GREMLIN Database
CITE - Citrate lyase subunit beta
UniProt: P0A9I1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13542
Length: 302 (270)
Sequences: 3790 (2516)
Seq/√Len: 153.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_R275_N4.3081.00
231_L240_L4.2031.00
205_Y213_G4.1041.00
215_L242_N4.0981.00
74_I99_V3.7121.00
22_G59_V3.5661.00
253_H257_V3.0841.00
51_E54_T3.0261.00
215_L219_A2.8601.00
141_P170_N2.7001.00
184_F188_S2.6911.00
146_R149_E2.6801.00
151_A160_I2.6641.00
209_N235_R2.4941.00
16_S241_H2.4431.00
56_R88_D2.4081.00
77_V85_G2.2631.00
217_E229_K2.1471.00
258_V291_L2.1431.00
14_R72_E2.1121.00
145_T188_S2.0911.00
74_I101_R2.0811.00
281_G285_D2.0741.00
136_A157_L2.0531.00
214_F240_L2.0431.00
256_R274_L2.0091.00
162_L167_Y1.9961.00
285_D288_R1.9751.00
247_T250_E1.9581.00
262_E288_R1.9231.00
238_D242_N1.9131.00
208_A273_S1.9051.00
106_D142_L1.8991.00
102_L114_I1.8631.00
57_R61_H1.8501.00
23_A51_E1.8471.00
167_Y171_L1.8441.00
115_E119_L1.8441.00
248_Q252_D1.8181.00
41_F59_V1.7941.00
257_V274_L1.7871.00
222_K250_E1.7721.00
218_A243_L1.7271.00
87_N90_E1.6881.00
115_E156_R1.6751.00
107_T110_D1.6731.00
112_L153_A1.6631.00
202_D229_K1.6541.00
133_G158_I1.6261.00
274_L279_V1.6141.00
23_A48_A1.5811.00
109_Q112_L1.5451.00
164_A203_T1.5431.00
251_V290_V1.5431.00
145_T195_S1.5341.00
252_D256_R1.5161.00
255_R295_E1.5121.00
35_P71_I1.5011.00
147_A192_A1.4581.00
161_A230_S1.4551.00
17_M38_A1.4481.00
207_D210_N1.4461.00
79_A82_S1.4221.00
53_D87_N1.4221.00
165_E206_S1.4171.00
80_L85_G1.4161.00
25_A58_M1.3911.00
49_L84_W1.3871.00
212_A215_L1.3871.00
17_M201_F1.3821.00
19_F230_S1.3701.00
24_N27_M1.3621.00
105_T150_I1.3451.00
111_V136_A1.3341.00
75_V92_V1.3251.00
289_L293_R1.3241.00
255_R259_E1.3061.00
138_I147_A1.3031.00
214_F239_L1.2991.00
209_N273_S1.2931.00
86_V117_E1.2901.00
54_T58_M1.2851.00
84_W87_N1.2701.00
15_R241_H1.2671.00
174_E223_Q1.2561.00
218_A229_K1.2541.00
215_L243_L1.2421.00
148_V188_S1.2401.00
183_L187_C1.2341.00
221_I244_Y1.2311.00
142_L146_R1.2181.00
148_V195_S1.1891.00
253_H290_V1.1801.00
169_R285_D1.1771.00
145_T148_V1.1741.00
143_G147_A1.1641.00
17_M40_M1.1641.00
288_R292_S1.1621.00
101_R161_A1.1601.00
144_I185_A1.1541.00
138_I144_I1.1531.00
38_A74_I1.1471.00
135_L161_A1.1451.00
284_I288_R1.1451.00
211_E215_L1.1441.00
136_A150_I1.1160.99
118_I134_L1.0940.99
165_E282_P1.0920.99
186_R202_D1.0880.99
108_A149_E1.0810.99
28_V41_F1.0760.99
251_V291_L1.0690.99
59_V75_V1.0690.99
86_V90_E1.0650.99
60_Y91_A1.0610.99
200_A227_D1.0560.99
61_H65_H1.0560.99
183_L224_L1.0370.99
147_A151_A1.0350.99
281_G288_R1.0330.99
261_A284_I1.0260.99
45_D104_K1.0240.99
210_N213_G1.0160.99
174_E250_E1.0110.99
205_Y217_E1.0010.99
239_L243_L0.9930.99
201_F230_S0.9920.99
253_H277_K0.9770.99
82_S85_G0.9730.99
259_E262_E0.9720.99
253_H275_N0.9720.99
28_V62_A0.9720.99
100_V118_I0.9710.99
53_D57_R0.9700.99
262_E266_R0.9670.99
206_S278_M0.9560.98
