	0.87
258_V	262_E	0.644	0.87
146_R	150_I	0.644	0.87
175_R	286_R	0.643	0.87
168_V	175_R	0.643	0.87
101_R	135_L	0.642	0.87
24_N	28_V	0.637	0.86
257_V	275_N	0.636	0.86
109_Q	113_D	0.636	0.86
52_K	56_R	0.636	0.86
119_L	130_G	0.635	0.86
15_R	245_A	0.634	0.86
139_E	163_G	0.634	0.86
252_D	259_E	0.631	0.86
258_V	288_R	0.627	0.86
56_R	78_N	0.625	0.85
28_V	31_S	0.623	0.85
112_L	116_K	0.622	0.85
63_L	73_T	0.621	0.85
106_D	110_D	0.620	0.85
253_H	256_R	0.620	0.85
100_V	134_L	0.619	0.85
137_A	230_S	0.615	0.84
208_A	232_I	0.612	0.84
26_A	34_Y	0.612	0.84
115_E	134_L	0.611	0.84
29_S	33_I	0.611	0.84
182_L	226_F	0.611	0.84
145_T	184_F	0.611	0.84
102_L	134_L	0.608	0.84
50_R	268_G	0.607	0.84
232_I	278_M	0.606	0.84
62_A	66_P	0.601	0.83
22_G	28_V	0.599	0.83
208_A	235_R	0.599	0.83
59_V	97_A	0.599	0.83
187_C	224_L	0.597	0.83
19_F	40_M	0.596	0.83
17_M	228_G	0.594	0.82
282_P	285_D	0.593	0.82
20_V	27_M	0.591	0.82
133_G	156_R	0.587	0.82
80_L	110_D	0.586	0.81
272_V	281_G	0.583	0.81
162_L	200_A	0.583	0.81
132_T	156_R	0.582	0.81
271_V	278_M	0.582	0.81
175_R	181_E	0.582	0.81
233_N	278_M	0.580	0.81
63_L	75_V	0.580	0.81
81_D	110_D	0.579	0.81
86_V	113_D	0.577	0.80
36_A	237_I	0.575	0.80
192_A	196_A	0.573	0.80
148_V	192_A	0.573	0.80
106_D	140_S	0.570	0.80
203_T	230_S	0.569	0.80
159_G	165_E	0.567	0.79
272_V	279_V	0.567	0.79
91_A	94_R	0.566	0.79
186_R	226_F	0.566	0.79
242_N	245_A	0.565	0.79
138_I	143_G	0.563	0.79
151_A	192_A	0.563	0.79
22_G	60_Y	0.562	0.79
119_L	131_S	0.562	0.79
87_N	91_A	0.562	0.79
92_V	97_A	0.561	0.79
99_V	159_G	0.561	0.79
44_E	163_G	0.561	0.79
149_E	152_H	0.560	0.79
205_Y	214_F	0.557	0.78
45_D	166_D	0.557	0.78
142_L	196_A	0.556	0.78
60_Y	94_R	0.556	0.78
177_P	210_N	0.555	0.78
269_L	272_V	0.555	0.78
32_F	66_P	0.554	0.78
270_G	280_D	0.554	0.78
289_L	292_S	0.553	0.78
101_R	137_A	0.553	0.78
15_R	237_I	0.550	0.77
173_T	190_L	0.549	0.77
50_R	53_D	0.549	0.77
16_S	231_L	0.547	0.77
207_D	213_G	0.547	0.77
19_F	101_R	0.546	0.77
111_V	114_I	0.544	0.77
162_L	186_R	0.544	0.77
219_A	243_L	0.544	0.77
174_E	286_R	0.540	0.76
204_V	217_E	0.539	0.76
173_T	185_A	0.538	0.76
204_V	283_V	0.533	0.75
41_F	73_T	0.533	0.75
208_A	236_Q	0.532	0.75
211_E	236_Q	0.532	0.75
190_L	194_R	0.530	0.75
174_E	222_K	0.529	0.75
63_L	97_A	0.528	0.74
165_E	169_R	0.528	0.74
111_V	134_L	0.525	0.74
51_E	58_M	0.524	0.74
255_R	294_A	0.523	0.74
157_L	198_I	0.518	0.73
92_V	100_V	0.518	0.73
229_K	244_Y	0.518	0.73
188_S	192_A	0.517	0.73
248_Q	255_R	0.515	0.73
104_K	140_S	0.515	0.73
111_V	153_A	0.513	0.72
197_G	262_E	0.513	0.72
77_V	86_V	0.512	0.72
256_R	259_E	0.512	0.72
250_E	253_H	0.511	0.72
253_H	286_R	0.508	0.72
260_A	274_L	0.507	0.71
216_Q	219_A	0.503	0.71
63_L	95_G	0.502	0.71
74_I	135_L	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l80A	5	0.9801	100	0.245	Contact Map
4l9zA	5	0.9735	100	0.245	Contact Map
4roqA	5	0.9801	100	0.246	Contact Map
1sgjA	3	0.7517	100	0.261	Contact Map
3oyzA	5	0.957	100	0.261	Contact Map
3qqwA	3	0.8841	100	0.265	Contact Map
1u5hA	3	0.7219	100	0.279	Contact Map
3r4iA	5	0.947	100	0.279	Contact Map
3qllA	3	0.7053	100	0.295	Contact Map
3cuxA	1	0.9636	100	0.326	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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