184_F187_C0.9530.98
211_E235_R0.9520.98
194_R227_D0.9520.98
189_I200_A0.9470.98
172_R289_L0.9450.98
97_A132_T0.9420.98
167_Y191_Q0.9300.98
32_F62_A0.9300.98
142_L152_H0.9290.98
193_A200_A0.9210.98
271_V280_D0.9200.98
251_V294_A0.9200.98
118_I132_T0.9190.98
94_R97_A0.9190.98
214_F218_A0.9190.98
54_T57_R0.9140.98
148_V152_H0.9120.98
165_E283_V0.9020.98
246_P251_V0.8960.98
214_F236_Q0.8960.98
212_A216_Q0.8920.98
29_S32_F0.8880.97
108_A112_L0.8830.97
107_T146_R0.8830.97
34_Y237_I0.8800.97
108_A153_A0.8800.97
190_L226_F0.8790.97
258_V261_A0.8780.97
160_I193_A0.8770.97
19_F204_V0.8740.97
218_A244_Y0.8730.97
184_F191_Q0.8730.97
85_G114_I0.8610.97
159_G193_A0.8610.97
183_L220_H0.8580.97
216_Q220_H0.8570.97
168_V182_L0.8570.97
47_V55_A0.8550.97
93_V132_T0.8550.97
110_D113_D0.8530.97
139_E166_D0.8510.97
249_K252_D0.8500.97
215_L239_L0.8500.97
119_L156_R0.8460.97
60_Y64_Q0.8430.97
25_A28_V0.8380.96
30_N33_I0.8370.96
107_T150_I0.8360.96
89_L114_I0.8360.96
180_T220_H0.8330.96
144_I191_Q0.8320.96
29_S65_H0.8300.96
161_A228_G0.8290.96
162_L185_A0.8240.96
35_P238_D0.8210.96
138_I150_I0.8200.96
44_E104_K0.8190.96
180_T183_L0.8190.96
93_V118_I0.8170.96
14_R38_A0.8160.96
202_D221_I0.8010.95
176_S181_E0.7940.95
207_D277_K0.7940.95
90_E117_E0.7940.95
72_E98_D0.7910.95
135_L159_G0.7890.95
205_Y236_Q0.7860.95
188_S191_Q0.7770.95
205_Y229_K0.7740.94
288_R295_E0.7690.94
58_M61_H0.7690.94
170_N194_R0.7670.94
292_S295_E0.7660.94
168_V173_T0.7660.94
77_V102_L0.7630.94
251_V255_R0.7630.94
165_E278_M0.7610.94
167_Y185_A0.7590.94
81_D85_G0.7590.94
144_I147_A0.7580.94
152_H196_A0.7580.94
52_K78_N0.7570.94
75_V91_A0.7570.94
144_I167_Y0.7560.94
17_M74_I0.7560.94
158_I199_Q0.7540.94
89_L100_V0.7490.93
77_V114_I0.7490.93
20_V39_L0.7470.93
44_E166_D0.7450.93
200_A280_D0.7440.93
282_P286_R0.7410.93
159_G201_F0.7390.93
255_R291_L0.7380.93
140_S170_N0.7360.93
26_A29_S0.7330.93
237_I241_H0.7320.93
67_L98_D0.7290.92
153_A156_R0.7290.92
40_M101_R0.7240.92
102_L105_T0.7230.92
176_S223_Q0.7200.92
135_L201_F0.7190.92
218_A240_L0.7180.92
31_S41_F0.7150.92
32_F73_T0.7140.92
44_E139_E0.7140.92
201_F228_G0.7140.92
28_V58_M0.7130.92
273_S276_G0.7120.92
102_L111_V0.7030.91
252_D255_R0.7030.91
14_R17_M0.7010.91
187_C190_L0.7000.91
261_A272_V0.6970.91
100_V132_T0.6960.91
280_D283_V0.6950.91
114_I134_L0.6950.91
138_I189_I0.6950.91
142_L195_S0.6930.90
52_K84_W0.6910.90
108_A146_R0.6900.90
35_P237_I0.6900.90
25_A29_S0.6890.90
202_D217_E0.6890.90
17_M135_L0.6860.90
88_D92_V0.6850.90
48_A51_E0.6850.90
15_R37_D0.6810.90
291_L295_E0.6790.90
141_P171_L0.6770.89
211_E239_L0.6760.89
147_A188_S0.6750.89
222_K243_L0.6740.89
162_L189_I0.6740.89
47_V52_K0.6710.89
219_A223_Q0.6690.89
21_P233_N0.6690.89
141_P195_S0.6650.89
14_R199_Q0.6630.88
178_E223_Q0.6630.88
106_D143_G0.6620.88
165_E280_D0.6620.88
218_A222_K0.6620.88
163_G166_D0.6560.88
199_Q227_D0.6560.88
286_R290_V0.6530.88
113_D116_K0.6500.87
253_H274_L0.6460.87
19_F164_A0.6450.87
258_V262_E0.6440.87
146_R150_I0.6440.87
175_R286_R0.6430.87
168_V175_R0.6430.87
101_R135_L0.6420.87
24_N28_V0.6370.86
257_V275_N0.6360.86
109_Q113_D0.6360.86
52_K56_R0.6360.86
119_L130_G0.6350.86
15_R245_A0.6340.86
139_E163_G0.6340.86
252_D259_E0.6310.86
258_V288_R0.6270.86
56_R78_N0.6250.85
28_V31_S0.6230.85
112_L116_K0.6220.85
63_L73_T0.6210.85
106_D110_D0.6200.85
253_H256_R0.6200.85
100_V134_L0.6190.85
137_A230_S0.6150.84
208_A232_I0.6120.84
26_A34_Y0.6120.84
115_E134_L0.6110.84
29_S33_I0.6110.84
182_L226_F0.6110.84
145_T184_F0.6110.84
102_L134_L0.6080.84
50_R268_G0.6070.84
232_I278_M0.6060.84
62_A66_P0.6010.83
22_G28_V0.5990.83
208_A235_R0.5990.83
59_V97_A0.5990.83
187_C224_L0.5970.83
19_F40_M0.5960.83
17_M228_G0.5940.82
282_P285_D0.5930.82
20_V27_M0.5910.82
133_G156_R0.5870.82
80_L110_D0.5860.81
272_V281_G0.5830.81
162_L200_A0.5830.81
132_T156_R0.5820.81
271_V278_M0.5820.81
175_R181_E0.5820.81
233_N278_M0.5800.81
63_L75_V0.5800.81
81_D110_D0.5790.81
86_V113_D0.5770.80
36_A237_I0.5750.80
192_A196_A0.5730.80
148_V192_A0.5730.80
106_D140_S0.5700.80
203_T230_S0.5690.80
159_G165_E0.5670.79
272_V279_V0.5670.79
91_A94_R0.5660.79
186_R226_F0.5660.79
242_N245_A0.5650.79
138_I143_G0.5630.79
151_A192_A0.5630.79
22_G60_Y0.5620.79
119_L131_S0.5620.79
87_N91_A0.5620.79
92_V97_A0.5610.79
99_V159_G0.5610.79
44_E163_G0.5610.79
149_E152_H0.5600.79
205_Y214_F0.5570.78
45_D166_D0.5570.78
142_L196_A0.5560.78
60_Y94_R0.5560.78
177_P210_N0.5550.78
269_L272_V0.5550.78
32_F66_P0.5540.78
270_G280_D0.5540.78
289_L292_S0.5530.78
101_R137_A0.5530.78
15_R237_I0.5500.77
173_T190_L0.5490.77
50_R53_D0.5490.77
16_S231_L0.5470.77
207_D213_G0.5470.77
19_F101_R0.5460.77
111_V114_I0.5440.77
162_L186_R0.5440.77
219_A243_L0.5440.77
174_E286_R0.5400.76
204_V217_E0.5390.76
173_T185_A0.5380.76
204_V283_V0.5330.75
41_F73_T0.5330.75
208_A236_Q0.5320.75
211_E236_Q0.5320.75
190_L194_R0.5300.75
174_E222_K0.5290.75
63_L97_A0.5280.74
165_E169_R0.5280.74
111_V134_L0.5250.74
51_E58_M0.5240.74
255_R294_A0.5230.74
157_L198_I0.5180.73
92_V100_V0.5180.73
229_K244_Y0.5180.73
188_S192_A0.5170.73
248_Q255_R0.5150.73
104_K140_S0.5150.73
111_V153_A0.5130.72
197_G262_E0.5130.72
77_V86_V0.5120.72
256_R259_E0.5120.72
250_E253_H0.5110.72
253_H286_R0.5080.72
260_A274_L0.5070.71
216_Q219_A0.5030.71
63_L95_G0.5020.71
74_I135_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l80A 5 0.9801 100 0.245 Contact Map
4l9zA 5 0.9735 100 0.245 Contact Map
4roqA 5 0.9801 100 0.246 Contact Map
1sgjA 3 0.7517 100 0.261 Contact Map
3oyzA 5 0.957 100 0.261 Contact Map
3qqwA 3 0.8841 100 0.265 Contact Map
1u5hA 3 0.7219 100 0.279 Contact Map
3r4iA 5 0.947 100 0.279 Contact Map
3qllA 3 0.7053 100 0.295 Contact Map
3cuxA 1 0.9636 100 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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